{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,13]],"date-time":"2026-07-13T16:53:35Z","timestamp":1783961615644,"version":"3.55.0"},"reference-count":19,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,2,1]],"date-time":"2024-02-01T00:00:00Z","timestamp":1706745600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,2,1]],"date-time":"2024-02-01T00:00:00Z","timestamp":1706745600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,2,1]],"date-time":"2024-02-01T00:00:00Z","timestamp":1706745600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2024,2,1]],"date-time":"2024-02-01T00:00:00Z","timestamp":1706745600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2024,2,1]],"date-time":"2024-02-01T00:00:00Z","timestamp":1706745600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2024,2,1]],"date-time":"2024-02-01T00:00:00Z","timestamp":1706745600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2024,2,1]],"date-time":"2024-02-01T00:00:00Z","timestamp":1706745600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Bioorganic Chemistry"],"published-print":{"date-parts":[[2024,2]]},"DOI":"10.1016\/j.bioorg.2023.107054","type":"journal-article","created":{"date-parts":[[2023,12,25]],"date-time":"2023-12-25T18:22:55Z","timestamp":1703528575000},"page":"107054","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":12,"special_numbering":"C","title":["Exploration of costunolide derivatives as potential anti-inflammatory agents for topical treatment of atopic dermatitis by inhibiting MAPK\/NF-\u03baB pathways"],"prefix":"10.1016","volume":"143","author":[{"given":"Cheng","family":"Lu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoyi","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenxia","family":"Du","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanping","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chunyan","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1851-9241","authenticated-orcid":false,"given":"Zewei","family":"Mao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruirui","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bioorg.2023.107054_b0005","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1016\/j.yapd.2023.03.006","article-title":"Update on atopic dermatitis","volume":"70","author":"Kellogg","year":"2023","journal-title":"Adv. Pediatr."},{"key":"10.1016\/j.bioorg.2023.107054_b0010","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejmech.2021.113171","article-title":"Design, synthesis and biological evaluation of novel benzoxaborole derivatives as potent PDE4 inhibitors for topical treatment of atopic dermatitis","volume":"213","author":"Chu","year":"2021","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.bioorg.2023.107054_b0015","doi-asserted-by":"crossref","first-page":"7825","DOI":"10.1039\/D3FO02455E","article-title":"From gut to skin: exploring the potential of natural products targeting microorganisms for atopic dermatitis treatment","volume":"14","author":"Zhao","year":"2023","journal-title":"Food Funct."},{"key":"10.1016\/j.bioorg.2023.107054_b0020","doi-asserted-by":"crossref","DOI":"10.1016\/j.pec.2023.107936","article-title":"The characteristics and efficacy of educational nurse-led interventions in the management of children with atopic dermatitis \u2013 an integrative review","volume":"116","author":"Brunner","year":"2023","journal-title":"Patient Educ. Couns."},{"key":"10.1016\/j.bioorg.2023.107054_b0025","doi-asserted-by":"crossref","unstructured":"Atopic Dermatitis Working Group, Immunology Group, Chinese Society of Dermatology. Guideline for diagnosis and treatment of atopic dermatitis in China (2020). Chinese Journal of Dermatology, 53 (2020) 81-88.","DOI":"10.35541\/cjd.20191000"},{"key":"10.1016\/j.bioorg.2023.107054_b0030","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejmech.2023.115785","article-title":"Design, synthesis and evaluation of ursodeoxycholic acid-cinnamic acid hybrids as potential anti-inflammatory agents by inhibiting Akt\/NF-\u03baB and MAPK signaling pathways","volume":"260","author":"Li","year":"2023","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.bioorg.2023.107054_b0035","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2021.112545","article-title":"Polyphenols inhibiting MAPK signalling pathway mediated oxidative stress and inflammation in depression","volume":"146","author":"Behl","year":"2022","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.bioorg.2023.107054_b0040","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1016\/j.biocel.2009.12.016","article-title":"The resolution of inflammation: anti-inflammatory roles for NF-\u03baB","volume":"42","author":"Lawrence","year":"2010","journal-title":"Int. J. Biochem. Cell Biol."