{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,3]],"date-time":"2026-07-03T17:08:53Z","timestamp":1783098533436,"version":"3.54.6"},"reference-count":48,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2022,12,1]],"date-time":"2022-12-01T00:00:00Z","timestamp":1669852800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,12,1]],"date-time":"2022-12-01T00:00:00Z","timestamp":1669852800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,12,1]],"date-time":"2022-12-01T00:00:00Z","timestamp":1669852800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2022,12,1]],"date-time":"2022-12-01T00:00:00Z","timestamp":1669852800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2022,12,1]],"date-time":"2022-12-01T00:00:00Z","timestamp":1669852800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2022,12,1]],"date-time":"2022-12-01T00:00:00Z","timestamp":1669852800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2022,12,1]],"date-time":"2022-12-01T00:00:00Z","timestamp":1669852800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Bioorganic Chemistry"],"published-print":{"date-parts":[[2022,12]]},"DOI":"10.1016\/j.bioorg.2022.106194","type":"journal-article","created":{"date-parts":[[2022,10,9]],"date-time":"2022-10-09T01:20:52Z","timestamp":1665278452000},"page":"106194","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":30,"special_numbering":"C","title":["Mesenchymal stem cells-derived HIF-1\u03b1-overexpressed extracellular vesicles ameliorate hypoxia-induced pancreatic \u03b2 cell apoptosis and senescence through activating YTHDF1-mediated protective autophagy"],"prefix":"10.1016","volume":"129","author":[{"given":"Jiali","family":"Fang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2843-2441","authenticated-orcid":false,"given":"Zheng","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xingqiang","family":"Lai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Yin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuhe","family":"Guo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weiting","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junjie","family":"Ma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guanghui","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lei","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"6","key":"10.1016\/j.bioorg.2022.106194_b0005","doi-asserted-by":"crossref","DOI":"10.1002\/ctm2.468","article-title":"Emerging roles of exosomal miRNAs in diabetes mellitus","volume":"11","author":"He","year":"2021","journal-title":"Clin. Transl. Med."},{"issue":"5","key":"10.1016\/j.bioorg.2022.106194_b0010","doi-asserted-by":"crossref","DOI":"10.1111\/dme.14528","article-title":"Continuous glucose monitoring: A review of the evidence in type 1 and 2 diabetes mellitus","volume":"38","author":"Lin","year":"2021","journal-title":"Diabet. Med."},{"issue":"8","key":"10.1016\/j.bioorg.2022.106194_b0015","doi-asserted-by":"crossref","first-page":"484","DOI":"10.1038\/s41574-021-00507-z","article-title":"Emerging therapeutic approaches for the treatment of NAFLD and type 2 diabetes mellitus","volume":"17","author":"Ferguson","year":"2021","journal-title":"Nat. Rev. Endocrinol."},{"issue":"10","key":"10.1016\/j.bioorg.2022.106194_b0020","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1038\/s41574-020-0381-5","article-title":"Diet and exercise in the prevention and treatment of type 2 diabetes mellitus","volume":"16","author":"Magkos","year":"2020","journal-title":"Nat. Rev. Endocrinol."},{"key":"10.1016\/j.bioorg.2022.106194_b0025","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2021.750816","article-title":"Carbon Monoxide in Pancreatic Islet Transplantation: A New Therapeutic Alternative to Patients With Severe Type 1 Diabetes Mellitus","volume":"12","author":"Dugbartey","year":"2021","journal-title":"Front. Pharmacol."},{"issue":"10","key":"10.1016\/j.bioorg.2022.106194_b0030","doi-asserted-by":"crossref","first-page":"1013","DOI":"10.1038\/s42255-020-0269-7","article-title":"Islet transplantation in the subcutaneous space achieves long-term euglycaemia in preclinical models of type 1 diabetes","volume":"2","author":"Yu","year":"2020","journal-title":"Nat. Metab."