{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T14:06:12Z","timestamp":1787753172041,"version":"build-2784847793"},"reference-count":57,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2023,2,1]],"date-time":"2023-02-01T00:00:00Z","timestamp":1675209600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,2,1]],"date-time":"2023-02-01T00:00:00Z","timestamp":1675209600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,2,1]],"date-time":"2023-02-01T00:00:00Z","timestamp":1675209600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2023,2,1]],"date-time":"2023-02-01T00:00:00Z","timestamp":1675209600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2023,2,1]],"date-time":"2023-02-01T00:00:00Z","timestamp":1675209600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2023,2,1]],"date-time":"2023-02-01T00:00:00Z","timestamp":1675209600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2023,2,1]],"date-time":"2023-02-01T00:00:00Z","timestamp":1675209600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Bioorganic Chemistry"],"published-print":{"date-parts":[[2023,2]]},"DOI":"10.1016\/j.bioorg.2022.106299","type":"journal-article","created":{"date-parts":[[2022,12,1]],"date-time":"2022-12-01T21:38:39Z","timestamp":1669930719000},"page":"106299","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":35,"special_numbering":"C","title":["Design, synthesis and molecular docking of novel substituted azepines as inhibitors of PI3K\/Akt\/TSC2\/mTOR signaling pathway in colorectal carcinoma"],"prefix":"10.1016","volume":"131","author":[{"given":"Ahmed A.","family":"Noser","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4616-0224","authenticated-orcid":false,"given":"Aboubakr H.","family":"Abdelmonsef","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maha M.","family":"Salem","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"2","key":"10.1016\/j.bioorg.2022.106299_b0005","doi-asserted-by":"crossref","first-page":"1445","DOI":"10.1021\/acsomega.0c05116","article-title":"Synthesis, anticancer evaluation, computer-aided docking studies, and ADMET prediction of 1,2,3-triazolyl-pyridine hybrids as human aurora B kinase inhibitors. ACS","volume":"6","author":"Rashdan","year":"2021","journal-title":"Omega"},{"key":"10.1016\/j.bioorg.2022.106299_b0010","doi-asserted-by":"crossref","first-page":"659","DOI":"10.2147\/DDDT.S291579","article-title":"Mahmoud HK Thiazole-Based Thiosemicarbazones : Synthesis, Cytotoxicity Evaluation and Molecular Docking Study","volume":"2021","author":"Gomha","year":"2021","journal-title":"Drug Des. Devel. Ther."},{"issue":"21","key":"10.1016\/j.bioorg.2022.106299_b0015","doi-asserted-by":"crossref","first-page":"4997","DOI":"10.3390\/molecules25214997","article-title":"Mahmoud HK Synthesis, Molecular Docking Screening and Anti-Proliferative Potency Evaluation of Some New Imidazo[2,1-b]Thiazole Linked Thiadiazole Conjugates","volume":"25","author":"Rashdan","year":"2020","journal-title":"Molecules"},{"key":"10.1016\/j.bioorg.2022.106299_b0020","first-page":"1","article-title":"A search for antiinflammatory therapies: Synthesis, in silico investigation of the mode of action, and in vitro analyses of new quinazolin-2,4-dione derivatives targeting phosphodiesterase-4 enzyme","volume":"1","author":"Abdelmonsef","year":"2021","journal-title":"J. Heterocycl. Chem."},{"key":"10.1016\/j.bioorg.2022.106299_b0025","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1155\/2020\/8196147","article-title":"Homology modeling and virtual screening studies of antigen MLAA-42Protein: Identification of noveldrugcandidates against leukemia-an in silico approach","volume":"2020","author":"Shehadi","year":"2020","journal-title":"Comput. Math. Methods Med."