{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T21:53:48Z","timestamp":1792792428158,"version":"4.5.0"},"reference-count":84,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,12,1]],"date-time":"2024-12-01T00:00:00Z","timestamp":1733011200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,12,1]],"date-time":"2024-12-01T00:00:00Z","timestamp":1733011200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,10,2]],"date-time":"2025-10-02T00:00:00Z","timestamp":1759363200000},"content-version":"am","delay-in-days":305,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,12,1]],"date-time":"2024-12-01T00:00:00Z","timestamp":1733011200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2024,12,1]],"date-time":"2024-12-01T00:00:00Z","timestamp":1733011200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2024,12,1]],"date-time":"2024-12-01T00:00:00Z","timestamp":1733011200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2024,12,1]],"date-time":"2024-12-01T00:00:00Z","timestamp":1733011200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2024,12,1]],"date-time":"2024-12-01T00:00:00Z","timestamp":1733011200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Bioorganic Chemistry"],"published-print":{"date-parts":[[2024,12]]},"DOI":"10.1016\/j.bioorg.2024.107840","type":"journal-article","created":{"date-parts":[[2024,9,21]],"date-time":"2024-09-21T06:24:11Z","timestamp":1726899851000},"page":"107840","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":6,"special_numbering":"C","title":["Evaluation of expanded 2-aminobenzothiazole library as inhibitors of a model histidine kinase and virulence suppressors in Pseudomonas aeruginosa"],"prefix":"10.1016","volume":"153","author":[{"given":"Conrad A.","family":"Fihn","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hannah K.","family":"Lembke","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeffrey","family":"Gaulin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patricia","family":"Bouchard","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alex R.","family":"Villarreal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mitchell R.","family":"Penningroth","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kathryn K.","family":"Crone","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Grace A.","family":"Vogt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adam J.","family":"Gilbertsen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yann","family":"Ayotte","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luciana","family":"Coutinho de Oliveira","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael H.","family":"Serrano-Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nathalie","family":"Drouin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Deborah T.","family":"Hung","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ryan C.","family":"Hunter","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erin E.","family":"Carlson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bioorg.2024.107840_b0005","unstructured":"World Health Organization: Antimicrobial resistance. https:\/\/www.who.int\/news-room\/fact-sheets\/detail\/antimicrobial-resistance (accessed May 17th, 2022)."},{"key":"10.1016\/j.bioorg.2024.107840_b0010","unstructured":"Boluarte, T.; Schulze, U. The Case for a Subscription Model to Tackle Antimicrobial Resistance; Boston Consulting Group: Boston Consulting Group, February 11th, 2022."