{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,28]],"date-time":"2026-10-28T22:19:43Z","timestamp":1793225983741,"version":"4.5.0"},"reference-count":163,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Bioorganic Chemistry"],"published-print":{"date-parts":[[2025,1]]},"DOI":"10.1016\/j.bioorg.2024.108092","type":"journal-article","created":{"date-parts":[[2024,12,24]],"date-time":"2024-12-24T19:33:04Z","timestamp":1735068784000},"page":"108092","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":64,"special_numbering":"C","title":["Indoles as promising Therapeutics: A review of recent drug discovery efforts"],"prefix":"10.1016","volume":"154","author":[{"given":"Naik Jui","family":"Pravin","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rohini S.","family":"Kavalapure","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shankar G.","family":"Alegaon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shankar","family":"Gharge","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shriram D.","family":"Ranade","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"132","key":"10.1016\/j.bioorg.2024.108092_b0005","article-title":"Research progress on the structure and biological diversities of 2-phenylindole derivatives in recent 20 years","volume":"1","author":"Wu","year":"2023","journal-title":"Bioorg Chem."},{"issue":"89","key":"10.1016\/j.bioorg.2024.108092_b0010","article-title":"Medicinal chemistry of indole derivatives: Current to future therapeutic prospectives","volume":"1","author":"Kumari","year":"2019","journal-title":"Bioorg Chem."},{"issue":"3","key":"10.1016\/j.bioorg.2024.108092_b0015","doi-asserted-by":"crossref","first-page":"488","DOI":"10.3390\/ddc3030029","article-title":"Biological Profile of Synthetic and Natural Indole Derivatives: Paving New Paths in Cancer Treatment","volume":"3","author":"Janeiro","year":"2024","journal-title":"DDC."},{"issue":"4","key":"10.1016\/j.bioorg.2024.108092_b0020","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1021\/cr60224a003","article-title":"The Fischer indole synthesis","volume":"63","author":"Robinson","year":"1963","journal-title":"Chem. Rev."},{"issue":"53","key":"10.1016\/j.bioorg.2024.108092_b0025","doi-asserted-by":"crossref","first-page":"33540","DOI":"10.1039\/D1RA05972F","article-title":"Synthesis of indole derivatives as prevalent moieties present in selected alkaloids","volume":"11","author":"Heravi","year":"2021","journal-title":"RSC Adv."},{"issue":"17","key":"10.1016\/j.bioorg.2024.108092_b0030","doi-asserted-by":"crossref","first-page":"5495","DOI":"10.1021\/ja00824a028","article-title":"General method for the synthesis of indoles","volume":"96","author":"Gassman","year":"1974","journal-title":"J Am Chem Soc."},{"issue":"21","key":"10.1016\/j.bioorg.2024.108092_b0035","doi-asserted-by":"crossref","first-page":"9967","DOI":"10.1021\/acs.jmedchem.6b01178","article-title":"The antioxidant additive approach for Alzheimer\u2019s disease therapy: new ferulic (lipoic) acid plus melatonin modified tacrines as cholinesterases inhibitors, direct antioxidants, and nuclear factor (erythroid-derived 2)-like 2 activators","volume":"59","author":"Benchekroun","year":"2016","journal-title":"J. Med. Chem."},{"issue":"3","key":"10.1016\/j.bioorg.2024.108092_b0040","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1039\/CO9940100145","article-title":"Recent developments in indole ring synthesis\u2014Methodology and applications","volume":"1","author":"Gribble","year":"1994","journal-title":"Contemp. Org. Synth."},{"issue":"38","key":"10.1016\/j.bioorg.2024.108092_b0045","doi-asserted-by":"crossref","first-page":"7195","DOI":"10.1016\/j.tet.2011.06.040","article-title":"Indole synthesis: a review and proposed classification","volume":"67","author":"Taber","year":"2011","journal-title":"Tetrahedron."},{"issue":"2","key":"10.1016\/j.bioorg.2024.108092_b0050","doi-asserted-by":"crossref","first-page":"163","DOI":"10.2174\/1385272053369204","article-title":"Bartoli indole synthesis","volume":"9","author":"Dalpozzo","year":"2005","journal-title":"Current Organic Chemistry."},{"issue":"218","key":"10.1016\/j.bioorg.2024.108092_b0055","article-title":"An insight in anti-malarial potential of indole scaffold: A review","volume":"5","author":"Chauhan","year":"2021","journal-title":"Eur. J. Med. Chem."},{"issue":"66","key":"10.1016\/j.bioorg.2024.108092_b0060","doi-asserted-by":"crossref","first-page":"466","DOI":"10.1016\/j.ejmech.2013.06.012","article-title":"Synthesis and anticancer activity of 2, 4-disubstituted furo [3, 2-b] indole derivatives","volume":"1","author":"Zhuang","year":"2013","journal-title":"Eur. J. Med. Chem."},{"issue":"11","key":"10.1016\/j.bioorg.2024.108092_b0065","doi-asserted-by":"crossref","first-page":"2372","DOI":"10.3390\/pharmaceutics14112372","article-title":"Synthesis and anticancer activity of indole-functionalized derivatives of betulin","volume":"14","author":"Rzepka","year":"2022","journal-title":"Pharmaceutics."