{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T01:40:02Z","timestamp":1790732402513,"version":"4.1.0"},"reference-count":89,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2022,2,1]],"date-time":"2022-02-01T00:00:00Z","timestamp":1643673600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,2,1]],"date-time":"2022-02-01T00:00:00Z","timestamp":1643673600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,2,1]],"date-time":"2022-02-01T00:00:00Z","timestamp":1643673600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2022,2,1]],"date-time":"2022-02-01T00:00:00Z","timestamp":1643673600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2022,2,1]],"date-time":"2022-02-01T00:00:00Z","timestamp":1643673600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2022,2,1]],"date-time":"2022-02-01T00:00:00Z","timestamp":1643673600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2022,2,1]],"date-time":"2022-02-01T00:00:00Z","timestamp":1643673600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100004686","name":"Deanship of Scientific Research, King Faisal University","doi-asserted-by":"publisher","award":["GRP-150- 41"],"award-info":[{"award-number":["GRP-150- 41"]}],"id":[{"id":"10.13039\/501100004686","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Bioorganic Chemistry"],"published-print":{"date-parts":[[2022,2]]},"DOI":"10.1016\/j.bioorg.2021.105571","type":"journal-article","created":{"date-parts":[[2021,12,20]],"date-time":"2021-12-20T20:09:29Z","timestamp":1640030969000},"page":"105571","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":81,"special_numbering":"C","title":["Development of novel indolin-2-one derivative incorporating thiazole moiety as DHFR and quorum sensing inhibitors: Synthesis, antimicrobial, and antibiofilm activities with molecular modelling study"],"prefix":"10.1016","volume":"119","author":[{"given":"Abdullah Y.","family":"Alzahrani","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yousry A.","family":"Ammar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammed","family":"Abu-Elghait","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohamed A.","family":"Salem","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammed A.","family":"Assiri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tarik E.","family":"Ali","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ahmed","family":"Ragab","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bioorg.2021.105571_b0005","doi-asserted-by":"crossref","first-page":"127569","DOI":"10.1016\/j.molstruc.2019.127569","article-title":"Investigation of photophysical behaviours and antimicrobial activity of novel benzo-15-crown-5 substituted coumarin and chromone derivatives","volume":"1204","author":"\u015eahin G\u00fcl","year":"2020","journal-title":"J. Mol. Struct."},{"key":"10.1016\/j.bioorg.2021.105571_b0010","doi-asserted-by":"crossref","first-page":"100503","DOI":"10.1016\/j.cdc.2020.100503","article-title":"Microwave assisted synthesis and biological activity of a novel Triazino indole-Coumarin hybrid: Crystal structure, Hirshfeld surface analysis and DFT calculations","volume":"29","author":"Mangasuli","year":"2020","journal-title":"Chem. Data Collect."},{"key":"10.1016\/j.bioorg.2021.105571_b0015","first-page":"1","article-title":"Antimicrobial Resistance in ESKAPE Pathogens","volume":"33","author":"De Oliveira","year":"2021","journal-title":"Clin. Microbiol. Rev."},{"key":"10.1016\/j.bioorg.2021.105571_b0020","doi-asserted-by":"crossref","first-page":"497","DOI":"10.3390\/pathogens9060497","article-title":"Transmission of Antibiotic Resistant Bacteria and Genes: Unveiling the Jigsaw Pieces of a One Health Problem","volume":"9","author":"Novais","year":"2020","journal-title":"Pathog."},{"key":"10.1016\/j.bioorg.2021.105571_b0025","doi-asserted-by":"crossref","first-page":"2240","DOI":"10.3389\/fmicb.2019.02240","article-title":"Crisis of Antimicrobial Resistance in China: Now and the Future","volume":"10","author":"Qu","year":"2019","journal-title":"Front. Microbiol."},{"issue":"5","key":"10.1016\/j.bioorg.2021.105571_b0030","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1038\/s41579-020-0348-5","article-title":"Resisting antimicrobial resistance","volume":"18","author":"Nathan","year":"2020","journal-title":"Nat. Rev. Microbiol."