{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T20:06:31Z","timestamp":1793131591346,"version":"4.5.0"},"reference-count":51,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T00:00:00Z","timestamp":1672531200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T00:00:00Z","timestamp":1672531200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T00:00:00Z","timestamp":1672531200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T00:00:00Z","timestamp":1672531200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T00:00:00Z","timestamp":1672531200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T00:00:00Z","timestamp":1672531200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T00:00:00Z","timestamp":1672531200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100004901","name":"Minas Gerais State Foundation of Support to the Research","doi-asserted-by":"publisher","award":["APQ-03059-21"],"award-info":[{"award-number":["APQ-03059-21"]}],"id":[{"id":"10.13039\/501100004901","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002322","name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior","doi-asserted-by":"publisher","award":["001"],"award-info":[{"award-number":["001"]}],"id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003593","name":"National Council for Scientific and Technological Development","doi-asserted-by":"publisher","award":["306873\/2021-4"],"award-info":[{"award-number":["306873\/2021-4"]}],"id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Bioorganic Chemistry"],"published-print":{"date-parts":[[2023,1]]},"DOI":"10.1016\/j.bioorg.2022.106249","type":"journal-article","created":{"date-parts":[[2022,11,5]],"date-time":"2022-11-05T19:45:15Z","timestamp":1667677515000},"page":"106249","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":5,"special_numbering":"C","title":["New amides derived from sclareolide as anticholinesterase agents"],"prefix":"10.1016","volume":"130","author":[{"given":"J\u00fanio G.","family":"Silva","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tatiane F.","family":"Borgati","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samuel M.G.","family":"Lopes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Niels","family":"Heise","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sophie","family":"Hoenke","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ren\u00e9","family":"Csuk","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luiz C.A.","family":"Barbosa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"580","key":"10.1016\/j.bioorg.2022.106249_b0005","first-page":"2021","article-title":"A comprehensive review of cholinesterase modeling and simulation","volume":"11","author":"Boer","year":"2021","journal-title":"Biomol."},{"issue":"8","key":"10.1016\/j.bioorg.2022.106249_b0010","doi-asserted-by":"crossref","first-page":"1053","DOI":"10.1039\/C9NP00010K","article-title":"Natural cholinesterase inhibitors from marine organisms","volume":"36","author":"Moodie","year":"2019","journal-title":"Nat. Prod. Rep."},{"issue":"2","key":"10.1016\/j.bioorg.2022.106249_b0015","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1111\/joim.13006","article-title":"Beyond neurotransmission: acetylcholine in immunity and inflammation","volume":"287","author":"Cox","year":"2020","journal-title":"J. Internal Med."},{"key":"10.1016\/j.bioorg.2022.106249_b0020","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3389\/fimmu.2021.660342","article-title":"Cholinergic system and its therapeutic importance in inflammation and autoimmunity","volume":"12","author":"Halder","year":"2021","journal-title":"Front. Immunol."},{"key":"10.1016\/j.bioorg.2022.106249_b0025","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1155\/2018\/3740461","article-title":"Current concepts of neurodegenerative mechanisms in Alzheimer\u2019s disease","volume":"2018","author":"Magalingam","year":"2018","journal-title":"Biomed. Res. Int."},{"key":"10.1016\/j.bioorg.2022.106249_b0030","first-page":"1","article-title":"The State of the Art on Acetylcholinesterase Inhibitors in the Treatment of Alzheimer\u2019s Disease","author":"Vecchio","year":"2021","journal-title":"J. Cent. Nerv. Syst. Dis."},{"key":"10.1016\/j.bioorg.2022.106249_b0035","unstructured":"WHO. Dementia. World Health Organization, 2021. https:\/\/www.who.int\/news-room\/fact-sheets\/detail\/dementia."},{"key":"10.1016\/j.bioorg.2022.106249_b0040","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1021\/acschemneuro.0c00627","article-title":"Recent advances in virtual screening for cholinesterase inhibitors","volume":"12","author":"Miles","year":"2020","journal-title":"ACS Chem. Neurosci."