},{"key":"10.1016\/j.bioorg.2024.108092_b0070","doi-asserted-by":"crossref","unstructured":"Tiwari RK, Singh D, Singh J, Yadav V, Pathak AK, Dabur R et al. Synthesis and antibacterial activity of substituted 1, 2, 3, 4-tetrahydropyrazino [1, 2-a] indoles Bioorg. Med. Chem. Lett. 2006, 15;16(2):413-6. https:\/\/doi.org\/10.1016\/j.bmcl.2005.09.066.","DOI":"10.1016\/j.bmcl.2005.09.066"},{"key":"10.1016\/j.bioorg.2024.108092_b0075","doi-asserted-by":"crossref","unstructured":"Gomha SM, Riyadh SM. Synthesis under microwave irradiation of [1, 2, 4] triazolo [3, 4-b] [1, 3, 4] thiadiazoles and other diazoles bearing indole moieties and their antimicrobial evaluation. Mol. 2011, 28;16(10):8244-56. https:\/\/doi.org\/10.3390\/molecules16108244.","DOI":"10.3390\/molecules16108244"},{"issue":"5","key":"10.1016\/j.bioorg.2024.108092_b0080","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1016\/j.ejmech.2003.11.002","article-title":"Synthesis and antiinflammatory activity of heterocyclic indole derivatives","volume":"39","author":"Rani","year":"2004","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.bioorg.2024.108092_b0085","doi-asserted-by":"crossref","unstructured":"Lin X, Tago K, Okazaki N, So T, Takahashi K, Mashino T, et al The indole-hydantoin derivative exhibits anti-inflammatory activity by preventing the transactivation of NF-\u03baB through the inhibition of NF-\u03baB p65 phosphorylation at Ser276. Int. Immunopharmacol. 2021, 1;100:108092. https:\/\/doi.org\/10.1016\/j.intimp.2021.108092.","DOI":"10.1016\/j.intimp.2021.108092"},{"issue":"89","key":"10.1016\/j.bioorg.2024.108092_b0090","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1016\/j.ejmech.2014.10.065","article-title":"A review on recent developments of indole-containing antiviral agents","volume":"7","author":"Zhang","year":"2015","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.bioorg.2024.108092_b0095","article-title":"Synthesis and antiviral activity of some novel indole-2-carboxylate derivatives","volume":"1;4(4):313\u201321","author":"Xue","year":"2014","journal-title":"Acta Pharm.sin.b."},{"issue":"12","key":"10.1016\/j.bioorg.2024.108092_b0100","doi-asserted-by":"crossref","first-page":"1335","DOI":"10.1039\/D0MD00288G","article-title":"Indole\u2013a promising pharmacophore in recent antiviral drug discovery","volume":"11","author":"Dorababu","year":"2020","journal-title":"RSC Med.chem."},{"key":"10.1016\/j.bioorg.2024.108092_b0105","article-title":"Novel indole-N-glucoside, TA-1887 as a sodium glucose cotransporter 2 inhibitor for treatment of type 2 diabetes","volume":"9;5(1):51\u20135","author":"Nomura","year":"2014","journal-title":"ACS Med.chem.lett."},{"issue":"74","key":"10.1016\/j.bioorg.2024.108092_b0110","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1016\/j.bioorg.2017.07.009","article-title":"Synthesis, \u03b1-glucosidase inhibitory activity and in silico study of tris-indole hybrid scaffold with oxadiazole ring: As potential leads for the management of type-II diabetes mellitus","volume":"1","author":"Taha","year":"2017","journal-title":"Bioorg Chem."},{"key":"10.1016\/j.bioorg.2024.108092_b0115","doi-asserted-by":"crossref","DOI":"10.1016\/j.bmcl.2011.04.117","article-title":"Practical synthesis, anticonvulsant, and antimicrobial activity of N-allyl and N-propargyl di (indolyl) indolin-2-ones","author":"Praveen","year":"2011121134072","journal-title":"Bioorg. Med. Chem. Lett."},{"issue":"5","key":"10.1016\/j.bioorg.2024.108092_b0120","doi-asserted-by":"crossref","DOI":"10.1016\/j.arabjc.2022.103756","article-title":"Antihypertensive activity of indole and indazole analogues: A review","volume":"15","author":"Tan","year":"2022","journal-title":"Arab. J. Chem."},{"issue":"156","key":"10.1016\/j.bioorg.2024.108092_b0125","article-title":"Indoles as essential mediators in the gut-brain axis. Their role in Alzheimer's disease","volume":"1","author":"Pappolla","year":"2021","journal-title":"Neurobiol. Dis."},{"issue":"98","key":"10.1016\/j.bioorg.2024.108092_b0130","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1016\/j.ejmech.2015.05.020","article-title":"Synthesis, antimalarial and antitubercular activities of meridianin derivatives","volume":"15","author":"Yadav","year":"2015","journal-title":"Eur. J. Med. Chem."},{"issue":"127","key":"10.1016\/j.bioorg.2024.108092_b0135","article-title":"Rational drug design strategies for the development of promising multi-target directed indole hybrids as Anti-Alzheimer agents","volume":"1","author":"George","year":"2022","journal-title":"Bioorg Chem."},{"key":"10.1016\/j.bioorg.2024.108092_b0140","unstructured":"MINDSET PHARMA INC., a Canadian Company of 217 Queen Street West, Suite 401, Toronto, Ontario M5V 0R2, Canada, 3-cyclic amine-indole derivatives as serotonergic agents for the treatment of CNS disorders, 2023, 202317044823."