{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T19:24:00Z","timestamp":1790882640124,"version":"4.1.0"},"reference-count":128,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2022,9,1]],"date-time":"2022-09-01T00:00:00Z","timestamp":1661990400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,9,1]],"date-time":"2022-09-01T00:00:00Z","timestamp":1661990400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,5,25]],"date-time":"2023-05-25T00:00:00Z","timestamp":1684972800000},"content-version":"am","delay-in-days":266,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,9,1]],"date-time":"2022-09-01T00:00:00Z","timestamp":1661990400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2022,9,1]],"date-time":"2022-09-01T00:00:00Z","timestamp":1661990400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2022,9,1]],"date-time":"2022-09-01T00:00:00Z","timestamp":1661990400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2022,9,1]],"date-time":"2022-09-01T00:00:00Z","timestamp":1661990400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2022,9,1]],"date-time":"2022-09-01T00:00:00Z","timestamp":1661990400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001665","name":"ANR","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001665","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002334","name":"Region Grand Est","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002334","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Bioorganic Chemistry"],"published-print":{"date-parts":[[2022,9]]},"DOI":"10.1016\/j.bioorg.2022.105824","type":"journal-article","created":{"date-parts":[[2022,5,11]],"date-time":"2022-05-11T22:00:22Z","timestamp":1652306422000},"page":"105824","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":27,"special_numbering":"C","title":["Targeted modifications of neomycin and paromomycin: Towards resistance-free antibiotics?"],"prefix":"10.1016","volume":"126","author":[{"given":"J.","family":"Obszynski","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H.","family":"Loidon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Blanc","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.-M.","family":"Weibel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3924-530X","authenticated-orcid":false,"given":"P.","family":"Pale","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bioorg.2022.105824_b0005","first-page":"525","volume":"2","author":"Vuillemin","year":"1889","journal-title":"Assoc. Fran\u00e7. Avanc. Sci."},{"key":"10.1016\/j.bioorg.2022.105824_b0010","unstructured":"\u201cIf\u2026.one inoculates \u2026an aerobic organism, such as one of the \u2018common bacteria\u2019, the anthrax bacillus does not grow or very slowly, and sooner or later is entirely destroyed. \u2026 These facts perhaps justify the highest hopes for therapeutics\u201d translated from L. Pasteur, C. R. Acad. Sci. Paris, 1877, 5, 101\u2013105."},{"key":"10.1016\/j.bioorg.2022.105824_b0015","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1080\/00275514.1947.12017635","volume":"39","author":"Waksman","year":"1947","journal-title":"Mycologia"},{"key":"10.1016\/j.bioorg.2022.105824_b0020","first-page":"321","volume":"7","author":"Babes","year":"1885","journal-title":"Connaiss. Med. Prat."},{"key":"10.1016\/j.bioorg.2022.105824_b0025","first-page":"1","volume":"31","author":"Emmerich","year":"1889","journal-title":"Hyg. InfektKr."},{"key":"10.1016\/j.bioorg.2022.105824_b0030","first-page":"278","volume":"74","author":"Vaudremer","year":"1913","journal-title":"C. R. Soc. Biol. Paris"},{"key":"10.1016\/j.bioorg.2022.105824_b0035","first-page":"958","author":"Rappin","year":"1912","journal-title":"Gaz. Med. Nantes"},{"key":"10.1016\/j.bioorg.2022.105824_b0040","first-page":"226","volume":"10","author":"Fleming","year":"1929","journal-title":"Br. J. Exp. Pathol."