},{"key":"10.1016\/j.bioorg.2024.107840_b0015","doi-asserted-by":"crossref","unstructured":"Lai, C. K.; Ng, R. W.; Leung, S. S.; Hui, M.; Margaret., I., Overcoming the rising incidence and evolving mechanisms of antibiotic resistance by novel drug delivery approaches - An overview. Adv. Drug Deliv. Rev. 2022, 181.","DOI":"10.1016\/j.addr.2021.114078"},{"key":"10.1016\/j.bioorg.2024.107840_b0020","doi-asserted-by":"crossref","unstructured":"Hasan, C. M.; Dutta, D.; Nguyen, A. N. T., Revisiting Antibiotic Resistance: Mechanistic Foundations to Evolutionary Outlook. Antibiotics (Basel, Switzerland) 2021, 11 (1).","DOI":"10.3390\/antibiotics11010040"},{"issue":"4","key":"10.1016\/j.bioorg.2024.107840_b0025","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1111\/cbdd.12517","article-title":"Virulence-targeted Antibacterials: Concept, Promise, and Susceptibility to Resistance Mechanisms","volume":"86","author":"Ruer","year":"2015","journal-title":"Chem. Biol. Drug Des."},{"key":"10.1016\/j.bioorg.2024.107840_b0030","doi-asserted-by":"crossref","unstructured":"Hotinger, J. A.; Morris, S. T.; May, A. E., The Case against Antibiotics and for Anti-Virulence Therapeutics. Microorganisms 2021, 9 (10).","DOI":"10.3390\/microorganisms9102049"},{"issue":"4","key":"10.1016\/j.bioorg.2024.107840_b0035","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1016\/j.tips.2017.01.004","article-title":"Small Molecules That Sabotage Bacterial Virulence","volume":"38","author":"Johnson","year":"2017","journal-title":"Trends Pharmacol. Sci."},{"issue":"2","key":"10.1016\/j.bioorg.2024.107840_b0040","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1038\/nrd3013","article-title":"Anti-virulence strategies to combat bacteria-mediated disease","volume":"9","author":"Rasko","year":"2010","journal-title":"Nat. Rev. Drug Discov."},{"issue":"9","key":"10.1016\/j.bioorg.2024.107840_b0045","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1038\/nchembio.2007.24","article-title":"Targeting virulence: a new paradigm for antimicrobial therapy","volume":"3","author":"Clatworthy","year":"2007","journal-title":"Nat. Chem. Biol."},{"issue":"9","key":"10.1016\/j.bioorg.2024.107840_b0050","doi-asserted-by":"crossref","first-page":"2449","DOI":"10.1021\/acschembio.8b00257","article-title":"Tackling Pseudomonas aeruginosa Virulence by a Hydroxamic Acid-Based LasB Inhibitor","volume":"13","author":"Kany","year":"2018","journal-title":"ACS Chem. Biol."},{"issue":"5","key":"10.1016\/j.bioorg.2024.107840_b0055","doi-asserted-by":"crossref","first-page":"1010","DOI":"10.1021\/acsinfecdis.1c00628","article-title":"Structure-Based Design of alpha-Substituted Mercaptoacetamides as Inhibitors of the Virulence Factor LasB from Pseudomonas aeruginosa","volume":"8","author":"Kaya","year":"2022","journal-title":"ACS Infect. Dis."},{"key":"10.1016\/j.bioorg.2024.107840_b0060","doi-asserted-by":"crossref","unstructured":"Kollaran, A. M.; Joge, S.; Kotian, H. S.; Badal, D.; Prakash, D.; Mishra, A.; Varma, M.; Singh, V., Context-Specific Requirement of Forty-Four Two-Component Loci in Pseudomonas aeruginosa Swarming. iScience 2019, 13, 305-317.","DOI":"10.1016\/j.isci.2019.02.028"},{"key":"10.1016\/j.bioorg.2024.107840_b0065","doi-asserted-by":"crossref","unstructured":"Little, A. S.; Okkotsu, Y.; Reinhart, A. A.; Damron, F. H.; Barbier, M.; Barrett, B.; Oglesby-Sherrouse, A. G.; Goldberg, J. B.; Cody, W. L.; Schurr, M. J.; Vasil, M. L.; Schurr, M. J., Pseudomonas aeruginosa AlgR Phosphorylation Status Differentially Regulates Pyocyanin and Pyoverdine Production. mBio 2018, 9 (1).","DOI":"10.1128\/mBio.02318-17"},{"key":"10.1016\/j.bioorg.2024.107840_b0070","first-page":"8","article-title":"Two-Component Signal Transduction Systems of Pathogenic Bacteria As Targets for Antimicrobial Therapy: An Overview","volume":"2017","author":"Tiwari","year":"1878","journal-title":"Front. Microbiol."