},{"key":"10.1016\/j.bioorg.2024.108092_b0145","volume":"202311059742","author":"Raba","year":"2023","journal-title":"Synthesis, Molecular Modeling and in-Silico Activity on Substituted Indole-3- Thiosemicarbazone Derivatives as Anticonvulsants"},{"key":"10.1016\/j.bioorg.2024.108092_b0150","volume":"202421044845","author":"Sasane","year":"2024","journal-title":"Indole Derivatives as Thioredoxin Inhibitor Study, Synthesis and Evaluation of Anti-Cancer Activity"},{"key":"10.1016\/j.bioorg.2024.108092_b0155","unstructured":"Novel indole derivatives as glycosidase inhibitors and their uses there off,2022, 202441004221."},{"key":"10.1016\/j.bioorg.2024.108092_b0160","volume":"202311054823","author":"Shrivastava","year":"2023","journal-title":"Schiff Bases of 1h-Indole-2,3-Dione Derivatives: Synthesis and Studies of Novel Anti-Inflammatory and Antioxidants"},{"key":"10.1016\/j.bioorg.2024.108092_b0165","article-title":"Indole-Based Compounds in the Development of Anti-Neurodegenerative Agents","volume":"3;29(9):2127","author":"Barresi","year":"2024","journal-title":"Molecules."},{"key":"10.1016\/j.bioorg.2024.108092_b0170","doi-asserted-by":"crossref","DOI":"10.1002\/slct.201803222","article-title":"Novel coumarin\u2010quinoline hybrids: Design of multitarget compounds for Alzheimer's disease","author":"Duarte","year":"20191742551","journal-title":"ChemistrySelect."},{"key":"10.1016\/j.bioorg.2024.108092_b0175","doi-asserted-by":"crossref","DOI":"10.1016\/j.bmcl.2017.02.001","article-title":"Discovery and characterization of novel indole and 7-azaindole derivatives as inhibitors of \u03b2-amyloid-42 aggregation for the treatment of Alzheimer\u2019s disease","author":"Sreenivasachary","year":"2017152761405","journal-title":"Bioorg. Med. Chem. Lett."},{"issue":"125","key":"10.1016\/j.bioorg.2024.108092_b0180","doi-asserted-by":"crossref","first-page":"288","DOI":"10.1016\/j.ejmech.2016.09.037","article-title":"New azepino [4, 3-b] indole derivatives as nanomolar selective inhibitors of human butyrylcholinesterase showing protective effects against NMDA-induced neurotoxicity","volume":"5","author":"De Candia","year":"2017","journal-title":"Eur. J. Med. Chem."},{"issue":"157","key":"10.1016\/j.bioorg.2024.108092_b0185","doi-asserted-by":"crossref","first-page":"294","DOI":"10.1016\/j.ejmech.2018.07.030","article-title":"Design and synthesis of multipotent 3-aminomethylindoles and 7-azaindoles with enhanced protein phosphatase 2A-activating profile and neuroprotection","volume":"5","author":"Lajar\u00edn-Cuesta","year":"2018","journal-title":"Eur. J. Med. Chem."},{"issue":"76","key":"10.1016\/j.bioorg.2024.108092_b0190","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1016\/j.bioorg.2017.11.003","article-title":"Modification of Bischler-M\u00f6hlau indole derivatives through palladium catalyzed Suzuki reaction as effective cholinesterase inhibitors, their kinetic and molecular docking studies","volume":"1","author":"Parveen","year":"2018","journal-title":"Bioorg Chem."},{"issue":"90","key":"10.1016\/j.bioorg.2024.108092_b0195","article-title":"Discovery of novel indole-based aroylhydrazones as anticonvulsants: Pharmacophore-based design","volume":"1","author":"Angelova","year":"2019","journal-title":"Bioorg Chem."},{"issue":"170","key":"10.1016\/j.bioorg.2024.108092_b0200","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1016\/j.ejmech.2019.03.017","article-title":"Fluorinated indole-imidazole conjugates: Selective orally bioavailable 5-HT7 receptor low-basicity agonists, potential neuropathic painkillers","volume":"15","author":"Hogendorf","year":"2019","journal-title":"Eur. J. Med. Chem."},{"issue":"177","key":"10.1016\/j.bioorg.2024.108092_b0205","doi-asserted-by":"crossref","first-page":"414","DOI":"10.1016\/j.ejmech.2019.05.062","article-title":"Investigating 1, 2, 3, 4, 5, 6-hexahydroazepino [4, 3-b] indole as scaffold of butyrylcholinesterase-selective inhibitors with additional neuroprotective activities for Alzheimer's disease","volume":"1","author":"Purgatorio","year":"2019","journal-title":"Eur. J. Med. Chem."},{"issue":"166","key":"10.1016\/j.bioorg.2024.108092_b0210","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1016\/j.ejmech.2019.01.031","article-title":"Synthesis of novel pyrido [1, 2-c] pyrimidine derivatives with rigidized tryptamine moiety as potential SSRI and 5-HT1A receptor ligands","volume":"15","author":"\u015alifirski","year":"2019","journal-title":"Eur. J. Med. Chem."},{"issue":"180","key":"10.1016\/j.bioorg.2024.108092_b0215","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1016\/j.ejmech.2019.07.050","article-title":"Synthesis, pharmacological and structural studies of 5-substituted-3-(1-arylmethyl-1, 2, 3, 6-tetrahydropyridin-4-yl)-1H-indoles as multi-target ligands of aminergic GPCRs","volume":"15","author":"Kondej","year":"2019","journal-title":"Eur. J. Med. Chem."