{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,27]],"date-time":"2025-12-27T15:04:05Z","timestamp":1766847845144,"version":"3.44.0"},"reference-count":44,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T00:00:00Z","timestamp":1672531200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T00:00:00Z","timestamp":1672531200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T00:00:00Z","timestamp":1672531200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T00:00:00Z","timestamp":1672531200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T00:00:00Z","timestamp":1672531200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T00:00:00Z","timestamp":1672531200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T00:00:00Z","timestamp":1672531200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100020582","name":"National Institute of Pharmaceutical Education and Research, Raebareli","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100020582","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Bioorganic Chemistry"],"published-print":{"date-parts":[[2023,1]]},"DOI":"10.1016\/j.bioorg.2022.106252","type":"journal-article","created":{"date-parts":[[2022,11,4]],"date-time":"2022-11-04T22:35:57Z","timestamp":1667601357000},"page":"106252","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":10,"special_numbering":"C","title":["Synthetic amino acids-derived peptides target Cryptococcus neoformans by inducing cell membrane disruption"],"prefix":"10.1016","volume":"130","author":[{"given":"Komal","family":"Sharma","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shams","family":"Aaghaz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Indresh Kumar","family":"Maurya","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Krishna K.","family":"Sharma","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shreya","family":"Singh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shivaprakash M.","family":"Rudramurthy","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vinod","family":"Kumar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kulbhushan","family":"Tikoo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rahul","family":"Jain","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"4","key":"10.1016\/j.bioorg.2022.106252_b0005","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijantimicag.2021.106324","article-title":"Increased antimicrobial resistance during the COVID-19 pandemic","volume":"57","author":"Lai","year":"2021","journal-title":"Int. J. Antimicrob. Agents"},{"key":"10.1016\/j.bioorg.2022.106252_b0010","unstructured":"World Health Organization, Global antimicrobial resistance and use surveillance system (GLASS) report: 2021, (2021)."},{"issue":"4","key":"10.1016\/j.bioorg.2022.106252_b0015","doi-asserted-by":"crossref","first-page":"619","DOI":"10.1016\/j.giec.2020.06.004","article-title":"Antimicrobial resistance","volume":"30","author":"Morrison","year":"2020","journal-title":"Gastrointest. Endosc. Clin."},{"issue":"1","key":"10.1016\/j.bioorg.2022.106252_b0020","doi-asserted-by":"crossref","first-page":"12","DOI":"10.2174\/1574891X13666180628105928","article-title":"Short antimicrobial peptides","volume":"13","author":"Sharma","year":"2018","journal-title":"Recent Pat. Antiinfect. Drug Discov."},{"issue":"7","key":"10.1016\/j.bioorg.2022.106252_b0025","doi-asserted-by":"crossref","first-page":"1646","DOI":"10.1021\/acs.accounts.1c00004","article-title":"Design and Syntheses of New Antibiotics Inspired by Nature\u2019s Quest for Iron in an Oxidative Climate","volume":"54","author":"Miller","year":"2021","journal-title":"Acc. Chem. Res."},{"issue":"10","key":"10.1016\/j.bioorg.2022.106252_b0030","doi-asserted-by":"crossref","first-page":"726","DOI":"10.1038\/s41570-021-00313-1","article-title":"Towards the sustainable discovery and development of new antibiotics","volume":"5","author":"Miethke","year":"2021","journal-title":"Nat. Rev. Chem."},{"key":"10.1016\/j.bioorg.2022.106252_b0035","doi-asserted-by":"crossref","DOI":"10.1016\/j.medidd.2020.100078","article-title":"Emerging peptide antibiotics with therapeutic potential","volume":"9","author":"Upert","year":"2021","journal-title":"Med. Drug Discov."