},{"issue":"10","key":"10.1016\/j.bioorg.2022.106194_b0035","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1089\/ars.2016.6755","article-title":"The role of oxidative stress and hypoxia in pancreatic beta-cell dysfunction in diabetes mellitus","volume":"26","author":"Gerber","year":"2017","journal-title":"Antioxid. Redox. Signal"},{"issue":"1","key":"10.1016\/j.bioorg.2022.106194_b0040","doi-asserted-by":"crossref","DOI":"10.1111\/xen.12441","article-title":"Vascularization of PLGA-based bio-artificial beds by hypoxia-preconditioned mesenchymal stem cells for subcutaneous xenogeneic islet transplantation","volume":"26","author":"Kim","year":"2019","journal-title":"Xenotransplantation"},{"issue":"20","key":"10.1016\/j.bioorg.2022.106194_b0045","doi-asserted-by":"crossref","DOI":"10.1002\/adhm.202100965","article-title":"Advances in Encapsulation and Delivery Strategies for Islet Transplantation","volume":"10","author":"Wu","year":"2021","journal-title":"Adv. Healthc. Mater"},{"issue":"3","key":"10.1016\/j.bioorg.2022.106194_b0050","doi-asserted-by":"crossref","first-page":"723","DOI":"10.1080\/15548627.2020.1731266","article-title":"Hypoxia-induced acetylation of PAK1 enhances autophagy and promotes brain tumorigenesis via phosphorylating ATG5","volume":"17","author":"Feng","year":"2021","journal-title":"Autophagy"},{"issue":"1","key":"10.1016\/j.bioorg.2022.106194_b0055","doi-asserted-by":"crossref","DOI":"10.1186\/s13046-021-02035-0","article-title":"Cellular senescence or stemness: hypoxia flips the coin","volume":"40","author":"Otero-Albiol","year":"2021","journal-title":"J. Exp. Clin. Cancer. Res"},{"issue":"9","key":"10.1016\/j.bioorg.2022.106194_b0060","doi-asserted-by":"crossref","first-page":"2041","DOI":"10.1016\/j.molcel.2021.03.018","article-title":"Physiological hypoxia restrains the senescence-associated secretory phenotype via AMPK-mediated mTOR suppression","volume":"81","author":"van Vliet","year":"2021","journal-title":"Mol. Cell"},{"issue":"1","key":"10.1016\/j.bioorg.2022.106194_b0065","doi-asserted-by":"crossref","DOI":"10.1186\/s13287-021-02697-9","article-title":"The application of mesenchymal stromal cells (MSCs) and their derivative exosome in skin wound healing: a comprehensive review","volume":"13","author":"Bian","year":"2022","journal-title":"Stem. Cell. Res. Ther"},{"key":"10.1016\/j.bioorg.2022.106194_b0070","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1016\/j.actbio.2020.12.046","article-title":"Exosomes from TNF-\u03b1-treated human gingiva-derived MSCs enhance M2 macrophage polarization and inhibit periodontal bone loss","volume":"122","author":"Nakao","year":"2021","journal-title":"Acta. Biomater"},{"issue":"1","key":"10.1016\/j.bioorg.2022.106194_b0075","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1007\/s10565-020-09530-8","article-title":"Human umbilical cord blood-derived MSCs exosome attenuate myocardial injury by inhibiting ferroptosis in acute myocardial infarction mice","volume":"37","author":"Song","year":"2021","journal-title":"Cell. Biol. Toxicol"},{"issue":"10","key":"10.1016\/j.bioorg.2022.106194_b0080","doi-asserted-by":"crossref","first-page":"722","DOI":"10.1080\/10715762.2020.1837793","article-title":"Protective effect of bone marrow mesenchymal stem cell-derived exosomes on cardiomyoblast hypoxia-reperfusion injury through the miR-149\/let-7c\/Faslg axis","volume":"54","author":"Zou","year":"2020","journal-title":"Free. Radic. Res."},{"issue":"1","key":"10.1016\/j.bioorg.2022.106194_b0085","article-title":"Mesenchymal stem cell-derived exosomes protect beta cells against hypoxia-induced apoptosis via miR-21 by alleviating ER stress and inhibiting p38 MAPK phosphorylation","volume":"11","author":"Chen","year":"2020","journal-title":"Stem. Cell. Res. Ther."