},{"issue":"104","key":"10.1016\/j.bioorg.2024.108092_b0220","article-title":"Aminotriazines with indole motif as novel, 5-HT7 receptor ligands with atypical binding mode","volume":"1","author":"Ku\u0142aga","year":"2020","journal-title":"Bioorg Chem."},{"issue":"97","key":"10.1016\/j.bioorg.2024.108092_b0225","article-title":"Synthesis of new 4-butyl-arylpiperazine-3-(1H-indol-3-yl) pyrrolidine-2, 5-dione derivatives and evaluation for their 5-HT1A and D2 receptor affinity and serotonin transporter inhibition","volume":"1","author":"Wr\u00f3bel","year":"2020","journal-title":"Bioorg Chem."},{"issue":"219","key":"10.1016\/j.bioorg.2024.108092_b0230","article-title":"Design, synthesis, and biological evaluation of diosgenin-indole derivatives as dual-functional agents for the treatment of Alzheimer\u2019s disease","volume":"5","author":"Zhou","year":"2021","journal-title":"Eur. J. Med. Chem."},{"issue":"116","key":"10.1016\/j.bioorg.2024.108092_b0235","article-title":"Discovery of 3, 4-dichloro-N-(1H-indol-5-yl) benzamide: A highly potent, selective, and competitive hMAO-B inhibitor with high BBB permeability profile and neuroprotective action","volume":"1","author":"Elkamhawy","year":"2021","journal-title":"Bioorg Chem."},{"issue":"49","key":"10.1016\/j.bioorg.2024.108092_b0240","article-title":"Design, synthesis and biological evaluation of novel deoxyvasicinone-indole as multi-target agents for Alzheimer\u2019s disease","volume":"1","author":"Nerella","year":"2021","journal-title":"Bioorg Med Chem Lett."},{"issue":"71","key":"10.1016\/j.bioorg.2024.108092_b0245","article-title":"Novel difluoromethylated 1-(phenylsulfonyl)-4-(piperazin-1-yl)-1H-indole derivatives as potent 5-HT6 receptor antagonist with AMDE-improving properties: Design, synthesis, and biological evaluation","volume":"1","author":"Yi","year":"2022","journal-title":"Bioorg. Med. Chem."},{"issue":"133","key":"10.1016\/j.bioorg.2024.108092_b0250","article-title":"Design, synthesis, anticonvulsant activity and structure-activity relationships of novel 7-Azaindole derivatives","volume":"1","author":"Meng","year":"2023","journal-title":"Bioorg Chem."},{"issue":"20","key":"10.1016\/j.bioorg.2024.108092_b0255","doi-asserted-by":"crossref","first-page":"11276","DOI":"10.3390\/ijms252011276","article-title":"Design and Synthesis of Potential Multi-Target Antidepressants: Exploration of 1-(4-(7-Azaindole)-3, 6-dihydropyridin-1-yl) alkyl-3-(1 H-indol-3-yl) pyrrolidine-2, 5-dione Derivatives with Affinity for the Serotonin Transporter","volume":"25","author":"Wr\u00f3bel","year":"2024","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.bioorg.2024.108092_b0260","doi-asserted-by":"crossref","DOI":"10.1016\/j.bmc.2024.117613","article-title":"Discovery of small molecule benzothiazole and indole derivatives tackling tau 2N4R and \u03b1-synuclein fibrils","volume":"100","author":"Elbatrawy","year":"2024","journal-title":"Bioorg. Med. Chem."},{"key":"10.1016\/j.bioorg.2024.108092_b0265","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejmech.2019.111691","article-title":"Indole: A privileged scaffold for the design of anti-cancer agents","volume":"183","author":"Wan","year":"2019","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.bioorg.2024.108092_b0270","doi-asserted-by":"crossref","DOI":"10.1016\/j.compbiolchem.2023.107881","article-title":"Design, synthesis, molecular dynamics simulation, MM\/GBSA studies and kinesin spindle protein inhibitory evaluation of some 4-aminoquinoline hybrids","volume":"105","author":"Ranade","year":"2023","journal-title":"Comput. Biol. Chem."},{"issue":"136","key":"10.1016\/j.bioorg.2024.108092_b0275","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1016\/j.ejmech.2017.05.012","article-title":"Synthesis of novel indole derivatives as promising DNA-binding agents and evaluation of antitumor and antitopoisomerase I activities","volume":"18","author":"Lafayette","year":"2017","journal-title":"Eur. J. Med. Chem."},{"issue":"146","key":"10.1016\/j.bioorg.2024.108092_b0280","doi-asserted-by":"crossref","first-page":"260","DOI":"10.1016\/j.ejmech.2018.01.042","article-title":"Design, synthesis, mechanistic and histopathological studies of small-molecules of novel indole-2-carboxamides and pyrazino [1, 2-a] indol-1 (2H)-ones as potential anticancer agents effecting the reactive oxygen species production","volume":"25","author":"Youssif","year":"2018","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.bioorg.2024.108092_b0285","article-title":"N-Arylsulfonylsubstituted-1H indole derivatives as small molecule dual inhibitors of signal transducer and activator of transcription 3 (STAT3) and tubulin","author":"Zhou","year":"2018126196","journal-title":"Bioorg. Med. Chem."