{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T16:46:55Z","timestamp":1786985215601,"version":"build-2736575974"},"reference-count":36,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Bioorganic Chemistry"],"published-print":{"date-parts":[[2025,1]]},"DOI":"10.1016\/j.bioorg.2024.107989","type":"journal-article","created":{"date-parts":[[2024,11,22]],"date-time":"2024-11-22T15:36:56Z","timestamp":1732289816000},"page":"107989","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":10,"special_numbering":"C","title":["Highly oxygenated ent-abietane diterpenoid lactones from Euphorbia peplus and their anti-inflammatory activity"],"prefix":"10.1016","volume":"154","author":[{"given":"Ying","family":"Yan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ming-You","family":"Peng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhi-Bi","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Long-Long","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lei","family":"Tang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xu-Jie","family":"Qin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuan-Yuan","family":"Cheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying-Tong","family":"Di","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao-Jiang","family":"Hao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"3","key":"10.1016\/j.bioorg.2024.107989_b0005","doi-asserted-by":"crossref","first-page":"359","DOI":"10.3390\/cells11030359","article-title":"Interconnections between inflammageing and immunosenescence during ageing","volume":"11","author":"Teissier","year":"2022","journal-title":"Cells"},{"key":"10.1016\/j.bioorg.2024.107989_b0010","first-page":"57","article-title":"Markers of inflammation","volume":"2018","author":"Germolec","year":"1803","journal-title":"Methods Mol. Biol."},{"key":"10.1016\/j.bioorg.2024.107989_b0015","first-page":"1","article-title":"The emerging role of thelper 9 (Th9) cells in immunopathophysiology: A comprehensive review of their effects and responsiveness in various disease states","volume":"12","author":"Khokhar","year":"2024","journal-title":"Int. Rev. Immunol."},{"issue":"3","key":"10.1016\/j.bioorg.2024.107989_b0020","doi-asserted-by":"crossref","first-page":"1478","DOI":"10.3390\/ijms22031478","article-title":"The Role of the FOXO1\/\u03b2(2)-AR\/p-NF-\u03baB p65 Pathway in the development of endometrial stromal cells in pregnant mice under restraint stress","volume":"22","author":"Lu","year":"2021","journal-title":"Int. J. Mol. Sci."},{"issue":"1","key":"10.1016\/j.bioorg.2024.107989_b0025","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1038\/s41573-020-0088-2","article-title":"Therapeutic strategies targeting FOXO transcription factors","volume":"20","author":"Calissi","year":"2021","journal-title":"Nat. Rev. Drug Discov."},{"issue":"4","key":"10.1016\/j.bioorg.2024.107989_b0030","doi-asserted-by":"crossref","first-page":"380","DOI":"10.2174\/1389557516666160923130814","article-title":"ent-Abietane lactones from Euphorbia","volume":"17","author":"Lai","year":"2017","journal-title":"Mini. Rev. Med. Chem."},{"key":"10.1016\/j.bioorg.2024.107989_b0035","doi-asserted-by":"crossref","first-page":"113261","DOI":"10.1016\/j.phytochem.2022.113261","article-title":"Ent-abietane diterpenoid lactone glycosides and a phenolic glycoside from Phlogacanthus pulcherrimus T. Anderson with Cytotoxic and Cancer Chemopreventive Activities","volume":"201","author":"Kheawchaum","year":"2022","journal-title":"Phytochemistry"},{"issue":"11","key":"10.1016\/j.bioorg.2024.107989_b0040","doi-asserted-by":"crossref","first-page":"2132","DOI":"10.1039\/D2NP00047D","article-title":"Euphorbia diterpenoids: isolation, structure, bioactivity, biosynthesis, and synthesis (2013-2021)","volume":"39","author":"Zhan","year":"2022","journal-title":"Nat. Prod. Rep."