},{"issue":"4","key":"10.1016\/j.bioorg.2021.105571_b0035","doi-asserted-by":"crossref","first-page":"e51","DOI":"10.1016\/S1473-3099(20)30003-7","article-title":"The Lancet Infectious Diseases Commission on antimicrobial resistance: 6 years later","volume":"20","author":"Laxminarayan","year":"2020","journal-title":"Lancet Infect. Dis."},{"key":"10.1016\/j.bioorg.2021.105571_b0040","doi-asserted-by":"crossref","first-page":"113696","DOI":"10.1016\/j.ejmech.2021.113696","article-title":"Discovery of metal-based complexes as promising antimicrobial agents","volume":"224","author":"Liang","year":"2021","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.bioorg.2021.105571_b0045","doi-asserted-by":"crossref","first-page":"322","DOI":"10.3390\/pharmaceutics11070322","article-title":"Biofilms: Novel Strategies Based on Antimicrobial Peptides","volume":"11","author":"Galdiero","year":"2019","journal-title":"Pharmaceutics."},{"issue":"11","key":"10.1016\/j.bioorg.2021.105571_b0050","doi-asserted-by":"crossref","first-page":"915","DOI":"10.1016\/j.tim.2019.07.004","article-title":"Nanoparticle-Biofilm Interactions: The Role of the EPS Matrix","volume":"27","author":"Fulaz","year":"2019","journal-title":"Trends Microbiol."},{"key":"10.1016\/j.bioorg.2021.105571_b0055","doi-asserted-by":"crossref","unstructured":"N. Talebian, H. Sadeghi Haddad Zavvare, Enhanced bactericidal action of SnO2 nanostructures having different morphologies under visible light: Influence of surfactant, J. Photochem. Photobiol. B Biol. 130 (2014) 132\u2013139. doi: 10.1016\/j.jphotobiol.2013.10.018.","DOI":"10.1016\/j.jphotobiol.2013.10.018"},{"issue":"5","key":"10.1016\/j.bioorg.2021.105571_b0060","doi-asserted-by":"crossref","first-page":"1044","DOI":"10.1016\/j.bbamem.2015.10.013","article-title":"Antimicrobial peptides and their interaction with biofilms of medically relevant bacteria","volume":"1858","author":"Batoni","year":"2016","journal-title":"Biochim. Biophys. Acta - Biomembr."},{"key":"10.1016\/j.bioorg.2021.105571_b0065","unstructured":"A. Beatriz, M. Mitrzyk, E.A.L. Wojciechowski, B. Id, Anti-infective Agents, in: Pharmacother. Adv. Nurs. Pract., 2019: 1\u2013124. http:\/\/samples.jblearning.com\/ 9781284154290\/Chapter_2.pdf."},{"key":"10.1016\/j.bioorg.2021.105571_b0070","doi-asserted-by":"crossref","first-page":"103781","DOI":"10.1016\/j.bioorg.2020.103781","article-title":"The rational design, synthesis, and antimicrobial investigation of 2-Amino-4-Methylthiazole analogues inhibitors of GlcN-6-P synthase","volume":"99","author":"Omar","year":"2020","journal-title":"Bioorg. Chem."},{"issue":"9","key":"10.1016\/j.bioorg.2021.105571_b0075","doi-asserted-by":"crossref","first-page":"6979","DOI":"10.1128\/JVI.72.9.6979-6987.1998","article-title":"Inhibition of Herpes Simplex Virus Replication by a 2-Amino Thiazole via Interactions with the Helicase Component of the UL5-UL8-UL52 Complex","volume":"72","author":"Spector","year":"1998","journal-title":"J. Virol."},{"issue":"2","key":"10.1016\/j.bioorg.2021.105571_b0080","doi-asserted-by":"crossref","first-page":"651","DOI":"10.1016\/j.ejmech.2009.11.008","article-title":"Synthesis, anti-bacterial and anti-fungal activities of some novel Schiff bases containing 2,4-disubstituted thiazole ring","volume":"45","author":"Bharti","year":"2010","journal-title":"Eur. J. Med. Chem."},{"issue":"15","key":"10.1016\/j.bioorg.2021.105571_b0085","doi-asserted-by":"crossref","first-page":"3268","DOI":"10.1016\/j.bmcl.2014.06.010","article-title":"Discovery of acylurea isosteres of 2-acylaminothiadiazole in the azaxanthene series of glucocorticoid receptor agonists","volume":"24","author":"Gong","year":"2014","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"10.1016\/j.bioorg.2021.105571_b0090","doi-asserted-by":"crossref","first-page":"7713","DOI":"10.1021\/jm201108k","volume":"54","author":"Gonz\u00e1lez Cabrera","year":"2011","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.bioorg.2021.105571_b0095","doi-asserted-by":"crossref","unstructured":"F.W. Bell, A.S. Cantrell, M. Hoegberg, S.R. Jaskunas, N.G. Johansson, C.L. Jordan, M.D. Kinnick, P. Lind, J.M. Morin, Phenethylthiazolethiourea (PETT) Compounds, a New Class of HIV-1 Reverse Transcriptase Inhibitors. 