{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T22:41:32Z","timestamp":1791499292810,"version":"4.3.4"},"reference-count":56,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2022,10,1]],"date-time":"2022-10-01T00:00:00Z","timestamp":1664582400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,10,1]],"date-time":"2022-10-01T00:00:00Z","timestamp":1664582400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,7,13]],"date-time":"2022-07-13T00:00:00Z","timestamp":1657670400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Bioorganic Chemistry"],"published-print":{"date-parts":[[2022,10]]},"DOI":"10.1016\/j.bioorg.2022.106008","type":"journal-article","created":{"date-parts":[[2022,7,15]],"date-time":"2022-07-15T02:15:15Z","timestamp":1657851315000},"page":"106008","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":11,"special_numbering":"C","title":["Novel chlorpromazine derivatives as anti-endometrial carcinoma agents with reduced extrapyramidal side effects"],"prefix":"10.1016","volume":"127","author":[{"given":"Lijuan","family":"Li","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaohu","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yunxia","family":"Cui","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yang","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huiwen","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaodi","family":"Gong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoyan","family":"Gao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Linlin","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jian","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fei","family":"Mao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yudong","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bioorg.2022.106008_b0005","doi-asserted-by":"crossref","DOI":"10.3389\/fonc.2019.01440","article-title":"Global, Regional, and National Burden of Endometrial Cancer, 1990\u20132017: Results From the Global Burden of Disease Study, 2017","volume":"9","author":"Zhang","year":"2019","journal-title":"Front. Oncol."},{"issue":"21","key":"10.1016\/j.bioorg.2022.106008_b0010","doi-asserted-by":"crossref","first-page":"2053","DOI":"10.1056\/NEJMra1514010","article-title":"Endometrial Cancer","volume":"383","author":"Longo","year":"2020","journal-title":"The New England J. Med."},{"key":"10.1016\/j.bioorg.2022.106008_b0015","unstructured":"M. Bethesda, Surveillance, Epidemiology, and End Results Program. Cancer Stat Facts: Uterine Cancer. National Cancer Institute. https:\/\/seer.cancer.gov\/statfacts\/html\/corp.html, in, https:\/\/seer.cancer.gov\/statfacts\/html\/corp.html, 2021."},{"key":"10.1016\/j.bioorg.2022.106008_b0020","doi-asserted-by":"crossref","unstructured":"J.T. Thigpen, M.F. Brady, R.D. Alvarez, et al., Oral medroxyprogesterone acetate in the treatment of advanced or recurrent endometrial carcinoma: a dose-response study by the Gynecologic Oncology Group, Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 17 (1999) 1736-1744. https:\/\/doi.org\/10.1200\/jco.1999.17.6.1736.","DOI":"10.1200\/JCO.1999.17.6.1736"},{"issue":"1994","key":"10.1016\/j.bioorg.2022.106008_b0025","first-page":"268","article-title":"Chlorpromazine treatment of mental disorders","volume":"151","author":"Kinross-Wright","year":"1955","journal-title":"Am. J. Psychiatry"},{"key":"10.1016\/j.bioorg.2022.106008_b0030","doi-asserted-by":"crossref","first-page":"338","DOI":"10.1016\/S0140-6736(72)92955-8","article-title":"Chlorpromazines and cancer","volume":"2","author":"Csatary","year":"1972","journal-title":"Lancet (London, England)"},{"key":"10.1016\/j.bioorg.2022.106008_b0035","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1002\/jat.4046","article-title":"In vitro anticancer activity of fluphenazine, perphenazine and prochlorperazine. A review","volume":"41","author":"Otr\u0119ba","year":"2021","journal-title":"J. Appl. Toxicol.: JAT"},{"key":"10.1016\/j.bioorg.2022.106008_b0040","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1016\/j.semcancer.2020.03.011","article-title":"Drug rechanneling: A novel paradigm for cancer treatment","volume":"68","author":"Kaushik","year":"2021","journal-title":"Semin. Cancer Biol."},{"key":"10.1016\/j.bioorg.2022.106008_b0045","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1016\/j.cbi.2019.01.033","article-title":"The antipsychotic chlorpromazine suppresses YAP signaling, stemness properties, and drug resistance in breast cancer cells","volume":"302","author":"Yang","year":"2019","journal-title":"Chem. Biol. Interact."},{"key":"10.1016\/j.bioorg.2022.106008_b0050","doi-asserted-by":"crossref","unstructured":"P. Kamgar-Dayhoff, T.I. Brelidze, Multifaceted effect of chlorpromazine in cancer: implications for cancer treatment, Oncotarget, 12 (2021) 1406-1426. https:\/\/doi.org\/10.18632\/oncotarget.28010.","DOI":"10.18632\/oncotarget.28010"},{"key":"10.1016\/j.bioorg.2022.106008_b0055","doi-asserted-by":"crossref","DOI":"10.3389\/fonc.2021.665832","article-title":"Chlorpromazine Sensitizes Progestin-Resistant Endometrial Cancer Cells to MPA by Upregulating PRB","volume":"11","author":"Cui","year":"2021","journal-title":"Front. Oncol."},{"issue":"1","key":"10.1016\/j.bioorg.2022.106008_b0060","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1021\/acschemneuro.8b00258","article-title":"Classics in Chemical Neuroscience: Chlorpromazine","volume":"10","author":"Boyd-Kimball","year":"2019","journal-title":"ACS Chem. Neurosci."},{"issue":"1","key":"10.1016\/j.bioorg.2022.106008_b0065","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1007\/s00213-004-1866-y","article-title":"Combined treatment of quetiapine with haloperidol in animal models of antipsychotic effect and extrapyramidal side effects: comparison with risperidone and chlorpromazine","volume":"176","author":"Tada","year":"2004","journal-title":"Psychopharmacology"},{"key":"10.1016\/j.bioorg.2022.106008_b0070","doi-asserted-by":"crossref","first-page":"1651","DOI":"10.1021\/ja01540a035","article-title":"Francis, 10-(Dialkylaminoalkyl)-pyrido[3,2-b][l,4]benzothiazine (1-Azaphenothiazine) and Related Compounds","volume":"80","author":"Yale","year":"1958","journal-title":"J. Am. Chem. Soc."},{"key":"10.1016\/j.bioorg.2022.106008_b0075","doi-asserted-by":"crossref","first-page":"646","DOI":"10.1016\/j.cell.2011.02.013","article-title":"Hallmarks of cancer: the next generation","volume":"144","author":"Hanahan","year":"2011","journal-title":"Cell"},{"key":"10.1016\/j.bioorg.2022.106008_b0080","doi-asserted-by":"crossref","first-page":"153486","DOI":"10.1016\/j.phymed.2021.153486","article-title":"In vitro anti-motile effects of Rhoifolin, a flavonoid extracted from Callicarpa nudiflora on breast cancer cells via downregulating Podocalyxin-Ezrin interaction during Epithelial Mesenchymal Transition","volume":"93","author":"Xiong","year":"2021","journal-title":"Phytomedicine : international journal of phytotherapy and phytopharmacology"},{"key":"10.1016\/j.bioorg.2022.106008_b0085","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1081\/DDC-120018376","article-title":"Transdermal Drug Delivery System of Haloperidol to Overcome Self-Induced Extrapyramidal Syndrome","volume":"29","author":"Samanta","year":"2003","journal-title":"Drug Dev. Ind. Pharm."