{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,27]],"date-time":"2026-07-27T12:18:33Z","timestamp":1785154713144,"version":"3.55.0"},"reference-count":47,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,2,1]],"date-time":"2024-02-01T00:00:00Z","timestamp":1706745600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,2,1]],"date-time":"2024-02-01T00:00:00Z","timestamp":1706745600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,2,1]],"date-time":"2024-02-01T00:00:00Z","timestamp":1706745600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2024,2,1]],"date-time":"2024-02-01T00:00:00Z","timestamp":1706745600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2024,2,1]],"date-time":"2024-02-01T00:00:00Z","timestamp":1706745600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2024,2,1]],"date-time":"2024-02-01T00:00:00Z","timestamp":1706745600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2024,2,1]],"date-time":"2024-02-01T00:00:00Z","timestamp":1706745600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100012245","name":"Science and Technology Planning Project of Guangdong Province","doi-asserted-by":"publisher","award":["2021JH1\/10400049"],"award-info":[{"award-number":["2021JH1\/10400049"]}],"id":[{"id":"10.13039\/501100012245","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82104037"],"award-info":[{"award-number":["82104037"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002858","name":"China Postdoctoral Science Foundation","doi-asserted-by":"publisher","award":["2020 M680987"],"award-info":[{"award-number":["2020 M680987"]}],"id":[{"id":"10.13039\/501100002858","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100013099","name":"Scientific Research Fund of Liaoning Provincial Education Department","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100013099","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Bioorganic Chemistry"],"published-print":{"date-parts":[[2024,2]]},"DOI":"10.1016\/j.bioorg.2023.107007","type":"journal-article","created":{"date-parts":[[2023,11,27]],"date-time":"2023-11-27T11:16:27Z","timestamp":1701083787000},"page":"107007","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":14,"special_numbering":"C","title":["A highly oxidized germacranolide from elephantopus tomentosus inhibits the growth of hepatocellular carcinoma cells by targeting EGFR in vitro and in vivo"],"prefix":"10.1016","volume":"143","author":[{"given":"Qian","family":"Li","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jia-Qi","family":"Niu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jian-Huan","family":"Jia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ming","family":"Bai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guo-Dong","family":"Yao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shao-Jiang","family":"Song","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bioorg.2023.107007_b0005","first-page":"209","article-title":"Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries","volume":"71","author":"Sung","year":"2021","journal-title":"CA Cancer J. Clinicians."},{"key":"10.1016\/j.bioorg.2023.107007_b0010","first-page":"1","article-title":"Hepatocellular carcinoma (HCC): epidemiology, etiology and molecular classification","volume":"149","author":"Chidambaranathan-Reghupaty","year":"2021","journal-title":"Adv. Cancer Res."},{"key":"10.1016\/j.bioorg.2023.107007_b0015","doi-asserted-by":"crossref","first-page":"745","DOI":"10.1053\/j.gastro.2016.11.048","article-title":"Liver cancer cell of origin, molecular class, and effects on patient prognosis","volume":"152","author":"Sia","year":"2017","journal-title":"Gastroenterology"},{"key":"10.1016\/j.bioorg.2023.107007_b0020","doi-asserted-by":"crossref","first-page":"2557","DOI":"10.1053\/j.gastro.2007.04.061","article-title":"Hepatocellular carcinoma: epidemiology and molecular carcinogenesis","volume":"132","author":"El-Serag","year":"2007","journal-title":"Gastroenterology"},{"key":"10.1016\/j.bioorg.2023.107007_b0025","doi-asserted-by":"crossref","first-page":"157","DOI":"10.15212\/AMM-2023-0008","article-title":"Emerging role of HJURP as a therapeutic target in cancers","volume":"2","author":"Tan","year":"2023","journal-title":"Acta Materia Medica."