{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,9]],"date-time":"2026-06-09T17:59:26Z","timestamp":1781027966998,"version":"3.54.1"},"reference-count":50,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2022,12,1]],"date-time":"2022-12-01T00:00:00Z","timestamp":1669852800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,12,1]],"date-time":"2022-12-01T00:00:00Z","timestamp":1669852800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,12,1]],"date-time":"2022-12-01T00:00:00Z","timestamp":1669852800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2022,12,1]],"date-time":"2022-12-01T00:00:00Z","timestamp":1669852800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2022,12,1]],"date-time":"2022-12-01T00:00:00Z","timestamp":1669852800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2022,12,1]],"date-time":"2022-12-01T00:00:00Z","timestamp":1669852800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2022,12,1]],"date-time":"2022-12-01T00:00:00Z","timestamp":1669852800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81973209"],"award-info":[{"award-number":["81973209"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82173716"],"award-info":[{"award-number":["82173716"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Bioorganic Chemistry"],"published-print":{"date-parts":[[2022,12]]},"DOI":"10.1016\/j.bioorg.2022.106168","type":"journal-article","created":{"date-parts":[[2022,9,28]],"date-time":"2022-09-28T11:31:33Z","timestamp":1664364693000},"page":"106168","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":28,"special_numbering":"C","title":["Discovery of novel \u03b2-carboline-1,2,3-triazole hybrids as AChE\/GSK-3\u03b2 dual inhibitors for Alzheimer's disease treatment"],"prefix":"10.1016","volume":"129","author":[{"given":"Wenjie","family":"Liu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liting","family":"Tian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Limeng","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huanhua","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nan","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Changhao","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhongchan","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaowen","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiong","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zihua","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenwu","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9468-1040","authenticated-orcid":false,"given":"Qingchun","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"9","key":"10.1016\/j.bioorg.2022.106168_b0005","doi-asserted-by":"crossref","first-page":"1823","DOI":"10.1021\/acschemneuro.7b00270","article-title":"Classics in chemical neuroscience: memantine","volume":"8","author":"Alam","year":"2017","journal-title":"ACS Chem. Neurosci."},{"issue":"1","key":"10.1016\/j.bioorg.2022.106168_b0010","doi-asserted-by":"crossref","first-page":"4","DOI":"10.2174\/1568026619666191203113745","article-title":"Progress in target drug molecules for Alzheimer's disease","volume":"20","author":"Xie","year":"2020","journal-title":"Curr. Top. Med. Chem."},{"issue":"5","key":"10.1016\/j.bioorg.2022.106168_b0015","doi-asserted-by":"crossref","first-page":"1578","DOI":"10.1002\/anie.201410456","article-title":"Multitarget drug discovery for Alzheimer's disease: triazinones as BACE-1 and GSK-3beta inhibitors","volume":"54","author":"Prati","year":"2015","journal-title":"Angew. Chem. Int. Ed. Engl."},{"issue":"10","key":"10.1016\/j.bioorg.2022.106168_b0020","doi-asserted-by":"crossref","first-page":"1471","DOI":"10.1021\/acschemneuro.0c00114","article-title":"A Multifunctional chemical agent as an attenuator of amyloid burden and neuroinflammation in Alzheimer's disease","volume":"11","author":"Cho","year":"2020","journal-title":"ACS Chem. Neurosci."},{"issue":"9","key":"10.1016\/j.bioorg.2022.106168_b0025","doi-asserted-by":"crossref","first-page":"2491","DOI":"10.1007\/s00204-019-02538-y","article-title":"Management of oxidative stress and other pathologies in Alzheimer's disease","volume":"93","author":"Simunkova","year":"2019","journal-title":"Arch. Toxicol."