1. Synthesis and Basic Structure-Activity Relationship Studies of PETT Analogs, J. Med. Chem. 38 (1995) 4929\u20134936. https:\/\/doi.org\/10.1021\/jm00025a010.","DOI":"10.1021\/jm00025a010"},{"key":"10.1016\/j.bioorg.2021.105571_b0100","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1016\/j.biopha.2016.05.038","article-title":"Antitumor and immunomodulatory activities of thiosemicarbazones and 1,3-Thiazoles in Jurkat and HT-29 cells","volume":"82","author":"dos Santos","year":"2016","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.bioorg.2021.105571_b0105","doi-asserted-by":"crossref","first-page":"253","DOI":"10.17311\/sciintl.2013.253.260","article-title":"A Review on Biological Activity of Imidazole and Thiazole Moieties and their Derivatives","volume":"1","author":"Gupta","year":"2013","journal-title":"Sci. Int."},{"key":"10.1016\/j.bioorg.2021.105571_b0110","first-page":"44","article-title":"Synthesis and in vitro antimicrobial activity of some new 1-thiazolyl-2-pyrazoline derivatives","volume":"1","author":"Dawane","year":"2010","journal-title":"Synthesis (Stuttg)."},{"key":"10.1016\/j.bioorg.2021.105571_b0115","doi-asserted-by":"crossref","first-page":"44","DOI":"10.3390\/molecules26030624","article-title":"An Overview of the Synthesis and Antimicrobial, Antiprotozoal, and Antitumor Activity of Thiazole and Bisthiazole Derivatives","volume":"26","author":"Borcea","year":"2021","journal-title":"Molecules."},{"key":"10.1016\/j.bioorg.2021.105571_b0120","doi-asserted-by":"crossref","first-page":"699","DOI":"10.1016\/j.ejmech.2015.04.015","article-title":"Recent applications of 1,3-thiazole core structure in the identification of new lead compounds and drug discovery","volume":"97","author":"Ayati","year":"2015","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.bioorg.2021.105571_b0125","first-page":"2741","article-title":"New classification and update on the quinolone antibiotics","volume":"61","author":"King","year":"2000","journal-title":"Am. Fam. Physician."},{"issue":"9","key":"10.1016\/j.bioorg.2021.105571_b0130","doi-asserted-by":"crossref","first-page":"1159","DOI":"10.1089\/mdr.2020.0301","article-title":"Does Fluoroquinolones and Third-Generation Cephalosporins Restriction Reverse Extended-Spectrum \u03b2-Lactamases Klebsiella pneumoniae Resistance Rates?","volume":"27","author":"Stani\u0107 Beni\u0107","year":"2021","journal-title":"Microb. Drug Resist."},{"key":"10.1016\/j.bioorg.2021.105571_b0135","doi-asserted-by":"crossref","first-page":"25","DOI":"10.21608\/absb.2018.33767","article-title":"Synthesis, spectral characterization and pharmacological evaluation of novel thiazole-oxoindole hybrid compounds as potential anticancer agents","volume":"29","author":"Ammar","year":"2018","journal-title":"Al-Azhar Bull. Sci."},{"key":"10.1016\/j.bioorg.2021.105571_b0140","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1016\/j.bioorg.2019.01.016","article-title":"Design, synthesis, molecular docking and biological activity evaluation of some novel indole derivatives as potent anticancer active agents and apoptosis inducers","volume":"85","author":"El-sharief","year":"2019","journal-title":"Bioorg. Chem."},{"key":"10.1016\/j.bioorg.2021.105571_b0145","first-page":"6170","article-title":"A Novel cdk2-selective Inhibitor, SU9516, Induces Apoptosis in Colon Carcinoma Cells","volume":"61","author":"Lane","year":"2001","journal-title":"Cancer Res."},{"key":"10.1016\/j.bioorg.2021.105571_b0150","doi-asserted-by":"crossref","first-page":"119669","DOI":"10.1016\/j.saa.2021.119669","article-title":"5-Substituted isatin thiosemicarbazones as inhibitors of tyrosinase: Insights of substituent effects, Spectrochim","volume":"255","author":"Cheng","year":"2021","journal-title":"Acta Part A Mol. Biomol. Spectrosc."},{"issue":"1","key":"10.1016\/j.bioorg.2021.105571_b0155","doi-asserted-by":"crossref","first-page":"e05756","DOI":"10.1016\/j.heliyon.2020.e05756","article-title":"Tryptanthrin from microwave-assisted reduction of isatin using solid-state-supported sodium borohydride: DFT calculations, molecular docking and evaluation of its analgesic and anti-inflammatory activity","volume":"7","author":"Obafemi","year":"2021","journal-title":"Heliyon."