},{"key":"10.1016\/j.bioorg.2023.107007_b0030","doi-asserted-by":"crossref","first-page":"1301","DOI":"10.1016\/S0140-6736(18)30010-2","article-title":"Hepatocellular carcinoma","volume":"391","author":"Forner","year":"2018","journal-title":"Lancet"},{"key":"10.1016\/j.bioorg.2023.107007_b0035","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2021.153575","article-title":"Fuzheng Jiedu Xiaoji formulation inhibits hepatocellular carcinoma progression in patients by targeting the AKT\/CyclinD1\/p21\/p27 pathway","volume":"87","author":"Yang","year":"2021","journal-title":"Phytomedicine"},{"issue":"6","key":"10.1016\/j.bioorg.2023.107007_b0040","doi-asserted-by":"crossref","first-page":"1465","DOI":"10.3390\/ijms20061465","article-title":"Treatment strategies for hepatocellular carcinoma-a multidisciplinary approach","volume":"20","author":"Lurje","year":"2019","journal-title":"Int. J. Mol. Sci."},{"issue":"1","key":"10.1016\/j.bioorg.2023.107007_b0045","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1016\/j.jphs.2021.05.005","article-title":"Calunduloside E inhibits HepG2 cell proliferation and migration via p38\/JNK-HMGB1 signalling axis","volume":"147","author":"Wang","year":"2021","journal-title":"J. Pharmacol. Sci."},{"key":"10.1016\/j.bioorg.2023.107007_b0050","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2019.153112","article-title":"Dulcitol suppresses proliferation and migration of hepatocellular carcinoma via regulating SIRT1\/p53 pathway","volume":"66","author":"Lin","year":"2020","journal-title":"Phytomedicine"},{"key":"10.1016\/j.bioorg.2023.107007_b0055","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1016\/j.fitote.2017.11.022","article-title":"Tomenphantadenine, an unprecedented germacranolide-adenine hybrid heterodimer from the medicinal plant Elephantopus tomentosus L","volume":"125","author":"Guo","year":"2018","journal-title":"Fitoterapia"},{"issue":"10","key":"10.1016\/j.bioorg.2023.107007_b0060","doi-asserted-by":"crossref","first-page":"2433","DOI":"10.1021\/acs.jnatprod.2c00630","article-title":"Highly oxidized germacranolides from elephantopus tomentosus and the configurational revision of some previously reported analogues","volume":"85","author":"Bai","year":"2022","journal-title":"J. Nat. Prod."},{"key":"10.1016\/j.bioorg.2023.107007_b0065","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1016\/j.biopha.2018.06.131","article-title":"Application of sesquiterpene lactone: a new promising way for cancer therapy based on anticancer activity","volume":"106","author":"Babaei","year":"2018","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.bioorg.2023.107007_b0070","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1016\/j.jep.2015.03.072","article-title":"Elephantopus scaber induces apoptosis through ROS-dependent mitochondrial signaling pathway in HCT116 human colorectal carcinoma cells","volume":"168","author":"Chan","year":"2015","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.bioorg.2023.107007_b0075","doi-asserted-by":"crossref","unstructured":"G. Stelzer, N. Rosen, I. Plaschkes, S. Zimmerman, M. Twik, S. Fishilevich, T.I. Stein, R. Nudel, I. Lieder, Y. Mazor, S. Kaplan, D. Dahary, D. Warshawsky, Y. Guan\u2010Golan, A. Kohn, N. Rappaport, M. Safran, D. Lancet, The GeneCards suite: from gene data mining to disease genome sequence analyses, Curr Protoc Bioinformatics. 