},{"key":"10.1016\/j.bioorg.2022.106008_b0090","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1111\/j.2042-7158.1967.tb08060.x","article-title":"The mechanism of the tranquillizing action of asarone from Acorus calamus Linn","volume":"19","author":"Menon","year":"1967","journal-title":"J. Pharm. Pharmacol."},{"issue":"12","key":"10.1016\/j.bioorg.2022.106008_b0095","doi-asserted-by":"crossref","first-page":"4507","DOI":"10.3390\/ijms21124507","article-title":"The PI3K-AKT-mTOR Pathway and Prostate Cancer: At the Crossroads of AR, MAPK, and WNT Signaling","volume":"21","author":"Shorning","year":"2020","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.bioorg.2022.106008_b0100","doi-asserted-by":"crossref","first-page":"1121","DOI":"10.1517\/14728220903170675","article-title":"Targeting MAPK (Ras\/ERK) and PI3K\/Akt pathways in pituitary tumorigenesis","volume":"13","author":"Cakir","year":"2009","journal-title":"Expert Opin. Therapeutic Targets"},{"issue":"D1","key":"10.1016\/j.bioorg.2022.106008_b0105","doi-asserted-by":"crossref","first-page":"D955","DOI":"10.1093\/nar\/gks1111","article-title":"Genomics of Drug Sensitivity in Cancer (GDSC): a resource for therapeutic biomarker discovery in cancer cells","volume":"41","author":"Yang","year":"2013","journal-title":"Nucleic Acids Res."},{"issue":"7","key":"10.1016\/j.bioorg.2022.106008_b0110","doi-asserted-by":"crossref","first-page":"2551","DOI":"10.1073\/pnas.1812963116","article-title":"Discovery of potent SOS1 inhibitors that block RAS activation via disruption of the RAS-SOS1 interaction","volume":"116","author":"Hillig","year":"2019","journal-title":"PNAS"},{"key":"10.1016\/j.bioorg.2022.106008_b0115","doi-asserted-by":"crossref","unstructured":"M.H. Hofmann, M. Gmachl, J. Ramharter, et al., BI-3406, a Potent and Selective SOS1-KRAS Interaction Inhibitor, Is Effective in KRAS-Driven Cancers through Combined MEK Inhibition, Cancer Discov, 11 (2021) 142-157. https:\/\/doi.org\/10.1158\/2159-8290.CD-20-0142.","DOI":"10.1158\/2159-8290.CD-20-0142"},{"key":"10.1016\/j.bioorg.2022.106008_b0120","doi-asserted-by":"crossref","first-page":"748","DOI":"10.1093\/humupd\/dmu012","article-title":"Risk of endometrial, ovarian and breast cancer in women with polycystic ovary syndrome: a systematic review and meta-analysis","volume":"20","author":"Barry","year":"2014","journal-title":"Human Reproduction Update"},{"issue":"2","key":"10.1016\/j.bioorg.2022.106008_b0125","doi-asserted-by":"crossref","first-page":"304","DOI":"10.1016\/0029-7844(94)00383-O","article-title":"Hormone replacement therapy and endometrial cancer risk: A meta-analysis","volume":"85","author":"Grady","year":"1995","journal-title":"Obstet. Gynecol."},{"key":"10.1016\/j.bioorg.2022.106008_b0130","doi-asserted-by":"crossref","first-page":"794","DOI":"10.1056\/NEJMsr1606602","article-title":"Body fatness and cancer\u2014viewpoint of the IARC Working Group","volume":"375","author":"Lauby-Secretan","year":"2016","journal-title":"N. Engl. J. Med."},{"issue":"1","key":"10.1016\/j.bioorg.2022.106008_b0135","doi-asserted-by":"crossref","DOI":"10.1186\/s12885-019-5748-4","article-title":"The effect of diabetes on the risk of endometrial Cancer: an updated a systematic review and meta-analysis","volume":"19","author":"Saed","year":"2019","journal-title":"BMC Cancer"},{"key":"10.1016\/j.bioorg.2022.106008_b0140","doi-asserted-by":"crossref","first-page":"1215","DOI":"10.1001\/jama.2017.2067","article-title":"Laparoscopic Hysterectomy for Endometrial Cancer: A Procedure 25 Years in the Making","volume":"317","author":"Wright","year":"2017","journal-title":"JAMA"},{"key":"10.1016\/j.bioorg.2022.106008_b0145","unstructured":"National Comprehensive Cancer Network. Uterine neoplasms, version 1. 