},{"key":"10.1016\/j.bioorg.2024.107989_b0045","doi-asserted-by":"crossref","first-page":"115574","DOI":"10.1016\/j.jep.2022.115574","article-title":"Phytochemical and pharmacological review of diterpenoids from the genus Euphorbia Linn (2012-2021)","volume":"298","author":"Zhao","year":"2022","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.bioorg.2024.107989_b0050","doi-asserted-by":"crossref","first-page":"155311","DOI":"10.1016\/j.phymed.2023.155311","article-title":"Jolkinolide B ameliorates rheumatoid arthritis by regulating the JAK2\/STAT3 signaling pathway","volume":"124","author":"Yan","year":"2024","journal-title":"Phytomedicine"},{"key":"10.1016\/j.bioorg.2024.107989_b0055","doi-asserted-by":"crossref","first-page":"113448","DOI":"10.1016\/j.phytochem.2022.113448","article-title":"Jolkinolide B: a comprehensive review of its physicochemical properties, analytical methods, synthesis and pharmacological activity","volume":"204","author":"Zhang","year":"2022","journal-title":"Phytochemistry"},{"key":"10.1016\/j.bioorg.2024.107989_b0060","doi-asserted-by":"crossref","unstructured":"X. Ran, Q.Y. Lu, Y.Y. Li, X.X. Pu, Y. Guo, M.R. Yuan, S.P. Guan, M. Sun, L. Jiao, Y.G. Yao, Y.T. Di, X.J. Hao, R. Luo, Euphejolkinolide A, a new ent-abietane lactone from Euphorbia peplus L. with promising biological activity in activating the autophagy-lysosomal pathway, Heliyon 9 (2) (2023) 13691\u201313704.","DOI":"10.1016\/j.heliyon.2023.e13691"},{"key":"10.1016\/j.bioorg.2024.107989_b0065","doi-asserted-by":"crossref","first-page":"113142","DOI":"10.1016\/j.phytochem.2022.113142","article-title":"Phorneroids A-M, diverse types of diterpenoids from Euphorbia neriifolia","volume":"198","author":"Gao","year":"2022","journal-title":"Phytochemistry"},{"issue":"4","key":"10.1016\/j.bioorg.2024.107989_b0070","doi-asserted-by":"crossref","first-page":"1003","DOI":"10.1021\/acs.jnatprod.3c00041","article-title":"Euphohelides A-C, ent-Abietane-Type Norditerpene Lactones from Euphorbia helioscopia and their anti-inflammatory activities","volume":"86","author":"Yang","year":"2023","journal-title":"J. Nat. Prod."},{"issue":"7","key":"10.1016\/j.bioorg.2024.107989_b0075","doi-asserted-by":"crossref","first-page":"553","DOI":"10.1016\/S1473-3099(14)70794-7","article-title":"Prehistoric schistosomiasis parasite found in the Middle East","volume":"14","author":"Anastasiou","year":"2014","journal-title":"Lancet Infect. Dis."},{"key":"10.1016\/j.bioorg.2024.107989_b0080","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1016\/j.fitote.2014.03.010","article-title":"Diterpenes inhibiting NO production from Euphorbia helioscopia","volume":"95","author":"Chen","year":"2014","journal-title":"Fitoterapia"},{"key":"10.1016\/j.bioorg.2024.107989_b0085","doi-asserted-by":"crossref","first-page":"105139","DOI":"10.1016\/j.fitote.2022.105139","article-title":"Euphzycopias A\u2212I, macrocyclic diterpenes with NLRP3 inflammasome inhibitory activity from Euphorbia helioscopia L","volume":"157","author":"Zhang","year":"2022","journal-title":"Fitoterapia"},{"issue":"10","key":"10.1016\/j.bioorg.2024.107989_b0090","doi-asserted-by":"crossref","first-page":"2818","DOI":"10.1021\/acs.jnatprod.9b00519","article-title":"Macrocyclic Diterpenoids from Euphorbia helioscopia and their potential anti-inflammatory activity","volume":"82","author":"Su","year":"2019","journal-title":"J. Nat. Prod."