54 (2016) 1.30.1-1.30.33. https:\/\/doi.org\/10.1002\/cpbi.5.","DOI":"10.1002\/cpbi.5"},{"issue":"W1","key":"10.1016\/j.bioorg.2023.107007_b0080","doi-asserted-by":"crossref","first-page":"W356","DOI":"10.1093\/nar\/gkx374","article-title":"PharmMapper 2017 update: a web server for potential drug target identification with a comprehensive target pharmacophore database","volume":"45","author":"Wang","year":"2017","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.bioorg.2023.107007_b0085","doi-asserted-by":"crossref","first-page":"D447","DOI":"10.1093\/nar\/gku1003","article-title":"STRING v10: protein\u2013protein interaction networks, integrated over the tree of life","volume":"43","author":"Szklarczyk","year":"2015","journal-title":"Nucleic Acids Res."},{"issue":"1","key":"10.1016\/j.bioorg.2023.107007_b0090","doi-asserted-by":"crossref","first-page":"1523","DOI":"10.1038\/s41467-019-09234-6","article-title":"Metascape provides a biologist-oriented resource for the analysis of systems-level datasets","volume":"10","author":"Zhou","year":"2019","journal-title":"Nat. Commun."},{"issue":"2","key":"10.1016\/j.bioorg.2023.107007_b0095","doi-asserted-by":"crossref","first-page":"702","DOI":"10.1002\/ptr.7654","article-title":"Deoxyelephantopin, a germacrane-type sesquiterpene lactone from Elephantopus scaber, induces mitochondrial apoptosis of hepatocarcinoma cells by targeting Hsp90\u03b1 in vitro and in vivo","volume":"37","author":"Chen","year":"2023","journal-title":"Phytother. Res."},{"issue":"2","key":"10.1016\/j.bioorg.2023.107007_b0100","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1016\/j.bbrc.2018.03.091","article-title":"Bigelovin, a sesquiterpene lactone, suppresses tumor growth through inducing apoptosis and autophagy via the inhibition of mTOR pathway regulated by ROS generation in liver cancer","volume":"499","author":"Wang","year":"2018","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.bioorg.2023.107007_b0105","first-page":"863","article-title":"Clotrimazole inhibits HCC migration and invasion by modulating the ERK-p65 signaling pathway","volume":"1Ther. 16","author":"Liu","year":"2022","journal-title":"Drug Des Devel"},{"issue":"3","key":"10.1016\/j.bioorg.2023.107007_b0110","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1016\/j.devcel.2019.04.010","article-title":"Epithelial-mesenchymal plasticity in cancer progression and metastasis","volume":"49","author":"Lu","year":"2019","journal-title":"Dev. Cell"},{"key":"10.1016\/j.bioorg.2023.107007_b0115","doi-asserted-by":"crossref","first-page":"5947304","DOI":"10.1155\/2020\/5947304","article-title":"Uncovering the mechanism of astragalus membranaceus in the treatment of diabetic nephropathy based on network pharmacology","volume":"2020","author":"Guo","year":"2020","journal-title":"J. Diabetes Res."},{"key":"10.1016\/j.bioorg.2023.107007_b0120","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1186\/s13020-019-0249-6","article-title":"A network pharmacology-based study on the anti-hepatoma effect of Radix Salviae Miltiorrhizae","volume":"14","author":"Luo","year":"2019","journal-title":"Chin. Med."},{"issue":"1","key":"10.1016\/j.bioorg.2023.107007_b0125","first-page":"15","article-title":"Targeting the EGFR signaling pathway in cancer therapy, expert opinion on therapeutic targets, expert opinion on therapeutic","volume":"16","author":"Seshacharyulu","year":"2012","journal-title":"Targets"},{"key":"10.1016\/j.bioorg.2023.107007_b0130","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/j.chmed.2017.12.003","article-title":"Ergosta-7,22-diene-2\u03b2,3\u03b1,9\u03b1-triol (EGDT) from Ganoderma lucidum inhibits nasopharyngeal carcinoma cells by blocking EGFR signaling pathway","volume":"10","author":"Wu","year":"2017","journal-title":"Chinese Herbal Medicines."},{"key":"10.1016\/j.bioorg.2023.107007_b0135","doi-asserted-by":"crossref","DOI":"10.1016\/j.fct.2019.110654","article-title":"Cucurbitacin IIa interferes with EGFR-MAPK signaling pathway leads to proliferation inhibition in A549 cells","volume":"132","author":"Zhang","year":"2019","journal-title":"Food Chem. Toxicol."