},{"key":"10.1016\/j.bioorg.2024.107840_b0075","doi-asserted-by":"crossref","unstructured":"Francis, V. I.; Stevenson, E. C.; Porter, S. L., Two-Component Systems Required for Virulence in Pseudomonas aeruginosa. FEMS Microbiol. Lett. 2017, 364 (11), fnx104.","DOI":"10.1093\/femsle\/fnx104"},{"issue":"2","key":"10.1016\/j.bioorg.2024.107840_b0080","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1016\/j.mib.2010.01.008","article-title":"Two-component signal transduction as potential drug targets in pathogenic bacteria","volume":"13","author":"Gotoh","year":"2010","journal-title":"Curr. Opin. Microbiol."},{"key":"10.1016\/j.bioorg.2024.107840_b0085","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1146\/annurev.genet.41.042007.170548","article-title":"Specificity in two-component signal transduction pathways","volume":"41","author":"Laub","year":"2007","journal-title":"Annu. Rev. Genet."},{"issue":"1","key":"10.1016\/j.bioorg.2024.107840_b0090","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1016\/S0968-0004(99)01503-0","article-title":"GHKL, an emergent ATPase\/kinase superfamily","volume":"25","author":"Dutta","year":"2000","journal-title":"Trends in Biochemical Sciences"},{"key":"10.1016\/j.bioorg.2024.107840_b0095","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1016\/S0065-2911(08)60167-8","article-title":"The Histidine Protein Kinase Superfamily","volume":"41","author":"Grebe","year":"1999","journal-title":"Adv. Microb. Physiol."},{"key":"10.1016\/j.bioorg.2024.107840_b0100","doi-asserted-by":"crossref","first-page":"3258","DOI":"10.1038\/ncomms4258","article-title":"Visualizing autophosphorylation in histidine kinases","volume":"5","author":"Casino","year":"2014","journal-title":"Nat. Commun."},{"issue":"2","key":"10.1016\/j.bioorg.2024.107840_b0105","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1016\/j.mib.2009.12.011","article-title":"Evolution and phyletic distribution of two-component signal transduction systems","volume":"13","author":"Wuichet","year":"2010","journal-title":"Curr. Opin. Microbiol"},{"key":"10.1016\/j.bioorg.2024.107840_b0110","doi-asserted-by":"crossref","unstructured":"Wolanin, P. M.; Thomason, P. A.; Stock, J. B., Histidine Protein Kinases: Key Signal Transducers Outside the Animal Kingdom. Genome Biol. 2002, 3 (10), Reviews3013.","DOI":"10.1186\/gb-2002-3-10-reviews3013"},{"issue":"1","key":"10.1016\/j.bioorg.2024.107840_b0115","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1016\/j.jmb.2008.03.036","article-title":"The Hsp90 inhibitor radicicol interacts with the ATP-binding pocket of bacterial sensor kinase PhoQ","volume":"379","author":"Guarnieri","year":"2008","journal-title":"J. Mol. Biol."},{"issue":"1","key":"10.1016\/j.bioorg.2024.107840_b0120","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1021\/cb5007135","article-title":"Bacterial Histidine Kinases As Novel Antibacterial Drug Targets","volume":"10","author":"Bem","year":"2015","journal-title":"ACS Chem. Biol."},{"issue":"2","key":"10.1016\/j.bioorg.2024.107840_b0125","doi-asserted-by":"crossref","first-page":"613","DOI":"10.1128\/JB.01502-07","article-title":"Bioinformatics and experimental analysis of proteins of two-component systems in Myxococcus xanthus","volume":"190","author":"Shi","year":"2008","journal-title":"J. Bacteriol."},{"key":"10.1016\/j.bioorg.2024.107840_b0130","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1016\/j.mib.2021.03.007","article-title":"Targeting a highly conserved domain in bacterial histidine kinases to generate inhibitors with broad spectrum activity","volume":"61","author":"Fihn","year":"2021","journal-title":"Curr. Opin. Microbiol."},{"issue":"76","key":"10.1016\/j.bioorg.2024.107840_b0135","first-page":"1223","article-title":"Discovery of Quorum Quenchers Targeting the Membrane-embedded Sensor Domain of the Staphylococcus aureus Receptor Histidine kinase","volume":"56","author":"Xie","year":"2020","journal-title":"AgrC. Chem. Commun. (camb)"},{"key":"10.1016\/j.bioorg.2024.107840_b0140","first-page":"11","article-title":"Monoclonal Antibodies Specific to the Extracellular Domain of Histidine Kinase YycG of Staphylococcus epidermidis Inhibit Biofilm Formation","volume":"2020","author":"Lyu","year":"1839","journal-title":"Front Microbiol."