{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,26]],"date-time":"2026-10-26T19:30:45Z","timestamp":1793043045616,"version":"4.5.0"},"reference-count":39,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,9,1]],"date-time":"2024-09-01T00:00:00Z","timestamp":1725148800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,9,1]],"date-time":"2024-09-01T00:00:00Z","timestamp":1725148800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,6,22]],"date-time":"2024-06-22T00:00:00Z","timestamp":1719014400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Bioorganic Chemistry"],"published-print":{"date-parts":[[2024,9]]},"DOI":"10.1016\/j.bioorg.2024.107567","type":"journal-article","created":{"date-parts":[[2024,6,20]],"date-time":"2024-06-20T07:01:57Z","timestamp":1718866917000},"page":"107567","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":6,"special_numbering":"C","title":["Homo and Hetero-Branched Lipopeptide Dendrimers: Synthesis and Antimicrobial Activity"],"prefix":"10.1016","volume":"150","author":[{"ORCID":"https:\/\/orcid.org\/0009-0004-8628-7168","authenticated-orcid":false,"given":"Saurabh","family":"Lamba","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gayan","family":"Heruka De Zoysa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kelvin","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0225-6643","authenticated-orcid":false,"given":"Jun","family":"Lu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simon","family":"Swift","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vijayalekshmi","family":"Sarojni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bioorg.2024.107567_b0005","doi-asserted-by":"crossref","first-page":"353","DOI":"10.3389\/fmicb.2013.00353","article-title":"Antibiotic development challenges: the various mechanisms of action of antimicrobial peptides and of bacterial resistance","volume":"4","author":"Guilhelmelli","year":"2013","journal-title":"Front. Microbiol."},{"key":"10.1016\/j.bioorg.2024.107567_b0010","article-title":"The past, present, and future of antibiotics","volume":"14(657):eabo7793","author":"Cook","year":"2022","journal-title":"Sci. Transl. Med."},{"issue":"9","key":"10.1016\/j.bioorg.2024.107567_b0015","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1016\/S0966-842X(00)01823-0","article-title":"The role of cationic antimicrobial peptides in innate host defences","volume":"8","author":"Hancock","year":"2000","journal-title":"Trends Microbiol."},{"key":"10.1016\/j.bioorg.2024.107567_b0020","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejmech.2023.115377","article-title":"Antimicrobial peptides: Structure, mechanism, and modification","volume":"255","author":"Chen","year":"2023","journal-title":"Eur. J. Med. Chem."},{"issue":"12","key":"10.1016\/j.bioorg.2024.107567_b0025","doi-asserted-by":"crossref","first-page":"1543","DOI":"10.3390\/ph6121543","article-title":"Antimicrobial peptides","volume":"6","author":"Bahar","year":"2013","journal-title":"Pharmaceuticals."},{"issue":"3","key":"10.1016\/j.bioorg.2024.107567_b0030","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1128\/CMR.00056-05","article-title":"Peptide antimicrobial agents","volume":"19","author":"Jenssen","year":"2006","journal-title":"Clin. Microbiol. Rev."},{"issue":"2","key":"10.1016\/j.bioorg.2024.107567_b0035","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1016\/j.chembiol.2015.01.002","article-title":"D-enantiomeric peptides that eradicate wild-type and multidrug-resistant biofilms and protect against lethal Pseudomonas aeruginosa infections","volume":"22","author":"De La Fuente-N\u00fa\u00f1ez","year":"2015","journal-title":"Chem. Biol."