{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T18:40:38Z","timestamp":1791916838368,"version":"4.3.4"},"reference-count":32,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,3,1]],"date-time":"2024-03-01T00:00:00Z","timestamp":1709251200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,3,1]],"date-time":"2024-03-01T00:00:00Z","timestamp":1709251200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,3,1]],"date-time":"2024-03-01T00:00:00Z","timestamp":1709251200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2024,3,1]],"date-time":"2024-03-01T00:00:00Z","timestamp":1709251200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2024,3,1]],"date-time":"2024-03-01T00:00:00Z","timestamp":1709251200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2024,3,1]],"date-time":"2024-03-01T00:00:00Z","timestamp":1709251200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2024,3,1]],"date-time":"2024-03-01T00:00:00Z","timestamp":1709251200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Bioorganic Chemistry"],"published-print":{"date-parts":[[2024,3]]},"DOI":"10.1016\/j.bioorg.2024.107174","type":"journal-article","created":{"date-parts":[[2024,2,3]],"date-time":"2024-02-03T11:04:30Z","timestamp":1706958270000},"page":"107174","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":16,"special_numbering":"C","title":["Ursonic acid attenuates spermatogenesis in oligozoospermia mice through inhibiting ferroptosis"],"prefix":"10.1016","volume":"144","author":[{"given":"Jin","family":"Dong","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanli","family":"Dong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hanqing","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Taowen","family":"Ye","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guangtong","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Boyi","family":"Fan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaorong","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianwu","family":"Shi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chengniu","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"5","key":"10.1016\/j.bioorg.2024.107174_b0005","doi-asserted-by":"crossref","first-page":"e266","DOI":"10.1016\/S2352-3026(19)30023-7","article-title":"Conditioning with busulfan plus melphalan versus melphalan alone before autologous haemopoietic cell transplantation for multiple myeloma: an open-label, randomised, phase 3 trial","volume":"6","author":"Bashir","year":"2019","journal-title":"Lancet Haematol."},{"issue":"11","key":"10.1016\/j.bioorg.2024.107174_b0010","doi-asserted-by":"crossref","first-page":"e526","DOI":"10.1016\/S2352-3026(16)30114-4","article-title":"Association of busulfan exposure with survival and toxicity after haemopoietic cell transplantation in children and young adults: a multicentre, retrospective cohort analysis","volume":"3","author":"Bartelink","year":"2016","journal-title":"Lancet Haematol."},{"key":"10.1016\/j.bioorg.2024.107174_b0015","doi-asserted-by":"crossref","DOI":"10.1016\/j.bioorg.2020.104295","article-title":"Two resveratrol analogs, pinosylvin and 4,4'-dihydroxystilbene, improve oligoasthenospermia in a mouse model by attenuating oxidative stress via the Nrf2-ARE pathway","volume":"104","author":"Wang","year":"2020","journal-title":"Bioorg Chem."},{"issue":"3","key":"10.1016\/j.bioorg.2024.107174_b0020","doi-asserted-by":"crossref","first-page":"e202100219","DOI":"10.1002\/open.202100219","article-title":"NBMA Promotes Spermatogenesis by Mediating Oct4 Pathway","volume":"11","author":"Yang","year":"2022","journal-title":"ChemistryOpen"},{"issue":"2","key":"10.1016\/j.bioorg.2024.107174_b0025","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1007\/s10616-017-0169-1","article-title":"Safety of clomiphene citrate: a literature review","volume":"70","author":"Yilmaz","year":"2018","journal-title":"Cytotechnol."},{"key":"10.1016\/j.bioorg.2024.107174_b0030","doi-asserted-by":"crossref","DOI":"10.1016\/j.virusres.2019.197741","article-title":"Ursolic acid from Prunella vulgaris L. efficiently inhibits IHNV infection in vitro and in vivo","volume":"273","author":"Li","year":"2019","journal-title":"Virus Res."},{"issue":"3","key":"10.1016\/j.bioorg.2024.107174_b0035","doi-asserted-by":"crossref","first-page":"842","DOI":"10.1016\/j.tiv.2009.12.008","article-title":"Oleanolic acid and ursolic acid induce apoptosis in four human liver cancer cell lines","volume":"24","author":"Yan","year":"2010","journal-title":"Toxicol. Vitro."