},{"key":"10.1016\/j.bioorg.2022.106168_b0030","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1016\/j.ejmech.2012.06.006","article-title":"Structure-based optimization of oxadiazole-based GSK-3 inhibitors","volume":"61","author":"Lo Monte","year":"2013","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.bioorg.2022.106168_b0035","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1016\/j.ejphar.2015.10.037","article-title":"Effects of harmine, an acetylcholinesterase inhibitor, on spatial learning and memory of APP\/PS1 transgenic mice and scopolamine-induced memory impairment mice","volume":"768","author":"He","year":"2015","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.bioorg.2022.106168_b0040","doi-asserted-by":"crossref","unstructured":"R. Azzouz, L. Peauger, V. Gembus, M.L. Tintas, J. Sopkova-de Oliveira Santos, C. Papamicael, V. Levacher, Novel donepezil-like N-benzylpyridinium salt derivatives as AChE inhibitors and their corresponding dihydropyridine \u201cbio-oxidizable\u201d prodrugs: synthesis, biological evaluation and structure-activity relationship, Eur. J. Med. Chem. 145 (2018) 165\u2013190.","DOI":"10.1016\/j.ejmech.2017.12.084"},{"key":"10.1016\/j.bioorg.2022.106168_b0045","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1016\/j.ejmech.2016.05.014","article-title":"Synthesis and anticholinesterase activity of coumarin-3-carboxamides bearing tryptamine moiety","volume":"121","author":"Ghanei-Nasab","year":"2016","journal-title":"Eur. J. Med. Chem."},{"issue":"4","key":"10.1016\/j.bioorg.2022.106168_b0050","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1358\/dot.2016.52.4.2479357","article-title":"Memantine and donepezil: a fixed drug combination for the treatment of moderate to severe Alzheimer's dementia","volume":"52","author":"Owen","year":"2016","journal-title":"Drugs Today (Barc)"},{"issue":"5","key":"10.1016\/j.bioorg.2022.106168_b0055","doi-asserted-by":"crossref","first-page":"3338","DOI":"10.1007\/s12035-015-9272-5","article-title":"Subthreshold concentrations of melatonin and galantamine improves pathological AD-hallmarks in hippocampal organotypic cultures","volume":"53","author":"Buendia","year":"2016","journal-title":"Mol. Neurobiol."},{"issue":"5","key":"10.1016\/j.bioorg.2022.106168_b0060","doi-asserted-by":"crossref","first-page":"828","DOI":"10.1002\/cmdc.200800414","article-title":"Tacrine-melatonin hybrids as multifunctional agents for Alzheimer's disease, with cholinergic, antioxidant, and neuroprotective properties","volume":"4","author":"Fernandez-Bachiller","year":"2009","journal-title":"ChemMedChem"},{"issue":"Suppl. 1","key":"10.1016\/j.bioorg.2022.106168_b0065","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1111\/j.1471-4159.2011.07507.x","article-title":"Cholinergic modulation of amyloid precursor protein processing with emphasis on M1 muscarinic receptor: perspectives and challenges in treatment of Alzheimer's disease","volume":"120","author":"Fisher","year":"2012","journal-title":"J. Neurochem."},{"issue":"2","key":"10.1016\/j.bioorg.2022.106168_b0070","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1111\/j.1471-4159.2007.04975.x","article-title":"GSK3beta mediates the induced expression of synaptic acetylcholinesterase during apoptosis","volume":"104","author":"Jing","year":"2008","journal-title":"J. Neurochem."},{"issue":"3","key":"10.1016\/j.bioorg.2022.106168_b0075","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1021\/acsmedchemlett.7b00463","article-title":"Dual GSK-3beta\/AChE inhibitors as a new strategy for multitargeting anti-Alzheimer's disease drug discovery","volume":"9","author":"Jiang","year":"2018","journal-title":"ACS Med. Chem. Lett."},{"key":"10.1016\/j.bioorg.2022.106168_b0080","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejmech.2020.112751","article-title":"Rational design and biological evaluation of a new class of thiazolopyridyl tetrahydroacridines as cholinesterase and GSK-3 dual inhibitors for Alzheimer's disease","volume":"207","author":"Jiang","year":"2020","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.bioorg.2022.106168_b0085","doi-asserted-by":"crossref","DOI":"10.1016\/j.bmc.2020.115940","article-title":"Discovery of potent glycogen synthase kinase 3\/cholinesterase inhibitors with neuroprotection as potential therapeutic agent for Alzheimer's disease","volume":"30","author":"Jiang","year":"2021","journal-title":"Bioorg. Med. Chem."