},{"issue":"7","key":"10.1016\/j.bioorg.2024.107989_b0095","doi-asserted-by":"crossref","first-page":"632","DOI":"10.1080\/10286020.2019.1611787","article-title":"Two new ent-abietane diterpenoids from Euphorbia helioscopia","volume":"22","author":"Yin","year":"2019","journal-title":"J. Asian Nat. Prod. Res."},{"issue":"4","key":"10.1016\/j.bioorg.2024.107989_b0100","doi-asserted-by":"crossref","first-page":"815","DOI":"10.1021\/acs.jnatprod.1c00879","article-title":"Jatrophane diterpenoids with Kv1.3 Ion channel inhibitory effects from Euphorbia helioscopia","volume":"85","author":"Zhou","year":"2022","journal-title":"J. Nat. Prod."},{"key":"10.1016\/j.bioorg.2024.107989_b0105","doi-asserted-by":"crossref","first-page":"105533","DOI":"10.1016\/j.bioorg.2021.105534","article-title":"Diterpenoids from Euphorbia helioscopia and their enhancement of NK cell-mediated killing of NSCLC cells","volume":"119","author":"Mu","year":"2022","journal-title":"Bioorg. Chem."},{"issue":"6","key":"10.1016\/j.bioorg.2024.107989_b0110","doi-asserted-by":"crossref","first-page":"1233","DOI":"10.3389\/fphar.2018.01233","article-title":"Xu, Maintenance chemotherapy with chinese herb medicine formulas vs. with placebo in patients with advanced non-small cell lung cancer after first-line chemotherapy: a multicenter, randomized, double-blind trial","volume":"9","author":"Wang","year":"2018","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.bioorg.2024.107989_b0115","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/j.phytochem.2017.10.012","article-title":"Highly oxygenated and structurally diverse diterpenoids from Euphorbia helioscopia","volume":"145","author":"Wang","year":"2018","journal-title":"Phytochemistry"},{"issue":"48","key":"10.1016\/j.bioorg.2024.107989_b0120","doi-asserted-by":"crossref","first-page":"8854","DOI":"10.1021\/acs.orglett.2c03649","article-title":"Euphylonoids A and B, two highly modified jatrophane diterpenoids with potent lipid-lowering activity from Euphorbia hylonoma","volume":"24","author":"Wu","year":"2022","journal-title":"Org. Lett."},{"issue":"2","key":"10.1016\/j.bioorg.2024.107989_b0125","doi-asserted-by":"crossref","first-page":"1088","DOI":"10.3390\/ijms24021088","article-title":"Jatrophane diterpenoids from Euphorbia peplus Linn. as activators of autophagy and inhibitors of Tau pathology","volume":"24","author":"Yan","year":"2023","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.bioorg.2024.107989_b0130","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1016\/j.phytol.2022.06.007","article-title":"Three new jatrophane diterpenoids from Euphorbia peplus Linn. with activity towards autophagic flux","volume":"50","author":"Pu","year":"2022","journal-title":"Phytochem. Lett."},{"key":"10.1016\/j.bioorg.2024.107989_b0135","doi-asserted-by":"crossref","first-page":"154550","DOI":"10.1016\/j.tetlet.2023.154550","article-title":"Pepluenone, a new pepluane-type diterpenoid with inhibitory activity on the release of NO from the whole plant of Euphorbia peplus L","volume":"123","author":"Huang","year":"2023","journal-title":"Tetrahedron Lett."},{"key":"10.1016\/j.bioorg.2024.107989_b0140","doi-asserted-by":"crossref","first-page":"12526","DOI":"10.1021\/acs.joc.5b02396","article-title":"Beyond DP4: an improved probability for the stereochemical assignment of isomeric compounds using quantum chemical calculations of NMR shifts","volume":"80","author":"Grimblat","year":"2015","journal-title":"J. Org. Chem."