},{"issue":"12","key":"10.1016\/j.bioorg.2021.105571_b0160","doi-asserted-by":"crossref","first-page":"3058","DOI":"10.1016\/j.bmcl.2005.04.027","article-title":"Synthesis and evaluation of isatin derivatives as effective SARS coronavirus 3CL protease inhibitors","volume":"15","author":"Chen","year":"2005","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"10.1016\/j.bioorg.2021.105571_b0165","first-page":"1","article-title":"Determination of potential inhibitors based on isatin derivatives against SARS-CoV-2 main protease (mpro): a molecular docking, molecular dynamics and structure-activity relationship studies","author":"Badavath","year":"2020","journal-title":"J. Biomol. Struct. Dyn."},{"key":"10.1016\/j.bioorg.2021.105571_b0170","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1016\/j.ejmech.2015.12.050","article-title":"Synthesis and anti-cancer activity evaluation of 5-(2-carboxyethenyl)-isatin derivatives","volume":"112","author":"Teng","year":"2016","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.bioorg.2021.105571_b0175","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejmech.2019.111977","article-title":"One-pot synthesis and molecular docking of some new spiropyranindol-2-one derivatives as immunomodulatory agents and in vitro antimicrobial potential with DNA gyrase inhibitor","volume":"188","author":"Salem","year":"2020","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.bioorg.2021.105571_b0180","doi-asserted-by":"crossref","first-page":"4451","DOI":"10.1016\/j.bmcl.2005.07.046","article-title":"Synthesis and evaluation of anti-HIV activity of isatin beta-thiosemicarbazone derivatives","volume":"15","author":"Bal","year":"2005","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"10.1016\/j.bioorg.2021.105571_b0185","series-title":"Contemporary heterocyclic chemistry: syntheses, reactions and applications","author":"Paudler","year":"1982"},{"issue":"7","key":"10.1016\/j.bioorg.2021.105571_b0190","doi-asserted-by":"crossref","first-page":"785","DOI":"10.1016\/j.cclet.2012.05.004","article-title":"Design, synthesis and in vitro evaluation of tetrahydropyrimidine\u2013isatin hybrids as potential antitubercular and antimalarial agents","volume":"23","author":"Akhaja","year":"2012","journal-title":"Chinese Chem. Lett."},{"key":"10.1016\/j.bioorg.2021.105571_b0195","doi-asserted-by":"crossref","first-page":"105300","DOI":"10.1016\/j.bioorg.2021.105300","article-title":"In Vivo Screening and Toxicity Studies of Indolinone Incorporated Thiosemicarbazone, Thiazole and Piperidinosulfonyl Moieties as Anticonvulsant Agents","volume":"116","author":"Fayed","year":"2021","journal-title":"Bioorg. Chem."},{"issue":"11","key":"10.1016\/j.bioorg.2021.105571_b0200","doi-asserted-by":"crossref","first-page":"6104","DOI":"10.1021\/cr300135y","article-title":"Isatins As Privileged Molecules in Design and Synthesis of Spiro-Fused Cyclic Frameworks","volume":"112","author":"Singh","year":"2012","journal-title":"Chem. Rev."},{"issue":"3","key":"10.1016\/j.bioorg.2021.105571_b0205","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1002\/jhet.1114","article-title":"Recent Progress on Routes to Spirooxindole Systems Derived from Isatin","volume":"51","author":"Xia","year":"2014","journal-title":"J. Heterocycl. Chem."},{"key":"10.1016\/j.bioorg.2021.105571_b0210","doi-asserted-by":"crossref","first-page":"103619","DOI":"10.1016\/j.bioorg.2020.103619","article-title":"Design, synthesis, in vitro antimicrobial evaluation and molecular docking studies of indol-2-one tagged with morpholinosulfonyl moiety as DNA gyrase inhibitors","volume":"96","author":"Salem","year":"2020","journal-title":"Bioorg. Chem."},{"key":"10.1016\/j.bioorg.2021.105571_b0215","doi-asserted-by":"crossref","first-page":"5165","DOI":"10.1039\/c2ob25184a","article-title":"Strategies for the enantioselective synthesis of spirooxindoles","volume":"10","author":"Ball-Jones","year":"2012","journal-title":"Org. Biomol. Chem."},{"issue":"7","key":"10.1016\/j.bioorg.2021.105571_b0220","doi-asserted-by":"crossref","first-page":"1077","DOI":"10.1007\/s12272-011-0705-z","article-title":"Synthesis of mono, bis-2-(2-arylideneaminophenyl) indole azomethines as potential antimicrobial agents","volume":"34","author":"Rohini","year":"2011","journal-title":"Arch. Pharm. Res."