},{"issue":"12","key":"10.1016\/j.bioorg.2023.107007_b0140","doi-asserted-by":"crossref","first-page":"1898","DOI":"10.1038\/s12276-020-00527-1","article-title":"Hepatocellular carcinoma: old friends and new tricks","volume":"52","author":"Kim","year":"2020","journal-title":"Exp. Mol. Med."},{"key":"10.1016\/j.bioorg.2023.107007_b0145","article-title":"Research advances on anti-cancer natural products","volume":"12","author":"Guo","year":"2022","journal-title":"Frontiers in Oncology, Front Oncol."},{"key":"10.1016\/j.bioorg.2023.107007_b0150","doi-asserted-by":"crossref","first-page":"1139","DOI":"10.1038\/s41401-020-00564-6","article-title":"EM-2 inhibited autophagy and promoted G2\/M phase arrest and apoptosis by activating the JNK pathway in hepatocellular carcinoma cells","volume":"42","author":"Yang","year":"2021","journal-title":"Acta Pharmacol. Sin."},{"issue":"6","key":"10.1016\/j.bioorg.2023.107007_b0155","doi-asserted-by":"crossref","first-page":"6790","DOI":"10.18632\/oncotarget.6828","article-title":"EM23, a natural sesquiterpene lactone, targets thioredoxin reductase to activate JNK and cell death pathways in human cervical cancer cells","volume":"7","author":"Shao","year":"2016","journal-title":"Oncotarget"},{"key":"10.1016\/j.bioorg.2023.107007_b0160","doi-asserted-by":"crossref","DOI":"10.1016\/j.etap.2020.103513","article-title":"The sesquiterpene lactone eupatolide induces apoptosis in non-small cell lung cancer cells by suppressing STAT3 signaling","volume":"81","author":"Ma","year":"2021","journal-title":"Environ. Toxicol. Pharmacol."},{"issue":"1","key":"10.1016\/j.bioorg.2023.107007_b0165","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1186\/s13046-017-0563-8","article-title":"Alantolactone, a natural sesquiterpene lactone, has potent antitumor activity against glioblastoma by targeting IKK\u03b2 kinase activity and interrupting NF-\u03baB\/COX-2-mediated signaling cascades","volume":"36","author":"Wang","year":"2017","journal-title":"J. Exp. Clin. Cancer Res."},{"issue":"6","key":"10.1016\/j.bioorg.2023.107007_b0170","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1007\/s10565-014-9288-z","article-title":"Deoxyelephantopin impairs growth of cervical carcinoma SiHa cells and induces apoptosis by targeting multiple molecular signaling pathways","volume":"30","author":"Farha","year":"2014","journal-title":"Cell Biol. Toxicol."},{"key":"10.1016\/j.bioorg.2023.107007_b0175","doi-asserted-by":"crossref","DOI":"10.1016\/j.bioorg.2022.106183","article-title":"Sesquiterpene lactones from Elephantopus scaber exhibit cytotoxic effects on glioma cells by targeting GSTP1","volume":"129","author":"Yan","year":"2022","journal-title":"Bioorg. Chem."},{"issue":"1","key":"10.1016\/j.bioorg.2023.107007_b0180","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1002\/1878-0261.12155","article-title":"Emerging functions of the EGFR in cancer","volume":"12","author":"Sigismund","year":"2018","journal-title":"Mol. Oncol."},{"key":"10.1016\/j.bioorg.2023.107007_b0185","doi-asserted-by":"crossref","DOI":"10.1016\/j.taap.2021.115739","article-title":"A network pharmacology approach to investigate the anticancer mechanism of cinobufagin against hepatocellular carcinoma via downregulation of EGFR-CDK2 signaling","volume":"431","author":"Yang","year":"2021","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.bioorg.2023.107007_b0190","doi-asserted-by":"crossref","first-page":"627","DOI":"10.1146\/annurev-pharmtox-070115-095427","article-title":"Epidermal growth factor receptor transactivation: mechanisms, pathophysiology, and potential therapies in the cardiovascular system","volume":"56","author":"Forrester","year":"2016","journal-title":"Annu. Rev. Pharmacol. Toxicol."},{"issue":"1","key":"10.1016\/j.bioorg.2023.107007_b0195","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1254\/jphs.FPJ06016X","article-title":"Oridonin-induced A431 cell apoptosis partially through blockage of the Ras\/Raf\/ERK signal pathway","volume":"103","author":"Li","year":"2007","journal-title":"J. Pharmacol. Sci."