{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T02:03:58Z","timestamp":1789092238821,"version":"build-2803163510"},"reference-count":34,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2023,9,1]],"date-time":"2023-09-01T00:00:00Z","timestamp":1693526400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,9,1]],"date-time":"2023-09-01T00:00:00Z","timestamp":1693526400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,9,1]],"date-time":"2023-09-01T00:00:00Z","timestamp":1693526400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2023,9,1]],"date-time":"2023-09-01T00:00:00Z","timestamp":1693526400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2023,9,1]],"date-time":"2023-09-01T00:00:00Z","timestamp":1693526400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2023,9,1]],"date-time":"2023-09-01T00:00:00Z","timestamp":1693526400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2023,9,1]],"date-time":"2023-09-01T00:00:00Z","timestamp":1693526400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81991525"],"award-info":[{"award-number":["81991525"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82073720"],"award-info":[{"award-number":["82073720"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007129","name":"Natural Science Foundation of Shandong Province","doi-asserted-by":"publisher","award":["ZR2021ZD28"],"award-info":[{"award-number":["ZR2021ZD28"]}],"id":[{"id":"10.13039\/501100007129","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Bioorganic Chemistry"],"published-print":{"date-parts":[[2023,9]]},"DOI":"10.1016\/j.bioorg.2023.106599","type":"journal-article","created":{"date-parts":[[2023,5,9]],"date-time":"2023-05-09T17:11:30Z","timestamp":1683652290000},"page":"106599","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":6,"special_numbering":"C","title":["Genome-directed discovery of antiproliferative bafilomycins from a deepsea-derived Streptomyces samsunensis"],"prefix":"10.1016","volume":"138","author":[{"given":"Runyi","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yilei","family":"Bao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yujing","family":"Dong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yun","family":"Dong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huayue","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"6","key":"10.1016\/j.bioorg.2023.106599_b0005","doi-asserted-by":"crossref","first-page":"543","DOI":"10.1007\/s12223-012-0173-y","article-title":"Identification of the biosynthetic gene cluster for the antibiotic polyketide L-155,175 in Streptomyces hygroscopicus","volume":"57","author":"Kim","year":"2012","journal-title":"Folia Microbiol."},{"issue":"3","key":"10.1016\/j.bioorg.2023.106599_b0010","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1002\/cbic.201200743","article-title":"Characterization of the bafilomycin biosynthetic gene cluster from Streptomyces lohii","volume":"14","author":"Zhang","year":"2013","journal-title":"Chembiochem."},{"issue":"2","key":"10.1016\/j.bioorg.2023.106599_b0015","doi-asserted-by":"crossref","first-page":"110","DOI":"10.7164\/antibiotics.37.110","article-title":"Metabolic products of microorganisms. 224. Bafilomycins, a new group of macrolide antibiotics. Production, isolation, chemical structure and biological activity","volume":"37","author":"Werner","year":"1984","journal-title":"J. Antibiot."},{"key":"10.1016\/j.bioorg.2023.106599_b0020","first-page":"2509","article-title":"The structures of novel insecticidal macrolides: bafilomycins D and E, and oxohygrolidin","volume":"49","author":"Kretschmer","year":"1985","journal-title":"Agric. Biol. Chem."},{"issue":"3","key":"10.1016\/j.bioorg.2023.106599_b0025","doi-asserted-by":"crossref","first-page":"422","DOI":"10.1021\/np900632r","article-title":"Bafilomycins produced in culture by Streptomyces spp. isolated from marine habitats are potent inhibitors of autophagy","volume":"73","author":"Carr","year":"2010","journal-title":"J. Nat. Prod."},{"issue":"5","key":"10.1016\/j.bioorg.2023.106599_b0030","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1038\/ja.2011.12","article-title":"Bafilomycin K, a new antifungal macrolide from Streptomyces flavotricini Y12\u201326","volume":"64","author":"Zhang","year":"2011","journal-title":"J. Antibiot."},{"issue":"2","key":"10.1016\/j.bioorg.2023.106599_b0035","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1038\/ja.2014.100","article-title":"Bafilomycin L, a new inhibitor of cholesteryl ester synthesis in mammalian cells, produced by marine-derived Streptomyces sp. OPMA00072","volume":"68","author":"Kobayashi","year":"2015","journal-title":"J. Antibiot."