},{"key":"10.1016\/j.bioorg.2022.106299_b0030","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1016\/j.ejmech.2018.11.031","article-title":"Pharmaceutical significance of azepane based motifs for drug discovery: A critical review","volume":"162","author":"Zha","year":"2019","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.bioorg.2022.106299_b0035","doi-asserted-by":"crossref","first-page":"3845","DOI":"10.1080\/00397911.2020.1828925","article-title":"Synthesis of N-substituted dibenzoazepine\u2013pyridazine derivatives as potential neurologically active drugs","volume":"50","author":"Erdo\u011fan","year":"2020","journal-title":"Synth. Commun."},{"key":"10.1016\/j.bioorg.2022.106299_b0040","doi-asserted-by":"crossref","first-page":"92","DOI":"10.3390\/molecules16010092","article-title":"Synthesis of substituted 1,4-diazepines and 1,5-benzodiazepines using an efficient heteropolyacid-catalyzed procedure","volume":"16","author":"Kaoua","year":"2011","journal-title":"Molecules"},{"key":"10.1016\/j.bioorg.2022.106299_b0045","doi-asserted-by":"crossref","first-page":"9231","DOI":"10.1021\/acs.joc.8b01232","article-title":"One-Pot Synthesis of Chiral Tetracyclic Dibenzo[b, f][1,4]oxazepine-Fused 1,2-Dihydropyridines (DHPs) under Metal-Free Conditions","volume":"83","author":"Choudhary","year":"2018","journal-title":"J. Org. Chem."},{"key":"10.1016\/j.bioorg.2022.106299_b0050","doi-asserted-by":"crossref","unstructured":"H.F. Rizk, A.A. Noser, S.A. Ibrahim, A.K. Fares, Ultrasonic-Assisted condensation of aromatic and aliphatic aldehydes with 3-(Thiophen-2-yl)-5-Pyrazolone: Synthesis, characterization and Stereoselective application, J. Heterocycl. Chem. 2022, n\/a, Doi: 10.1002\/jhet.4551.","DOI":"10.1002\/jhet.4551"},{"key":"10.1016\/j.bioorg.2022.106299_b0055","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1007\/s00706-014-1303-9","article-title":"Synthesis, characterization, and pharmacological evaluation of some novel thiadiazoles and thiazoles incorporating pyrazole moiety as anticancer agents","volume":"146","author":"Gomha","year":"2015","journal-title":"Monatshefte fur Chemie"},{"key":"10.1016\/j.bioorg.2022.106299_b0060","doi-asserted-by":"crossref","first-page":"441","DOI":"10.3906\/kim-1506-13","article-title":"Synthesis and evaluation of some novel thiazoles and 1,3-thiazines as potent agents against the rabies virus","volume":"40","author":"Abdalla","year":"2016","journal-title":"Turkish J. Chem."},{"key":"10.1016\/j.bioorg.2022.106299_b0065","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1186\/s13065-017-0266-4","article-title":"Microwave-assisted one pot three-component synthesis of some novel pyrazole scaffolds as potent anticancer agents","volume":"11","author":"Gomha","year":"2017","journal-title":"Chem. Cent. J."},{"key":"10.1016\/j.bioorg.2022.106299_b0070","doi-asserted-by":"crossref","first-page":"1943","DOI":"10.1002\/jhet.2790","article-title":"Synthetic Utility of Pyridinium Bromide: Synthesis and Antimicrobial Activity of Novel 2,4,6-Trisubstituted Pyridines Having Pyrazole Moiety","volume":"54","author":"Gomha","year":"2017","journal-title":"J. Heterocycl. Chem."},{"key":"10.1016\/j.bioorg.2022.106299_b0075","doi-asserted-by":"crossref","first-page":"1960","DOI":"10.1002\/jhet.3235","article-title":"Facile Synthesis of Pyrazolo[3,4-c]pyrazoles Bearing Coumarine Ring as Anticancer Agents","volume":"55","author":"Gomha","year":"2018","journal-title":"J. Heterocycl. Chem."