{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,17]],"date-time":"2026-07-17T04:04:53Z","timestamp":1784261093342,"version":"3.55.0"},"reference-count":25,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,9,1]],"date-time":"2024-09-01T00:00:00Z","timestamp":1725148800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,9,1]],"date-time":"2024-09-01T00:00:00Z","timestamp":1725148800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,9,1]],"date-time":"2024-09-01T00:00:00Z","timestamp":1725148800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2024,9,1]],"date-time":"2024-09-01T00:00:00Z","timestamp":1725148800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2024,9,1]],"date-time":"2024-09-01T00:00:00Z","timestamp":1725148800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2024,9,1]],"date-time":"2024-09-01T00:00:00Z","timestamp":1725148800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2024,9,1]],"date-time":"2024-09-01T00:00:00Z","timestamp":1725148800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100013076","name":"National Major Science and Technology Projects of China","doi-asserted-by":"publisher","award":["2018ZX09711003"],"award-info":[{"award-number":["2018ZX09711003"]}],"id":[{"id":"10.13039\/501100013076","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Bioorganic Chemistry"],"published-print":{"date-parts":[[2024,9]]},"DOI":"10.1016\/j.bioorg.2024.107532","type":"journal-article","created":{"date-parts":[[2024,6,5]],"date-time":"2024-06-05T07:45:14Z","timestamp":1717573514000},"page":"107532","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":5,"special_numbering":"C","title":["Novel antibody-antibiotic conjugate using KRM-1657 as payload eliminates intracellular MRSA in vitro and in vivo"],"prefix":"10.1016","volume":"150","author":[{"given":"Shiyong","family":"Fan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuefan","family":"Bai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qilong","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lianqi","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanming","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fei","family":"Xie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuchao","family":"Dong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zihao","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kai","family":"Lv","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"He","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongkai","family":"Bi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinbo","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bioorg.2024.107532_b0005","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejmech.2023.115823","article-title":"2,4-Diacetylphloroglucinol (DAPG) derivatives rapidly eradicate methicillin-resistant staphylococcus aureus without resistance development by disrupting membrane","volume":"261","author":"Zhong","year":"2023","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.bioorg.2024.107532_b0010","doi-asserted-by":"crossref","DOI":"10.1016\/j.micres.2022.127238","article-title":"Biofunction and clinical potential of extracellular vesicles from methicillin-resistant Staphylococcus aureus","volume":"266","author":"Liu","year":"2023","journal-title":"Microbiol. Res."},{"key":"10.1016\/j.bioorg.2024.107532_b0015","doi-asserted-by":"crossref","DOI":"10.1016\/j.biomaterials.2023.122344","article-title":"Antimicrobial-loaded biodegradable nanoemulsions for efficient clearance of intracellular pathogens in bacterial peritonitis","volume":"302","author":"Makabenta","year":"2023","journal-title":"Biomaterials"},{"key":"10.1016\/j.bioorg.2024.107532_b0020","article-title":"Antibacterial sensitizers from natural plants: A powerful weapon against methicillin-resistant Staphylococcus aureus","volume":"14","author":"Li","year":"2023","journal-title":"Front. Pharmacol."