},{"issue":"37","key":"10.1016\/j.bioorg.2024.107840_b0145","doi-asserted-by":"crossref","first-page":"7332","DOI":"10.1039\/C8SC02496K","article-title":"Disarming the Virulence Arsenal of Pseudomonas aeruginosa by Blocking Two-Component System Signaling","volume":"9","author":"Goswami","year":"2018","journal-title":"Chem. Sci."},{"issue":"19","key":"10.1016\/j.bioorg.2024.107840_b0150","doi-asserted-by":"crossref","first-page":"8170","DOI":"10.1021\/acs.jmedchem.7b01066","article-title":"Rational Design of Selective Adenine-Based Scaffolds for Inactivation of Bacterial Histidine Kinases","volume":"60","author":"Goswami","year":"2017","journal-title":"J. Med. Chem."},{"issue":"23","key":"10.1016\/j.bioorg.2024.107840_b0155","doi-asserted-by":"crossref","first-page":"5235","DOI":"10.1016\/j.bmcl.2017.10.036","article-title":"Repurposing Hsp90 Inhibitors as Antibiotics Targeting Histidine Kinases","volume":"27","author":"Vo","year":"2017","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"10.1016\/j.bioorg.2024.107840_b0160","doi-asserted-by":"crossref","first-page":"26085","DOI":"10.1038\/srep26085","article-title":"Putative Histidine Kinase Inhibitors with Antibacterial Effect Against Multi-Drug Resistant Clinical Isolates Identified by In Vitro and In Silico Screens","volume":"6","author":"Velikova","year":"2016","journal-title":"Sci. Rep."},{"key":"10.1016\/j.bioorg.2024.107840_b0165","doi-asserted-by":"crossref","first-page":"328","DOI":"10.1021\/cb5008019","article-title":"Inactivation of Multiple Bacterial Histidine Kinases by Targeting the ATP-Binding Domain","volume":"10","author":"Wilke","year":"2015","journal-title":"ACS Chem. Biol."},{"issue":"8","key":"10.1016\/j.bioorg.2024.107840_b0170","doi-asserted-by":"crossref","first-page":"e23100","DOI":"10.1371\/journal.pone.0023100","article-title":"The effect of the potential PhoQ histidine kinase inhibitors on Shigella flexneri virulence","volume":"6","author":"Cai","year":"2011","journal-title":"PLoS One"},{"issue":"10","key":"10.1016\/j.bioorg.2024.107840_b0175","doi-asserted-by":"crossref","first-page":"726","DOI":"10.1038\/s41570-021-00313-1","article-title":"Towards the sustainable discovery and development of new antibiotics","volume":"5","author":"Miethke","year":"2021","journal-title":"Nat. Rev. Chem."},{"issue":"3","key":"10.1016\/j.bioorg.2024.107840_b0180","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1038\/s41579-018-0141-x","article-title":"Drug combinations: a strategy to extend the life of antibiotics in the 21st century","volume":"17","author":"Tyers","year":"2019","journal-title":"Nat. Rev. Microbiol."},{"issue":"22","key":"10.1016\/j.bioorg.2024.107840_b0185","doi-asserted-by":"crossref","first-page":"9150","DOI":"10.1021\/ja3041702","article-title":"Activity-based Probe For Histidine Kinase Signaling","volume":"134","author":"Wilke","year":"2012","journal-title":"J. Am. Chem. Soc."},{"key":"10.1016\/j.bioorg.2024.107840_b0190","first-page":"61","article-title":"Riluzole: real-world evidence supports significant extension of median survival times in patients with amyotrophic lateral sclerosis","volume":"7","author":"Hinchcliffe","year":"2017","journal-title":"Degener. Neurol. Neuromuscul. Dis."