},{"key":"10.1016\/j.bioorg.2024.107989_b0145","doi-asserted-by":"crossref","first-page":"3449","DOI":"10.1021\/acs.orglett.0c00903","article-title":"Eleucanainones A and B: two dimeric structures from the bulbs of Eleutherine americana with anti-MRSA activity","volume":"22","author":"Chen","year":"2020","journal-title":"Org. Lett."},{"key":"10.1016\/j.bioorg.2024.107989_b0150","doi-asserted-by":"crossref","first-page":"6684","DOI":"10.1021\/acs.jafc.3c07422","article-title":"Novel cyclopenta[c]pyridine derivatives based on natural cerbinal as potential agrochemical anti-TMV agents and insecticides","volume":"72","author":"Li","year":"2024","journal-title":"J. Agric. Food Chem."},{"key":"10.1016\/j.bioorg.2024.107989_b0155","doi-asserted-by":"crossref","first-page":"13373","DOI":"10.1021\/acs.jafc.1c03857","article-title":"Design, synthesis, and antifungal activity of novel thiophene\/furan-1,3,4-oxadiazole carboxamides as potent succinate dehydrogenase inhibitors","volume":"69","author":"Yang","year":"2021","journal-title":"J. Agric. Food Chem."},{"key":"10.1016\/j.bioorg.2024.107989_b0160","doi-asserted-by":"crossref","first-page":"773","DOI":"10.1021\/np960127v","article-title":"Identification of new diterpenoids from Euphorbia calyptrata cell cultures","volume":"59","author":"CrespiPerellino","year":"1996","journal-title":"J. Nat. Prod."},{"issue":"6","key":"10.1016\/j.bioorg.2024.107989_b0165","doi-asserted-by":"crossref","first-page":"1503","DOI":"10.1021\/np50078a003","article-title":"Structure elucidation of helioscopinolides D and E from Euphorbia calyptrata cell cultures","volume":"54","author":"Borghi","year":"1991","journal-title":"J. Nat. Prod."},{"key":"10.1016\/j.bioorg.2024.107989_b0170","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1016\/S0367-326X(99)00134-3","article-title":"Polycyclic diterpenoids from Euphorbia characias","volume":"71","author":"Appendino","year":"2000","journal-title":"Fitoterapia"},{"key":"10.1016\/j.bioorg.2024.107989_b0175","doi-asserted-by":"crossref","first-page":"749","DOI":"10.1021\/np970507w","article-title":"Macrocyclic diterpenoids from Euphorbia semiperfoliata","volume":"61","author":"Appendino","year":"1998","journal-title":"J. Nat. Prod."},{"issue":"4","key":"10.1016\/j.bioorg.2024.107989_b0180","doi-asserted-by":"crossref","first-page":"1003","DOI":"10.1021\/acs.jnatprod.3c00041","article-title":"Euphohelides A\u2013C, ent-Abietane-type norditerpene lactones from Euphorbia helioscopia and their anti-inflammatory activities","volume":"86","author":"Yang","year":"2023","journal-title":"J. Nat. Prod."}],"container-title":["Bioorganic Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0045206824008940?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0045206824008940?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,1,9]],"date-time":"2025-01-09T21:01:35Z","timestamp":1736456495000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0045206824008940"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,1]]},"references-count":36,"alternative-id":["S0045206824008940"],"URL":"https:\/\/doi.org\/10.1016\/j.bioorg.2024.107989","relation":{},"ISSN":["0045-2068"],"issn-type":[{"value":"0045-2068","type":"print"}],"subject":[],"published":{"date-parts":[[2025,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Highly oxygenated ent-abietane diterpenoid lactones from Euphorbia peplus and their anti-inflammatory activity","name":"articletitle","label":"Article Title"},{"value":"Bioorganic Chemistry","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bioorg.2024.107989","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"107989"}}