},{"key":"10.1016\/j.bioorg.2022.106299_b0080","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s13065-019-0632-5","article-title":"Design, efficient synthesis and molecular docking of some novel thiazolyl-pyrazole derivatives as anticancer agents","volume":"13","author":"Sayed","year":"2019","journal-title":"BMC Chem."},{"key":"10.1016\/j.bioorg.2022.106299_b0085","doi-asserted-by":"crossref","DOI":"10.3390\/molecules25194565","article-title":"Clean grinding technique: A facile synthesis and in silico antiviral activity of hydrazones, pyrazoles, and pyrazines bearing thiazole moiety against SARS-CoV-2 main protease (Mpro)","volume":"25","author":"Abu-Melha","year":"2020","journal-title":"Molecules"},{"key":"10.1016\/j.bioorg.2022.106299_b0090","first-page":"26","article-title":"Pyrazolones as a potential anticancer scaffold: Recent trends and future perspectives","volume":"11","author":"Adhikari","year":"2021","journal-title":"J. Appl. Pharm. Sci."},{"issue":"29","key":"10.1016\/j.bioorg.2022.106299_b0095","doi-asserted-by":"crossref","first-page":"25265","DOI":"10.1021\/acsomega.2c02181","article-title":"Newly Synthesized Pyrazolinone Chalcones as Anticancer Agents via Inhibiting the PI3K\/Akt\/ERK1\/2 Signaling Pathway","volume":"7","author":"Noser","year":"2022","journal-title":"ACS Omega"},{"key":"10.1016\/j.bioorg.2022.106299_b0100","doi-asserted-by":"crossref","first-page":"683","DOI":"10.1136\/gutjnl-2015-310912","article-title":"Global patterns and trends in colorectal cancer incidence and mortality","volume":"66","author":"Arnold","year":"2017","journal-title":"Gut"},{"key":"10.1016\/j.bioorg.2022.106299_b0105","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1038\/nrclinonc.2016.171","article-title":"From tumour heterogeneity to advances in precision treatment of colorectal cancer","volume":"14","author":"Punt","year":"2017","journal-title":"Nat. Rev. Clin. Oncol."},{"key":"10.1016\/j.bioorg.2022.106299_b0110","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1146\/annurev-med-062913-051343","article-title":"The PI3K\/AKT Pathway as a Target for Cancer Treatment","volume":"67","author":"Mayer","year":"2016","journal-title":"Annu. Rev. Med."},{"key":"10.1016\/j.bioorg.2022.106299_b0115","doi-asserted-by":"crossref","first-page":"606","DOI":"10.1038\/nrg1879","article-title":"The evolution of phosphatidylinositol 3-kinases as regulators of growth and metabolism","volume":"7","author":"Engelman","year":"2006","journal-title":"Nat. Rev. Genet."},{"key":"10.1016\/j.bioorg.2022.106299_b0120","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1007\/s00280-021-04291-5","article-title":"Autophagy inhibitor potentiates the antitumor efficacy of apatinib in uterine sarcoma by stimulating PI3K\/Akt\/mTOR pathway","volume":"88","author":"Chen","year":"2021","journal-title":"Cancer Chemother. Pharmacol."},{"key":"10.1016\/j.bioorg.2022.106299_b0125","doi-asserted-by":"crossref","first-page":"605","DOI":"10.1080\/14737140.2021.1918001","article-title":"How can we turn the PI3K\/AKT\/mTOR pathway down? Insights into inhibition and treatment of cancer","volume":"21","author":"Afify","year":"2021","journal-title":"Expert Rev. Anticancer Ther."},{"key":"10.1016\/j.bioorg.2022.106299_b0130","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3389\/fmed.2020.554134","article-title":"Possible Novel Therapeutic Targets in Lymphangioleiomyomatosis Treatment","volume":"7","author":"Song","year":"2020","journal-title":"Front. Med."},{"issue":"9","key":"10.1016\/j.bioorg.2022.106299_b0135","doi-asserted-by":"crossref","first-page":"118731","DOI":"10.1016\/j.bbamcr.2020.118731","article-title":"Deregulated PTEN\/PI3K\/AKT\/mTOR signaling in prostate cancer: Still a potential druggable target? Biochim","volume":"1867","author":"Braglia","year":"2020","journal-title":"Biophys. Acta - Mol. Cell Res."