},{"key":"10.1016\/j.bioorg.2024.107840_b0195","doi-asserted-by":"crossref","first-page":"3500","DOI":"10.1002\/cbic.202000422","article-title":"2-Aminobenzothiazoles inhibit virulence gene expression and block polymyxin resistance in Salmonella enterica","volume":"21","author":"Thielen","year":"2020","journal-title":"ChemBioChem"},{"issue":"2","key":"10.1016\/j.bioorg.2024.107840_b0200","doi-asserted-by":"crossref","first-page":"e1010307","DOI":"10.1371\/journal.ppat.1010307","article-title":"High-level carbapenem tolerance requires antibiotic-induced outer membrane modifications","volume":"18","author":"Murtha","year":"2022","journal-title":"PLoS Pathogens"},{"key":"10.1016\/j.bioorg.2024.107840_b0205","unstructured":"CDC CDC. COVID-19: U.S. Impact on Antimicrobial Resistance, Special Report 2022; Atlanta, GA: U.S. Department of Health and Human Services, CDC, 2022."},{"key":"10.1016\/j.bioorg.2024.107840_b0210","unstructured":"WHO, WHO publishes list of bacteria for which new antibiotics are urgently needed. 2017."},{"issue":"1","key":"10.1016\/j.bioorg.2024.107840_b0215","doi-asserted-by":"crossref","first-page":"350","DOI":"10.1016\/j.drudis.2018.07.003","article-title":"Updates on the pathogenicity status of Pseudomonas aeruginosa","volume":"24","author":"Azam","year":"2019","journal-title":"Drug Discov. Today"},{"key":"10.1016\/j.bioorg.2024.107840_b0220","unstructured":"Antibiotic Resistance Threats in the United States; Centers for Disease Control and Prevention: Atlanta, GA, 2013."},{"issue":"6","key":"10.1016\/j.bioorg.2024.107840_b0225","doi-asserted-by":"crossref","DOI":"10.1093\/femsre\/fuab026","article-title":"Pseudomonas aeruginosa: a clinical and genomics update","volume":"45","author":"Pelegrin","year":"2021","journal-title":"FEMS Microbiol Rev"},{"issue":"11","key":"10.1016\/j.bioorg.2024.107840_b0230","doi-asserted-by":"crossref","DOI":"10.1128\/AEM.03089-20","article-title":"Two-Component Signaling Systems Regulate Diverse Virulence-Associated Traits in Pseudomonas aeruginosa","volume":"87","author":"Wang","year":"2021","journal-title":"Applied and Environmental Microbiology"},{"issue":"6","key":"10.1016\/j.bioorg.2024.107840_b0235","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0253259","article-title":"High pyocyanin production and non-motility of Pseudomonas aeruginosa isolates are correlated with septic shock or death in bacteremic patients","volume":"16","author":"Gupte","year":"2021","journal-title":"PloS One"},{"issue":"8","key":"10.1016\/j.bioorg.2024.107840_b0240","doi-asserted-by":"crossref","DOI":"10.3390\/toxins8080236","article-title":"Cellular Effects of Pyocyanin, a Secreted Virulence Factor of Pseudomonas aeruginosa","volume":"8","author":"Hall","year":"2016","journal-title":"Toxins"},{"issue":"12","key":"10.1016\/j.bioorg.2024.107840_b0245","doi-asserted-by":"crossref","first-page":"599","DOI":"10.1016\/j.molmed.2004.10.002","article-title":"The role of pyocyanin in Pseudomonas aeruginosa infection","volume":"10","author":"Lau","year":"2004","journal-title":"Trends Mol. Med."},{"issue":"22","key":"10.1016\/j.bioorg.2024.107840_b0250","doi-asserted-by":"crossref","DOI":"10.3390\/ijms222212152","article-title":"Roles of Two-Component Systems in Pseudomonas aeruginosa Virulence","volume":"22","author":"Sultan","year":"2021","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.bioorg.2024.107840_b0255","doi-asserted-by":"crossref","unstructured":"Kilmury, S. L. N.; Burrows, L. L., The Pseudomonas aeruginosa PilSR Two-Component System Regulates Both Twitching and Swimming Motilities. mBio 2018, 9 (4).","DOI":"10.1128\/mBio.01310-18"},{"issue":"8","key":"10.1016\/j.bioorg.2024.107840_b0260","doi-asserted-by":"crossref","first-page":"2671","DOI":"10.1128\/JB.01659-07","article-title":"Swarming of Pseudomonas aeruginosa is a complex adaptation leading to increased production of virulence factors and antibiotic resistance","volume":"190","author":"Overhage","year":"2008","journal-title":"J. Bacteriol."