},{"issue":"3","key":"10.1016\/j.bioorg.2024.107532_b0025","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1080\/14656566.2022.2161885","article-title":"Current and emerging drug treatment strategies to tackle invasive community-associated methicillin-resistant Staphylococcus aureus (MRSA) infection: what are the challenges?","volume":"24","author":"Vena","year":"2023","journal-title":"Expert Opin. Pharmacother."},{"issue":"10","key":"10.1016\/j.bioorg.2024.107532_b0030","doi-asserted-by":"crossref","first-page":"e0224096","DOI":"10.1371\/journal.pone.0224096","article-title":"Sustained activity of novel THIOMAB antibody-antibiotic conjugate against Staphylococcus aureus in a mouse model: Longitudinal pharmacodynamic assessment by bioluminescence imaging","volume":"14","author":"Zhou","year":"2019","journal-title":"PLoS One"},{"key":"10.1016\/j.bioorg.2024.107532_b0035","doi-asserted-by":"crossref","DOI":"10.7759\/cureus.31486","article-title":"An update on treatment options for methicillin-resistant Staphylococcus aureus (MRSA) Bacteremia: A Systematic Review","author":"Mahjabeen","year":"2022","journal-title":"Cureus"},{"issue":"7578","key":"10.1016\/j.bioorg.2024.107532_b0040","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1038\/nature16057","article-title":"Novel antibody-antibiotic conjugate eliminates intracellular S. aureus","volume":"527","author":"Lehar","year":"2015","journal-title":"Nature"},{"key":"10.1016\/j.bioorg.2024.107532_b0045","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1016\/j.jconrel.2022.12.014","article-title":"Polymeric nano-system for macrophage reprogramming and intracellular MRSA eradication","volume":"353","author":"Yu","year":"2023","journal-title":"J. Control. Release"},{"key":"10.1016\/j.bioorg.2024.107532_b0050","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1016\/j.jconrel.2023.03.053","article-title":"Bacteria-mimetic nanomedicine for targeted eradication of intracellular MRSA","volume":"357","author":"Xie","year":"2023","journal-title":"J. Control. Release"},{"key":"10.1016\/j.bioorg.2024.107532_b0055","doi-asserted-by":"crossref","first-page":"410","DOI":"10.1016\/j.actbio.2023.08.004","article-title":"Natural antibacterial agent-based nanoparticles for effective treatment of intracellular MRSA infection","volume":"169","author":"Zou","year":"2023","journal-title":"Acta Biomater."},{"key":"10.1016\/j.bioorg.2024.107532_b0060","doi-asserted-by":"crossref","first-page":"454","DOI":"10.1016\/j.jconrel.2020.11.045","article-title":"Eradicating intracellular MRSA via targeted delivery of lysostaphin and vancomycin with mannose-modified exosomes","volume":"329","author":"Yang","year":"2021","journal-title":"J. Control. Release"},{"key":"10.1016\/j.bioorg.2024.107532_b0065","doi-asserted-by":"crossref","DOI":"10.3389\/fmicb.2022.835677","article-title":"The Use of Antibody-Antibiotic Conjugates to Fight Bacterial Infections","volume":"13","author":"Cavaco","year":"2022","journal-title":"Front. Microbiol."},{"issue":"1","key":"10.1016\/j.bioorg.2024.107532_b0070","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1038\/nrd.2015.24","article-title":"Antibody\u2013antibiotic conjugate tracks down hidden S. aureus","volume":"15","author":"Bray","year":"2015","journal-title":"Nat. Rev. Drug Discov."},{"issue":"11","key":"10.1016\/j.bioorg.2024.107532_b0075","doi-asserted-by":"crossref","first-page":"1161","DOI":"10.1124\/dmd.120.000092","article-title":"Characterization of tissue distribution, catabolism, and elimination of an anti-Staphylococcus aureusTHIOMAB antibody-antibiotic conjugate in rats","volume":"48","author":"Cai","year":"2020","journal-title":"Drug Metab. Dispos."},{"key":"10.1016\/j.bioorg.2024.107532_b0080","doi-asserted-by":"crossref","DOI":"10.1016\/j.taap.2021.115811","article-title":"Nonclinical toxicology development of a novel antibody antibiotic conjugate for treating invasive Staphylococcus Aureus infections","volume":"435","author":"Stagg","year":"2022","journal-title":"Toxicol. Appl. Pharmacol."