},{"issue":"43","key":"10.1016\/j.bioorg.2023.106599_b0040","doi-asserted-by":"crossref","first-page":"4863","DOI":"10.1016\/j.tetlet.2016.09.066","article-title":"Bafilomycin M, a new cytotoxic bafilomycin produced by a Streptomyces sp. isolated from a marine sponge Theonella sp","volume":"57","author":"Chen","year":"2016","journal-title":"Tetrahedron Lett."},{"issue":"34","key":"10.1016\/j.bioorg.2023.106599_b0045","doi-asserted-by":"crossref","first-page":"5170","DOI":"10.1016\/j.tet.2017.07.009","article-title":"Bafilomycins N and O, novel cytotoxic bafilomycin analogues produced by Streptomyces sp. GIC10-1 isolated from marine sponge Theonella sp","volume":"73","author":"Chen","year":"2017","journal-title":"Tetrahedron Lett."},{"key":"10.1016\/j.bioorg.2023.106599_b0050","article-title":"Cytotoxic bafilomycin analogues 6\/5\/5 with tricyclic ring system from a marine-derived Streptomyces sp","volume":"61","author":"Li","year":"2020","journal-title":"Tetrahedron Lett."},{"issue":"5","key":"10.1016\/j.bioorg.2023.106599_b0055","doi-asserted-by":"crossref","first-page":"610","DOI":"10.7164\/antibiotics.37.610","article-title":"The isolation and structures of hygrolidin amide and defumarylhygrolidin","volume":"37","author":"Seto","year":"1984","journal-title":"J. Antibiot."},{"issue":"40","key":"10.1016\/j.bioorg.2023.106599_b0060","doi-asserted-by":"crossref","first-page":"8463","DOI":"10.1016\/S0040-4020(01)00843-2","article-title":"Micromonospolides A-C, new macrolides from Micromonospora sp","volume":"57","author":"Ohta","year":"2001","journal-title":"Tetrahedron"},{"key":"10.1016\/j.bioorg.2023.106599_b0065","doi-asserted-by":"crossref","DOI":"10.1016\/j.bmcl.2020.127005","article-title":"Catenulisporidins A and B, 16-membered macrolides of the hygrolidin family produced by the chemically underexplored actinobacterium Catenulispora species","volume":"30","author":"Son","year":"2020","journal-title":"Bioorg. Med. Chem."},{"key":"10.1016\/j.bioorg.2023.106599_b0070","first-page":"2841","article-title":"Isolation and structure of isobutyrylleucanicidin [an insecticidal macrolide] produced by Streptomyces halstedii","volume":"51","author":"Sakuda","year":"1988","journal-title":"Agric. Biol. Chem."},{"key":"10.1016\/j.bioorg.2023.106599_b0075","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1038\/ja.2012.24","article-title":"Isolation and structural determination of a new macrolide, makinolide, from the newly isolated Streptomyces sp. MK-30","volume":"65","author":"Kodani","year":"2012","journal-title":"J. Antibiot."},{"key":"10.1016\/j.bioorg.2023.106599_b0080","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1038\/ja.2010.52","article-title":"Hygrobafilomycin, a cytotoxic and antifungal macrolide bearing a unique monoalkylmaleic anhydride moiety, from Streptomyces varsoviensis","volume":"63","author":"Ndejouong","year":"2010","journal-title":"J. Antibiot."},{"issue":"2","key":"10.1016\/j.bioorg.2023.106599_b0085","doi-asserted-by":"crossref","first-page":"537","DOI":"10.1021\/acs.jnatprod.0c01243","article-title":"Antiviral bafilomycins from a Feces-Inhabiting Streptomyces sp","volume":"84","author":"Xie","year":"2021","journal-title":"J. Nat. Prod."},{"key":"10.1016\/j.bioorg.2023.106599_b0090","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1186\/s12985-023-01971-x","article-title":"Bafilomycin A1 inhibits SARS-CoV-2 infection in a human lung xenograft mouse model","volume":"20","author":"Zhang","year":"2023","journal-title":"Virol. J."},{"key":"10.1016\/j.bioorg.2023.106599_b0095","doi-asserted-by":"crossref","first-page":"161","DOI":"10.7164\/antibiotics.38.161","article-title":"L-155,175: a new antiparasitic macrolide. Fermentation, isolation and structure","volume":"38","author":"Goetz","year":"1985","journal-title":"J. Antibiot."},{"issue":"8","key":"10.1016\/j.bioorg.2023.106599_b0100","doi-asserted-by":"crossref","first-page":"707","DOI":"10.1016\/j.ctrv.2009.08.003","article-title":"V-ATPase inhibitors and implication in cancer treatment","volume":"35","author":"P\u00e9rez-Say\u00e1ns","year":"2009","journal-title":"Cancer Treat. Rev."},{"key":"10.1016\/j.bioorg.2023.106599_b0105","first-page":"1130","article-title":"Immunosuppressive effects of the macrolide antibiotic bafilomycin towards lymphocytes and lymphoid cell lines","volume":"38","author":"Heinle","year":"1988","journal-title":"Arzneimittel-Forschung"},{"issue":"Pt 1","key":"10.1016\/j.bioorg.2023.106599_b0110","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1242\/jeb.200.1.1","article-title":"Bafilomycins and concanamycins as inhibitors of V-ATPases and P-ATPases","volume":"200","author":"Dr\u00f6se","year":"1997","journal-title":"J. Exp. Biol."