},{"issue":"10","key":"10.1016\/j.bioorg.2022.106252_b0040","doi-asserted-by":"crossref","first-page":"2700","DOI":"10.1016\/j.bmc.2017.06.052","article-title":"Therapeutic peptides: Historical perspectives, current development trends, and future directions","volume":"26","author":"Lau","year":"2018","journal-title":"Bioorg. Med. Chem."},{"issue":"4","key":"10.1016\/j.bioorg.2022.106252_b0045","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1038\/s41573-020-00135-8","article-title":"Trends in peptide drug discovery","volume":"20","author":"Muttenthaler","year":"2021","journal-title":"Nat. Rev. Drug Discov."},{"key":"10.1016\/j.bioorg.2022.106252_b0050","doi-asserted-by":"crossref","DOI":"10.1007\/s15010-022-01805-y","article-title":"COVID-19-associated Cryptococcus infection (CACI): a review of literature and clinical pearls","author":"Regalla","year":"2022","journal-title":"Infection"},{"issue":"1","key":"10.1016\/j.bioorg.2022.106252_b0055","doi-asserted-by":"crossref","first-page":"127","DOI":"10.3390\/biomed2010014","article-title":"Disseminated Cryptococcosis Complicating Severe SARS-CoV-2 Infection","volume":"2","author":"Lupia","year":"2022","journal-title":"BioMed"},{"issue":"7","key":"10.1016\/j.bioorg.2022.106252_b0060","doi-asserted-by":"crossref","first-page":"454","DOI":"10.1038\/s41579-021-00511-0","article-title":"Treatment strategies for cryptococcal infection: challenges, advances and future outlook","volume":"19","author":"Iyer","year":"2021","journal-title":"Nat. Rev. Microbiol."},{"issue":"11","key":"10.1016\/j.bioorg.2022.106252_b0065","doi-asserted-by":"crossref","first-page":"3438","DOI":"10.3390\/molecules26113438","article-title":"Activity and Mechanism of Action of Antifungal Peptides from Microorganisms: A Review","volume":"26","author":"Li","year":"2021","journal-title":"Molecules"},{"issue":"1","key":"10.1016\/j.bioorg.2022.106252_b0070","doi-asserted-by":"crossref","first-page":"822","DOI":"10.1080\/21505594.2018.1431087","article-title":"The capsule of Cryptococcus neoformans","volume":"10","author":"Casadevall","year":"2019","journal-title":"Virulence"},{"issue":"7","key":"10.1016\/j.bioorg.2022.106252_b0075","first-page":"3919","article-title":"The antimicrobial peptides and their potential clinical applications","volume":"11","author":"Lei","year":"2019","journal-title":"Am. J. Transl. Res."},{"issue":"16","key":"10.1016\/j.bioorg.2022.106252_b0080","doi-asserted-by":"crossref","first-page":"2047","DOI":"10.4155\/fmc-2019-0167","article-title":"Antimicrobial peptides with protease stability: progress and perspective","volume":"11","author":"Shao","year":"2019","journal-title":"Future Med. Chem."},{"issue":"38","key":"10.1016\/j.bioorg.2022.106252_b0085","doi-asserted-by":"crossref","first-page":"34609","DOI":"10.1021\/acsami.9b10028","article-title":"Hydrophobic Control of the Bioactivity and Cytotoxicity of de Novo-Designed Antimicrobial Peptides","volume":"11","author":"Gong","year":"2019","journal-title":"ACS Appl. Mater. Interfaces"},{"key":"10.1016\/j.bioorg.2022.106252_b0090","doi-asserted-by":"crossref","DOI":"10.1016\/j.bioorg.2022.106002","article-title":"Antifungal evaluation and mechanistic investigations of membrane active short synthetic peptides-based amphiphiles","volume":"127","author":"Sharma","year":"2022","journal-title":"Bioorg. Chem."},{"issue":"2","key":"10.1016\/j.bioorg.2022.106252_b0095","doi-asserted-by":"crossref","first-page":"430","DOI":"10.3390\/molecules26020430","article-title":"A global review on short peptides: Frontiers and perspectives","volume":"26","author":"Apostolopoulos","year":"2021","journal-title":"Molecules"},{"issue":"15","key":"10.1016\/j.bioorg.2022.106252_b0100","doi-asserted-by":"crossref","first-page":"6607","DOI":"10.1021\/acs.jmedchem.7b00481","article-title":"Discovery of a membrane-active, ring-modified histidine containing ultrashort amphiphilic peptide that exhibits potent inhibition of Cryptococcus neoformans","volume":"60","author":"Sharma","year":"2017","journal-title":"J. Med. Chem."},{"issue":"4","key":"10.1016\/j.bioorg.2022.106252_b0105","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1021\/ml500011v","article-title":"Discovery of short peptides exhibiting high potency against Cryptococcus neoformans","volume":"5","author":"Mahindra","year":"2014","journal-title":"ACS Med. Chem. Lett."