},{"key":"10.1016\/j.bioorg.2021.105571_b0225","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1016\/j.bioorg.2017.01.006","article-title":"Dihydropyrimidinone-isatin hybrids as novel non-nucleoside HIV-1 reverse transcriptase inhibitors","volume":"70","author":"Devale","year":"2017","journal-title":"Bioorg. Chem."},{"issue":"1","key":"10.1016\/j.bioorg.2021.105571_b0230","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1016\/j.bmc.2010.11.028","article-title":"Inhibition of monoamine oxidase by selected C5- and C6-substituted isatin analogues","volume":"19","author":"Manley-King","year":"2011","journal-title":"Bioorg. Med. Chem."},{"key":"10.1016\/j.bioorg.2021.105571_b0235","doi-asserted-by":"crossref","first-page":"128030","DOI":"10.1016\/j.bmcl.2021.128030","article-title":"Isatin-derived azoles as new potential antimicrobial agents: Design, synthesis and biological evaluation","volume":"41","author":"Tangadanchu","year":"2021","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"10.1016\/j.bioorg.2021.105571_b0240","doi-asserted-by":"crossref","first-page":"103841","DOI":"10.1016\/j.bioorg.2020.103841","article-title":"Antimicrobial evaluation of thiadiazino and thiazolo quinoxaline hybrids as potential DNA gyrase inhibitors; design, synthesis, characterization and morphological studies","volume":"99","author":"Ammar","year":"2020","journal-title":"Bioorg. Chem."},{"key":"10.1016\/j.bioorg.2021.105571_b0245","doi-asserted-by":"crossref","first-page":"104164","DOI":"10.1016\/j.bioorg.2020.104164","article-title":"Design, synthesis, antimicrobial activity and molecular docking studies of some novel di-substituted sulfonylquinoxaline derivatives","volume":"104","author":"Ammar","year":"2020","journal-title":"Bioorg. Chem."},{"key":"10.1016\/j.bioorg.2021.105571_b0250","doi-asserted-by":"crossref","first-page":"131314","DOI":"10.1016\/j.molstruc.2021.131314","article-title":"Experimental and theoretical investigation for 6-Morpholinosulfonylquinoxalin-2(1H)-one and its haydrazone derivate: synthesis, characterization, tautomerization and antimicrobial evaluation","volume":"1247","author":"Elsisi","year":"2022","journal-title":"J. Mol. Struct."},{"key":"10.1016\/j.bioorg.2021.105571_b0255","doi-asserted-by":"crossref","first-page":"113486","DOI":"10.1016\/j.ejmech.2021.113486","article-title":"Novel benzenesulfonamides aryl and arylsulfone conjugates adopting tail\/dual tail approaches: Synthesis, carbonic anhydrase inhibitory activity and molecular modeling studies","volume":"221","author":"Eldeeb","year":"2021","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.bioorg.2021.105571_b0260","doi-asserted-by":"crossref","first-page":"104575","DOI":"10.1016\/j.bioorg.2020.104575","article-title":"Novel Schiff base-bridged multi-component sulfonamide imidazole hybrids as potentially highly selective DNA-targeting membrane active repressors against methicillin-resistant Staphylococcus aureus","volume":"107","author":"Hu","year":"2021","journal-title":"Bioorg. Chem."},{"issue":"14","key":"10.1016\/j.bioorg.2021.105571_b0265","doi-asserted-by":"crossref","first-page":"4002","DOI":"10.1021\/acs.jafc.9b00225","article-title":"First Evidence of the Cysteine and Glutathione Conjugates of 3-Sulfanylpentan-1-ol in Hop (Humulus lupulus L.)","volume":"67","author":"Chenot","year":"2019","journal-title":"J. Agric. Food Chem."},{"key":"10.1016\/j.bioorg.2021.105571_b0270","doi-asserted-by":"crossref","first-page":"875","DOI":"10.1515\/znb-2016-0054","article-title":"New 1,3-diaryl-5-thioxo-imidazolidin-2,4-dione derivatives: synthesis, reactions and evaluation of antibacterial and antifungal activities","volume":"71","author":"El-Sharief","year":"2016","journal-title":"Z. Naturforsch."},{"key":"10.1016\/j.bioorg.2021.105571_b0275","doi-asserted-by":"crossref","first-page":"466","DOI":"10.2174\/1570179412666150817221755","article-title":"New Imidazolidineiminothione, Imidazolidin-2-one and Imidazoquinoxaline Derivatives: Synthesis and Evaluation of Antibacterial and Antifungal Activities","volume":"13","author":"Ammar","year":"2016","journal-title":"Curr. Org. Synth."},{"key":"10.1016\/j.bioorg.2021.105571_b0280","doi-asserted-by":"crossref","first-page":"104794","DOI":"10.1016\/j.bioorg.2021.104794","article-title":"Development of adamantane scaffold containing 1,3,4-thiadiazole derivatives: Design, synthesis, anti-proliferative activity and molecular docking study targeting EGFR","volume":"110","author":"Wassel","year":"2021","journal-title":"Bioorg. Chem."