},{"issue":"1","key":"10.1016\/j.bioorg.2022.106194_b0090","doi-asserted-by":"crossref","DOI":"10.1186\/s13287-018-1004-0","article-title":"Exosomes derived from miR-92a-3p-overexpressing human mesenchymal stem cells enhance chondrogenesis and suppress cartilage degradation via targeting WNT5A","volume":"9","author":"Mao","year":"2018","journal-title":"Stem. Cell. Res. Ther."},{"key":"10.1016\/j.bioorg.2022.106194_b0095","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1016\/j.omtn.2019.08.010","article-title":"Exosomes Derived from miR-143-Overexpressing MSCs Inhibit Cell Migration and Invasion in Human Prostate Cancer by Downregulating TFF3","volume":"18","author":"Che","year":"2019","journal-title":"Mol. Ther. Nucleic. Acids"},{"key":"10.1016\/j.bioorg.2022.106194_b0100","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1016\/j.neuroscience.2020.09.036","article-title":"Hypoxia Inducible Factor-1\u03b1 (HIF-1\u03b1) Mediates NLRP3 Inflammasome-Dependent-Pyroptotic and Apoptotic Cell Death Following Ischemic Stroke","volume":"448","author":"Jiang","year":"2020","journal-title":"Neuroscience"},{"issue":"1","key":"10.1016\/j.bioorg.2022.106194_b0105","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1113\/JP280572","article-title":"Regulation of glycolysis by the hypoxia-inducible factor (HIF): implications for cellular physiology","volume":"599","author":"Kierans","year":"2021","journal-title":"J. Physiol"},{"issue":"1","key":"10.1016\/j.bioorg.2022.106194_b0110","doi-asserted-by":"crossref","DOI":"10.1186\/s13287-020-01881-7","article-title":"HIF-1\u03b1 overexpression in mesenchymal stem cell-derived exosomes mediates cardioprotection in myocardial infarction by enhanced angiogenesis","volume":"11","author":"Sun","year":"2020","journal-title":"Stem. Cell. Res. Ther."},{"issue":"9","key":"10.1016\/j.bioorg.2022.106194_b0115","doi-asserted-by":"crossref","first-page":"4298","DOI":"10.7150\/thno.51342","article-title":"N6-methyladenosine-induced circ1662 promotes metastasis of colorectal cancer by accelerating YAP1 nuclear localization","volume":"11","author":"Chen","year":"2021","journal-title":"Theranostics"},{"issue":"4","key":"10.1016\/j.bioorg.2022.106194_b0120","doi-asserted-by":"crossref","first-page":"1183","DOI":"10.1053\/j.gastro.2021.12.269","article-title":"N6-Methyladenosine Reader YTHDF1 Promotes ARHGEF2 Translation and RhoA Signaling in Colorectal Cancer","volume":"162","author":"Wang","year":"2022","journal-title":"Gastroenterology"},{"issue":"1","key":"10.1016\/j.bioorg.2022.106194_b0125","doi-asserted-by":"crossref","DOI":"10.1186\/s12943-019-1065-4","article-title":"METTL3-mediated N6-methyladenosine modification is critical for epithelial-mesenchymal transition and metastasis of gastric cancer","volume":"18","author":"Yue","year":"2019","journal-title":"Mol. Cancer"},{"issue":"3","key":"10.1016\/j.bioorg.2022.106194_b0130","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1016\/j.molcel.2020.06.017","article-title":"METTL3 and N6-Methyladenosine Promote Homologous Recombination-Mediated Repair of DSBs by Modulating DNA-RNA Hybrid Accumulation","volume":"79","author":"Zhang","year":"2020","journal-title":"Mol. Cell"},{"issue":"1","key":"10.1016\/j.bioorg.2022.106194_b0135","article-title":"HIF-1\u03b1-induced expression of m6A reader YTHDF1 drives hypoxia-induced autophagy and malignancy of hepatocellular carcinoma by promoting ATG2A and ATG14 translation","volume":"6","author":"Li","year":"2021","journal-title":"Signal. Transduct. Target. Ther."},{"key":"10.1016\/j.bioorg.2022.106194_b0140","doi-asserted-by":"crossref","unstructured":"F. Dong, X. Qin, B. Wang, Q. Li, J. Hu, X. Cheng, D. Guo, F. Cheng, C. Fang, Y. Tan, H. Yan, Y. He, X. Sun, Y. Yuan, H. Liu, T. Li, Y. Zhao, C. Kang, X. Wu, ALKBH5 Facilitates Hypoxia-Induced Paraspeckle Assembly and IL8 Secretion to Generate an Immunosuppressive Tumor Microenvironment. Cancer Res, 2021. 