},{"issue":"85","key":"10.1016\/j.bioorg.2024.108092_b0290","doi-asserted-by":"crossref","first-page":"568","DOI":"10.1016\/j.bioorg.2019.02.007","article-title":"Indole derivatives as multifunctional drugs: Synthesis and evaluation of antioxidant, photoprotective and antiproliferative activity of indole hydrazones","volume":"1","author":"Demurtas","year":"2019","journal-title":"Bioorg Chem."},{"issue":"184","key":"10.1016\/j.bioorg.2024.108092_b0295","article-title":"Novel thiosemicarbazone derivatives containing indole fragment as potent and selective anticancer agent","volume":"15","author":"He","year":"2019","journal-title":"Eur. J. Med. Chem."},{"issue":"208","key":"10.1016\/j.bioorg.2024.108092_b0300","article-title":"Design, synthesis and biological evaluation of indole-2-one derivatives as potent BRD4 inhibitors","volume":"15","author":"Xu","year":"2020","journal-title":"Eur. J. Med. Chem."},{"issue":"99","key":"10.1016\/j.bioorg.2024.108092_b0305","article-title":"Discovery of novel pyrazoline derivatives containing methyl-1H-indole moiety as potential inhibitors for blocking APC-Asef interactions","volume":"1","author":"Qi","year":"2020","journal-title":"Bioorg Chem."},{"issue":"18","key":"10.1016\/j.bioorg.2024.108092_b0310","doi-asserted-by":"crossref","first-page":"2830","DOI":"10.1080\/00397911.2020.1786124","article-title":"Synthesis and anticancer activity evaluation of 3-(4-oxo-2-thioxothiazolidin-5-yl)-1 H-indole-carboxylic acids derivatives","volume":"50","author":"Kryshchyshyn-Dylevych","year":"2020","journal-title":"Synth.commun."},{"key":"10.1016\/j.bioorg.2024.108092_b0315","doi-asserted-by":"crossref","first-page":"483","DOI":"10.2147\/DDDT.S227862","article-title":"New isatin\u2013indole conjugates: synthesis, characterization, and a plausible mechanism of their in vitro antiproliferative activity","author":"Al-Wabli","year":"2020","journal-title":"Drug Des Devel Ther."},{"key":"10.1016\/j.bioorg.2024.108092_b0320","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejmech.2019.111815","article-title":"Synthesis, biological evaluation, and docking study of indole aryl sulfonamides as aromatase inhibitors","volume":"185","author":"Fantacuzzi","year":"2020","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.bioorg.2024.108092_b0325","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s13065-021-00793-8","article-title":"Synthesis of novel indole-isoxazole hybrids and evaluation of their cytotoxic activities on hepatocellular carcinoma cell lines","volume":"15","author":"Hawash","year":"2021","journal-title":"BMC Chem."},{"key":"10.1016\/j.bioorg.2024.108092_b0330","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejmech.2021.113656","article-title":"Anticancer properties of indole derivatives as IsoCombretastatin A-4 analogues","volume":"223","author":"Pecnard","year":"2021","journal-title":"Eur. J. Med. Chem."},{"issue":"8","key":"10.1016\/j.bioorg.2024.108092_b0335","doi-asserted-by":"crossref","DOI":"10.1016\/j.arabjc.2021.103256","article-title":"Synthesis and antitumor activity of novel indole derivatives containing \u03b1-aminophosphonate moieties","volume":"14","author":"Ma","year":"2021","journal-title":"Arabian Journal of Chemistry."},{"issue":"129","key":"10.1016\/j.bioorg.2024.108092_b0340","article-title":"Design, synthesis and antitumor activity evaluation of novel indole acrylamide derivatives as IMPDH inhibitors","volume":"1","author":"Jia","year":"2022","journal-title":"Bioorg Chem."},{"issue":"55","key":"10.1016\/j.bioorg.2024.108092_b0345","article-title":"Design, synthesis and biological evaluation of novel 1, 3, 4, 9-tetrahydropyrano [3, 4-b] indoles as potential treatment of triple negative breast cancer by suppressing PI3K\/AKT\/mTOR pathway","volume":"1","author":"Qin","year":"2022","journal-title":"Bioorg. Med. Chem."},{"issue":"368","key":"10.1016\/j.bioorg.2024.108092_b0350","article-title":"Novel indole-guanidine hybrids as potential anticancer agents: Design, synthesis and biological evaluation","volume":"1","author":"Li","year":"2022","journal-title":"Chem.biol.interact."},{"issue":"244","key":"10.1016\/j.bioorg.2024.108092_b0355","article-title":"Discovery of 5-((4-(pyridin-3-yl) pyrimidin-2-yl) amino)-1H-indole-2-carboxamide derivatives as novel anti-cancer agents targeting Nur77","volume":"15","author":"Qin","year":"2022","journal-title":"Eur. J. Med. Chem."},{"issue":"125","key":"10.1016\/j.bioorg.2024.108092_b0360","article-title":"Discovery and structure-activity relationship studies of novel Bcl-2\/Mcl-1 dual inhibitors with indole scaffold","volume":"1","author":"Zhang","year":"2022","journal-title":"Bioorg Chem."},{"key":"10.1016\/j.bioorg.2024.108092_b0365","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejmech.2022.114467","article-title":"Discovery of novel coumarin-indole derivatives as tubulin polymerization inhibitors with potent anti-gastric cancer activities","volume":"238","author":"Song","year":"2022","journal-title":"European Journal of Medicinal Chemistry."