},{"key":"10.1016\/j.bioorg.2021.105571_b0285","doi-asserted-by":"crossref","first-page":"2593","DOI":"10.3390\/molecules25112593","article-title":"Discovery of new schiff bases tethered pyrazole moiety: Design, synthesis, biological evaluation, and molecular docking study as dual targeting DHFR\/DNA gyrase inhibitors with immunomodulatory activity","volume":"25","author":"Hassan","year":"2020","journal-title":"Molecules."},{"key":"10.1016\/j.bioorg.2021.105571_b0290","doi-asserted-by":"crossref","first-page":"103951","DOI":"10.1016\/j.bioorg.2020.103951","article-title":"In vitro cytotoxic activity of thiazole-indenoquinoxaline hybrids as apoptotic agents, design, synthesis, physicochemical and pharmacokinetic studies","volume":"100","author":"Fayed","year":"2020","journal-title":"Bioorg. Chem."},{"key":"10.1016\/j.bioorg.2021.105571_b0295","doi-asserted-by":"crossref","first-page":"918","DOI":"10.1016\/j.ejmech.2018.06.061","article-title":"Design, synthesis, antiproliferative activity, molecular docking and cell cycle analysis of some novel (morpholinosulfonyl) isatins with potential EGFR inhibitory activity","volume":"156","author":"Ammar","year":"2018","journal-title":"Eur. J. Med. Chem."},{"issue":"1","key":"10.1016\/j.bioorg.2021.105571_b0300","doi-asserted-by":"crossref","DOI":"10.1186\/s12866-017-0936-3","article-title":"Determination of antibacterial activity and minimum inhibitory concentration of larval extract of fly via resazurin-based turbidometric assay","volume":"17","author":"Teh","year":"2017","journal-title":"BMC Microbiol."},{"key":"10.1016\/j.bioorg.2021.105571_b0305","first-page":"731","article-title":"Determination of some virulence factors in Staphylococcus spp. isolated from clinical samples of different Egyptian patients","volume":"32","author":"Desouky","year":"2014","journal-title":"World Appl Sci J."},{"key":"10.1016\/j.bioorg.2021.105571_b0310","first-page":"217","article-title":"Dihydrofolate reductase as a versatile drug target in healthcare","volume":"7","author":"Rashid","year":"2016","journal-title":"J. Proteins Proteomics."},{"key":"10.1016\/j.bioorg.2021.105571_b0315","doi-asserted-by":"crossref","first-page":"130748","DOI":"10.1016\/j.molstruc.2021.130748","article-title":"One-pot strategy for thiazole tethered 7-ethoxy quinoline hybrids: Synthesis and potential antimicrobial agents as dihydrofolate reductase (DHFR) inhibitors with molecular docking study","volume":"1242","author":"Ammar","year":"2021","journal-title":"J. Mol. Struct."},{"issue":"2","key":"10.1016\/j.bioorg.2021.105571_b0320","doi-asserted-by":"crossref","DOI":"10.1002\/aoc.6102","article-title":"New pyrazole-4-carbothioamide-based metal complexes: Synthesis, spectral characterization, computational, antimicrobial, and antitumor investigations","volume":"35","author":"Ramadan","year":"2021","journal-title":"Appl. Organomet. Chem."},{"key":"10.1016\/j.bioorg.2021.105571_b0325","article-title":"Synthesis, molecular docking, and in silico ADME prediction of some fused pyrazolo[1,5-a]pyrimidine and pyrazole derivatives as potential antimicrobial agents","author":"Hassan","year":"2021","journal-title":"J. Iran. Chem. Soc."},{"key":"10.1016\/j.bioorg.2021.105571_b0330","doi-asserted-by":"crossref","first-page":"104803","DOI":"10.1016\/j.bioorg.2021.104803","article-title":"Novel structural hybrids of quinoline and thiazole moieties: Synthesis and evaluation of antibacterial and antifungal activities with molecular modeling studies","volume":"110","author":"Eissa","year":"2021","journal-title":"Bioorg. Chem."},{"key":"10.1016\/j.bioorg.2021.105571_b0335","first-page":"162","article-title":"Sulfaguanidine Hybrid with Some New Pyridine-2-One Derivatives: Design","volume":"10","author":"Ragab","year":"2021","journal-title":"Synthesis, and Antimicrobial Activity against Multidrug-Resistant Bacteria as Dual DNA Gyrase and DHFR Inhibitors, Antibiotics."},{"key":"10.1016\/j.bioorg.2021.105571_b0340","first-page":"2155","article-title":"M El-Hawash, Synthesis of pyrazolo-1,2,4-triazolo[4,3-a]quinoxalines as antimicrobial agents with potential inhibition of DHPS enzyme, Future","volume":"10","author":"El-Attar","year":"2018","journal-title":"Med. Chem."