81(23): p. 5876-5888.https:\/\/doi.org\/10.1158\/0008-5472.Can-21-1456.","DOI":"10.1158\/0008-5472.CAN-21-1456"},{"key":"10.1016\/j.bioorg.2022.106194_b0145","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/j.jare.2021.10.001","article-title":"Hypoxia inducible lncRNA-CBSLR modulates ferroptosis through m6A-YTHDF2-dependent modulation of CBS in gastric cancer","volume":"37","author":"Yang","year":"2022","journal-title":"J. Adv. Res."},{"key":"10.1016\/j.bioorg.2022.106194_b0150","doi-asserted-by":"crossref","DOI":"10.1016\/j.molmet.2021.101209","article-title":"RNA m6A reader IMP2\/IGF2BP2 promotes pancreatic \u03b2-cell proliferation and insulin secretion by enhancing PDX1 expression","volume":"48","author":"Regu\u00e9","year":"2021","journal-title":"Mol. Metab."},{"key":"10.1016\/j.bioorg.2022.106194_b0155","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejphar.2022.174960","article-title":"Exenatide ameliorates hydrogen peroxide-induced pancreatic \u03b2-cell apoptosis through regulation of METTL3-mediated m(6)A methylation","volume":"924","author":"Zhou","year":"2022","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.bioorg.2022.106194_b0160","doi-asserted-by":"crossref","DOI":"10.3389\/fendo.2022.910868","article-title":"The m(6)A Methyltransferase METTL3 Ameliorates Methylglyoxal-Induced Impairment of Insulin Secretion in Pancreatic \u03b2 Cells by Regulating MafA Expression","volume":"13","author":"Cheng","year":"2022","journal-title":"Front. Endocrinol. (Lausanne)"},{"issue":"23","key":"10.1016\/j.bioorg.2022.106194_b0165","doi-asserted-by":"crossref","first-page":"7435","DOI":"10.1007\/s00018-021-03988-3","article-title":"The lysosome as an imperative regulator of autophagy and cell death","volume":"78","author":"Mahapatra","year":"2021","journal-title":"Cell. Mol. Life. Sci"},{"issue":"7","key":"10.1016\/j.bioorg.2022.106194_b0170","doi-asserted-by":"crossref","first-page":"2029","DOI":"10.1038\/s41418-021-00814-y","article-title":"Molecular mechanisms of cell death in neurological diseases","volume":"28","author":"Moujalled","year":"2021","journal-title":"Cell. Death. Differ"},{"issue":"11","key":"10.1016\/j.bioorg.2022.106194_b0175","doi-asserted-by":"crossref","first-page":"3338","DOI":"10.1080\/15548627.2021.1872227","article-title":"HIF1A Alleviates compression-induced apoptosis of nucleus pulposus derived stem cells via upregulating autophagy","volume":"17","author":"He","year":"2021","journal-title":"Autophagy"},{"issue":"10","key":"10.1016\/j.bioorg.2022.106194_b0180","doi-asserted-by":"crossref","first-page":"2975","DOI":"10.1080\/15548627.2020.1848971","article-title":"Inhibiting NLRP3 inflammasome attenuates apoptosis in contrast-induced acute kidney injury through the upregulation of HIF1A and BNIP3-mediated mitophagy","volume":"17","author":"Lin","year":"2021","journal-title":"Autophagy"},{"key":"10.1016\/j.bioorg.2022.106194_b0185","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1155\/2021\/5555590","article-title":"Proteomic analysis of hypoxia-induced senescence of human bone marrow mesenchymal stem cells","volume":"2021","author":"Mai","year":"2021","journal-title":"Stem. Cells. Int"},{"key":"10.1016\/j.bioorg.2022.106194_b0190","article-title":"Pulmonary Artery Smooth Muscle Cell Senescence Promotes the Proliferation of PASMCs by Paracrine IL-6 in Hypoxia-Induced Pulmonary Hypertension","volume":"12","author":"Wang","year":"2021","journal-title":"Front. Physiol"},{"issue":"8","key":"10.1016\/j.bioorg.2022.106194_b0195","doi-asserted-by":"crossref","first-page":"3965","DOI":"10.3390\/ijms22083965","article-title":"Inhibition of Autophagy at Different Stages by ATG5 Knockdown and Chloroquine Supplementation Enhances Consistent Human Disc Cellular Apoptosis and Senescence Induction rather than Extracellular Matrix Catabolism","volume":"22","author":"Ito","year":"2021","journal-title":"Int. J. Mol. Sci."