{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,19]],"date-time":"2026-09-19T09:41:31Z","timestamp":1789810891949,"version":"4.0.1"},"reference-count":25,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2022,11,1]],"date-time":"2022-11-01T00:00:00Z","timestamp":1667260800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,11,1]],"date-time":"2022-11-01T00:00:00Z","timestamp":1667260800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,11,1]],"date-time":"2022-11-01T00:00:00Z","timestamp":1667260800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2022,11,1]],"date-time":"2022-11-01T00:00:00Z","timestamp":1667260800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2022,11,1]],"date-time":"2022-11-01T00:00:00Z","timestamp":1667260800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2022,11,1]],"date-time":"2022-11-01T00:00:00Z","timestamp":1667260800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2022,11,1]],"date-time":"2022-11-01T00:00:00Z","timestamp":1667260800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/100016694","name":"Science and Technology Development Plan of Shandong Province","doi-asserted-by":"publisher","award":["2018WS061"],"award-info":[{"award-number":["2018WS061"]}],"id":[{"id":"10.13039\/100016694","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81803343"],"award-info":[{"award-number":["81803343"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81903468"],"award-info":[{"award-number":["81903468"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007129","name":"Natural Science Foundation of Shandong Province","doi-asserted-by":"publisher","award":["ZR2019BH068"],"award-info":[{"award-number":["ZR2019BH068"]}],"id":[{"id":"10.13039\/501100007129","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007129","name":"Natural Science Foundation of Shandong Province","doi-asserted-by":"publisher","award":["ZR2019QH005"],"award-info":[{"award-number":["ZR2019QH005"]}],"id":[{"id":"10.13039\/501100007129","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100018627","name":"Science and Technology Support Plan for Youth Innovation of Colleges and Universities of Shandong Province of China","doi-asserted-by":"publisher","award":["2019KJM001"],"award-info":[{"award-number":["2019KJM001"]}],"id":[{"id":"10.13039\/501100018627","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Bioorganic Chemistry"],"published-print":{"date-parts":[[2022,11]]},"DOI":"10.1016\/j.bioorg.2022.106052","type":"journal-article","created":{"date-parts":[[2022,7,25]],"date-time":"2022-07-25T19:48:17Z","timestamp":1658778497000},"page":"106052","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":11,"special_numbering":"C","title":["Design, synthesis and biological evaluation of novel dihydrobenzodioxine derivatives as HBV capsid protein inhibitors"],"prefix":"10.1016","volume":"128","author":[{"given":"Linyue","family":"Liu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mei","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chuanju","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xianghui","family":"Han","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yong","family":"Xie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kairui","family":"Feng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lei","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yunfu","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haiyong","family":"Jia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bioorg.2022.106052_b0005","unstructured":"World Health Organization. Global hepatitis report, 2021. Available from: <https:\/\/www.who.int\/news\/item\/28-07-2021-hepatitis-can-t-wait---who-commemorates-world-hepatitis-day-2021>."},{"key":"10.1016\/j.bioorg.2022.106052_b0010","unstructured":"Collaborators, G. B. D. H. B., Global, regional, and national burden of hepatitis B, 1990-2019: a systematic analysis for the Global Burden of Disease Study 2019. Lancet Gastroenterol. Hepatol. 2022."},{"key":"10.1016\/j.bioorg.2022.106052_b0015","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejmech.2020.112495","article-title":"Design, diversity-oriented synthesis and biological evaluation of novel heterocycle derivatives as non-nucleoside HBV capsid protein inhibitors","volume":"202","author":"Jia","year":"2020","journal-title":"Eur. J. Med. Chem."