},{"issue":"21","key":"10.1016\/j.bioorg.2024.107840_b0265","doi-asserted-by":"crossref","first-page":"7351","DOI":"10.1128\/JB.187.21.7351-7361.2005","article-title":"Rhamnolipids modulate swarming motility patterns of Pseudomonas aeruginosa","volume":"187","author":"Caiazza","year":"2005","journal-title":"J. Bacteriol."},{"key":"10.1016\/j.bioorg.2024.107840_b0270","first-page":"64 (3)","article-title":"Multidrug Adaptive Resistance of Pseudomonas aeruginosa Swarming Cells","author":"Coleman","year":"2020","journal-title":"Antimicrob. Agents Chemother."},{"issue":"11","key":"10.1016\/j.bioorg.2024.107840_b0275","doi-asserted-by":"crossref","first-page":"6892","DOI":"10.1167\/iovs.15-17556","article-title":"Relationship of Virulence Factors and Clinical Features in Keratitis Caused by Pseudomonas aeruginosa","volume":"56","author":"Oka","year":"2015","journal-title":"Invest. Ophthalmol. vis. Sci."},{"issue":"8016","key":"10.1016\/j.bioorg.2024.107840_b0280","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1038\/s41586-024-07487-w","article-title":"Accurate structure prediction of biomolecular interactions with AlphaFold 3","volume":"630","author":"Abramson","year":"2024","journal-title":"Nature"},{"issue":"19","key":"10.1016\/j.bioorg.2024.107840_b0285","doi-asserted-by":"crossref","first-page":"5322","DOI":"10.1016\/j.bmc.2018.04.047","article-title":"Screening Serine\/Threonine and Tyrosine Kinase Inhibitors for Histidine Kinase Inhibition","volume":"26","author":"Wilke","year":"2018","journal-title":"Bioorg. Med. Chem."},{"issue":"5","key":"10.1016\/j.bioorg.2024.107840_b0290","doi-asserted-by":"crossref","first-page":"1374","DOI":"10.1007\/s00044-018-2154-4","article-title":"Synthesis, crystal structure, and antinociceptive effects of some new riluzole derivatives","volume":"27","author":"Wu","year":"2018","journal-title":"Med. Chem. Res."},{"issue":"5","key":"10.1016\/j.bioorg.2024.107840_b0295","doi-asserted-by":"crossref","first-page":"1371","DOI":"10.1021\/ci500183u","article-title":"Heteroaromatic pi-stacking energy landscapes","volume":"54","author":"Huber","year":"2014","journal-title":"J. Chem. Inf. Model"},{"issue":"28","key":"10.1016\/j.bioorg.2024.107840_b0300","doi-asserted-by":"crossref","first-page":"11027","DOI":"10.1021\/jacs.9b00936","article-title":"Predicting the Strength of Stacking Interactions between Heterocycles and Aromatic Amino Acid Side Chains","volume":"141","author":"Bootsma","year":"2019","journal-title":"J. Am. Chem. Soc."},{"issue":"5","key":"10.1016\/j.bioorg.2024.107840_b0305","doi-asserted-by":"crossref","first-page":"933","DOI":"10.3390\/molecules24050933","article-title":"Structural Basis for the Inhibition of the Autophosphorylation Activity of HK853 by Luteolin","volume":"24","author":"Zhou","year":"2019","journal-title":"Molecules"},{"issue":"17","key":"10.1016\/j.bioorg.2024.107840_b0310","doi-asserted-by":"crossref","first-page":"7885","DOI":"10.1021\/acs.jmedchem.9b00653","article-title":"Exposing Small-Molecule Nanoentities by a Nuclear Magnetic Resonance Relaxation Assay","volume":"62","author":"Ayotte","year":"2019","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.bioorg.2024.107840_b0315","doi-asserted-by":"crossref","unstructured":"Hutchison, M. L.; Govan, J. R., Pathogenicity of microbes associated with cystic fibrosis. Microbes Infect. 1999, 1 (12).","DOI":"10.1016\/S1286-4579(99)80518-8"},{"key":"10.1016\/j.bioorg.2024.107840_b0320","doi-asserted-by":"crossref","unstructured":"Morales-Soto, N.; Anyan, M. E.; Mattingly, A. E.; Madukoma, C. S.; Harvey, C. W.; Alber, M.; Deziel, E.; Kearns, D. B.; Shrout, J. D., Preparation, imaging, and quantification of bacterial surface motility assays. Journal of visualized experiments : JoVE 2015, (98).","DOI":"10.3791\/52338"},{"issue":"6","key":"10.1016\/j.bioorg.2024.107840_b0325","doi-asserted-by":"crossref","first-page":"1520","DOI":"10.1021\/acs.accounts.0c00895","article-title":"Facilitating Compound Entry as a Means to Discover Antibiotics for Gram-Negative Bacteria","volume":"54","author":"Munoz","year":"2021","journal-title":"Acc. Chem. Res."