},{"issue":"8","key":"10.1016\/j.bioorg.2024.107532_b0085","doi-asserted-by":"crossref","first-page":"1612","DOI":"10.1080\/19420862.2016.1229722","article-title":"Pharmacokinetics and pharmacodynamics of DSTA4637A: A Novel THIOMAB\u2122 antibody antibiotic conjugate against Staphylococcus Aureus in mice","volume":"8","author":"Zhou","year":"2016","journal-title":"mAbs"},{"issue":"6","key":"10.1016\/j.bioorg.2024.107532_b0090","doi-asserted-by":"crossref","DOI":"10.1128\/AAC.02588-18","article-title":"A Phase 1, randomized, single-ascending-dose study to investigate the safety, tolerability, and pharmacokinetics of DSTA4637S, an anti-Staphylococcus aureus thiomab antibody-antibiotic conjugate, in healthy volunteers","volume":"63","author":"Peck","year":"2019","journal-title":"Antimicrob. Agents Chemother."},{"issue":"5","key":"10.1016\/j.bioorg.2024.107532_b0095","doi-asserted-by":"crossref","first-page":"1118","DOI":"10.1128\/AAC.38.5.1118","article-title":"In vitro and in vivo antibacterial activities of KRM-1648 and KRM-1657, new rifamycin derivatives","volume":"38","author":"Fujii","year":"1994","journal-title":"Antimicrob. Agents Chemother."},{"issue":"3","key":"10.1016\/j.bioorg.2024.107532_b0100","doi-asserted-by":"crossref","first-page":"542","DOI":"10.1128\/AAC.35.3.542","article-title":"In vitro antimycobacterial activities of newly synthesized benzoxazinorifamycins","volume":"35","author":"Saito","year":"1991","journal-title":"Antimicrob. Agents Chemother."},{"key":"10.1016\/j.bioorg.2024.107532_b0105","unstructured":"E.J. Brown, J. Flygare, W. Hazenbos, S.M. Lehar, S. Mariathasan, H.H. Morisaki, T.H. Pillow, L. Staben, R. Vandlen, K. Koefoed, M. Strandlh, P.S. Andersen, Anti-wall teichoic antibodies and conjugates, US20150366985\uff0c United States Patent and Trademark Office, GENENTECH. INC, USA, 2015,12.24."},{"key":"10.1016\/j.bioorg.2024.107532_b0110","doi-asserted-by":"crossref","DOI":"10.1016\/j.biomaterials.2023.122258","article-title":"A novel antibody-KSP inhibitor conjugate improves KSP inhibitor efficacy in vitro and in vivo","volume":"301","author":"Li","year":"2023","journal-title":"Biomaterials"},{"issue":"9","key":"10.1016\/j.bioorg.2024.107532_b0115","doi-asserted-by":"crossref","DOI":"10.3390\/ijms18091860","article-title":"Development and properties of valine-alanine based antibody-drug conjugates with monomethyl auristatin E as the potent payload","volume":"18","author":"Wang","year":"2017","journal-title":"Int. J. Mol. Sci."},{"issue":"23","key":"10.1016\/j.bioorg.2024.107532_b0120","doi-asserted-by":"crossref","DOI":"10.1002\/advs.202301340","article-title":"Antibody-drug conjugates to treat bacterial biofilms via targeting and extracellular drug release","volume":"10","author":"Tvilum","year":"2023","journal-title":"Adv. Sci."},{"issue":"3","key":"10.1016\/j.bioorg.2024.107532_b0125","doi-asserted-by":"crossref","DOI":"10.1128\/mBio.00202-21","article-title":"Potent killing of Pseudomonas aeruginosa by an antibody-antibiotic conjugate","volume":"12","author":"Kajihara","year":"2021","journal-title":"mBio"}],"container-title":["Bioorganic Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0045206824004371?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0045206824004371?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,7,17]],"date-time":"2024-07-17T09:02:42Z","timestamp":1721206962000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0045206824004371"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,9]]},"references-count":25,"alternative-id":["S0045206824004371"],"URL":"https:\/\/doi.org\/10.1016\/j.bioorg.2024.107532","relation":{},"ISSN":["0045-2068"],"issn-type":[{"value":"0045-2068","type":"print"}],"subject":[],"published":{"date-parts":[[2024,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Novel antibody-antibiotic conjugate using KRM-1657 as payload eliminates intracellular MRSA in vitro and in vivo","name":"articletitle","label":"Article Title"},{"value":"Bioorganic Chemistry","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bioorg.2024.107532","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"107532"}}