},{"key":"10.1016\/j.bioorg.2022.106299_b0140","article-title":"Naringin inhibits colorectal cancer cell growth by repressing the PI3K\/AKT\/mTOR signaling pathway","volume":"3798\u20133804","author":"Cheng","year":"2020","journal-title":"Exp. Ther. Med."},{"key":"10.1016\/j.bioorg.2022.106299_b0145","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1155\/2020\/9258396","article-title":"Signal Transduction Pathways in Breast Cancer: The Important Role of PI3K\/Akt\/mTOR","volume":"2020","author":"Ortega","year":"2020","journal-title":"J. Oncol."},{"key":"10.1016\/j.bioorg.2022.106299_b0150","doi-asserted-by":"crossref","DOI":"10.1016\/j.lfs.2020.117277","article-title":"Berberine mitigates high glucose-induced podocyte apoptosis by modulating autophagy via the mTOR\/P70S6K\/4EBP1 pathway","volume":"243","author":"Li","year":"2020","journal-title":"Life Sci."},{"key":"10.1016\/j.bioorg.2022.106299_b0155","doi-asserted-by":"crossref","DOI":"10.1016\/j.molstruc.2022.133659","article-title":"Towards Covid-19 TMPRSS2 enzyme inhibitors and antimicrobial agents : Synthesis, antimicrobial potency, molecular docking, and drug-likeness prediction of thiadiazole-triazole hybrids","author":"Rashdan","year":"2022","journal-title":"J. Mol. Struct."},{"issue":"5","key":"10.1016\/j.bioorg.2022.106299_b0160","doi-asserted-by":"crossref","first-page":"1727","DOI":"10.1007\/s11224-022-01985-1","article-title":"In silico study to identify novel potential thiadiazole-based molecules as anti-Covid-19 candidates by hierarchical virtual screening and molecular dynamics simulations","volume":"33","author":"Rashdan","year":"2022","journal-title":"Struct. Chem."},{"key":"10.1016\/j.bioorg.2022.106299_b0165","doi-asserted-by":"crossref","unstructured":"S. Dallakyan, A.J. Olson, Small-Molecule Library Screening by Docking with PyRx. In Chemical Biology; springer, 2015; Vol. 1263, pp. 243\u2013250 ISBN 9780123944474.","DOI":"10.1007\/978-1-4939-2269-7_19"},{"key":"10.1016\/j.bioorg.2022.106299_b0170","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1093\/nar\/28.1.235","article-title":"Bourne PE The protein data bank","volume":"28","author":"Berman","year":"2000","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.bioorg.2022.106299_b0175","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1186\/1758-2946-3-33","article-title":"Open Babel: An Open chemical toolbox","volume":"3","author":"O\u2019Boyle","year":"2011","journal-title":"J. Cheminform."},{"key":"10.1016\/j.bioorg.2022.106299_b0180","doi-asserted-by":"crossref","DOI":"10.1016\/j.molstruc.2022.133673","article-title":"Design, synthesis, in-silico and biological evaluation of novel inhibitors with potential anticancer effects","volume":"1268","author":"Ibrahim","year":"2022","journal-title":"J. Mol. Struct."},{"key":"10.1016\/j.bioorg.2022.106299_b0185","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3390\/molecules26175332","article-title":"New Amino Acid Schiff Bases as Anticancer Agents via Potential Mitochondrial Complex I-Associated Hexokinase Inhibition and Targeting AMP-Protein Kinases\/mTOR Signaling Pathway","volume":"26","author":"Noser","year":"2021","journal-title":"Molecules"},{"issue":"1","key":"10.1016\/j.bioorg.2022.106299_b0190","doi-asserted-by":"crossref","DOI":"10.1038\/srep16519","article-title":"Single cell analysis of cancer cells using an improved RT-MLPA method has potential for cancer diagnosis and monitoring","volume":"5","author":"Kvastad","year":"2015","journal-title":"Sci. Rep."