},{"key":"10.1016\/j.bioorg.2022.105824_b0045","doi-asserted-by":"crossref","first-page":"250","DOI":"10.1055\/s-0028-1129486","volume":"61","author":"Domagk","year":"1935","journal-title":"Dtsch. Med. Wochenschr."},{"key":"10.1016\/j.bioorg.2022.105824_b0050","first-page":"756","volume":"120","author":"Tr\u00e9fou\u00ebl","year":"1935","journal-title":"Soc. Biol. Paris"},{"key":"10.1016\/j.bioorg.2022.105824_b0055","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1016\/S0140-6736(01)08728-1","volume":"2","author":"Chain","year":"1940","journal-title":"Lancet"},{"key":"10.1016\/j.bioorg.2022.105824_b0060","doi-asserted-by":"crossref","first-page":"66","DOI":"10.3181\/00379727-55-14461","volume":"55","author":"Bugie","year":"1944","journal-title":"Proc. Nat. Exp. Biol. Med."},{"key":"10.1016\/j.bioorg.2022.105824_b0065","first-page":"232","volume":"3","author":"Umezawa","year":"1949","journal-title":"J. Antibiot."},{"key":"10.1016\/j.bioorg.2022.105824_b0070","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1126\/science.109.2830.305","volume":"109","author":"Waksman","year":"1949","journal-title":"Science"},{"key":"10.1016\/j.bioorg.2022.105824_b0075","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1111\/j.1749-6632.1948.tb27262.x","volume":"51","author":"Duggar","year":"1948","journal-title":"Ann. N.Y. Acad. Sci."},{"key":"10.1016\/j.bioorg.2022.105824_b0080","doi-asserted-by":"crossref","unstructured":"For more historical details, see: Nelson, M. L.; Levy, S. B. Ann. N-Y. Acad. Sci. 2011, 1241, 17\u201332.","DOI":"10.1111\/j.1749-6632.2011.06354.x"},{"key":"10.1016\/j.bioorg.2022.105824_b0085","doi-asserted-by":"crossref","first-page":"2458","DOI":"10.1021\/ja01175a065","volume":"71","author":"Rebstock","year":"1949","journal-title":"J. Am. Chem. Soc."},{"key":"10.1016\/j.bioorg.2022.105824_b0090","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/j.cell.2020.02.056","volume":"181","author":"Lewis","year":"2020","journal-title":"Cell"},{"key":"10.1016\/j.bioorg.2022.105824_b0095","doi-asserted-by":"crossref","first-page":"1188","DOI":"10.2174\/1568026618666180816162846","volume":"18","author":"Campanini-Salinas","year":"2018","journal-title":"Curr. Top. Med. Chem."},{"key":"10.1016\/j.bioorg.2022.105824_b0100","doi-asserted-by":"crossref","DOI":"10.15190\/d.2019.15","volume":"7","author":"Andrei","year":"2019","journal-title":"Discoveries"},{"key":"10.1016\/j.bioorg.2022.105824_b0105","doi-asserted-by":"crossref","first-page":"775","DOI":"10.1038\/35021219","volume":"406","author":"Walsh","year":"2000","journal-title":"Nature"},{"key":"10.1016\/j.bioorg.2022.105824_b0110","doi-asserted-by":"crossref","first-page":"3508","DOI":"10.1002\/1521-3773(20011001)40:19<3508::AID-ANIE3508>3.0.CO;2-I","volume":"40","author":"Ritter","year":"2001","journal-title":"Angew. Chem. Int. Ed."},{"key":"10.1016\/j.bioorg.2022.105824_b0115","doi-asserted-by":"crossref","first-page":"604","DOI":"10.3399\/bjgp14X682561","volume":"64","author":"Shallcross","year":"2014","journal-title":"Br. J. Gen. Pract."},{"key":"10.1016\/j.bioorg.2022.105824_b0120","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0034953","volume":"7","author":"Bhullar","year":"2012","journal-title":"PLOS ONE"},{"key":"10.1016\/j.bioorg.2022.105824_b0125","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1038\/nature10388","volume":"477","author":"D\u2019Costa","year":"2011","journal-title":"Nature"},{"key":"10.1016\/j.bioorg.2022.105824_b0130","unstructured":"Antibiotic resistance threats in the United States. Atlanta, GA: US Centers for Disease Control and Prevention; 2019. https:\/\/www.cdc.gov\/drugresistance\/biggest-threats.html (accessed the 23 June 2020)."