},{"key":"10.1016\/j.bioorg.2021.105571_b0345","doi-asserted-by":"crossref","DOI":"10.1016\/j.micpath.2019.103674","article-title":"Antibacterial, antibiofilm and molecular modeling study of some antitumor thiazole based chalcones as a new class of DHFR inhibitors","volume":"136","author":"Alrohily","year":"2019","journal-title":"Microb. Pathog."},{"key":"10.1016\/j.bioorg.2021.105571_b0350","first-page":"804","article-title":"Triazolo Based-Thiadiazole Derivatives","volume":"10","author":"Kamoutsis","year":"2021","journal-title":"Synthesis, Biological Evaluation and Molecular Docking Studies, Antibiotics."},{"key":"10.1016\/j.bioorg.2021.105571_b0355","article-title":"Performance Standards for Antimicrobial Susceptibility Testing; CLSI document M100\u2013S20; in","author":"Wayne","year":"2018","journal-title":"Clin. Lab. Stand."},{"issue":"11","key":"10.1016\/j.bioorg.2021.105571_b0360","doi-asserted-by":"crossref","first-page":"2023","DOI":"10.1007\/s00044-019-02433-2","article-title":"Synthesis, antimicrobial activity, and determination of the lipophilicity of ((cyclohex-3-enylmethylene)hydrazinyl)thiazole derivatives","volume":"28","author":"Biernasiuk","year":"2019","journal-title":"Med. Chem. Res."},{"issue":"5","key":"10.1016\/j.bioorg.2021.105571_b0365","doi-asserted-by":"crossref","first-page":"104107","DOI":"10.1016\/j.jece.2020.104107","article-title":"Hybrid three MOFs composites (ZIF-67@ZIF-8@MIL-125-NH2): Enhancement the biological and visible-light photocatalytic activity","volume":"8","author":"Abdelhameed","year":"2020","journal-title":"J. Environ. Chem. Eng."},{"issue":"02","key":"10.1016\/j.bioorg.2021.105571_b0370","doi-asserted-by":"crossref","first-page":"811","DOI":"10.31788\/RJC.2021.1426165","article-title":"Synadenium grantii hook f.: Hplc\/qtof-ms\/ms tentative identification of the phytoconstituents, antioxidant, antimicrobial and antibiofilm evaluation of the aerial parts","volume":"14","author":"Abd Elkarim","year":"2021","journal-title":"Rasayan J. Chem."},{"key":"10.1016\/j.bioorg.2021.105571_b0375","doi-asserted-by":"crossref","first-page":"81","DOI":"10.3390\/molecules26010081","article-title":"Thiazole Analogues of the Marine Alkaloid Nortopsentin as Inhibitors of Bacterial Biofilm Formation","volume":"26","author":"Carbone","year":"2021","journal-title":"Molecules."},{"key":"10.1016\/j.bioorg.2021.105571_b0380","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2021.114658","article-title":"UPLC-ESI-MS\/MS profiling of the underground parts of common Iris species in relation to their anti-virulence activities against Staphylococcus aureus","volume":"282","author":"Okba","year":"2022","journal-title":"Journal of Ethnopharmacology"},{"key":"10.1016\/j.bioorg.2021.105571_b0385","doi-asserted-by":"crossref","first-page":"761","DOI":"10.3390\/antibiotics10070761","article-title":"HPLC-PDA-ESI-MS\/MS Profiling and Anti-Biofilm Potential of Eucalyptussideroxylon Flowers","volume":"10","author":"Okba","year":"2021","journal-title":"Antibiotics."},{"key":"10.1016\/j.bioorg.2021.105571_b0390","first-page":"466","article-title":"Effect of Salvia egypticae and Foeniculum vulgara extracts on quorum sensing and biofilm formation of methicillin resistant\/sensitive staphylococcus aureus isolates","volume":"3","author":"Desouky","year":"2017","journal-title":"World J. Pharm. Med. Res."},{"key":"10.1016\/j.bioorg.2021.105571_b0395","doi-asserted-by":"crossref","first-page":"2820","DOI":"10.33263\/LIANBS104.28202830","article-title":"Isolation, Identification and Antibiotic Susceptibility Pattern of Urinary Tract Infection Bacterial Isolates","volume":"10","author":"Said","year":"2021","journal-title":"Lett. Appl. NanoBioScience."