},{"key":"10.1016\/j.bioorg.2022.106299_b0195","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1006\/meth.2001.1262","article-title":"Analysis of relative gene expression data using real-time quantitative PCR and the 2-\u0394\u0394CT method","volume":"25","author":"Livak","year":"2001","journal-title":"Methods"},{"key":"10.1016\/j.bioorg.2022.106299_b0200","doi-asserted-by":"crossref","first-page":"460","DOI":"10.1080\/01635581.2019.1640884","article-title":"Propolis Potentiates Methotrexate Anticancer Mechanism and Reduces its Toxic Effects","volume":"72","author":"Salem","year":"2020","journal-title":"Nutr. Cancer"},{"key":"10.1016\/j.bioorg.2022.106299_b0205","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1016\/0003-2697(76)90527-3","article-title":"A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding","volume":"72","author":"Bradford","year":"1976","journal-title":"Anal Biochem"},{"key":"10.1016\/j.bioorg.2022.106299_b0210","doi-asserted-by":"crossref","first-page":"2787","DOI":"10.1002\/jhet.3658","article-title":"An Eco-friendly Synthesis and Biological Screening of Fused Heterocyclic Compounds Containing a Thiophene Moiety via Gewald Reaction","volume":"56","author":"El-Borai","year":"2019","journal-title":"J. Heterocycl. Chem."},{"key":"10.1016\/j.bioorg.2022.106299_b0215","doi-asserted-by":"crossref","first-page":"4780","DOI":"10.3390\/molecules25204780","article-title":"Synthesis, In Silico and In Vitro Assessment of New Quinazolinones as Anticancer Agents via Potential AKT Inhibition","volume":"25","author":"Noser","year":"2020","journal-title":"Molecules"},{"key":"10.1016\/j.bioorg.2022.106299_b0220","doi-asserted-by":"crossref","DOI":"10.3892\/ol.2021.12753","article-title":"Silymarin inhibits proliferation of human breast cancer cells via regulation of the MAPK signaling pathway and induction of apoptosis","volume":"21","author":"Kim","year":"2021","journal-title":"Oncol. Lett."},{"key":"10.1016\/j.bioorg.2022.106299_b0225","first-page":"4557","article-title":"Study of EGCG induced apoptosis in lung cancer cells by inhibiting PI3K\/Akt signaling pathway","volume":"22","author":"Gu","year":"2018","journal-title":"Eur. Rev. Med. Pharmacol. Sci."},{"key":"10.1016\/j.bioorg.2022.106299_b0230","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3892\/ol.2021.12892","article-title":"Rosmanol induces breast cancer cells apoptosis by regulating PI3K\/AKT and STAT3\/JAK2 signaling pathways","volume":"22","author":"Jiang","year":"2021","journal-title":"Oncol. Lett."},{"key":"10.1016\/j.bioorg.2022.106299_b0235","doi-asserted-by":"crossref","first-page":"627","DOI":"10.3390\/cancers11050627","article-title":"Antitumor Activity of DFX117 by Dual Inhibition of","volume":"11","author":"Fan","year":"2019","journal-title":"Cancers (Basel)"},{"issue":"9","key":"10.1016\/j.bioorg.2022.106299_b0240","doi-asserted-by":"crossref","first-page":"2739","DOI":"10.3390\/ijms19092739","article-title":"Cryptotanshinone induces cell cycle arrest and apoptosis of NSCLC cells through the PI3k\/AKt\/GSK-3\u03b2 pathway","volume":"19","author":"Kim","year":"2018","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.bioorg.2022.106299_b0245","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1007\/s12640-020-00210-3","article-title":"Pyrroloquinoline Quinine and LY294002 Changed Cell Cycle and Apoptosis by Regulating PI3K-AKT-GSK3\u03b2 Pathway in SH-SY5Y Cells","volume":"38","author":"Ji","year":"2020","journal-title":"Neurotox. Res."