2020, in, https:\/\/www.nccn.org\/professionals\/physician_gls\/pdf\/uterine.pdf."},{"issue":"3","key":"10.1016\/j.bioorg.2022.106008_b0150","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1016\/j.ygyno.2005.07.104","article-title":"The efficacy of adjuvant platinum-based chemotherapy in Stage I uterine papillary serous carcinoma (UPSC)","volume":"99","author":"Dietrichiii","year":"2005","journal-title":"Gynecol. Oncol."},{"issue":"3","key":"10.1016\/j.bioorg.2022.106008_b0155","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1016\/j.ygyno.2005.06.012","article-title":"Improved survival in surgical stage I patients with uterine papillary serous carcinoma (UPSC) treated with adjuvant platinum-based chemotherapy","volume":"98","author":"Kelly","year":"2005","journal-title":"Gynecol. Oncol."},{"issue":"21","key":"10.1016\/j.bioorg.2022.106008_b0160","doi-asserted-by":"crossref","first-page":"1810","DOI":"10.1200\/JCO.18.01575","article-title":"Phase III Trial: Adjuvant Pelvic Radiation Therapy Versus Vaginal Brachytherapy Plus Paclitaxel\/Carboplatin in High-Intermediate and High-Risk Early Stage Endometrial Cancer, Journal of clinical oncology : official journal of the American Society of","volume":"37","author":"Randall","year":"2019","journal-title":"Clini. Oncol."},{"issue":"33","key":"10.1016\/j.bioorg.2022.106008_b0165","doi-asserted-by":"crossref","first-page":"3841","DOI":"10.1200\/JCO.20.01076","article-title":"Carboplatin and Paclitaxel for Advanced Endometrial Cancer: Final Overall Survival and Adverse Event Analysis of a Phase III Trial (NRG Oncology\/GOG0209)","volume":"38","author":"Miller","year":"2020","journal-title":"J. Clin. Oncol."},{"issue":"29","key":"10.1016\/j.bioorg.2022.106008_b0170","doi-asserted-by":"crossref","first-page":"3388","DOI":"10.1200\/JCO.20.00549","article-title":"Molecular Classification of the PORTEC-3 Trial for High-Risk Endometrial Cancer: Impact on Prognosis and Benefit From Adjuvant Therapy","volume":"38","author":"Le\u00f3n-Castillo","year":"2020","journal-title":"J. Clin. Oncol.: Off. J. Am. Soc. Clin. Oncol."},{"issue":"5","key":"10.1016\/j.bioorg.2022.106008_b0175","doi-asserted-by":"crossref","first-page":"711","DOI":"10.1016\/S1470-2045(19)30020-8","article-title":"Lenvatinib plus pembrolizumab in patients with advanced endometrial cancer: an interim analysis of a multicentre, open-label, single-arm, phase 2 trial","volume":"20","author":"Makker","year":"2019","journal-title":"The Lancet Oncol."},{"issue":"2","key":"10.1016\/j.bioorg.2022.106008_b0180","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1016\/j.ygyno.2012.01.003","article-title":"Oncologic and reproductive outcomes with progestin therapy in women with endometrial hyperplasia and grade 1 adenocarcinoma: a systematic review","volume":"125","author":"Gunderson","year":"2012","journal-title":"Gynecol. Oncol."},{"issue":"2","key":"10.1016\/j.bioorg.2022.106008_b0185","doi-asserted-by":"crossref","first-page":"191.e1","DOI":"10.1016\/j.ajog.2020.08.032","article-title":"Prospective phase II trial of levonorgestrel intrauterine device: nonsurgical approach for complex atypical hyperplasia and early-stage endometrial cancer","volume":"224","author":"Westin","year":"2021","journal-title":"Am. J. Obstet. Gynecol."