},{"issue":"5","key":"10.1016\/j.bioorg.2022.106252_b0110","doi-asserted-by":"crossref","first-page":"671","DOI":"10.1039\/C4MD00041B","article-title":"Synthesis and antimicrobial activities of His(2-aryl)-Arg and Trp-His(2-aryl) classes of dipeptidomimetics","volume":"5","author":"Mahindra","year":"2014","journal-title":"MedChemComm"},{"issue":"14","key":"10.1016\/j.bioorg.2022.106252_b0115","doi-asserted-by":"crossref","first-page":"3150","DOI":"10.1016\/j.bmcl.2014.04.120","article-title":"Synthetically modified L-histidine-rich peptidomimetics exhibit potent activity against Cryptococcus neoformans","volume":"24","author":"Mahindra","year":"2014","journal-title":"Bioorg. Med. Chem. Lett."},{"issue":"23","key":"10.1016\/j.bioorg.2022.106252_b0120","doi-asserted-by":"crossref","first-page":"7421","DOI":"10.1021\/jm900622d","article-title":"Discovery of Trp-His and His-Arg analogues as new structural classes of short antimicrobial peptides","volume":"52","author":"Sharma","year":"2009","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.bioorg.2022.106252_b0125","article-title":"Modified histidine containing amphipathic ultrashort antifungal peptide, His-[2-p-(n-butyl) phenyl]-Trp-Arg-OMe exhibits potent anticryptococcal activity","volume":"113635","author":"Sharma","year":"2021","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.bioorg.2022.106252_b0130","first-page":"e202200196","article-title":"Peptide-Heterocycle Conjugates as Antifungals Against Cryptococcosis, Asian","author":"Sharma","year":"2022","journal-title":"J. Org. Chem."},{"issue":"2","key":"10.1016\/j.bioorg.2022.106252_b0135","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijantimicag.2020.106048","article-title":"Evaluation of peptoid mimics of short, lipophilic peptide antimicrobials","volume":"56","author":"Green","year":"2020","journal-title":"Int. J. Antimicrob. Agents"},{"issue":"13","key":"10.1016\/j.bioorg.2022.106252_b0140","doi-asserted-by":"crossref","first-page":"4427","DOI":"10.1016\/j.bmc.2007.04.027","article-title":"Brucella suis histidinol dehydrogenase: synthesis and inhibition studies of a series of substituted benzylic ketones derived from histidine","volume":"15","author":"Abdo","year":"2007","journal-title":"Bioorg. Med. Chem."},{"issue":"38","key":"10.1016\/j.bioorg.2022.106252_b0145","doi-asserted-by":"crossref","first-page":"8937","DOI":"10.1039\/C6OB01753C","article-title":"Regioselective copper-catalyzed N(1)-(hetero)arylation of protected histidine","volume":"14","author":"Sharma","year":"2016","journal-title":"Org. Biomol. Chem."},{"issue":"3","key":"10.1016\/j.bioorg.2022.106252_b0150","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1002\/bip.20911","article-title":"Effects of net charge and the number of positively charged residues on the biological activity of amphipathic alpha-helical cationic antimicrobial peptides","volume":"90","author":"Jiang","year":"2008","journal-title":"Biopolymers"},{"issue":"10","key":"10.1016\/j.bioorg.2022.106252_b0155","doi-asserted-by":"crossref","first-page":"7738","DOI":"10.1074\/jbc.M111.303602","article-title":"Roles of hydrophobicity and charge distribution of cationic antimicrobial peptides in peptide-membrane interactions","volume":"287","author":"Yin","year":"2012","journal-title":"J. Biol. Chem."},{"issue":"6","key":"10.1016\/j.bioorg.2022.106252_b0160","doi-asserted-by":"crossref","first-page":"2410","DOI":"10.1021\/ac801267s","article-title":"Detection of apoptosis based on the interaction between annexin V and phosphatidylserine","volume":"81","author":"Liu","year":"2009","journal-title":"Anal. Chem."},{"key":"10.1016\/j.bioorg.2022.106252_b0165","doi-asserted-by":"crossref","first-page":"445","DOI":"10.3389\/fcimb.2018.00445","article-title":"Antifungal activity of coumarin against Candida albicans is related to apoptosis","volume":"8","author":"Jia","year":"2019","journal-title":"Front. Cell. Infect. Microbiol."