},{"issue":"141","key":"10.1016\/j.bioorg.2024.108092_b0370","article-title":"Synthesis of 3-sulfenylindole derivatives from 4-hydroxy-2H-chromene-2-thione and indole using oxidative cross-dehydrogenative coupling reaction and anti-proliferative activity study of some of their sulfone derivatives","volume":"1","author":"Xalxo","year":"2023","journal-title":"Bioorg Chem."},{"issue":"135","key":"10.1016\/j.bioorg.2024.108092_b0375","article-title":"Structure optimization of an F-indole-chalcone (FC116) on 4-methoxyphenyl group and therapeutic potential against colorectal cancers with low cytotoxicity","volume":"1","author":"Du","year":"2023","journal-title":"Bioorg Chem."},{"issue":"8","key":"10.1016\/j.bioorg.2024.108092_b0380","doi-asserted-by":"crossref","DOI":"10.1016\/j.arabjc.2023.104970","article-title":"Bis-indole based triazine derivatives: Synthesis, characterization, in vitro \u03b2-glucuronidase anti-cancer and anti-bacterial evaluation along with in silico molecular docking and ADME analysis","volume":"16","author":"Khan","year":"2023","journal-title":"Arab.j.chem."},{"issue":"147","key":"10.1016\/j.bioorg.2024.108092_b0385","article-title":"Design, synthesis, in silico and biological evaluation of new indole based oxadiazole derivatives targeting estrogen receptor alpha","volume":"1","author":"Kaur","year":"2024","journal-title":"Bioorg Chem."},{"issue":"268","key":"10.1016\/j.bioorg.2024.108092_b0390","article-title":"Design, synthesis, and bioactivity evaluation of novel indole-selenide derivatives as P-glycoprotein inhibitors against multi-drug resistance in MCF-7\/ADR cell","volume":"15","author":"Yang","year":"2024","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.bioorg.2024.108092_b0395","article-title":"Efficient synthesis of indole-chalcones based glycohybrids and their anticancer activity","volume":"30","author":"Tyagi","year":"2024","journal-title":"Bioorg. Med. Chem."},{"key":"10.1016\/j.bioorg.2024.108092_b0400","doi-asserted-by":"crossref","DOI":"10.1016\/j.bioorg.2024.107966","article-title":"Expression of PPAR-\u03b3 TF by newly synthesized thiazolidine-2, 4-diones to manage glycemic control: Insights from in silico, in vitro and experimental pharmacology in wistar rats","author":"Gharge","year":"2024","journal-title":"Bioorg Chem."},{"key":"10.1016\/j.bioorg.2024.108092_b0405","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejmech.2021.113665","article-title":"Research progress of indole compounds with potential antidiabetic activity","volume":"223","author":"Zhu","year":"2021","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.bioorg.2024.108092_b0410","article-title":"Design, synthesis, characterization and antidiabetic evaluation of 3, 5-substituted thiazolidinediones: Evidenced by network pharmacology, Molecular docking, dynamic simulation, in vitro and in vivo assessment","volume":"12","author":"Gharge","year":"2024","journal-title":"Eur. J. Med. Chem. Reports."},{"key":"10.1016\/j.bioorg.2024.108092_b0415","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/j.bioorg.2017.06.007","article-title":"Synthesis and biological evaluation of indole derivatives as \u03b1-amylase inhibitor","volume":"73","author":"Imran","year":"2017","journal-title":"Bioorg Chem."},{"issue":"79","key":"10.1016\/j.bioorg.2024.108092_b0420","doi-asserted-by":"crossref","first-page":"350","DOI":"10.1016\/j.bioorg.2018.05.004","article-title":"Catalytic asymmetric synthesis of indole derivatives as novel \u03b1-glucosidase inhibitors in vitro","volume":"1","author":"Islam","year":"2018","journal-title":"Bioorg Chem."},{"issue":"81","key":"10.1016\/j.bioorg.2024.108092_b0425","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1016\/j.bioorg.2018.08.010","article-title":"New indole-based hybrid oxadiazole scaffolds with N-substituted acetamides: As potent anti-diabetic agents","volume":"1","author":"Nazir","year":"2018","journal-title":"Bioorg Chem."},{"issue":"80","key":"10.1016\/j.bioorg.2024.108092_b0430","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1016\/j.bioorg.2018.05.021","article-title":"Synthesis, \u03b1-amylase inhibitory potential and molecular docking study of indole derivatives","volume":"1","author":"Taha","year":"2018","journal-title":"Bioorg Chem."},{"issue":"92","key":"10.1016\/j.bioorg.2024.108092_b0435","article-title":"Design, synthesis, in-vitro evaluation and molecular docking studies of novel indole derivatives as inhibitors of SIRT1 and SIRT2","volume":"1","author":"Manjula","year":"2019","journal-title":"Bioorg Chem."},{"issue":"83","key":"10.1016\/j.bioorg.2024.108092_b0440","doi-asserted-by":"crossref","first-page":"520","DOI":"10.1016\/j.bioorg.2018.11.006","article-title":"Synthesis and biological evaluation of N-glucosyl indole derivatives as sodium-dependent glucose co-transporter 2 inhibitors","volume":"1","author":"Chu","year":"2019","journal-title":"Bioorg Chem."