},{"key":"10.1016\/j.bioorg.2022.105824_b0135","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1016\/S1473-3099(18)30605-4","volume":"19","author":"Cassini","year":"2019","journal-title":"Lancet Infect. Dis"},{"key":"10.1016\/j.bioorg.2022.105824_b0140","unstructured":"WHO list: Priority 1: Acinetobacter baumannii, Pseudomonas aeruginosa, Enterobacter species; priority 2: Enterococcus faecium, Staphylococcus aureus, Helicobacter pylori, Campylobacter spp., Salmonellae, Neisseria gonorrhoeae: priority 3: Streptococcus pneumoniae, Haemophilus influenzae, Shigella spp."},{"key":"10.1016\/j.bioorg.2022.105824_b0145","unstructured":"2019 WHO AWaRe Classification Database of Antibiotics. Geneva, Swizerland. World Health Organization, 2019. https:\/\/www.who.int\/medicines\/publications\/essentialmedicines\/en\/."},{"key":"10.1016\/j.bioorg.2022.105824_b0150","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1111\/j.1749-6632.1958.tb54688.x","volume":"76","author":"Umezawa","year":"2006","journal-title":"Ann. NY Acad. Sci."},{"key":"10.1016\/j.bioorg.2022.105824_b0155","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1021\/jm00340a034","volume":"6","author":"Weinstein","year":"1963","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.bioorg.2022.105824_b0160","doi-asserted-by":"crossref","first-page":"695","DOI":"10.7164\/antibiotics.25.695","volume":"25","author":"Kawaguchi","year":"1972","journal-title":"J. Antibiot."},{"key":"10.1016\/j.bioorg.2022.105824_b0165","unstructured":"Wright, J. J.; Daniels, P. J. L. US4029882A, June 14, 1977."},{"key":"10.1016\/j.bioorg.2022.105824_b0170","doi-asserted-by":"crossref","first-page":"705","DOI":"10.1080\/14787210.2020.1759419","volume":"18","author":"Bilinskaya","year":"2020","journal-title":"Expert Rev. Infect. Ther."},{"key":"10.1016\/j.bioorg.2022.105824_b0175","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1128\/mr.51.3.341-350.1987","volume":"51","author":"Davis","year":"1987","journal-title":"Microbiol. Rev."},{"key":"10.1016\/j.bioorg.2022.105824_b0180","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1128\/mr.51.4.439-457.1987","volume":"51","author":"Taber","year":"1987","journal-title":"Microbiol. Rev."},{"key":"10.1016\/j.bioorg.2022.105824_b0185","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1016\/j.drup.2010.08.003","volume":"13","author":"Ramirez","year":"2010","journal-title":"Drug Resist. Updates"},{"key":"10.1016\/j.bioorg.2022.105824_b0190","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1093\/infdis\/125.3.295","volume":"125","author":"Kislak","year":"1972","journal-title":"J. Infect. Dis."},{"key":"10.1016\/j.bioorg.2022.105824_b0195","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1128\/AAC.1.2.148","volume":"1","author":"Martin","year":"1972","journal-title":"Antimicrob. Agents Chemother."},{"key":"10.1016\/j.bioorg.2022.105824_b0200","doi-asserted-by":"crossref","first-page":"2723","DOI":"10.1074\/jbc.M205726200","volume":"278","author":"Ennifar","year":"2003","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bioorg.2022.105824_b0205","doi-asserted-by":"crossref","first-page":"2328","DOI":"10.1093\/nar\/gkl317","volume":"34","author":"Ennifar","year":"2006","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.bioorg.2022.105824_b0210","doi-asserted-by":"crossref","first-page":"1018","DOI":"10.1002\/cbic.200300684","volume":"4","author":"Vicens","year":"2003","journal-title":"ChemBioChem"},{"key":"10.1016\/j.bioorg.2022.105824_b0215","doi-asserted-by":"crossref","first-page":"869","DOI":"10.1016\/S0300-9084(02)01460-8","volume":"84","author":"Hermann","year":"2002","journal-title":"Biochimie"},{"key":"10.1016\/j.bioorg.2022.105824_b0220","doi-asserted-by":"crossref","first-page":"2414","DOI":"10.1128\/AAC.45.9.2414-2419.2001","volume":"45","author":"Recht","year":"2001","journal-title":"Antimicrob. Agents Chemother."