},{"key":"10.1016\/j.bioorg.2022.106168_b0090","volume":"223","author":"Jiang","year":"2021","journal-title":"Eur. J. Med. Chem."},{"issue":"11","key":"10.1016\/j.bioorg.2022.106168_b0095","doi-asserted-by":"crossref","first-page":"7483","DOI":"10.1021\/acs.jmedchem.1c00160","article-title":"Discovery of novel tacrine-pyrimidone hybrids as potent dual AChE\/GSK-3 inhibitors for the treatment of Alzheimer's disease","volume":"64","author":"Yao","year":"2021","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.bioorg.2022.106168_b0100","doi-asserted-by":"crossref","first-page":"656","DOI":"10.1016\/j.ejmech.2019.07.059","article-title":"Triazole derivatives as inhibitors of Alzheimer's disease: current developments and structure-activity relationships","volume":"180","author":"Xu","year":"2019","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.bioorg.2022.106168_b0105","doi-asserted-by":"crossref","first-page":"799","DOI":"10.1016\/j.ejmech.2015.01.044","article-title":"Potent acetylcholinesterase inhibitors: design, synthesis, biological evaluation, and docking study of acridone linked to 1,2,3-triazole derivatives","volume":"92","author":"Mohammadi-Khanaposhtani","year":"2015","journal-title":"Eur. J. Med. Chem."},{"issue":"5","key":"10.1016\/j.bioorg.2022.106168_b0110","doi-asserted-by":"crossref","first-page":"1611","DOI":"10.1021\/jacs.5b11384","article-title":"Steric and dynamic parameters influencing in situ cycloadditions to form triazole inhibitors with crystalline acetylcholinesterase","volume":"138","author":"Bourne","year":"2016","journal-title":"J. Am. Chem. Soc."},{"key":"10.1016\/j.bioorg.2022.106168_b0115","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejmech.2019.111787","article-title":"6-Methyluracil derivatives as peripheral site ligand-hydroxamic acid conjugates: reactivation for paraoxon-inhibited acetylcholinesterase","volume":"185","author":"Semenov","year":"2020","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.bioorg.2022.106168_b0120","doi-asserted-by":"crossref","first-page":"1200","DOI":"10.1016\/j.ejmech.2016.11.008","article-title":"Novel tacrine-1,2,3-triazole hybrids: In vitro, in vivo biological evaluation and docking study of cholinesterase inhibitors","volume":"125","author":"Najafi","year":"2017","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.bioorg.2022.106168_b0125","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejmech.2021.113554","article-title":"Design, synthesis and biological evaluation of harmine derivatives as potent GSK-3beta\/DYRK1A dual inhibitors for the treatment of Alzheimer's disease","volume":"222","author":"Liu","year":"2021","journal-title":"Eur. J. Med. Chem."},{"issue":"9","key":"10.1016\/j.bioorg.2022.106168_b0130","doi-asserted-by":"crossref","first-page":"1025","DOI":"10.1021\/acsmedchemlett.5b00281","article-title":"Novel fluorinated 8-hydroxyquinoline based metal ionophores for exploring the metal hypothesis of Alzheimer's disease","volume":"6","author":"Liang","year":"2015","journal-title":"ACS Med. Chem. Lett."},{"issue":"9","key":"10.1016\/j.bioorg.2022.106168_b0135","doi-asserted-by":"crossref","first-page":"1824","DOI":"10.1021\/acs.chemrestox.9b00168","article-title":"Multifunctional mono-triazole derivatives inhibit Abeta42 aggregation and Cu(2+)-mediated Abeta42 aggregation and protect against Abeta42-induced cytotoxicity","volume":"32","author":"Kaur","year":"2019","journal-title":"Chem. Res. Toxicol."},{"issue":"50","key":"10.1016\/j.bioorg.2022.106168_b0140","doi-asserted-by":"crossref","first-page":"15084","DOI":"10.1021\/acs.jafc.1c02144","article-title":"Synthesis, structural characterization, and antibacterial and antifungal activities of novel 1,2,4-triazole thioether and thiazolo[3,2-b]-1,2,4-triazole derivatives bearing the 6-fluoroquinazolinyl moiety","volume":"69","author":"Ding","year":"2021","journal-title":"J. Agric. Food Chem."