},{"key":"10.1016\/j.bioorg.2024.108092_b0445","article-title":"Indole acrylonitriles as potential anti-hyperglycemic agents: Synthesis, \u03b1-glucosidase inhibitory activity and molecular docking studies","volume":"1;28(21):115605","author":"Solangi","year":"2020","journal-title":"Bioorg. Med. Chem."},{"key":"10.1016\/j.bioorg.2024.108092_b0450","doi-asserted-by":"crossref","unstructured":"Exploring efficacy of indole-based dual inhibitors for \u03b1-glucosidase and \u03b1-amylase enzymes: In silico, biochemical and kinetic studies https:\/\/doi.org\/10.1016\/j.ijbiomac.2020.03.090.","DOI":"10.1016\/j.ijbiomac.2020.03.090"},{"key":"10.1016\/j.bioorg.2024.108092_b0455","doi-asserted-by":"crossref","DOI":"10.1016\/j.cdc.2020.100396","article-title":"Synthesis, in vitro alpha glucosidase, urease activities and molecular docking study of bis-indole bearing Schiff base analogs","volume":"28","author":"Uddin","year":"2020","journal-title":"Chem. Data Collect."},{"issue":"107","key":"10.1016\/j.bioorg.2024.108092_b0460","article-title":"Oleanolic acid indole derivatives as novel \u03b1-glucosidase inhibitors: Synthesis, biological evaluation, and mechanistic analysis","volume":"1","author":"Wu","year":"2021","journal-title":"Bioorg Chem."},{"issue":"3","key":"10.1016\/j.bioorg.2024.108092_b0465","doi-asserted-by":"crossref","first-page":"2264","DOI":"10.1021\/acsomega.0c05581","article-title":"Indole-3-acetamides: As potential antihyperglycemic and antioxidant agents; synthesis, in vitro \u03b1-amylase inhibitory activity, structure\u2013activity relationship, and in silico studies","volume":"6","author":"Kanwal","year":"2021","journal-title":"ACS Omega."},{"key":"10.1016\/j.bioorg.2024.108092_b0470","doi-asserted-by":"crossref","DOI":"10.1016\/j.bioorg.2021.104638","article-title":"Synthesis of indole-based-thiadiazole derivatives as a potent inhibitor of \u03b1-glucosidase enzyme along with in silico study","volume":"108","author":"Alomari","year":"2021","journal-title":"Bioorg Chem."},{"issue":"1","key":"10.1016\/j.bioorg.2024.108092_b0475","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1186\/s13065-022-00882-2","article-title":"Design, synthesis, in vitro, and in silico biological evaluations of coumarin-indole hybrids as new anti-\u03b1-glucosidase agents","volume":"16","author":"Niri","year":"2022","journal-title":"BMC Chem."},{"issue":"19","key":"10.1016\/j.bioorg.2024.108092_b0480","doi-asserted-by":"crossref","first-page":"6564","DOI":"10.3390\/molecules27196564","article-title":"New biologically hybrid pharmacophore thiazolidinone-based indole derivatives: synthesis, in vitro alpha-amylase and alpha-glucosidase along with molecular docking investigations","volume":"27","author":"Khan","year":"2022","journal-title":"Molecules."},{"issue":"97","key":"10.1016\/j.bioorg.2024.108092_b0485","article-title":"In silico and in vitro studies of thiosemicarbazone-indole hybrid compounds as potent \u03b1-glycosidase inhibitors","volume":"1","author":"Bakherad","year":"2022","journal-title":"Comput.biol.chem."},{"issue":"139","key":"10.1016\/j.bioorg.2024.108092_b0490","article-title":"Design, synthesis and antidiabetic study of triazole clubbed indole derivatives as \u03b1-glucosidase inhibitors","volume":"1","author":"Sharma","year":"2023","journal-title":"Bioorg Chem."},{"key":"10.1016\/j.bioorg.2024.108092_b0495","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejmech.2023.115957","article-title":"Synthesis and biological evaluation of indole derivatives containing thiazolidine-2, 4-dione as \u03b1-glucosidase inhibitors with antidiabetic activity","volume":"264","author":"Hu","year":"2024","journal-title":"European Journal of Medicinal Chemistry."},{"issue":"1","key":"10.1016\/j.bioorg.2024.108092_b0500","doi-asserted-by":"crossref","first-page":"15791","DOI":"10.1038\/s41598-024-66201-y","article-title":"Design, synthesis, in vitro, and in silico anti-\u03b1-glucosidase assays of N-phenylacetamide-1, 2, 3-triazole-indole-2-carboxamide derivatives as new anti-diabetic agents","volume":"14","author":"Sayahi","year":"2024","journal-title":"Sci.rep."},{"issue":"110","key":"10.1016\/j.bioorg.2024.108092_b0505","article-title":"Evaluation and docking of indole sulfonamide as a potent inhibitor of \u03b1-glucosidase enzyme in streptozotocin\u2013induced diabetic albino wistar rats","volume":"1","author":"Taha","year":"2021","journal-title":"Bioorg Chem."},{"key":"10.1016\/j.bioorg.2024.108092_b0510","doi-asserted-by":"crossref","DOI":"10.1016\/j.rechem.2024.101707","article-title":"Experimental and computational pharmacological approaches decoding the anti-diabetic molecular mechanism of indole based triazole bearing sulfonothioate derivatives","volume":"10","author":"Khan","year":"2024","journal-title":"Results Chem."