},{"key":"10.1016\/j.bioorg.2023.107054_b0045","doi-asserted-by":"crossref","first-page":"12383","DOI":"10.1039\/D2FO02518C","article-title":"Daphnetin contributes to allergen-induced Th2 cytokine expression and type 2-immune responses in atopic dermatitis and asthma","volume":"13","author":"Zhang","year":"2022","journal-title":"Food Funct."},{"key":"10.1016\/j.bioorg.2023.107054_b0050","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1177\/12034754211027858","article-title":"Prominent role of Type 2 immunity in skin diseases: beyond atopic dermatitis","volume":"26","author":"Belmesk","year":"2022","journal-title":"J. Cutan. Med. Surg."},{"key":"10.1016\/j.bioorg.2023.107054_b0055","doi-asserted-by":"crossref","first-page":"1045","DOI":"10.1080\/10286020802274037","volume":"10","author":"Zhao","year":"2008","journal-title":"J. Asian Nat. Prod. Res."},{"key":"10.1016\/j.bioorg.2023.107054_b0060","doi-asserted-by":"crossref","first-page":"678","DOI":"10.1016\/j.apsb.2022.09.014","article-title":"Costunolide covalently targets NACHT domain of NLRP3 to inhibit inflammasome activation and alleviate NLRP3-driven inflammatory diseases","volume":"13","author":"Xu","year":"2023","journal-title":"Acta Pharm. Sin. B"},{"key":"10.1016\/j.bioorg.2023.107054_b0065","doi-asserted-by":"crossref","first-page":"508","DOI":"10.1016\/j.intimp.2016.10.006","article-title":"Costunolide, a sesquiterpene lactone, inhibits the differentiation of pro-inflammatory CD4+ T cells through the modulation of mitogen-activated protein kinases","volume":"40","author":"Park","year":"2016","journal-title":"Int. Immunopharmacol."},{"key":"10.1016\/j.bioorg.2023.107054_b0070","doi-asserted-by":"crossref","first-page":"2392","DOI":"10.1039\/D2FO02545K","article-title":"Potential skin health promoting benefits of costunolide: a therapeutic strategy to improve skin inflammation in imiquimod-induced psoriasis","volume":"14","author":"Zhan","year":"2023","journal-title":"Food Funct."},{"key":"10.1016\/j.bioorg.2023.107054_b0075","doi-asserted-by":"crossref","first-page":"4195","DOI":"10.1016\/j.bmcl.2006.05.083","article-title":"Synthesis of 13-amino costunolide derivatives as anticancer agents","volume":"16","author":"Srivastava","year":"2006","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"10.1016\/j.bioorg.2023.107054_b0080","doi-asserted-by":"crossref","first-page":"1063","DOI":"10.1080\/10286020.2016.1193012","article-title":"\u201cClick\u201d reaction mediated synthesis of costunolide and dehydrocostuslactone derivatives and evaluation of their cytotoxic activity","volume":"18","author":"Kumar","year":"2016","journal-title":"J. Asian Nat. Prod. Res."},{"key":"10.1016\/j.bioorg.2023.107054_b0085","doi-asserted-by":"crossref","first-page":"2871","DOI":"10.1007\/s00044-015-1337-5","article-title":"Synthesis of costunolide derivatives by Pd-catalyzed Heck arylation and evaluation of their cytotoxic activities","volume":"24","author":"Vadaparthi","year":"2015","journal-title":"Med. Chem. Res."},{"key":"10.1016\/j.bioorg.2023.107054_b0090","first-page":"240","article-title":"Synthesis and anti-inflammatory activity of dehydrocostuslactone derivatives","volume":"86","author":"Li","year":"2023","journal-title":"Chemistry (chinese)"},{"key":"10.1016\/j.bioorg.2023.107054_b0095","doi-asserted-by":"crossref","DOI":"10.1016\/j.bioorg.2020.103748","article-title":"Synthesis and anti-inflammatory evaluation of new chalcone derivatives bearing bispiperazine linker as IL-1\u03b2 inhibitors","volume":"98","author":"Tang","year":"2020","journal-title":"Bioorg. Chem."}],"container-title":["Bioorganic Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0045206823007150?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0045206823007150?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,23]],"date-time":"2025-09-23T08:59:20Z","timestamp":1758617960000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0045206823007150"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,2]]},"references-count":19,"alternative-id":["S0045206823007150"],"URL":"https:\/\/doi.org\/10.1016\/j.bioorg.2023.107054","relation":{},"ISSN":["0045-2068"],"issn-type":[{"value":"0045-2068","type":"print"}],"subject":[],"published":{"date-parts":[[2024,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Exploration of costunolide derivatives as potential anti-inflammatory agents for topical treatment of atopic dermatitis by inhibiting MAPK\/NF-\u03baB pathways","name":"articletitle","label":"Article Title"},{"value":"Bioorganic Chemistry","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bioorg.2023.107054","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"107054"}}