},{"issue":"3","key":"10.1016\/j.bioorg.2024.107567_b0040","doi-asserted-by":"crossref","first-page":"349","DOI":"10.3390\/antibiotics11030349","article-title":"Antimicrobial peptides: From design to clinical application","volume":"11","author":"Zhang","year":"2022","journal-title":"Antibiotics"},{"issue":"3","key":"10.1016\/j.bioorg.2024.107567_b0045","doi-asserted-by":"crossref","first-page":"923","DOI":"10.1046\/j.0014-2956.2001.02728.x","article-title":"Antimicrobial dendrimeric peptides","volume":"269","author":"Tam","year":"2002","journal-title":"Eur. J. Biochem."},{"key":"10.1016\/j.bioorg.2024.107567_b0050","doi-asserted-by":"crossref","DOI":"10.3389\/fchem.2021.795433","article-title":"The potential of modified and multimeric antimicrobial peptide materials as superbug killers","volume":"9","author":"Matthyssen","year":"2022","journal-title":"Front. Chem."},{"key":"10.1016\/j.bioorg.2024.107567_b0055","doi-asserted-by":"crossref","unstructured":"Tam JP. Synthetic peptide vaccine design: synthesis and properties of a high-density multiple antigenic peptide system. Proceedings of the National Academy of Sciences. 1988;85(15):5409-13.","DOI":"10.1073\/pnas.85.15.5409"},{"issue":"4","key":"10.1016\/j.bioorg.2024.107567_b0060","doi-asserted-by":"crossref","first-page":"1719","DOI":"10.1016\/S0021-9258(19)77935-6","article-title":"A novel method for producing anti-peptide antibodies. Production of site-specific antibodies to the T cell antigen receptor beta-chain","volume":"263","author":"Posnett","year":"1988","journal-title":"J. Biol. Chem."},{"issue":"3","key":"10.1016\/j.bioorg.2024.107567_b0065","doi-asserted-by":"crossref","first-page":"542","DOI":"10.3390\/ijms18030542","article-title":"Antimicrobial dendrimeric peptides: Structure, activity and new therapeutic applications","volume":"18","author":"Scorciapino","year":"2017","journal-title":"Int. J. Mol. Sci."},{"issue":"1","key":"10.1016\/j.bioorg.2024.107567_b0070","doi-asserted-by":"crossref","first-page":"22","DOI":"10.3109\/10837450.2013.862264","article-title":"Dendrimers\u2013from organic synthesis to pharmaceutical applications: an update","volume":"20","author":"Kalhapure","year":"2015","journal-title":"Pharm. Dev. Technol."},{"issue":"3","key":"10.1016\/j.bioorg.2024.107567_b0075","doi-asserted-by":"crossref","first-page":"1458","DOI":"10.1128\/AAC.05580-11","article-title":"Battacin (Octapeptin B5), a new cyclic lipopeptide antibiotic from Paenibacillus tianmuensis active against multidrug-resistant Gram-negative bacteria","volume":"56","author":"Qian","year":"2012","journal-title":"Antimicrob. Agents Chemother."},{"issue":"2","key":"10.1016\/j.bioorg.2024.107567_b0080","doi-asserted-by":"crossref","first-page":"625","DOI":"10.1021\/jm501084q","article-title":"Antimicrobial peptides with potential for biofilm eradication: synthesis and structure activity relationship studies of battacin peptides","volume":"58","author":"De Zoysa","year":"2015","journal-title":"J. Med. Chem."},{"issue":"2","key":"10.1016\/j.bioorg.2024.107567_b0085","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1038\/nprot.2007.521","article-title":"Agar and broth dilution methods to determine the minimal inhibitory concentration (MIC) of antimicrobial substances","volume":"3","author":"Wiegand","year":"2008","journal-title":"Nat. Protoc."},{"key":"10.1016\/j.bioorg.2024.107567_b0090","first-page":"M27","article-title":"Reference method for broth dilution antifungal susceptibility testing of yeasts, approved standard","author":"Pa","year":"2002","journal-title":"CLSI Document"},{"issue":"9","key":"10.1016\/j.bioorg.2024.107567_b0095","doi-asserted-by":"crossref","first-page":"e12684","DOI":"10.1371\/journal.pone.0012684","article-title":"Serum stabilities of short tryptophan-and arginine-rich antimicrobial peptide analogs","volume":"5","author":"Nguyen","year":"2010","journal-title":"PLoS One"},{"issue":"42","key":"10.1016\/j.bioorg.2024.107567_b0100","doi-asserted-by":"crossref","first-page":"36918","DOI":"10.1021\/acsomega.2c03931","article-title":"Application of \u201cClick\u201d Chemistry in Biomedical Hydrogels","volume":"7","author":"Li","year":"2022","journal-title":"ACS Omega"},{"issue":"8","key":"10.1016\/j.bioorg.2024.107567_b0105","doi-asserted-by":"crossref","first-page":"2497","DOI":"10.1021\/acs.bioconjchem.8b00252","article-title":"Covalent modification of biomolecules through maleimide-based labeling strategies","volume":"29","author":"Renault","year":"2018","journal-title":"Bioconjug. Chem."