},{"key":"10.1016\/j.bioorg.2022.105824_b0225","doi-asserted-by":"crossref","first-page":"340","DOI":"10.1038\/35030019","volume":"407","author":"Carter","year":"2000","journal-title":"Nature"},{"key":"10.1016\/j.bioorg.2022.105824_b0230","doi-asserted-by":"crossref","first-page":"897","DOI":"10.1126\/science.1060612","volume":"292","author":"Ogle","year":"2001","journal-title":"Science"},{"key":"10.1016\/j.bioorg.2022.105824_b0235","doi-asserted-by":"crossref","first-page":"3201","DOI":"10.1016\/j.jmb.2014.04.029","volume":"426","author":"Zeng","year":"2014","journal-title":"J. Mol. Biol."},{"key":"10.1016\/j.bioorg.2022.105824_b0240","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1016\/j.celrep.2013.01.027","volume":"3","author":"Tsai","year":"2013","journal-title":"Cell Rep."},{"key":"10.1016\/j.bioorg.2022.105824_b0245","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1038\/nchembio.274","volume":"6","author":"Feldman","year":"2010","journal-title":"Nat. Chem. Biol."},{"key":"10.1016\/j.bioorg.2022.105824_b0250","doi-asserted-by":"crossref","first-page":"284","DOI":"10.3390\/molecules23020284","volume":"23","author":"Z\u00e1rate","year":"2018","journal-title":"Molecules"},{"key":"10.1016\/j.bioorg.2022.105824_b0255","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1080\/07853890701195262","volume":"39","author":"Poole","year":"2007","journal-title":"Ann. Med."},{"key":"10.1016\/j.bioorg.2022.105824_b0260","doi-asserted-by":"crossref","first-page":"1888","DOI":"10.1016\/S0140-6736(03)14959-8","volume":"362","author":"Yokoyama","year":"2003","journal-title":"The Lancet"},{"key":"10.1016\/j.bioorg.2022.105824_b0265","doi-asserted-by":"crossref","first-page":"3789","DOI":"10.1128\/AAC.00457-07","volume":"51","author":"Go\u0142\u0119biewski","year":"2007","journal-title":"Antimicrob. Agents Chemother."},{"key":"10.1016\/j.bioorg.2022.105824_b0270","doi-asserted-by":"crossref","first-page":"2565","DOI":"10.1128\/AAC.47.8.2565-2571.2003","volume":"47","author":"Galimand","year":"2003","journal-title":"Antimicrob. Agents Chemother."},{"key":"10.1016\/j.bioorg.2022.105824_b0275","doi-asserted-by":"crossref","first-page":"159","DOI":"10.2133\/dmpk.19.159","volume":"19","author":"Nagai","year":"2004","journal-title":"Drug Metab. Pharmacok."},{"key":"10.1016\/j.bioorg.2022.105824_b0280","doi-asserted-by":"crossref","first-page":"1003","DOI":"10.1128\/AAC.43.5.1003","volume":"2","author":"Mingeot-Leclerc","year":"1999","journal-title":"Antimicrob. Agents Chemother"},{"key":"10.1016\/j.bioorg.2022.105824_b0285","doi-asserted-by":"crossref","first-page":"4174","DOI":"10.1093\/nar\/21.18.4174","volume":"21","author":"Hutchin","year":"1993","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.bioorg.2022.105824_b0290","doi-asserted-by":"crossref","DOI":"10.1136\/bmjopen-2011-000411","volume":"2","author":"Rahman","year":"2012","journal-title":"BMJ Open"},{"key":"10.1016\/j.bioorg.2022.105824_b0295","doi-asserted-by":"crossref","first-page":"1189","DOI":"10.1039\/C7CS00407A","volume":"47","author":"Chandrika","year":"2018","journal-title":"Chem. Soc. Rev."},{"key":"10.1016\/j.bioorg.2022.105824_b0300","doi-asserted-by":"crossref","first-page":"5677","DOI":"10.1093\/nar\/gki862","volume":"33","author":"Fran\u00e7ois","year":"2005","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.bioorg.2022.105824_b0305","doi-asserted-by":"crossref","first-page":"379","DOI":"10.7164\/antibiotics.31.379","volume":"31","author":"Cassinelli","year":"1978","journal-title":"J. Antibiot."