},{"issue":"3","key":"10.1016\/j.bioorg.2022.106168_b0145","doi-asserted-by":"crossref","first-page":"1392","DOI":"10.1021\/acs.jmedchem.0c01887","article-title":"beta-Carboline as a privileged scaffold for multitarget strategies in Alzheimer's disease therapy","volume":"64","author":"Beato","year":"2021","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.bioorg.2022.106168_b0150","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1016\/j.ejmech.2018.12.063","article-title":"Design, biological evaluation and X-ray crystallography of nanomolar multifunctional ligands targeting simultaneously acetylcholinesterase and glycogen synthase kinase-3","volume":"168","author":"Oukoloff","year":"2019","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.bioorg.2022.106168_b0155","doi-asserted-by":"crossref","DOI":"10.1016\/j.fitote.2019.104196","article-title":"Pre-clinical investigations of beta-carboline alkaloids as antidepressant agents: a systematic review","volume":"137","author":"Ferraz","year":"2019","journal-title":"Fitoterapia"},{"key":"10.1016\/j.bioorg.2022.106168_b0160","doi-asserted-by":"crossref","first-page":"622","DOI":"10.1016\/j.ejmech.2018.08.027","article-title":"beta-Carboline alkaloid monomers and dimers: occurrence, structural diversity, and biological activities","volume":"157","author":"Dai","year":"2018","journal-title":"Eur. J. Med. Chem."},{"issue":"4","key":"10.1016\/j.bioorg.2022.106168_b0165","doi-asserted-by":"crossref","first-page":"667","DOI":"10.1007\/s11307-018-1165-3","article-title":"[(11)C]Harmine Binding to brain monoamine oxidase A: test-retest properties and noninvasive quantification","volume":"20","author":"Zanderigo","year":"2018","journal-title":"Mol. Imaging Biol."},{"key":"10.1016\/j.bioorg.2022.106168_b0170","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1016\/j.intimp.2018.04.050","article-title":"Harmine, a small molecule derived from natural sources, inhibits enterovirus 71 replication by targeting NF-kappaB pathway","volume":"60","author":"Chen","year":"2018","journal-title":"Int. Immunopharmacol."},{"issue":"1","key":"10.1016\/j.bioorg.2022.106168_b0175","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1080\/02791072.2016.1260189","article-title":"Effects of the natural beta-carboline alkaloid harmine, a main constituent of Ayahuasca, memory and in the hippocampus: a systematic literature review of preclinical studies","volume":"49","author":"Dos Santos","year":"2017","journal-title":"J. Psychoact. Drugs"},{"issue":"8","key":"10.1016\/j.bioorg.2022.106168_b0180","doi-asserted-by":"crossref","first-page":"660","DOI":"10.1016\/S2221-1691(12)60116-6","article-title":"A review on medicinal importance, pharmacological activity and bioanalytical aspects of beta-carboline alkaloid \u201cHarmine\u201d","volume":"2","author":"Patel","year":"2012","journal-title":"Asian Pac. J. Trop Biomed"},{"key":"10.1016\/j.bioorg.2022.106168_b0185","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejmech.2021.114095","article-title":"Discovery of novel beta-carboline derivatives as selective AChE inhibitors with GSK-3beta inhibitory property for the treatment of Alzheimer's disease","volume":"229","author":"Liu","year":"2022","journal-title":"Eur. J. Med. Chem."},{"issue":"22","key":"10.1016\/j.bioorg.2022.106168_b0190","doi-asserted-by":"crossref","first-page":"10282","DOI":"10.1021\/jm300871x","article-title":"Structures of human acetylcholinesterase in complex with pharmacologically important ligands","volume":"55","author":"Cheung","year":"2012","journal-title":"J. Med. Chem."},{"issue":"3","key":"10.1016\/j.bioorg.2022.106168_b0195","doi-asserted-by":"crossref","DOI":"10.3390\/molecules26030663","article-title":"Recent advances in the synthesis of beta-carboline alkaloids","volume":"26","author":"Szabo","year":"2021","journal-title":"Molecules"},{"issue":"9","key":"10.1016\/j.bioorg.2022.106168_b0200","doi-asserted-by":"crossref","first-page":"3546","DOI":"10.1039\/C9NJ06330G","article-title":"Recent advances in organic dyes and fluorophores comprising a 1,2,3-triazole moiety","volume":"44","author":"Brunel","year":"2020","journal-title":"New J. Chem."},{"issue":"17","key":"10.1016\/j.bioorg.2022.106168_b0205","doi-asserted-by":"crossref","first-page":"7450","DOI":"10.1039\/D0NJ06267G","article-title":"Diverse synthesis of pyrrolo\/indolo[3,2-c]coumarins as isolamellarin-A scaffolds: a brief update","volume":"45","author":"Samanta","year":"2021","journal-title":"New J. Chem."