},{"key":"10.1016\/j.bioorg.2024.107567_b0110","article-title":"Click chemistry: a transformative technology in nuclear medicine","volume":"1\u201310","author":"Bauer","year":"2023","journal-title":"Nat. Protoc."},{"issue":"24","key":"10.1016\/j.bioorg.2024.107567_b0115","doi-asserted-by":"crossref","first-page":"1128","DOI":"10.1016\/S1359-6446(03)02933-7","article-title":"The growing impact of click chemistry on drug discovery","volume":"8","author":"Kolb","year":"2003","journal-title":"Drug Discov. Today"},{"issue":"46","key":"10.1016\/j.bioorg.2024.107567_b0120","doi-asserted-by":"crossref","first-page":"13437","DOI":"10.1021\/bi7015553","article-title":"Enhanced membrane pore formation by multimeric\/oligomeric antimicrobial peptides","volume":"46","author":"Arnusch","year":"2007","journal-title":"Biochemistry"},{"issue":"33","key":"10.1016\/j.bioorg.2024.107567_b0125","doi-asserted-by":"crossref","first-page":"21359","DOI":"10.1021\/acsomega.1c01854","article-title":"Tuning the Activity of Anoplin by Dendrimerization of Lysine and Lipidation of the N-Terminal","volume":"6","author":"Gou","year":"2021","journal-title":"ACS Omega"},{"issue":"27","key":"10.1016\/j.bioorg.2024.107567_b0130","doi-asserted-by":"crossref","first-page":"30052","DOI":"10.1021\/acsami.0c05944","article-title":"Impact of multivalence and self-assembly in the design of polymeric antimicrobial peptide mimics","volume":"12","author":"Laroque","year":"2020","journal-title":"ACS Appl. Mater. Interfaces"},{"key":"10.1016\/j.bioorg.2024.107567_b0135","doi-asserted-by":"crossref","first-page":"344","DOI":"10.1016\/j.ejmech.2018.01.023","article-title":"Unexplored antifungal activity of linear battacin lipopeptides against planktonic and mature biofilms of C. albicans","volume":"146","author":"De Zoysa","year":"2018","journal-title":"Eur. J. Med. Chem."},{"issue":"4","key":"10.1016\/j.bioorg.2024.107567_b0140","doi-asserted-by":"crossref","first-page":"553","DOI":"10.1016\/S0092-8674(00)81895-4","article-title":"Human \u03b2-defensin-1 is a salt-sensitive antibiotic in lung that is inactivated in cystic fibrosis","volume":"88","author":"Goldman","year":"1997","journal-title":"Cell"},{"issue":"22","key":"10.1016\/j.bioorg.2024.107567_b0145","doi-asserted-by":"crossref","first-page":"7235","DOI":"10.1021\/bi9826299","article-title":"Mechanism of interaction of different classes of cationic antimicrobial peptides with planar bilayers and with the cytoplasmic membrane of Escherichia coli","volume":"38","author":"Wu","year":"1999","journal-title":"Biochemistry"},{"issue":"7","key":"10.1016\/j.bioorg.2024.107567_b0150","doi-asserted-by":"crossref","first-page":"2898","DOI":"10.1128\/iai.65.7.2898-2903.1997","article-title":"Effects of pH and salinity on the antimicrobial properties of clavanins","volume":"65","author":"Lee","year":"1997","journal-title":"Infect. Immun."},{"issue":"9049","key":"10.1016\/j.bioorg.2024.107567_b0155","doi-asserted-by":"crossref","first-page":"418","DOI":"10.1016\/S0140-6736(97)80051-7","article-title":"Peptide antibiotics","volume":"349","author":"Hancock","year":"1997","journal-title":"Lancet"},{"issue":"1","key":"10.1016\/j.bioorg.2024.107567_b0160","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1007\/s00284-006-0554-z","article-title":"Effects of cations on antimicrobial activity of ostricacins-1 and 2 on E. coli O157: H7 and S. aureus 1056MRSA","volume":"55","author":"Sugiarto","year":"2007","journal-title":"Curr. Microbiol."