},{"key":"10.1016\/j.bioorg.2022.106249_b0045","doi-asserted-by":"crossref","first-page":"860","DOI":"10.1016\/j.biopha.2018.03.007","article-title":"Flavonoids as acetylcholinesterase inhibitors: Current therapeutic standing and future prospects","volume":"101","author":"Khan","year":"2018","journal-title":"Biomed. Pharmacother."},{"issue":"10","key":"10.1016\/j.bioorg.2022.106249_b0050","doi-asserted-by":"crossref","first-page":"6856","DOI":"10.1021\/acs.jmedchem.1c00167","article-title":"Highly potent and selective butyrylcholinesterase inhibitors for cognitive improvement and neuroprotection","volume":"64","author":"Li","year":"2021","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.bioorg.2022.106249_b0055","first-page":"1479","article-title":"Cholinesterase inhibitors as Alzheimer's therapeutics","volume":"20","author":"Sharma","year":"2019","journal-title":"Mol. Med. Rep."},{"key":"10.1016\/j.bioorg.2022.106249_b0060","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.neuint.2021.105008","article-title":"Biomaterials in treatment of Alzheimer\u2019s disease","volume":"145","author":"Agrawal","year":"2021","journal-title":"Neurochem. Int."},{"key":"10.1016\/j.bioorg.2022.106249_b0065","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1016\/j.bios.2016.01.065","article-title":"Nano-biosensors to detect beta-amyloid for the treatment of Alzheimer's disease","volume":"15","author":"Kaushik","year":"2016","journal-title":"Biosens. Bioelectron."},{"issue":"7","key":"10.1016\/j.bioorg.2022.106249_b0070","doi-asserted-by":"crossref","first-page":"1037","DOI":"10.1002\/ps.3891","article-title":"Tetraoxanes as a new class of efficient herbicides comparable with commercial products","volume":"71","author":"Cusati","year":"2015","journal-title":"Pest Manage. Sci."},{"issue":"7","key":"10.1016\/j.bioorg.2022.106249_b0075","doi-asserted-by":"crossref","first-page":"909","DOI":"10.1590\/S0100-204X2007000700001","article-title":"Plant compounds insecticide activity against Coleoptera pests of stored products","volume":"42","author":"Moreira","year":"2007","journal-title":"Pesq. Agrop. Bras."},{"issue":"25","key":"10.1016\/j.bioorg.2022.106249_b0080","doi-asserted-by":"crossref","first-page":"5772","DOI":"10.1021\/jf5014605","article-title":"Cyclopent-4-ene-1,3-diones: A new class of herbicides acting as potent photosynthesis inhibitors","volume":"62","author":"Varej\u00e3o","year":"2014","journal-title":"J. Agric. Food Chem."},{"issue":"2","key":"10.1016\/j.bioorg.2022.106249_b0085","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1039\/C5MD00459D","article-title":"Rubrolide analogues and their derived lactams as potential anticancer agents","volume":"7","author":"Pereira","year":"2016","journal-title":"MedChemComm."},{"key":"10.1016\/j.bioorg.2022.106249_b0090","first-page":"1","article-title":"Tetroxanes as New Agents against Leishmania amazonensis","volume":"17","author":"Antol\u00ednez","year":"2020","journal-title":"Chem. Biod."},{"key":"10.1016\/j.bioorg.2022.106249_b0095","doi-asserted-by":"crossref","first-page":"770","DOI":"10.1021\/acs.jnatprod.9b01285","article-title":"Natural products as sources of new drugs from 01\/1981 to 09\/2019","volume":"83","author":"Newman","year":"2020","journal-title":"J. Nat. Prod."},{"issue":"2","key":"10.1016\/j.bioorg.2022.106249_b0100","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1038\/nrd4510","article-title":"The re-emergence of natural products for drug discovery in the genomics era","volume":"14","author":"Harvey","year":"2015","journal-title":"Nat. Rev. Drug Discovery"},{"issue":"6","key":"10.1016\/j.bioorg.2022.106249_b0105","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1038\/nchem.2479","article-title":"Counting on natural products for drug design","volume":"8","author":"Rodrigues","year":"2016","journal-title":"Nat. Chem."},{"key":"10.1016\/j.bioorg.2022.106249_b0110","doi-asserted-by":"crossref","first-page":"1578","DOI":"10.3390\/ijms19061578","article-title":"Natural products for drug discovery in the 21st century: innovations for novel drug discovery","volume":"19","author":"Thomford","year":"2018","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.bioorg.2022.106249_b0115","doi-asserted-by":"crossref","first-page":"6113","DOI":"10.3390\/md12126113","article-title":"Territrem and butyrolactone derivatives from a marine-derived fungus Aspergillus terreus","volume":"12","author":"Nong","year":"2014","journal-title":"Mar. Drugs"},{"key":"10.1016\/j.bioorg.2022.106249_b0120","doi-asserted-by":"crossref","first-page":"1572","DOI":"10.1055\/s-0033-1350896","article-title":"A new anti-acetylcholinesterase \u03b1-pyrone meroterpene, arigsugacin I, from mangrove endophytic fungus Penicillium sp. sk5GW1L of Kandelia candel","volume":"79","author":"Huang","year":"2013","journal-title":"Planta Med."