},{"key":"10.1016\/j.bioorg.2022.106299_b0250","doi-asserted-by":"crossref","first-page":"39","DOI":"10.4161\/cbt.1.1.39","article-title":"Apoptosis inhibitor as a suppressor of tumor progression: Expression of Bcl-2 eliminates selective advantages for p53-deficient cells in the tumor","volume":"1","author":"Gurova","year":"2002","journal-title":"Cancer Biol. Ther."},{"key":"10.1016\/j.bioorg.2022.106299_b0255","first-page":"1109","article-title":"Bcl-x(L) overexpression inhibits progression of molecular events leading to paclitaxel-induced apoptosis of human acute myeloid leukemia HL-60 cells","volume":"57","author":"Ibrado","year":"1997","journal-title":"Cancer Res."},{"key":"10.1016\/j.bioorg.2022.106299_b0260","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1016\/S0278-5846(03)00016-2","article-title":"Apoptotic signaling cascades","volume":"27","author":"Ashe","year":"2003","journal-title":"Prog. Neuro-Psychopharmacology Biol. Psychiatry"},{"key":"10.1016\/j.bioorg.2022.106299_b0265","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1002\/jbt.22752","article-title":"ROR1-AS1 knockdown inhibits growth and invasion and promotes apoptosis in NSCLC cells by suppression of the PI3K\/Akt\/mTOR pathway","volume":"35","author":"Li","year":"2021","journal-title":"J. Biochem. Mol. Toxicol."},{"key":"10.1016\/j.bioorg.2022.106299_b0270","doi-asserted-by":"crossref","first-page":"342","DOI":"10.1002\/biof.1784","article-title":"Redox-sensitive signaling pathways in renal cell carcinoma","volume":"48","author":"Cruz-Gregorio","year":"2022","journal-title":"BioFactors"},{"key":"10.1016\/j.bioorg.2022.106299_b0275","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1083\/jcb.200507119","article-title":"Activity of TSC2 is inhibited by AKT-mediated phosphorylation and membrane partitioning","volume":"173","author":"Cai","year":"2006","journal-title":"J. Cell Biol."},{"key":"10.1016\/j.bioorg.2022.106299_b0280","first-page":"1","article-title":"ZDQ-0620, a Novel Phosphatidylinositol 3-Kinase Inhibitor, Inhibits Colorectal Carcinoma Cell Proliferation and Suppresses Angiogenesis by Attenuating PI3K\/AKT\/mTOR Pathway","volume":"12","author":"Qin","year":"2022","journal-title":"Front. Oncol."},{"key":"10.1016\/j.bioorg.2022.106299_b0285","doi-asserted-by":"crossref","first-page":"2882","DOI":"10.1016\/j.arabjc.2015.06.010","article-title":"Synthesis, antimicrobial, anticancer and QSAR studies of 1-[4-(substituted phenyl)-2-(substituted phenyl azomethyl)-benzo[b]-[1,4]diazepin-1-yl]-2-substituted phenylaminoethanones","volume":"12","author":"Verma","year":"2019","journal-title":"Arab. J. Chem."}],"container-title":["Bioorganic Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0045206822007052?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0045206822007052?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,23]],"date-time":"2025-09-23T08:39:37Z","timestamp":1758616777000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0045206822007052"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,2]]},"references-count":57,"alternative-id":["S0045206822007052"],"URL":"https:\/\/doi.org\/10.1016\/j.bioorg.2022.106299","relation":{},"ISSN":["0045-2068"],"issn-type":[{"value":"0045-2068","type":"print"}],"subject":[],"published":{"date-parts":[[2023,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Design, synthesis and molecular docking of novel substituted azepines as inhibitors of PI3K\/Akt\/TSC2\/mTOR signaling pathway in colorectal carcinoma","name":"articletitle","label":"Article Title"},{"value":"Bioorganic Chemistry","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bioorg.2022.106299","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"106299"}}