},{"issue":"17","key":"10.1016\/j.bioorg.2023.106599_b0115","doi-asserted-by":"crossref","first-page":"7095","DOI":"10.1074\/jbc.M116.751255","article-title":"Complete elucidation of the late steps of bafilomycin biosynthesis in Streptomyces lohii","volume":"292","author":"Li","year":"2017","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bioorg.2023.106599_b0120","doi-asserted-by":"crossref","first-page":"29","DOI":"10.3390\/md19010029","article-title":"Engineering bafilomycin high-producers by manipulating regulatory and biosynthetic genes in the marine bacterium Streptomyces lohii","volume":"19","author":"Li","year":"2021","journal-title":"Mar. Drugs"},{"key":"10.1016\/j.bioorg.2023.106599_b0125","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1186\/2191-0855-3-24","article-title":"Organization and characterization of a biosynthetic gene cluster for bafilomycin from Streptomyces griseus DSM 2608","volume":"3","author":"Hwang","year":"2013","journal-title":"AMB Express"},{"issue":"24","key":"10.1016\/j.bioorg.2023.106599_b0130","doi-asserted-by":"crossref","first-page":"6276","DOI":"10.1016\/j.bmc.2016.05.021","article-title":"Biological characterization of the hygrobafilomycin antibiotic JBIR-100 and bioinformatic insights into the hygrolide family of natural products","volume":"24","author":"Molloy","year":"2016","journal-title":"Bioorg. Med. Chem."},{"issue":"1","key":"10.1016\/j.bioorg.2023.106599_b0135","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1007\/s12275-015-4340-0","article-title":"Analysis of a draft genome sequence of Kitasatospora cheerisanensis KCTC 2395 producing bafilomycin antibiotics","volume":"53","author":"Hwang","year":"2015","journal-title":"J. Microbiol."},{"issue":"5","key":"10.1016\/j.bioorg.2023.106599_b0140","doi-asserted-by":"crossref","first-page":"616","DOI":"10.1038\/ja.2017.33","article-title":"Characterization of bafilomycin biosynthesis in Kitasatospora setae KM-6054 and comparative analysis of gene clusters in Actinomycetales microorganisms","volume":"70","author":"Nara","year":"2017","journal-title":"J. Antibiot."},{"issue":"W1","key":"10.1016\/j.bioorg.2023.106599_b0145","doi-asserted-by":"crossref","first-page":"W29","DOI":"10.1093\/nar\/gkab335","article-title":"AntiSMASH 6.0: improving cluster detection and comparison capabilities","volume":"49","author":"Blin","year":"2021","journal-title":"Nucleic Acids Res."},{"issue":"6","key":"10.1016\/j.bioorg.2023.106599_b0150","doi-asserted-by":"crossref","first-page":"753","DOI":"10.1021\/np50084a008","article-title":"Isolation and structure determination of new macrolide antibiotics","volume":"55","author":"Hatfield","year":"1992","journal-title":"J. Nat. Prod."},{"issue":"12","key":"10.1016\/j.bioorg.2023.106599_b0155","doi-asserted-by":"crossref","first-page":"1375","DOI":"10.1016\/j.tetlet.2016.02.061","article-title":"A new antifungal macrolide from Streptomyces sp. KIB-H869 and structure revision of halichomycin","volume":"57","author":"Yu","year":"2016","journal-title":"Tetrahedron Lett."},{"key":"10.1016\/j.bioorg.2023.106599_b0160","first-page":"1","article-title":"Isolation of geldanamycin antibiotics from deepsea-derived Streptomyces samsunensis","volume":"39","author":"Dong","year":"2020","journal-title":"Chin. J. Mar. Drug."},{"issue":"3","key":"10.1016\/j.bioorg.2023.106599_b0165","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1016\/S0022-2836(05)80360-2","article-title":"Basic local alignment search tool (BLAST)","volume":"215","author":"Altschul","year":"1990","journal-title":"J. Mol. Biol."},{"issue":"Web Server","key":"10.1016\/j.bioorg.2023.106599_b0170","doi-asserted-by":"crossref","first-page":"W327","DOI":"10.1093\/nar\/gkh454","article-title":"CD-Search: protein domain annotations on the fly","volume":"32","author":"Marchler-Bauer","year":"2004","journal-title":"Nucleic Acids Res."}],"container-title":["Bioorganic Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0045206823002602?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0045206823002602?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,23]],"date-time":"2025-09-23T08:53:30Z","timestamp":1758617610000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0045206823002602"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,9]]},"references-count":34,"alternative-id":["S0045206823002602"],"URL":"https:\/\/doi.org\/10.1016\/j.bioorg.2023.106599","relation":{},"ISSN":["0045-2068"],"issn-type":[{"value":"0045-2068","type":"print"}],"subject":[],"published":{"date-parts":[[2023,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Genome-directed discovery of antiproliferative bafilomycins from a deepsea-derived Streptomyces samsunensis","name":"articletitle","label":"Article Title"},{"value":"Bioorganic Chemistry","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bioorg.2023.106599","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"106599"}}