},{"issue":"24","key":"10.1016\/j.bioorg.2024.107174_b0040","doi-asserted-by":"crossref","first-page":"8981","DOI":"10.3390\/molecules27248981","article-title":"Ursolic Acid Analogs as Potential Therapeutics for Cancer","volume":"27","author":"Panda","year":"2022","journal-title":"Molecules"},{"issue":"2016","key":"10.1016\/j.bioorg.2024.107174_b0045","first-page":"7","article-title":"Evaluation of Ursolic Acid as the Main Component Isolated from Catharanthus roseus against Hyperglycemia","volume":"50","author":"Khanh","year":"2016","journal-title":"Int. Lett. Nat. Sci."},{"issue":"3","key":"10.1016\/j.bioorg.2024.107174_b0050","doi-asserted-by":"crossref","first-page":"422","DOI":"10.2174\/1389557521666210913113522","article-title":"Advances in Anti-inflammatory Activity, Mechanism and Therapeutic Application of Ursolic Acid","volume":"22","author":"Luan","year":"2022","journal-title":"Mini Rev. Med. Chem."},{"issue":"5","key":"10.1016\/j.bioorg.2024.107174_b0055","doi-asserted-by":"crossref","first-page":"601","DOI":"10.1016\/j.ijantimicag.2019.07.015","article-title":"Ursolic acid: A novel antiviral compound inhibiting rotavirus infection in vitro","volume":"54","author":"Tohm\u00e9","year":"2019","journal-title":"Int. J. Antimicrob. Agents."},{"key":"10.1016\/j.bioorg.2024.107174_b0060","doi-asserted-by":"crossref","first-page":"414","DOI":"10.1016\/j.clnesp.2021.12.030","article-title":"The possible role of ursolic acid in Covid-19: A real game changer","volume":"47","author":"Al-Kuraishy","year":"2022","journal-title":"Clin. Nutr. ESPEN"},{"key":"10.1016\/j.bioorg.2024.107174_b0065","doi-asserted-by":"crossref","first-page":"8512048","DOI":"10.1155\/2019\/8512048","article-title":"Antioxidant and Anti-inflammatory Mechanisms of Neuroprotection by Ursolic Acid: Addressing Brain Injury, Cerebral Ischemia, Cognition Deficit, Anxiety, and Depression","volume":"2019","author":"Habtemariam","year":"2019","journal-title":"Oxid. Med. Cell. Longev."},{"key":"10.1016\/j.bioorg.2024.107174_b0070","doi-asserted-by":"crossref","first-page":"8716927","DOI":"10.1155\/2020\/8716927","article-title":"Antioxidant and Antiproliferative Potential of Bioactive Molecules Ursolic Acid and Thujone Isolated from Memecylon edule and Elaeagnus indica and Their Inhibitory Effect on Topoisomerase II by Molecular Docking Approach","volume":"2020","author":"Srinivasan","year":"2020","journal-title":"Biomed. Res. Int."},{"issue":"14","key":"10.1016\/j.bioorg.2024.107174_b0075","doi-asserted-by":"crossref","first-page":"1953","DOI":"10.2174\/1389201021666201027155413","article-title":"Protective Effect of Ursolic Acid in Prunella vulgaris L. on LPS-Induced Asthenozoospermia via Bcl-2\/Bax Apoptosis Signaling Pathway","volume":"22","author":"Sun","year":"2021","journal-title":"Curr. Pharm. Biotechnol."},{"issue":"16","key":"10.1016\/j.bioorg.2024.107174_b0080","doi-asserted-by":"crossref","first-page":"5920","DOI":"10.3390\/ijms21165920","article-title":"Ursolic Acid-Based Derivatives as Potential Anti-Cancer Agents: An Update","volume":"21","author":"Khwaza","year":"2020","journal-title":"Int. J. Mol. Sci."},{"issue":"2","key":"10.1016\/j.bioorg.2024.107174_b0085","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1038\/aja.2009.67","article-title":"Optimal dose of busulfan for depleting testicular germ cells of recipient mice before spermatogonial transplantation","volume":"12","author":"Wang","year":"2010","journal-title":"Asian J. Androl."},{"issue":"5","key":"10.1016\/j.bioorg.2024.107174_b0090","doi-asserted-by":"crossref","first-page":"1225","DOI":"10.1016\/j.cell.2015.10.029","article-title":"Post-transcriptional Wnt Signaling Governs Epididymal Sperm Maturation","volume":"163","author":"Koch","year":"2015","journal-title":"Cell"},{"issue":"8","key":"10.1016\/j.bioorg.2024.107174_b0095","doi-asserted-by":"crossref","first-page":"1425","DOI":"10.1080\/15548627.2016.1187366","article-title":"Autophagy promotes ferroptosis by degradation of ferritin","volume":"12","author":"Hou","year":"2016","journal-title":"Autophagy"},{"issue":"2","key":"10.1016\/j.bioorg.2024.107174_b0100","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/j.jphotobiol.2010.02.005","article-title":"Antioxidant activity of various solvent extracts from Allomyrina dichotoma (Arthropoda: Insecta) larvae","volume":"99","author":"Suh","year":"2010","journal-title":"J. Photochem. Photobiol. B."},{"issue":"8","key":"10.1016\/j.bioorg.2024.107174_b0105","doi-asserted-by":"crossref","first-page":"8929","DOI":"10.3390\/molecules18088929","article-title":"Cytotoxic activity of ursolic acid derivatives obtained by isolation and oxidative derivatization","volume":"18","author":"Mazumder","year":"2013","journal-title":"Molecules"},{"key":"10.1016\/j.bioorg.2024.107174_b0110","doi-asserted-by":"crossref","DOI":"10.1016\/j.cbi.2023.110452","article-title":"Ursonic acid from Artemisia montana exerts anti-diabetic effects through anti-glycating properties, and by inhibiting PTP1B and activating the PI3K\/Akt signaling pathway in insulin-resistant C2C12 cells","volume":"376","author":"Ali","year":"2023","journal-title":"Chem. Bio. Interact."