},{"issue":"7654","key":"10.1016\/j.bioorg.2024.107840_b0330","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1038\/nature22308","article-title":"Predictive compound accumulation rules yield a broad-spectrum antibiotic","volume":"545","author":"Richter","year":"2017","journal-title":"Nature"},{"issue":"12","key":"10.1016\/j.bioorg.2024.107840_b0335","doi-asserted-by":"crossref","first-page":"1293","DOI":"10.1038\/s41589-020-00674-6","article-title":"Defining new chemical space for drug penetration into Gram-negative bacteria","volume":"16","author":"Zhao","year":"2020","journal-title":"Nat. Chem. Biol."},{"issue":"13","key":"10.1016\/j.bioorg.2024.107840_b0340","doi-asserted-by":"crossref","first-page":"1213","DOI":"10.1016\/j.micinf.2003.08.009","article-title":"Antimicrobial resistance of Pseudomonas aeruginosa biofilms","volume":"5","author":"Drenkard","year":"2003","journal-title":"Microbes Infect."},{"key":"10.1016\/j.bioorg.2024.107840_b0345","doi-asserted-by":"crossref","unstructured":"Li, X. Z.; Ma, D.; Livermore, D. M.; Nikaido, H., Role of efflux pump(s) in intrinsic resistance of Pseudomonas aeruginosa: active efflux as a contributing factor to beta-lactam resistance. Antimicrob. Agents Chemother. 1994, 38 (8).","DOI":"10.1128\/AAC.38.8.1742"},{"issue":"1","key":"10.1016\/j.bioorg.2024.107840_b0350","doi-asserted-by":"crossref","first-page":"2219","DOI":"10.1038\/s41467-018-04640-8","article-title":"Multiple communication mechanisms between sensor kinases are crucial for virulence in Pseudomonas aeruginosa","volume":"9","author":"Francis","year":"2018","journal-title":"Nat. Commun."},{"issue":"8","key":"10.1016\/j.bioorg.2024.107840_b0355","doi-asserted-by":"crossref","first-page":"4462","DOI":"10.1128\/IAI.00575-06","article-title":"Mutational analysis of RetS, an unusual sensor kinase-response regulator hybrid required for Pseudomonas aeruginosa virulence","volume":"74","author":"Laskowski","year":"2006","journal-title":"Infect. Immun."},{"issue":"Pt 3","key":"10.1016\/j.bioorg.2024.107840_b0360","doi-asserted-by":"crossref","first-page":"699","DOI":"10.1099\/mic.0.024554-0","article-title":"The sensor kinase PhoQ mediates virulence in Pseudomonas aeruginosa","volume":"155","author":"Gooderham","year":"2009","journal-title":"Microbiology (reading)"},{"issue":"2","key":"10.1016\/j.bioorg.2024.107840_b0365","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/j.tim.2012.10.004","article-title":"Pyocyanin effects on respiratory epithelium: relevance in Pseudomonas aeruginosa airway infections","volume":"21","author":"Rada","year":"2013","journal-title":"Trends Microbiol."},{"issue":"9","key":"10.1016\/j.bioorg.2024.107840_b0370","doi-asserted-by":"crossref","first-page":"5492","DOI":"10.1128\/AAC.03069-14","article-title":"Pyocyanin production by Pseudomonas aeruginosa confers resistance to ionic silver","volume":"58","author":"Muller","year":"2014","journal-title":"Antimicrob. Agents Chemother."