},{"issue":"3","key":"10.1016\/j.bioorg.2023.107007_b0200","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1002\/mc.10103","article-title":"Hepatocyte growth factor, transforming growth factor alpha, and their receptors as combined markers of prognosis in hepatocellular carcinoma","volume":"36","author":"Daveau","year":"2003","journal-title":"Mol. Carcinog."},{"issue":"1","key":"10.1016\/j.bioorg.2023.107007_b0205","doi-asserted-by":"crossref","first-page":"30","DOI":"10.3390\/ijms17010030","article-title":"EGFR signaling in liver diseases","volume":"17","author":"Komposch","year":"2015","journal-title":"Int. J. Mol. Sci."},{"issue":"11","key":"10.1016\/j.bioorg.2023.107007_b0210","doi-asserted-by":"crossref","first-page":"3325","DOI":"10.7150\/jca.56426","article-title":"The Yunnan national medicine Maytenus compound inhibits the proliferation of hepatocellular carcinoma (HCC) by suppressing the activation of the EGFR-PI3K-AKT signaling pathway","volume":"12","author":"Zhao","year":"2021","journal-title":"J. Cancer"},{"issue":"3","key":"10.1016\/j.bioorg.2023.107007_b0215","doi-asserted-by":"crossref","first-page":"996","DOI":"10.7150\/thno.51646","article-title":"The 14\u20133-3\u03c3 protein promotes HCC anoikis resistance by inhibiting EGFR degradation and thereby activating the EGFR-dependent ERK1\/2 signaling pathway","volume":"11","author":"Song","year":"2021","journal-title":"Theranostics."},{"issue":"10","key":"10.1016\/j.bioorg.2023.107007_b0220","doi-asserted-by":"crossref","first-page":"972","DOI":"10.1038\/ncb3031","article-title":"EGFR has a tumour-promoting role in liver macrophages during hepatocellular carcinoma formation","volume":"16","author":"Lanaya","year":"2014","journal-title":"Nat. Cell Biol."},{"issue":"1","key":"10.1016\/j.bioorg.2023.107007_b0225","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1016\/j.jhep.2012.02.019","article-title":"Epidermal growth factor receptor and HER-3 restrict cell response to sorafenib in hepatocellular carcinoma cells","volume":"57","author":"Eggelpo\u00ebl","year":"2012","journal-title":"J. Hepatol."},{"issue":"12","key":"10.1016\/j.bioorg.2023.107007_b0230","doi-asserted-by":"crossref","first-page":"2961","DOI":"10.1002\/ijc.27604","article-title":"EGFR activation is a potential determinant of primary resistance of hepatocellular carcinoma cells to sorafenib","volume":"131","author":"Ezzoukhry","year":"2012","journal-title":"Int. J. Cancer"},{"issue":"21","key":"10.1016\/j.bioorg.2023.107007_b0235","doi-asserted-by":"crossref","first-page":"667","DOI":"10.3390\/molecules26216677","article-title":"Globally approved EGFR inhibitors: insights into their syntheses, target kinases, biological activities, receptor interactions, and metabolism","volume":"26","author":"Abourehab","year":"2021","journal-title":"Molecules"}],"container-title":["Bioorganic Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0045206823006685?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0045206823006685?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,13]],"date-time":"2026-05-13T08:25:14Z","timestamp":1778660714000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0045206823006685"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,2]]},"references-count":47,"alternative-id":["S0045206823006685"],"URL":"https:\/\/doi.org\/10.1016\/j.bioorg.2023.107007","relation":{},"ISSN":["0045-2068"],"issn-type":[{"value":"0045-2068","type":"print"}],"subject":[],"published":{"date-parts":[[2024,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"A highly oxidized germacranolide from elephantopus tomentosus inhibits the growth of hepatocellular carcinoma cells by targeting EGFR in vitro and in vivo","name":"articletitle","label":"Article Title"},{"value":"Bioorganic Chemistry","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bioorg.2023.107007","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"107007"}}