},{"key":"10.1016\/j.bioorg.2022.106249_b0125","doi-asserted-by":"crossref","first-page":"177","DOI":"10.3390\/md16060177","article-title":"Asperversins A and B, two novel meroterpenoids with an unusual 5\/6\/6\/6 ring from the marine-derived fungus Aspergillus versicolor","volume":"16","author":"Li","year":"2018","journal-title":"Mar. Drugs"},{"key":"10.1016\/j.bioorg.2022.106249_b0130","doi-asserted-by":"crossref","first-page":"324","DOI":"10.1039\/b204748a","article-title":"Hybrid systems through natural product leads: An approach towards new molecular entities","volume":"31","author":"Metha","year":"2002","journal-title":"Chem. Soc. Rev."},{"key":"10.1016\/j.bioorg.2022.106249_b0135","first-page":"829","article-title":"Molecular hybridization: a useful tool in the design of new drug prototypes","volume":"14","author":"Viegas-Junior","year":"2007","journal-title":"Curr. Med. Chem."},{"key":"10.1016\/j.bioorg.2022.106249_b0140","doi-asserted-by":"crossref","first-page":"304","DOI":"10.1007\/s11094-015-1274-0","article-title":"Synthesis, anticholinesterase, and antibacterial activity of N-aroyl-\u03b1-aminoacrylic acid dialkylamino-alkylamides","volume":"49","author":"Topuzyan","year":"2015","journal-title":"Pharma Chem. J."},{"key":"10.1016\/j.bioorg.2022.106249_b0145","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1016\/j.bioorg.2016.11.011","article-title":"Synthesis of novel chromenones linked to 1,2,3-triazole ring system: Investigation of biological activities against Alzheimer\u2019s disease","volume":"70","author":"Saeedi","year":"2017","journal-title":"Bioorg. Chem."},{"key":"10.1016\/j.bioorg.2022.106249_b0150","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.bioorg.2021.105149","article-title":"Pharmacophore-based drug design of AChE and BChE dual inhibitors as potencial anti-Alzheimer\u2019s disease agents","volume":"114","author":"Gao","year":"2021","journal-title":"Bioorg. Chem."},{"issue":"1","key":"10.1016\/j.bioorg.2022.106249_b0155","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1021\/ol203007s","article-title":"AlMe3-promoted formation of amides from acids and amines","volume":"14","author":"Li","year":"2012","journal-title":"Org. Lett."},{"key":"10.1016\/j.bioorg.2022.106249_b0160","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1016\/j.ejmech.2016.03.018","article-title":"Novel hederagenin-traizolylderivatives as potential anti-cancer agents","volume":"115","author":"Rodr\u00edgues-Hern\u00e1ndez","year":"2016","journal-title":"European J. Med Chem."},{"key":"10.1016\/j.bioorg.2022.106249_b0165","series-title":"Espectroscopia no Infravermelho na Caracteriza\u00e7\u00e3o de Compostos Org\u00e2nicos","author":"Barbosa","year":"2007"},{"issue":"20","key":"10.1016\/j.bioorg.2022.106249_b0170","doi-asserted-by":"crossref","first-page":"3315","DOI":"10.1016\/j.bmcl.2018.09.013","article-title":"Unexpected AChE inhibitory activity of (2E)\u03b1, \u03b2-unsaturated fatty acids","volume":"28","author":"Loesche","year":"2018","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"10.1016\/j.bioorg.2022.106249_b0175","unstructured":"Thomsen; Christensen. Molegro Virtual Docker. 2006. Version: 1.0."},{"issue":"20","key":"10.1016\/j.bioorg.2022.106249_b0180","doi-asserted-by":"crossref","first-page":"5912","DOI":"10.1021\/jm050362n","article-title":"A critical assessment of docking programs and scoring functions","volume":"49","author":"Warren","year":"2006","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.bioorg.2022.106249_b0185","doi-asserted-by":"crossref","first-page":"558","DOI":"10.1021\/jm0302997","article-title":"Evaluation of docking performance: comparative data on docking algorithms","volume":"47","author":"Kontoyianni","year":"2004","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.bioorg.2022.106249_b0190","doi-asserted-by":"crossref","first-page":"5851","DOI":"10.1021\/jm060999m","article-title":"Prediction of protein-ligand interactions. docking and scoring: successes and gaps","volume":"49","author":"Leach","year":"2006","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.bioorg.2022.106249_b0195","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1185\/03007990152673800","article-title":"A new therapeutic target in alzheimer\u2019s disease treatment: attention to butyrycloholinesterase","volume":"17","author":"Greig","year":"2001","journal-title":"Curr. Med. Res. Opin."