},{"issue":"11","key":"10.1016\/j.bioorg.2024.107174_b0115","doi-asserted-by":"crossref","first-page":"1505","DOI":"10.3390\/biom10111505","article-title":"Therapeutic Potential of Ursonic Acid: Comparison with Ursolic Acid","volume":"10","author":"Son","year":"2020","journal-title":"Biomolecules"},{"issue":"8","key":"10.1016\/j.bioorg.2024.107174_b0120","doi-asserted-by":"crossref","first-page":"470","DOI":"10.1038\/nrurol.2017.69","article-title":"Oxidative stress and male infertility","volume":"14","author":"Bisht","year":"2017","journal-title":"Nat. Rev. Urol."},{"issue":"49","key":"10.1016\/j.bioorg.2024.107174_b0125","doi-asserted-by":"crossref","first-page":"38500","DOI":"10.1074\/jbc.M002734200","article-title":"Identification of two novel zinc finger modules and nuclear localization signal in rat spermatidal protein TP2 by site-directed mutagenesis","volume":"275","author":"Meetei","year":"2000","journal-title":"J. Biol. Chem."},{"issue":"7","key":"10.1016\/j.bioorg.2024.107174_b0130","first-page":"736","article-title":"Dynamic Expression and Chromatin Incorporation of ACT and CREM Transcription Factors in Testis Tissues of Infertile Men","volume":"23","author":"Jazireian","year":"2021","journal-title":"Cell J."},{"issue":"6","key":"10.1016\/j.bioorg.2024.107174_b0135","doi-asserted-by":"crossref","first-page":"1934","DOI":"10.1111\/andr.13076","article-title":"Spermatozoa retrieval in azoospermia and expression profile of JMJD1A, TNP2, and PRM2 in a subset of the Karachi population","volume":"9","author":"Amjad","year":"2021","journal-title":"Andrology"},{"issue":"3","key":"10.1016\/j.bioorg.2024.107174_b0140","doi-asserted-by":"crossref","first-page":"e13964","DOI":"10.1111\/and.13964","article-title":"Tobacco smoking and its impact on the expression level of sperm nuclear protein genes: H2BFWT, TNP1, TNP2, PRM1 and PRM2","volume":"53","author":"Amor","year":"2021","journal-title":"Andrologia"},{"issue":"2","key":"10.1016\/j.bioorg.2024.107174_b0145","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1210\/er.2008-0025","article-title":"Androgen receptor roles in spermatogenesis and fertility: lessons from testicular cell-specific androgen receptor knockout mice","volume":"30","author":"Wang","year":"2009","journal-title":"Endoc. Rev."},{"issue":"6","key":"10.1016\/j.bioorg.2024.107174_b0150","doi-asserted-by":"crossref","first-page":"1397","DOI":"10.1111\/cbdd.12608","article-title":"Synthesis and Biological Evaluation of Novel Ursolic acid Derivatives as Potential Anticancer Prodrugs","volume":"86","author":"Yang","year":"2015","journal-title":"Chem. Biol. Drug Des."},{"issue":"D1","key":"10.1016\/j.bioorg.2024.107174_b0155","doi-asserted-by":"crossref","first-page":"D1074","DOI":"10.1093\/nar\/gkx1037","article-title":"DrugBank 5.0: a major update to the DrugBank database for 2018","volume":"46","author":"Wishart","year":"2018","journal-title":"Nucleic Acids Res."},{"issue":"2","key":"10.1016\/j.bioorg.2024.107174_b0160","doi-asserted-by":"crossref","first-page":"1279","DOI":"10.1093\/bib\/bbaa300","article-title":"Network Pharmacology and bioinformatics analyses identify intersection genes of niacin and COVID-19 as potential therapeutic targets","volume":"22","author":"Li","year":"2021","journal-title":"Brief. Bioinform."}],"container-title":["Bioorganic Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0045206824000798?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0045206824000798?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,23]],"date-time":"2025-09-23T08:55:58Z","timestamp":1758617758000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0045206824000798"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,3]]},"references-count":32,"alternative-id":["S0045206824000798"],"URL":"https:\/\/doi.org\/10.1016\/j.bioorg.2024.107174","relation":{},"ISSN":["0045-2068"],"issn-type":[{"value":"0045-2068","type":"print"}],"subject":[],"published":{"date-parts":[[2024,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Ursonic acid attenuates spermatogenesis in oligozoospermia mice through inhibiting ferroptosis","name":"articletitle","label":"Article Title"},{"value":"Bioorganic Chemistry","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bioorg.2024.107174","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"107174"}}