},{"key":"10.1016\/j.bioorg.2022.105824_b0310","doi-asserted-by":"crossref","first-page":"1718","DOI":"10.1021\/acsinfecdis.9b00128","volume":"5","author":"Sati","year":"2019","journal-title":"ACS Infect. Dis."},{"key":"10.1016\/j.bioorg.2022.105824_b0315","doi-asserted-by":"crossref","first-page":"678","DOI":"10.1021\/jo00002a035","volume":"56","author":"Ballestri","year":"1991","journal-title":"J. Org. Chem."},{"key":"10.1016\/j.bioorg.2022.105824_b0320","doi-asserted-by":"crossref","first-page":"240","DOI":"10.7164\/antibiotics.34.240","volume":"34","author":"Battistini","year":"1981","journal-title":"J. Antibiot."},{"key":"10.1016\/j.bioorg.2022.105824_b0325","doi-asserted-by":"crossref","first-page":"4621","DOI":"10.1039\/C4SC01626B","volume":"5","author":"Hanessian","year":"2014","journal-title":"Chem. Sci."},{"key":"10.1016\/j.bioorg.2022.105824_b0330","doi-asserted-by":"crossref","first-page":"368","DOI":"10.1021\/acsinfecdis.6b00214","volume":"3","author":"Sati","year":"2017","journal-title":"ACS Infect. Dis."},{"key":"10.1016\/j.bioorg.2022.105824_b0335","doi-asserted-by":"crossref","first-page":"98","DOI":"10.7164\/antibiotics.35.98","volume":"35","author":"Battistini","year":"1982","journal-title":"J. Antibiot."},{"key":"10.1016\/j.bioorg.2022.105824_b0340","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1139\/v68-010","volume":"46","author":"Lemieux","year":"1968","journal-title":"Can. J. Chem."},{"key":"10.1016\/j.bioorg.2022.105824_b0345","doi-asserted-by":"crossref","first-page":"6476","DOI":"10.1021\/ol2027703","volume":"13","author":"Hanessian","year":"2011","journal-title":"Org. Lett."},{"key":"10.1016\/j.bioorg.2022.105824_b0350","unstructured":"Migawa, M.; Wang, X.; Swayze, E. E.; Griffey, R. H. PCT Int. Appl. 2007, WO 2007028012."},{"key":"10.1016\/j.bioorg.2022.105824_b0355","doi-asserted-by":"crossref","first-page":"87","DOI":"10.7164\/antibiotics.36.87","volume":"36","author":"Toda","year":"1983","journal-title":"J. Antibiot."},{"key":"10.1016\/j.bioorg.2022.105824_b0360","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1128\/AAC.2.2.89","volume":"2","author":"Heifetz","year":"1972","journal-title":"Antimicrob. Agents Chemother."},{"key":"10.1016\/j.bioorg.2022.105824_b0365","doi-asserted-by":"crossref","first-page":"2625","DOI":"10.1016\/S0040-4039(01)96935-7","author":"Woo","year":"1971","journal-title":"Tetrahedron Lett."},{"key":"10.1016\/j.bioorg.2022.105824_b0370","unstructured":"Naito, T.; Nakagawa, S.; Oka, M. FR2209546 (A1)."},{"key":"10.1016\/j.bioorg.2022.105824_b0375","doi-asserted-by":"crossref","first-page":"10773","DOI":"10.1021\/ja0264605","volume":"124","author":"Nyffeler","year":"2002","journal-title":"J. Am. Chem. Soc."},{"key":"10.1016\/j.bioorg.2022.105824_b0380","doi-asserted-by":"crossref","first-page":"4055","DOI":"10.1021\/jo062588j","volume":"72","author":"Li","year":"2007","journal-title":"J. Org. Chem."},{"key":"10.1016\/j.bioorg.2022.105824_b0385","unstructured":"A.A. Bastian, A. Herrmann, PCT Int. App. 2013, WO2013191550."},{"key":"10.1016\/j.bioorg.2022.105824_b0390","doi-asserted-by":"crossref","first-page":"6735","DOI":"10.1002\/anie.200462092","volume":"43","author":"Fran\u00e7ois","year":"2004","journal-title":"Angew. Chem. Int. Ed."},{"key":"10.1016\/j.bioorg.2022.105824_b0395","doi-asserted-by":"crossref","first-page":"2352","DOI":"10.1021\/jm061200+","volume":"50","author":"Hanessian","year":"2007","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.bioorg.2022.105824_b0400","doi-asserted-by":"crossref","first-page":"2243","DOI":"10.1021\/jm900028n","volume":"52","author":"Pokrovskaya","year":"2009","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.bioorg.2022.105824_b0405","doi-asserted-by":"crossref","first-page":"560","DOI":"10.1016\/j.carres.2011.01.015","volume":"346","author":"Bera","year":"2011","journal-title":"Carbohydr. Res."