},{"issue":"24","key":"10.1016\/j.bioorg.2024.107567_b0165","doi-asserted-by":"crossref","first-page":"5642","DOI":"10.1021\/bi900272r","article-title":"Antimicrobial action of prototypic amphipathic cationic decapeptides and their branched dimers","volume":"48","author":"Dewan","year":"2009","journal-title":"Biochemistry"},{"issue":"2","key":"10.1016\/j.bioorg.2024.107567_b0170","doi-asserted-by":"crossref","first-page":"596","DOI":"10.1021\/acs.molpharmaceut.3c00734","article-title":"Size-Controlled Synthesis of Gold Nanoparticles Tethering Antimicrobial Peptides with Potent Broad-Spectrum Antimicrobial and Antibiofilm Activities","volume":"21","author":"Rajchakit","year":"2024","journal-title":"Mol. Pharm."},{"issue":"2\u20133","key":"10.1016\/j.bioorg.2024.107567_b0175","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1016\/S0304-4165(00)00122-7","article-title":"Ovotransferrin antimicrobial peptide (OTAP-92) kills bacteria through a membrane damage mechanism","volume":"1523","author":"Ibrahim","year":"2000","journal-title":"Biochimica Et Biophysica Acta (BBA)-General Subjects."},{"issue":"9","key":"10.1016\/j.bioorg.2024.107567_b0180","doi-asserted-by":"crossref","first-page":"1436","DOI":"10.1016\/j.bbamem.2006.03.021","article-title":"Alpha-helical antimicrobial peptides\u2014Using a sequence template to guide structure\u2013activity relationship studies","volume":"1758","author":"Zelezetsky","year":"2006","journal-title":"Biochimica Et Biophysica Acta (BBA)-Biomembranes."},{"issue":"4","key":"10.1016\/j.bioorg.2024.107567_b0185","doi-asserted-by":"crossref","first-page":"721","DOI":"10.1021\/acsinfecdis.0c00805","article-title":"Selective permeabilization of gram-negative bacterial membranes using multivalent peptide constructs for antibiotic sensitization","volume":"7","author":"Chan","year":"2021","journal-title":"ACS Infect. Dis."},{"key":"10.1016\/j.bioorg.2024.107567_b0190","doi-asserted-by":"crossref","DOI":"10.1016\/j.biotechadv.2022.107962","article-title":"Strategies employed in the design of antimicrobial peptides with enhanced proteolytic stability","volume":"59","author":"Lai","year":"2022","journal-title":"Biotechnol. Adv."},{"issue":"12","key":"10.1016\/j.bioorg.2024.107567_b0195","doi-asserted-by":"crossref","first-page":"1900147","DOI":"10.1002\/adtp.201900147","article-title":"Molecular Architecture and Charging Effects Enhance the In Vitro and In Vivo Performance of Multi-Arm Antimicrobial Agents Based on Star-Shaped Poly (l-lysine)","volume":"2","author":"Lu","year":"2019","journal-title":"Advanced Therapeutics."}],"container-title":["Bioorganic Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0045206824004723?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0045206824004723?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,7,17]],"date-time":"2024-07-17T09:05:02Z","timestamp":1721207102000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0045206824004723"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,9]]},"references-count":39,"alternative-id":["S0045206824004723"],"URL":"https:\/\/doi.org\/10.1016\/j.bioorg.2024.107567","relation":{},"ISSN":["0045-2068"],"issn-type":[{"value":"0045-2068","type":"print"}],"subject":[],"published":{"date-parts":[[2024,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Homo and Hetero-Branched Lipopeptide Dendrimers: Synthesis and Antimicrobial Activity","name":"articletitle","label":"Article Title"},{"value":"Bioorganic Chemistry","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bioorg.2024.107567","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 The Authors. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"107567"}}