},{"issue":"2","key":"10.1016\/j.bioorg.2024.107840_b0375","doi-asserted-by":"crossref","first-page":"e0244142","DOI":"10.1371\/journal.pone.0244142","article-title":"The three NADH dehydrogenases of Pseudomonas aeruginosa: Their roles in energy metabolism and links to virulence","volume":"16","author":"Hreha","year":"2021","journal-title":"PloS One"},{"key":"10.1016\/j.bioorg.2024.107840_b0380","doi-asserted-by":"crossref","unstructured":"VanDrisse, C. M.; Lipsh-Sokolik, R.; Khersonsky, O.; Fleishman, S. J.; Newman, D. K., Computationally designed pyocyanin demethylase acts synergistically with tobramycin to kill recalcitrant Pseudomonas aeruginosa biofilms. Proc. Natl. Acad. Sci. U.S.A. 2021, 118 (12).","DOI":"10.1073\/pnas.2022012118"},{"key":"10.1016\/j.bioorg.2024.107840_b0385","doi-asserted-by":"crossref","unstructured":"Arzumanian, V. A.; Kiseleva, O. I.; Poverennaya, E. V., The Curious Case of the HepG2 Cell Line: 40 Years of Expertise. International journal of molecular sciences 2021, 22 (23).","DOI":"10.3390\/ijms222313135"},{"issue":"4","key":"10.1016\/j.bioorg.2024.107840_b0390","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1165\/rcmb.2021-0048ED","article-title":"Repurposing A549 Adenocarcinoma Cells: New Options for Drug Discovery","volume":"64","author":"Garcia-de-Alba","year":"2021","journal-title":"Am J Respir Cell Mol Biol"},{"key":"10.1016\/j.bioorg.2024.107840_b0395","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/bs.mie.2022.01.003","article-title":"Activity-based ATP analog probes for bacterial histidine kinases","volume":"664","author":"Lembke","year":"2022","journal-title":"Methods Enzymol."},{"key":"10.1016\/j.bioorg.2024.107840_b0400","unstructured":"Rasband, W. S., ImageJ. U. S. National Institutes of Health, Bethesda, Maryland, USA, http:\/\/imagej.nih.gov\/ij\/, 1997-2014."},{"issue":"4","key":"10.1016\/j.bioorg.2024.107840_b0405","doi-asserted-by":"crossref","first-page":"387","DOI":"10.3390\/bios4040387","article-title":"Development of a Pseudomonas aeruginosa Agmatine Biosensor","volume":"4","author":"Gilbertsen","year":"2014","journal-title":"Biosensors (basel)"},{"key":"10.1016\/j.bioorg.2024.107840_b0410","doi-asserted-by":"crossref","unstructured":"Hwang, T. L.; Shaka, A. J., Water Suppression That Works. Excitation Sculpting Using Arbitrary Wave-Forms and Pulsed Field Gradients. J. Magn. Reson. 1995, 112 (2), 275-279.","DOI":"10.1006\/jmra.1995.1047"},{"issue":"23","key":"10.1016\/j.bioorg.2024.107840_b0415","doi-asserted-by":"crossref","first-page":"12366","DOI":"10.1073\/pnas.94.23.12366","article-title":"Attenuated T2 relaxation by mutual cancellation of dipole\u2013dipole coupling and chemical shift anisotropy indicates an avenue to NMR structures of very large biological macromolecules in solution","volume":"94","author":"Pervushin","year":"1997","journal-title":"Proc. Natl. Acad. Sci. u.s.a."},{"key":"10.1016\/j.bioorg.2024.107840_b0420","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.pnmrs.2013.02.001","article-title":"Using chemical shift perturbation to characterise ligand binding","volume":"73","author":"Williamson","year":"2013","journal-title":"Prog. Nucl. Magn. Reson. Spectrosc."}],"container-title":["Bioorganic Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0045206824007454?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0045206824007454?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,1,30]],"date-time":"2025-01-30T02:23:55Z","timestamp":1738203835000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0045206824007454"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,12]]},"references-count":84,"alternative-id":["S0045206824007454"],"URL":"https:\/\/doi.org\/10.1016\/j.bioorg.2024.107840","relation":{},"ISSN":["0045-2068"],"issn-type":[{"value":"0045-2068","type":"print"}],"subject":[],"published":{"date-parts":[[2024,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Evaluation of expanded 2-aminobenzothiazole library as inhibitors of a model histidine kinase and virulence suppressors in Pseudomonas aeruginosa","name":"articletitle","label":"Article Title"},{"value":"Bioorganic Chemistry","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bioorg.2024.107840","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"107840"}}