},{"issue":"3","key":"10.1016\/j.bioorg.2022.106252_b0170","doi-asserted-by":"crossref","first-page":"1373","DOI":"10.7150\/thno.39157","article-title":"Potent antibacterial activity of MSI-1 derived from the magainin 2 peptide against drug-resistant bacteria","volume":"10","author":"Ma","year":"2020","journal-title":"Theranostics"},{"key":"10.1016\/j.bioorg.2022.106252_b0175","doi-asserted-by":"crossref","DOI":"10.1016\/j.peptides.2020.170334","article-title":"Antifungal activity of peptide MSI-1 against Cryptococcus neoformans infection in vitro and in murine cryptococcal meningoencephalitis","volume":"130","author":"Ma","year":"2020","journal-title":"Peptides"},{"issue":"17","key":"10.1016\/j.bioorg.2022.106252_b0180","doi-asserted-by":"crossref","first-page":"5641","DOI":"10.1016\/j.bmc.2015.07.022","article-title":"Synthesis of CNS active thyrotropin-releasing hormone (TRH)-like peptides: Biological evaluation and effect on cognitive impairment induced by cerebral ischemia in mice","volume":"23","author":"Meena","year":"2015","journal-title":"Bioorg. Med. Chem."},{"issue":"51","key":"10.1016\/j.bioorg.2022.106252_b0185","doi-asserted-by":"crossref","first-page":"6931","DOI":"10.1016\/j.tetlet.2012.10.028","article-title":"Rapid microwave-assisted solution-phase peptide synthesis","volume":"53","author":"Mahindra","year":"2012","journal-title":"Tetrahedron Lett."},{"year":"2017","series-title":"Reference Method for Broth Dilution Antifungal Susceptibility Testing of Yeasts","author":"CLSI","key":"10.1016\/j.bioorg.2022.106252_b0190"},{"year":"2017","series-title":"Reference Method for Broth Dilution Antifungal Susceptibility Testing of Filamentous Fungi, CLSI supplement M38","author":"CLSI","key":"10.1016\/j.bioorg.2022.106252_b0195"},{"year":"2018","series-title":"Methods for Dilution Antimicrobial Susceptibility Tests for Bacteria That Grow Aerobically, CLSI supplement M07","author":"CLSI","key":"10.1016\/j.bioorg.2022.106252_b0200"},{"issue":"3","key":"10.1016\/j.bioorg.2022.106252_b0205","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1016\/j.mycmed.2018.04.008","article-title":"Phytochemical analysis and mode of action against Candida glabrata of Paeonia emodi extracts","volume":"28","author":"Sharma","year":"2018","journal-title":"J. Mycol. Med."},{"issue":"11","key":"10.1016\/j.bioorg.2022.106252_b0210","doi-asserted-by":"crossref","first-page":"5193","DOI":"10.1016\/j.bbagen.2013.07.016","article-title":"Mechanism of action of novel synthetic dodecapeptides against Candida albicans","volume":"1830","author":"Maurya","year":"2013","journal-title":"Biochim. Biophys. Acta"},{"issue":"2","key":"10.1016\/j.bioorg.2022.106252_b0215","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1016\/j.ijantimicag.2018.10.002","article-title":"Synergistic microbicidal effect of cationic antimicrobial peptides and teicoplanin against planktonic and biofilm-encased Staphylococcus aureus","volume":"53","author":"Koppen","year":"2019","journal-title":"Int. J. Antimicrob. Agents"},{"issue":"1","key":"10.1016\/j.bioorg.2022.106252_b0220","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1016\/j.bbrc.2010.02.138","article-title":"Melittin induces apoptotic features in Candida albicans","volume":"394","author":"Park","year":"2010","journal-title":"Biochem. Biophys. Res. Commun."}],"container-title":["Bioorganic Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0045206822006587?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0045206822006587?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,23]],"date-time":"2025-09-23T08:38:43Z","timestamp":1758616723000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0045206822006587"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,1]]},"references-count":44,"alternative-id":["S0045206822006587"],"URL":"https:\/\/doi.org\/10.1016\/j.bioorg.2022.106252","relation":{},"ISSN":["0045-2068"],"issn-type":[{"type":"print","value":"0045-2068"}],"subject":[],"published":{"date-parts":[[2023,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Synthetic amino acids-derived peptides target Cryptococcus neoformans by inducing cell membrane disruption","name":"articletitle","label":"Article Title"},{"value":"Bioorganic Chemistry","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bioorg.2022.106252","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"106252"}}