},{"key":"10.1016\/j.bioorg.2022.105824_b0410","doi-asserted-by":"crossref","first-page":"3575","DOI":"10.1021\/ol035213i","volume":"5","author":"Fridman","year":"2003","journal-title":"Org. Lett."},{"key":"10.1016\/j.bioorg.2022.105824_b0415","doi-asserted-by":"crossref","first-page":"342","DOI":"10.1016\/S0008-6215(00)80362-6","volume":"18","author":"Ponpipom","year":"1971","journal-title":"Carbohydr. Res."},{"key":"10.1016\/j.bioorg.2022.105824_b0420","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/S0008-6215(00)82258-2","volume":"24","author":"Hanessian","year":"1972","journal-title":"Carbohydr. Res."},{"key":"10.1016\/j.bioorg.2022.105824_b0425","doi-asserted-by":"crossref","first-page":"893","DOI":"10.7164\/antibiotics.30.893","volume":"30","author":"Hanessian","year":"1977","journal-title":"J. Antibiot."},{"key":"10.1016\/j.bioorg.2022.105824_b0430","doi-asserted-by":"crossref","first-page":"829","DOI":"10.1021\/ja00956a040","volume":"88","author":"Lohrmann","year":"1966","journal-title":"J. Am. Chem. Soc."},{"key":"10.1016\/j.bioorg.2022.105824_b0435","doi-asserted-by":"crossref","first-page":"1361","DOI":"10.1016\/S0968-0896(99)00071-1","volume":"7","author":"Michael","year":"1999","journal-title":"Bioorg. Med. Chem."},{"key":"10.1016\/j.bioorg.2022.105824_b0440","doi-asserted-by":"crossref","first-page":"6160","DOI":"10.1021\/jm800345u","volume":"51","author":"Bera","year":"2008","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.bioorg.2022.105824_b0445","doi-asserted-by":"crossref","first-page":"1366","DOI":"10.1039\/C6CC08292K","volume":"53","author":"Zhang","year":"2017","journal-title":"Chem. Commun."},{"key":"10.1016\/j.bioorg.2022.105824_b0450","doi-asserted-by":"crossref","first-page":"1951","DOI":"10.1016\/S0960-894X(97)00339-9","volume":"7","author":"Wang","year":"1997","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"10.1016\/j.bioorg.2022.105824_b0455","doi-asserted-by":"crossref","first-page":"1593","DOI":"10.1016\/S0960-894X(00)00299-7","volume":"10","author":"Tok","year":"2000","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"10.1016\/j.bioorg.2022.105824_b0460","doi-asserted-by":"crossref","first-page":"2987","DOI":"10.1016\/S0960-894X(01)00602-3","volume":"11","author":"Tok","year":"2001","journal-title":"Bioorg. Med. Chem. Lett."},{"issue":"7","key":"10.1016\/j.bioorg.2022.105824_b0465","doi-asserted-by":"crossref","first-page":"1956","DOI":"10.1021\/ja038937y","volume":"126","author":"Lee","year":"2004","journal-title":"J. Am. Chem. Soc."},{"key":"10.1016\/j.bioorg.2022.105824_b0470","doi-asserted-by":"crossref","first-page":"1664","DOI":"10.5012\/bkcs.2006.27.10.1664","volume":"27","author":"Kwon","year":"2006","journal-title":"Bull. Korean Chem. Soc."},{"key":"10.1016\/j.bioorg.2022.105824_b0475","doi-asserted-by":"crossref","first-page":"980","DOI":"10.1021\/ja993387i","volume":"122","author":"Kirk","year":"2000","journal-title":"J. Am. Chem. Soc."},{"key":"10.1016\/j.bioorg.2022.105824_b0480","doi-asserted-by":"crossref","unstructured":"Story, S.; Skriba, M. J.; Maiti, K.; Nihar Ranjan; Degtyareva, N. N.; Green, K. D.; Khodaverdian, M.; Oyelere, A. K.; Garneau-Tsodokova, S.; Arya, D.P., 2019. Eur. J. Med. Chem., 163, 381\u2013393.","DOI":"10.1016\/j.ejmech.2018.11.022"},{"key":"10.1016\/j.bioorg.2022.105824_b0485","doi-asserted-by":"crossref","first-page":"1309","DOI":"10.1016\/j.bmc.2016.11.003","volume":"25","author":"Watkins","year":"2017","journal-title":"Bioorg. Med. Chem."