},{"issue":"136","key":"10.1016\/j.bioorg.2022.106052_b0020","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1016\/j.ejmech.2017.04.048","article-title":"Design, synthesis and primary biological evaluation of the novel 2-pyridone derivatives as potent non-nucleoside HBV inhibitors","volume":"18","author":"Jia","year":"2017","journal-title":"Eur. J. Med. Chem."},{"issue":"7","key":"10.1016\/j.bioorg.2022.106052_b0025","doi-asserted-by":"crossref","first-page":"3319","DOI":"10.1128\/jvi.64.7.3319-3330.1990","article-title":"Hepatitis B virus nucleocapsid assembly: primary structure requirements in the core protein","volume":"64","author":"Birnbaum","year":"1990","journal-title":"J. Virol."},{"key":"10.1016\/j.bioorg.2022.106052_b0030","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejmech.2020.112714","article-title":"Discovery and optimization of benzenesulfonamides-based hepatitis B virus capsid modulators via contemporary medicinal chemistry strategies","volume":"206","author":"Ren","year":"2020","journal-title":"Eur. J. Med. Chem."},{"issue":"6","key":"10.1016\/j.bioorg.2022.106052_b0035","doi-asserted-by":"crossref","first-page":"542","DOI":"10.1002\/jmr.801","article-title":"41\u20134109 has multiple effects on Hepatitis B virus capsid assembly","volume":"19","author":"Stray","year":"2006","journal-title":"J. Mol. Recognit."},{"issue":"11","key":"10.1016\/j.bioorg.2022.106052_b0040","doi-asserted-by":"crossref","first-page":"5344","DOI":"10.1128\/AAC.01091-13","article-title":"Preclinical characterization of GLS4, an inhibitor of hepatitis B virus core particle assembly","volume":"57","author":"Wu","year":"2013","journal-title":"Antimicrob. Agents Chemother."},{"issue":"225","key":"10.1016\/j.bioorg.2022.106052_b0045","article-title":"Design, synthesis and evaluation of heteroaryldihydropyrimidine analogues bearing spiro ring as hepatitis B virus capsid protein inhibitors","volume":"5","author":"Ma","year":"2021","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.bioorg.2022.106052_b0050","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1016\/S0168-8278(16)00175-6","article-title":"NVR 3\u2013778, a first-in-class HBV core inhibitor, alone and in combination with peg-interferon (PegIFN), in treatment-naive HBeAg-positive patients: early reductions in HBV DNA and HBeAg","volume":"64","author":"Yuen","year":"2016","journal-title":"J. Hepatol."},{"issue":"8","key":"10.1016\/j.bioorg.2022.106052_b0055","doi-asserted-by":"crossref","first-page":"1406","DOI":"10.1016\/j.str.2013.06.013","article-title":"Assembly-directed antivirals differentially bind quasiequivalent pockets to modify hepatitis B virus capsid tertiary and quaternary structure","volume":"21","author":"Katen","year":"2013","journal-title":"Structure"},{"issue":"11","key":"10.1016\/j.bioorg.2022.106052_b0060","doi-asserted-by":"crossref","first-page":"6066","DOI":"10.1021\/acs.jmedchem.0c00292","article-title":"Discovery of (1H-Pyrazolo[3,4-c] pyridin-5-yl) sulfonamide analogues as hepatitis B virus capsid assembly modulators by conformation constraint","volume":"63","author":"Wang","year":"2020","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.bioorg.2022.106052_b0065","doi-asserted-by":"crossref","unstructured":"N. Hwang, H. Ban, S. Wua, M.G. Kelly, H. Ellen, J. Chen, Q. Zhao, S. Manasa, et al., 4-oxooctahydroquinoline-1(2H)-carboxamides as Hepatitis B Virus (HBV) Capsid Core Protein Assembly Modulators, Bioorg. Med. Chem. Lett. 2021 Dec 31; 58 (2022) 128518.","DOI":"10.1016\/j.bmcl.2021.128518"},{"issue":"2","key":"10.1016\/j.bioorg.2022.106052_b0070","doi-asserted-by":"crossref","first-page":"328","DOI":"10.1021\/acs.jcim.7b00471","article-title":"Identification of factors promoting HBV capsid self-assembly by assembly-promoting antivirals","volume":"58","author":"Rath","year":"2018","journal-title":"J. Chem. Inf. Model."},{"key":"10.1016\/j.bioorg.2022.106052_b0075","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1016\/j.antiviral.2018.07.011","article-title":"Novel non-heteroarylpyrimidine (HAP) capsid assembly modifiers have a different mode of action from HAPs in vitro","volume":"158","author":"Corcuera","year":"2018","journal-title":"Antiviral. Res."