},{"key":"10.1016\/j.bioorg.2022.106008_b0190","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1016\/j.ygyno.2003.11.008","article-title":"Phase II trial of alternating courses of megestrol acetate and tamoxifen in advanced endometrial carcinoma: a Gynecologic Oncology Group study","volume":"92","author":"Fiorica","year":"2004","journal-title":"Gynecol. Oncol."},{"key":"10.1016\/j.bioorg.2022.106008_b0195","doi-asserted-by":"crossref","first-page":"563","DOI":"10.1177\/030089168507100608","article-title":"Cancer therapy: phenothiazines in an unexpected role","volume":"71","author":"Jones","year":"1985","journal-title":"Tumori"},{"key":"10.1016\/j.bioorg.2022.106008_b0200","doi-asserted-by":"crossref","first-page":"1284","DOI":"10.1016\/j.cell.2012.03.049","article-title":"Identification of drugs including a dopamine receptor antagonist that selectively target cancer stem cells","volume":"149","author":"Sachlos","year":"2012","journal-title":"Cell"},{"key":"10.1016\/j.bioorg.2022.106008_b0205","first-page":"2767","article-title":"The important application of thioridazine in the endometrial cancer","volume":"8","author":"Meng","year":"2016","journal-title":"Am. J. Transl. Res."},{"issue":"4","key":"10.1016\/j.bioorg.2022.106008_b0210","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1038\/bjc.2017.200","article-title":"Modulating cancer cell survival by targeting intracellular cholesterol transport","volume":"117","author":"Kuzu","year":"2017","journal-title":"Br. J. Cancer"},{"issue":"14","key":"10.1016\/j.bioorg.2022.106008_b0215","doi-asserted-by":"crossref","first-page":"127239","DOI":"10.1016\/j.bmcl.2020.127239","article-title":"Repurposing of antipsychotics perphenazine for the treatment of endometrial cancer","volume":"30","author":"Chen","year":"2020","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"10.1016\/j.bioorg.2022.106008_b0220","unstructured":"\u90d1.\u9759.\u5b59.\u7b11.\u738b. \u6676, \u7b49, \u4e09\u6c1f\u62c9\u55ea\u5bf9\u4eba\u5b50\u5bab\u5185\u819c\u764cIshikawa\u7ec6\u80de\u7684\u6291\u5236\u4f5c\u7528, 34 (2014) 609-. https:\/\/doi.org\/10.3969\/j.issn.1674-8115.2014.05.008."},{"key":"10.1016\/j.bioorg.2022.106008_b0225","first-page":"206","article-title":"A new vegetative stabilizer; 4560 R.P","volume":"60","author":"Laborit","year":"1952","journal-title":"Presse Med."},{"key":"10.1016\/j.bioorg.2022.106008_b0230","unstructured":"D.D. Miller, Review and management of clozapine side effects, J Clin Psychiatry, 61 Suppl 8 (2000) 14-17; discussion 18-19."},{"key":"10.1016\/j.bioorg.2022.106008_b0235","doi-asserted-by":"crossref","first-page":"757","DOI":"10.2147\/TCRM.S117321","article-title":"Safety, tolerability, and risks associated with first- and second-generation antipsychotics: a state-of-the-art clinical review","volume":"13","author":"Solmi","year":"2017","journal-title":"Ther. Clin. Risk Manag."},{"key":"10.1016\/j.bioorg.2022.106008_b0240","doi-asserted-by":"crossref","first-page":"474","DOI":"10.3181\/00379727-155-39833","article-title":"Adverse effects of chlorpromazine metabolites on isolated hepatocytes","volume":"155","author":"Abernathy","year":"1977","journal-title":"Proc. Soc. Exp. Biol. Med."},{"issue":"9","key":"10.1016\/j.bioorg.2022.106008_b0245","doi-asserted-by":"crossref","first-page":"1556","DOI":"10.1124\/dmd.114.058123","article-title":"Impact of inflammation on chlorpromazine-induced cytotoxicity and cholestatic features in HepaRG cells","volume":"42","author":"Bachour-El Azzi","year":"2014","journal-title":"Drug Metab. Dispos."