},{"key":"10.1016\/j.bioorg.2022.105824_b0490","doi-asserted-by":"crossref","first-page":"4717","DOI":"10.1128\/AAC.00671-13","volume":"57","author":"King","year":"2013","journal-title":"Antimicrob. Agents Chemother."},{"key":"10.1016\/j.bioorg.2022.105824_b0495","doi-asserted-by":"crossref","first-page":"7361","DOI":"10.1021\/ja108118v","volume":"133","author":"Kumar","year":"2011","journal-title":"J. Am. Chem. Soc."},{"key":"10.1016\/j.bioorg.2022.105824_b0500","doi-asserted-by":"crossref","first-page":"4443","DOI":"10.1055\/s-0035-1562727","volume":"48","author":"Sganappa","year":"2016","journal-title":"Synthesis"},{"key":"10.1016\/j.bioorg.2022.105824_b0505","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1002\/anie.200462003","volume":"44","author":"Fridman","year":"2005","journal-title":"Angew. Chem. Int. Ed."},{"key":"10.1016\/j.bioorg.2022.105824_b0510","doi-asserted-by":"crossref","first-page":"927","DOI":"10.1002\/anie.200461182","volume":"44","author":"Boer","year":"2005","journal-title":"Angew. Chem. Int. Ed."},{"key":"10.1016\/j.bioorg.2022.105824_b0515","doi-asserted-by":"crossref","first-page":"7563","DOI":"10.1021\/jm800997s","volume":"51","author":"Zhang","year":"2008","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.bioorg.2022.105824_b0520","doi-asserted-by":"crossref","first-page":"3031","DOI":"10.1016\/j.bmcl.2010.03.116","volume":"20","author":"Bera","year":"2010","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"10.1016\/j.bioorg.2022.105824_b0525","doi-asserted-by":"crossref","first-page":"1499","DOI":"10.1016\/j.bmcl.2012.01.025","volume":"22","author":"Findlay","year":"2012","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"10.1016\/j.bioorg.2022.105824_b0530","doi-asserted-by":"crossref","first-page":"4788","DOI":"10.1016\/j.bmcl.2011.06.058","volume":"21","author":"Kumar","year":"2011","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"10.1016\/j.bioorg.2022.105824_b0535","doi-asserted-by":"crossref","first-page":"2331","DOI":"10.1021\/bi201657k","volume":"51","author":"Kumar","year":"2012","journal-title":"Biochemistry"},{"key":"10.1016\/j.bioorg.2022.105824_b0540","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1039\/C5MD00427F","volume":"7","author":"Jin","year":"2016","journal-title":"Med. Chem. Commun."},{"key":"10.1016\/j.bioorg.2022.105824_b0545","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1038\/ja.2009.66","volume":"62","author":"Zhang","year":"2009","journal-title":"Antibiotics"},{"key":"10.1016\/j.bioorg.2022.105824_b0550","doi-asserted-by":"crossref","first-page":"1278","DOI":"10.1021\/cb5010367","volume":"10","author":"Jiang","year":"2015","journal-title":"ACS Chem. Biol."},{"key":"10.1016\/j.bioorg.2022.105824_b0555","doi-asserted-by":"crossref","first-page":"300","DOI":"10.1016\/j.ab.2012.12.003","volume":"434","author":"Watkins","year":"2013","journal-title":"Anal. Biochem."},{"key":"10.1016\/j.bioorg.2022.105824_b0560","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1021\/acsinfecdis.6b00176","volume":"3","author":"Degtyareva","year":"2017","journal-title":"ACS Infect. Dis."},{"key":"10.1016\/j.bioorg.2022.105824_b0565","doi-asserted-by":"crossref","first-page":"2064","DOI":"10.1039\/b505280g","volume":"3","author":"Hernandez Linares","year":"2005","journal-title":"Org. Biomol. Chem."},{"key":"10.1016\/j.bioorg.2022.105824_b0570","doi-asserted-by":"crossref","first-page":"2064","DOI":"10.1039\/B513113H","volume":"4","author":"Quader","year":"2006","journal-title":"Org. Biomol. Chem."