},{"key":"10.1016\/j.bioorg.2021.105571_b0400","doi-asserted-by":"crossref","first-page":"111669","DOI":"10.1016\/j.ejmech.2019.111669","article-title":"Design, synthesis and biological evaluation of novel diazaspiro[4.5]decan-1-one derivatives as potential chitin synthase inhibitors and antifungal agents","volume":"182","author":"Li","year":"2019","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.bioorg.2021.105571_b0405","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1016\/j.ejmech.2019.06.046","article-title":"A new exploration towards aminothiazolquinolone oximes as potentially multi-targeting antibacterial agents: Design, synthesis and evaluation acting on microbes, DNA, HSA and topoisomerase IV","volume":"179","author":"Wang","year":"2019","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.bioorg.2021.105571_b0410","doi-asserted-by":"crossref","first-page":"130317","DOI":"10.1016\/j.molstruc.2021.130317","article-title":"Design, synthesis, antiproliferative evaluation, and molecular docking study of new quinoxaline derivatives as apoptotic inducers and EGFR inhibitors","volume":"1236","author":"Fayed","year":"2021","journal-title":"J. Mol. Struct."},{"key":"10.1016\/j.bioorg.2021.105571_b0415","doi-asserted-by":"crossref","first-page":"109504","DOI":"10.1016\/j.dyepig.2021.109504","article-title":"Design, synthesis of new magenta dyestuffs based on thiazole azomethine disperse reactive dyes with antibacterial potential on both dyes and gamma-irradiated dyed fabric","volume":"193","author":"Ibrahim","year":"2021","journal-title":"Dye. Pigment."},{"issue":"10","key":"10.1016\/j.bioorg.2021.105571_b0420","doi-asserted-by":"crossref","first-page":"2493","DOI":"10.1007\/s13738-020-01944-9","article-title":"Design, synthesis, biological evaluation and molecular docking study based on novel fused pyrazolothiazole scaffold","volume":"17","author":"Rizk","year":"2020","journal-title":"J IRAN CHEM SOC"},{"issue":"1","key":"10.1016\/j.bioorg.2021.105571_b0425","doi-asserted-by":"crossref","first-page":"103497","DOI":"10.1016\/j.arabjc.2021.103497","article-title":"Design, synthesis of new novel quinoxalin-2(1H)-one derivatives incorporating hydrazone, hydrazine, and pyrazole moieties as antimicrobial potential with in-silico ADME and molecular docking simulation","volume":"15","author":"Ragab","year":"2022","journal-title":"Arab. J. Chem."},{"key":"10.1016\/j.bioorg.2021.105571_b0430","first-page":"1","article-title":"Therapeutic strategies for Covid-19 based on molecular docking and dynamic studies to the ACE-2 receptors, Furin, and viral spike proteins","volume":"39","author":"Khattab","year":"2021","journal-title":"J. Biomol. Struct. Dyn."},{"key":"10.1016\/j.bioorg.2021.105571_b0435","doi-asserted-by":"crossref","first-page":"105339","DOI":"10.1016\/j.bioorg.2021.105339","article-title":"Hydrazonoyl bromide precursors as DHFR inhibitors for the synthesis of bis-thiazolyl pyrazole derivatives; antimicrobial activities, antibiofilm, and drug combination studies against MRSA","volume":"116","author":"Ibrahim","year":"2021","journal-title":"Bioorg. Chem."},{"key":"10.1016\/j.bioorg.2021.105571_bib436","article-title":"A Novel of Azo-Thiazole Moiety Alternative for Benzidine-Based Pigments: Design, Synthesis, Characterization, Biological Evaluation, and Molecular Docking Study","year":"2021","journal-title":"Polycycl. Aromat. Compd."},{"key":"10.1016\/j.bioorg.2021.105571_bib437","first-page":"132004","article-title":"Synthesis, spectral characterization, antimicrobial evaluation and molecular docking studies of new Cu (II), Zn (II) thiosemicarbazone based on sulfonyl isatin","year":"2021","journal-title":"J. Mol. Struct."}],"container-title":["Bioorganic Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0045206821009494?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0045206821009494?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,23]],"date-time":"2025-09-23T08:30:11Z","timestamp":1758616211000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0045206821009494"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,2]]},"references-count":89,"alternative-id":["S0045206821009494"],"URL":"https:\/\/doi.org\/10.1016\/j.bioorg.2021.105571","relation":{},"ISSN":["0045-2068"],"issn-type":[{"value":"0045-2068","type":"print"}],"subject":[],"published":{"date-parts":[[2022,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Development of novel indolin-2-one derivative incorporating thiazole moiety as DHFR and quorum sensing inhibitors: Synthesis, antimicrobial, and antibiofilm activities with molecular modelling study","name":"articletitle","label":"Article Title"},{"value":"Bioorganic Chemistry","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bioorg.2021.105571","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"105571"}}