},{"key":"10.1016\/j.bioorg.2022.106168_b0210","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1016\/0006-2952(61)90145-9","article-title":"A new and rapid colorimetric determination of acetylcholinesterase activity","volume":"7","author":"Ellman","year":"1961","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.bioorg.2022.106168_b0215","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejmech.2022.114689","article-title":"Design, synthesis and biological evaluation of novel coumarin derivatives as multifunctional ligands for the treatment of Alzheimer's disease","volume":"242","author":"Liu","year":"2022","journal-title":"Eur. J. Med. Chem."},{"issue":"9","key":"10.1016\/j.bioorg.2022.106168_b0220","doi-asserted-by":"crossref","first-page":"1856","DOI":"10.1016\/j.bmcl.2015.03.046","article-title":"Discovery of new acylaminopyridines as GSK-3 inhibitors by a structure guided in-depth exploration of chemical space around a pyrrolopyridinone core","volume":"25","author":"Sivaprakasam","year":"2015","journal-title":"Bioorg. Med. Chem. Lett."},{"issue":"3","key":"10.1016\/j.bioorg.2022.106168_b0225","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1016\/S0223-5234(03)00012-6","article-title":"High throughput artificial membrane permeability assay for blood\u2013brain barrier","volume":"38","author":"Di","year":"2003","journal-title":"Eur. J. Med. Chem."},{"issue":"13","key":"10.1016\/j.bioorg.2022.106168_b0230","doi-asserted-by":"crossref","first-page":"1618","DOI":"10.4103\/0366-6999.235112","article-title":"Research progress in the pathogenesis of Alzheimer's disease","volume":"131","author":"Chen","year":"2018","journal-title":"Chin. Med. J. (Engl.)"},{"issue":"82","key":"10.1016\/j.bioorg.2022.106168_b0235","doi-asserted-by":"crossref","first-page":"11558","DOI":"10.1039\/C8CC06897F","article-title":"Synthesis and evaluation of pyrazine and quinoxaline fluorophores for in vivo detection of cerebral tau tangles in Alzheimer's models","volume":"54","author":"Zhu","year":"2018","journal-title":"Chem. Commun. (Camb.)"},{"key":"10.1016\/j.bioorg.2022.106168_b0240","doi-asserted-by":"crossref","DOI":"10.1016\/j.bioorg.2022.105659","article-title":"Facile synthesis of C1-substituted beta-carbolines as CDK4 inhibitors for the treatment of cancer","volume":"121","author":"Li","year":"2022","journal-title":"Bioorg. Chem."},{"issue":"33","key":"10.1016\/j.bioorg.2022.106168_b0245","doi-asserted-by":"crossref","first-page":"9601","DOI":"10.1002\/anie.201603797","article-title":"Discovery of a highly selective glycogen synthase kinase-3 inhibitor (PF-04802367) that modulates tau phosphorylation in the brain: translation for PET neuroimaging","volume":"55","author":"Liang","year":"2016","journal-title":"Angew. Chem. Int. Ed. Engl."},{"issue":"30","key":"10.1016\/j.bioorg.2022.106168_b0250","doi-asserted-by":"crossref","first-page":"12293","DOI":"10.1002\/anie.202003115","article-title":"The Huisgen reaction: milestones of the 1,3-dipolar cycloaddition","volume":"59","author":"Breugst","year":"2020","journal-title":"Angew. Chem. Int. Ed. Engl."}],"container-title":["Bioorganic Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0045206822005740?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0045206822005740?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,23]],"date-time":"2025-09-23T08:40:43Z","timestamp":1758616843000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0045206822005740"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,12]]},"references-count":50,"alternative-id":["S0045206822005740"],"URL":"https:\/\/doi.org\/10.1016\/j.bioorg.2022.106168","relation":{},"ISSN":["0045-2068"],"issn-type":[{"value":"0045-2068","type":"print"}],"subject":[],"published":{"date-parts":[[2022,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Discovery of novel \u03b2-carboline-1,2,3-triazole hybrids as AChE\/GSK-3\u03b2 dual inhibitors for Alzheimer's disease treatment","name":"articletitle","label":"Article Title"},{"value":"Bioorganic Chemistry","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bioorg.2022.106168","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"106168"}}