},{"key":"10.1016\/j.bioorg.2022.105824_b0575","doi-asserted-by":"crossref","first-page":"1962","DOI":"10.1021\/jo0620967","volume":"72","author":"Quader","year":"2007","journal-title":"J. Org. Chem."},{"key":"10.1016\/j.bioorg.2022.105824_b0580","doi-asserted-by":"crossref","first-page":"924","DOI":"10.1021\/ml200202y","volume":"2","author":"Hanessian","year":"2011","journal-title":"ACS Med. Chem. Lett."},{"key":"10.1016\/j.bioorg.2022.105824_b0585","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1055\/s-1979-28724","author":"Garegg","year":"1979","journal-title":"Synthesis"},{"key":"10.1016\/j.bioorg.2022.105824_b0590","doi-asserted-by":"crossref","first-page":"338","DOI":"10.1016\/S0008-6215(00)81770-X","volume":"1","author":"Tipson","year":"1965","journal-title":"Carbohydr. Res."},{"key":"10.1016\/j.bioorg.2022.105824_b0595","doi-asserted-by":"crossref","first-page":"432","DOI":"10.1021\/jm00190a015","volume":"22","author":"Kumar","year":"1979","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.bioorg.2022.105824_b0600","doi-asserted-by":"crossref","first-page":"2067","DOI":"10.1021\/cb5003416","volume":"9","author":"Maianti","year":"2014","journal-title":"ACS Chem. Biol."},{"key":"10.1016\/j.bioorg.2022.105824_b0605","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1039\/C5MD00429B","volume":"7","author":"Maianti","year":"2016","journal-title":"Med. Chem. Commun."},{"key":"10.1016\/j.bioorg.2022.105824_b0610","doi-asserted-by":"crossref","first-page":"7097","DOI":"10.1016\/j.bmcl.2010.09.084","volume":"20","author":"Hanessian","year":"2010","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"10.1016\/j.bioorg.2022.105824_b0615","series-title":"Biotransformations in Organic Chemistry","author":"Faber","year":"2004"},{"key":"10.1016\/j.bioorg.2022.105824_b0620","doi-asserted-by":"crossref","first-page":"2587","DOI":"10.1039\/C9SC05746C","volume":"11","author":"Sheldon","year":"2020","journal-title":"Chem. Sci."},{"key":"10.1016\/j.bioorg.2022.105824_b0625","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1002\/cbic.200900584","volume":"11","author":"Green","year":"2010","journal-title":"ChemBioChem"},{"key":"10.1016\/j.bioorg.2022.105824_b0630","doi-asserted-by":"crossref","first-page":"1682","DOI":"10.1002\/adsc.200800229","volume":"350","author":"Nudelman","year":"2008","journal-title":"Adv. Synth. Catal."},{"key":"10.1016\/j.bioorg.2022.105824_b0635","doi-asserted-by":"crossref","first-page":"3786","DOI":"10.1039\/b802248h","author":"Llewellyn","year":"2008","journal-title":"Chem. Commun."},{"key":"10.1016\/j.bioorg.2022.105824_b0640","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/j.copbio.2017.03.019","volume":"48","author":"Park","year":"2017","journal-title":"J. Curr. Opin. Biotech."}],"container-title":["Bioorganic Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0045206822002292?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0045206822002292?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,23]],"date-time":"2025-09-23T08:33:07Z","timestamp":1758616387000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0045206822002292"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,9]]},"references-count":128,"alternative-id":["S0045206822002292"],"URL":"https:\/\/doi.org\/10.1016\/j.bioorg.2022.105824","relation":{},"ISSN":["0045-2068"],"issn-type":[{"value":"0045-2068","type":"print"}],"subject":[],"published":{"date-parts":[[2022,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Targeted modifications of neomycin and paromomycin: Towards resistance-free antibiotics?","name":"articletitle","label":"Article Title"},{"value":"Bioorganic Chemistry","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bioorg.2022.105824","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"105824"}}