},{"key":"10.1016\/j.bioorg.2022.106249_b0200","doi-asserted-by":"crossref","first-page":"99","DOI":"10.2174\/1389203720666191107094949","article-title":"Butyrylcholinesterase: A multifaceted pharmacological target and tool","volume":"21","author":"Ha","year":"2019","journal-title":"Curr. Protein Pept. Sci."},{"issue":"13","key":"10.1016\/j.bioorg.2022.106249_b0205","doi-asserted-by":"crossref","first-page":"3370","DOI":"10.1016\/j.bmc.2014.04.046","article-title":"Amino derivatives of glycyrrhetinic acid as potential inhibitors of cholinesterases","volume":"22","author":"Schwarz","year":"2014","journal-title":"Bioorg. Med. Chem."},{"key":"10.1016\/j.bioorg.2022.106249_b0210","doi-asserted-by":"crossref","first-page":"1202","DOI":"10.3390\/plants11091202","article-title":"Biological activities of some isoquinoline alkaloids from Fumaria schleicheri Soy","volume":"11","author":"Paltinean","year":"2022","journal-title":"Will. Plants"},{"key":"10.1016\/j.bioorg.2022.106249_b0215","doi-asserted-by":"crossref","first-page":"6379","DOI":"10.3390\/molecules26216379","article-title":"Fractionation of Lycopodiaceae alkaloids and evaluation of their anticholinesterase and cytotoxic activities","volume":"26","author":"Dymek","year":"2021","journal-title":"Molecules"},{"issue":"15","key":"10.1016\/j.bioorg.2022.106249_b0220","doi-asserted-by":"crossref","first-page":"2272","DOI":"10.3390\/cells11152272","article-title":"Canadian Contributions in Fibroblast Biology","volume":"11","author":"Al-Hattab","year":"2022","journal-title":"Cells."},{"issue":"46","key":"10.1016\/j.bioorg.2022.106249_b0225","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/S0169-409X(00)00129-0","article-title":"Experimental and computational approaches to estimate solubility and permeability in drug discovery and development settings","volume":"2011","author":"Lipinski","year":"2001","journal-title":"Adv. Drug Deliv. Rev."},{"key":"10.1016\/j.bioorg.2022.106249_b0230","unstructured":"Swiss institute bioinformatics, http:\/\/www.swissadme.ch\/, accessed in August 2022."},{"key":"10.1016\/j.bioorg.2022.106249_b0235","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1042\/BJ20130013","article-title":"Crystal structures of human cholinesterases in complex with huprine w and tacrine: elements of specificity for anti-alzheimer\u2019s drugs targeting acetyl- and butyryl-cholinesterase","volume":"453","author":"Nachon","year":"2013","journal-title":"Biochem. J."},{"key":"10.1016\/j.bioorg.2022.106249_b0240","unstructured":"Hehre, D. Spartan. 2014. Version: 1.1.4."},{"key":"10.1016\/j.bioorg.2022.106249_b0245","unstructured":"Simas AM, Rocha GB. M\u00e9todos Semi-Emp\u00edricos de Estrutura Eletr\u00f4nica Em Qu\u00edmica Qu\u00e2ntica.; Editora Livraria da F\u00edsica, S\u00e3o Paulo, 2007."},{"key":"10.1016\/j.bioorg.2022.106249_b0250","doi-asserted-by":"crossref","first-page":"652","DOI":"10.1016\/j.ejmech.2016.11.056","article-title":"Amino derivatives of platanic acid act as selective and potent inhibitors of butyrylcholinesterase","volume":"26","author":"Heller","year":"2017","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.bioorg.2022.106249_b0255","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/j.bioorg.2018.12.013","article-title":"Csuk R Ursolic and oleanolic acid derivatives with cholinesterase inhibiting potential","volume":"85","author":"Loesche","year":"2019","journal-title":"Bioorg. Chem."}],"container-title":["Bioorganic Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0045206822006551?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0045206822006551?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T11:55:27Z","timestamp":1777463727000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0045206822006551"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,1]]},"references-count":51,"alternative-id":["S0045206822006551"],"URL":"https:\/\/doi.org\/10.1016\/j.bioorg.2022.106249","relation":{},"ISSN":["0045-2068"],"issn-type":[{"value":"0045-2068","type":"print"}],"subject":[],"published":{"date-parts":[[2023,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"New amides derived from sclareolide as anticholinesterase agents","name":"articletitle","label":"Article Title"},{"value":"Bioorganic Chemistry","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bioorg.2022.106249","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"106249"}}