},{"issue":"10","key":"10.1016\/j.bioorg.2022.106194_b0200","doi-asserted-by":"crossref","DOI":"10.1038\/s41419-021-04157-x","article-title":"Fibroblast growth factor 21 (FGF21) alleviates senescence, apoptosis, and extracellular matrix degradation in osteoarthritis via the SIRT1-mTOR signaling pathway","volume":"12","author":"Lu","year":"2021","journal-title":"Cell. Death. Dis"},{"key":"10.1016\/j.bioorg.2022.106194_b0205","article-title":"Exosomes derived from human mesenchymal stem cells preserve mouse islet survival and insulin secretion function","volume":"19","author":"Keshtkar","year":"2020","journal-title":"Excli. j"},{"issue":"5","key":"10.1016\/j.bioorg.2022.106194_b0210","doi-asserted-by":"crossref","DOI":"10.1111\/xen.12405","article-title":"Human mesenchymal-stem-cells-derived exosomes are important in enhancing porcine islet resistance to hypoxia","volume":"25","author":"Nie","year":"2018","journal-title":"Xenotransplantation"},{"issue":"1","key":"10.1016\/j.bioorg.2022.106194_b0215","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-018-36063-2","article-title":"HIF-1\u03b1 triggers ER stress and CHOP-mediated apoptosis in alveolar epithelial cells, a key event in pulmonary fibrosis","volume":"8","author":"Delbrel","year":"2018","journal-title":"Sci. Rep"},{"key":"10.1016\/j.bioorg.2022.106194_b0220","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2021.153678","article-title":"Demethyleneberberine induces cell cycle arrest and cellular senescence of NSCLC cells via c-Myc\/HIF-1\u03b1 pathway","volume":"91","author":"Liu","year":"2021","journal-title":"Phytomedicine"},{"key":"10.1016\/j.bioorg.2022.106194_b0225","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2019.109464","article-title":"HIF-1\u03b1\/BNIP3 signaling pathway-induced-autophagy plays protective role during myocardial ischemia-reperfusion injury","volume":"120","author":"Zhang","year":"2019","journal-title":"Biomed. Pharmacother"},{"key":"10.1016\/j.bioorg.2022.106194_b0230","doi-asserted-by":"crossref","unstructured":"J. Pi, W. Wang, M. Ji, X. Wang, X. Wei, J. Jin, T. Liu, J. Qiang, Z. Qi, F. Li, Y. Liu, Y. Ma, Y. Si, Y. Huo, Y. Gao, Y. Chen, L. Dong, R. Su, J. Chen, S. Rao, P. Yi, S. Yu, F. Wang, J. Yu, YTHDF1 Promotes Gastric Carcinogenesis by Controlling Translation of FZD7. Cancer Res, 2021. 81(10): p. 2651-2665.https:\/\/doi.org\/10.1158\/0008-5472.Can-20-0066.","DOI":"10.1158\/0008-5472.CAN-20-0066"},{"issue":"1","key":"10.1016\/j.bioorg.2022.106194_b0235","doi-asserted-by":"crossref","DOI":"10.1038\/s41419-020-03315-x","article-title":"ALKBH5 suppresses tumor progression via an m(6)A-dependent epigenetic silencing of pre-miR-181b-1\/YAP signaling axis in osteosarcoma","volume":"12","author":"Yuan","year":"2021","journal-title":"Cell. Death. Dis."},{"key":"10.1016\/j.bioorg.2022.106194_b0240","doi-asserted-by":"crossref","DOI":"10.3389\/fnagi.2022.890134","article-title":"Methyltransferase-Like 3 Rescues the Amyloid-beta protein-Induced Reduction of Activity-Regulated Cytoskeleton Associated Protein Expression via YTHDF1-Dependent N6-Methyladenosine Modification","volume":"14","author":"Xu","year":"2022","journal-title":"Front. Aging. Neurosci."}],"container-title":["Bioorganic Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0045206822006009?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0045206822006009?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,23]],"date-time":"2025-09-23T08:43:54Z","timestamp":1758617034000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0045206822006009"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,12]]},"references-count":48,"alternative-id":["S0045206822006009"],"URL":"https:\/\/doi.org\/10.1016\/j.bioorg.2022.106194","relation":{},"ISSN":["0045-2068"],"issn-type":[{"value":"0045-2068","type":"print"}],"subject":[],"published":{"date-parts":[[2022,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Mesenchymal stem cells-derived HIF-1\u03b1-overexpressed extracellular vesicles ameliorate hypoxia-induced pancreatic \u03b2 cell apoptosis and senescence through activating YTHDF1-mediated protective autophagy","name":"articletitle","label":"Article Title"},{"value":"Bioorganic Chemistry","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bioorg.2022.106194","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"106194"}}