},{"issue":"4","key":"10.1016\/j.bioorg.2022.106008_b0250","doi-asserted-by":"crossref","first-page":"352","DOI":"10.1192\/bjp.135.4.352","article-title":"Clinical significance of plasma drug and prolactin levels during acute chlorpromazine treatment: a replication study","volume":"135","author":"Kolakowska","year":"1979","journal-title":"Br. J. Psychiatry"},{"issue":"05","key":"10.1016\/j.bioorg.2022.106008_b0255","doi-asserted-by":"crossref","DOI":"10.1017\/S1461145706007218","article-title":"A comparative study of the plasma membrane permeabilization and fluidization induced by antipsychotic drugs in the rat brain","volume":"10","author":"Murata","year":"2007","journal-title":"Int. J. Neuropsychopharmacol."},{"key":"10.1016\/j.bioorg.2022.106008_b0260","doi-asserted-by":"crossref","first-page":"121296","DOI":"10.1016\/j.ijpharm.2021.121296","article-title":"Repurposing chlorpromazine for anti-leukaemic therapy by nanoparticle encapsulation","volume":"612","author":"Gundersen","year":"2022","journal-title":"Int. J. Pharm."},{"issue":"1","key":"10.1016\/j.bioorg.2022.106008_b0265","doi-asserted-by":"crossref","DOI":"10.1038\/s41467-020-17666-8","article-title":"Chlorpromazine eliminates acute myeloid leukemia cells by perturbing subcellular localization of FLT3-ITD and KIT-D816V","volume":"11","author":"Rai","year":"2020","journal-title":"Nat. Commun."},{"key":"10.1016\/j.bioorg.2022.106008_b0270","doi-asserted-by":"crossref","first-page":"114403","DOI":"10.1016\/j.bcp.2020.114403","article-title":"Chlorpromazine, an antipsychotic agent, induces G2\/M phase arrest and apoptosis via regulation of the PI3K\/AKT\/mTOR-mediated autophagy pathways in human oral cancer","volume":"184","author":"Jhou","year":"2021","journal-title":"Biochem. Pharmacol."},{"issue":"7","key":"10.1016\/j.bioorg.2022.106008_b0275","doi-asserted-by":"crossref","first-page":"968","DOI":"10.1038\/s41591-018-0022-x","article-title":"Targeting wild-type KRAS-amplified gastroesophageal cancer through combined MEK and SHP2 inhibition","volume":"24","author":"Wong","year":"2018","journal-title":"Nat. Med."},{"key":"10.1016\/j.bioorg.2022.106008_b0280","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1007\/BF00300234","article-title":"Determination of subcutaneous tumor size in athymic (nude) mice","volume":"24","author":"Tomayko","year":"1989","journal-title":"Cancer Chemother. Pharmacol."}],"container-title":["Bioorganic Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S004520682200414X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S004520682200414X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,23]],"date-time":"2025-09-23T08:44:21Z","timestamp":1758617061000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S004520682200414X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,10]]},"references-count":56,"alternative-id":["S004520682200414X"],"URL":"https:\/\/doi.org\/10.1016\/j.bioorg.2022.106008","relation":{},"ISSN":["0045-2068"],"issn-type":[{"value":"0045-2068","type":"print"}],"subject":[],"published":{"date-parts":[[2022,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Novel chlorpromazine derivatives as anti-endometrial carcinoma agents with reduced extrapyramidal side effects","name":"articletitle","label":"Article Title"},{"value":"Bioorganic Chemistry","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bioorg.2022.106008","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 The Author(s). Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"106008"}}