},{"issue":"18","key":"10.1016\/j.bioorg.2022.106052_b0080","doi-asserted-by":"crossref","first-page":"10091","DOI":"10.1021\/acs.jmedchem.9b01596","article-title":"Facts, patterns, and principles in drug discovery: appraising the rule of 5 with measured physicochemical data","volume":"63","author":"Tinworth","year":"2020","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.bioorg.2022.106052_b0085","doi-asserted-by":"crossref","unstructured":"A. Daina, O. Michielin, V. Zoete, SwissADME: a free web tool to evaluate pharmacokinetics, drug-likeness and medicinal chemistry friendliness of small molecules, Sci. Rep. 7 (2017) 42717. Available from: <http:\/\/www.swissadme.ch\/>.","DOI":"10.1038\/srep42717"},{"issue":"12","key":"10.1016\/j.bioorg.2022.106052_b0090","doi-asserted-by":"crossref","first-page":"3284","DOI":"10.1021\/ci500467k","article-title":"iLOGP: a simple, robust, and efficient description of n-octanol\/water partition coefficient for drug design using the GB\/SA approach","volume":"54","author":"Daina","year":"2014","journal-title":"J. Chem. Inf. Model."},{"key":"10.1016\/j.bioorg.2022.106052_b0095","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1023\/A:1008763405023","article-title":"Calculating partition coefficient by atom-additive method","volume":"19","author":"Wang","year":"2000","journal-title":"Perspect. Drug Des."},{"issue":"5","key":"10.1016\/j.bioorg.2022.106052_b0100","doi-asserted-by":"crossref","first-page":"868","DOI":"10.1021\/ci990307l","article-title":"Prediction of physicochemical parameters by atomic contributions","volume":"39","author":"Wildman","year":"1999","journal-title":"J. Chem. Inf. Model. Comput. Sci."},{"issue":"1\u20133","key":"10.1016\/j.bioorg.2022.106052_b0105","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/S0169-409X(00)00129-0","article-title":"Experimental and computational approaches to estimate solubility and permeability in drug discovery and development settings","volume":"46","author":"Lipinski","year":"2001","journal-title":"Adv. Drug Deliv. Rev."},{"key":"10.1016\/j.bioorg.2022.106052_b0110","unstructured":"SILICOS-IT. Available from: <http:\/\/www.silicos-it.com>."},{"issue":"8","key":"10.1016\/j.bioorg.2022.106052_b0115","doi-asserted-by":"crossref","first-page":"1715","DOI":"10.1128\/AAC.41.8.1715","article-title":"Inducible expression of human hepatitis B virus (HBV) in stably transfected hepatoblastoma cells: a novel system for screening potential inhibitors of HBV replication","volume":"41","author":"Ladner","year":"1997","journal-title":"Antimicrob. Agents Chemother."},{"issue":"1\u20132","key":"10.1016\/j.bioorg.2022.106052_b0120","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1007\/s11010-006-9167-x","article-title":"Hepatitis B virus replication causes oxidative stress in HepAD38 liver cells","volume":"290","author":"Severi","year":"2006","journal-title":"Mol. Cell Biochem."},{"issue":"3","key":"10.1016\/j.bioorg.2022.106052_b0125","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1016\/j.bbrc.2014.08.029","article-title":"Formation of covalently closed circular DNA in Hep38.7-Tet cells, a tetracycline inducible hepatitis B virus expression cell line","volume":"452","author":"Ogura","year":"2014","journal-title":"Biochem. Biophys. Res. Commun."}],"container-title":["Bioorganic Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0045206822004588?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0045206822004588?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,23]],"date-time":"2025-09-23T08:35:39Z","timestamp":1758616539000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0045206822004588"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,11]]},"references-count":25,"alternative-id":["S0045206822004588"],"URL":"https:\/\/doi.org\/10.1016\/j.bioorg.2022.106052","relation":{},"ISSN":["0045-2068"],"issn-type":[{"value":"0045-2068","type":"print"}],"subject":[],"published":{"date-parts":[[2022,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Design, synthesis and biological evaluation of novel dihydrobenzodioxine derivatives as HBV capsid protein inhibitors","name":"articletitle","label":"Article Title"},{"value":"Bioorganic Chemistry","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bioorg.2022.106052","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"106052"}}