},{"issue":"107205","key":"10.1016\/j.bioorg.2024.108092_b0515","article-title":"Anti-diabetic and anti-inflammatory indole diterpenes from the marine-derived fungus Penicillium sp. ZYX-Z-143","volume":"145","author":"Dai","year":"2024","journal-title":"Bioorg Chem."},{"key":"10.1016\/j.bioorg.2024.108092_b0520","doi-asserted-by":"crossref","DOI":"10.1016\/j.bmc.2023.117510","article-title":"Synthesis, anti-inflammatory activity, inverse molecular docking, and acid dissociation constants of new naphthoquinone-thiazole hybrids","volume":"95","author":"Efeoglu","year":"2023","journal-title":"Bioorg. Med. Chem."},{"key":"10.1016\/j.bioorg.2024.108092_b0525","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1016\/j.ejmech.2017.09.003","article-title":"TNF-\u03b1 and IL-6 inhibitors: Conjugates of N-substituted indole and aminophenylmorpholin-3-one as anti-inflammatory agents","volume":"140","author":"Singh","year":"2017","journal-title":"Eur. J. Med. Chem."},{"issue":"6","key":"10.1016\/j.bioorg.2024.108092_b0530","doi-asserted-by":"crossref","first-page":"1250","DOI":"10.3390\/molecules23061250","article-title":"Indole derivatives as cyclooxygenase inhibitors: synthesis, biological evaluation and docking studies","volume":"23","author":"Bhat","year":"2018","journal-title":"Molecules."},{"key":"10.1016\/j.bioorg.2024.108092_b0535","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.cbi.2018.02.026","article-title":"Evidence for the involvement of TNF-\u03b1, IL-1\u03b2 and IL-10 in the antinociceptive and anti-inflammatory effects of indole-3-guanylhydrazone hydrochloride, an aromatic aminoguanidine, in rodents","volume":"286","author":"Sandes","year":"2018","journal-title":"Chem.biol.interact."},{"issue":"171","key":"10.1016\/j.bioorg.2024.108092_b0540","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1016\/j.ejmech.2019.03.022","article-title":"Base promoted synthesis of novel indole-dithiocarbamate compounds as potential anti-inflammatory therapeutic agents for treatment of acute lung injury","volume":"1","author":"Song","year":"2019","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.bioorg.2024.108092_b0545","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/j.ejmech.2019.07.004","article-title":"Design, synthesis, biological evaluation and docking study of novel indole-2-amide as anti-inflammatory agents with dual inhibition of COX and 5-LOX","volume":"180","author":"Huang","year":"2019","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.bioorg.2024.108092_b0550","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s13065-020-00675-5","article-title":"Synthesis and biological evaluation of 2-(4-methylsulfonyl phenyl) indole derivatives: multi-target compounds with dual antimicrobial and anti-inflammatory activities","volume":"14","author":"Shaker","year":"2020","journal-title":"BMC Chem."},{"key":"10.1016\/j.bioorg.2024.108092_b0555","article-title":"Anti-inflammatory and anti-oxidative activity of indole-3-acetic acid involves induction of HO-1 and neutralization of free radicals in RAW264. 7 cells","volume":"21(5):1579","author":"Ji","year":"2020","journal-title":"Int.j.mol.sci."},{"issue":"113","key":"10.1016\/j.bioorg.2024.108092_b0560","article-title":"The in vitro and in vivo study of oleanolic acid indole derivatives as novel anti-inflammatory agents: Synthesis, biological evaluation, and mechanistic analysis","volume":"1","author":"Jin","year":"2021","journal-title":"Bioorg Chem."},{"issue":"114","key":"10.1016\/j.bioorg.2024.108092_b0565","article-title":"Investigation of indole functionalized pyrazoles and oxadiazoles as anti-inflammatory agents: Synthesis, in-vivo, in-vitro and in-silico analysis","volume":"1","author":"Kumar","year":"2021","journal-title":"Bioorg Chem."},{"issue":"225","key":"10.1016\/j.bioorg.2024.108092_b0570","article-title":"Design, synthesis and structure-activity relationship studies of 4-indole-2-arylaminopyrimidine derivatives as anti-inflammatory agents for acute lung injury","volume":"5","author":"Chen","year":"2021","journal-title":"Eur. J. Med. Chem."},{"issue":"4","key":"10.1016\/j.bioorg.2024.108092_b0575","doi-asserted-by":"crossref","DOI":"10.1016\/j.jksus.2022.102023","article-title":"Rational drug design, synthesis, and in vivo biological activity of new indolyl-imidazolone hybrids as potential and safer non-steroidal anti-inflammatory agents","volume":"34","author":"Husain","year":"2022","journal-title":"J.king Saud Univ.sci."},{"issue":"136","key":"10.1016\/j.bioorg.2024.108092_b0580","article-title":"Design and synthesis optimization of novel diimide indoles derivatives for ameliorating acute lung injury through modulation of NF-\u03baB signaling pathway","volume":"1","author":"Zheng","year":"2023","journal-title":"Bioorg Chem."},{"issue":"1","key":"10.1016\/j.bioorg.2024.108092_b0585","doi-asserted-by":"crossref","first-page":"8639","DOI":"10.1038\/s41598-023-35640-4","article-title":"Evaluation of the anti-inflammatory, analgesic, anti-pyretic and anti-ulcerogenic potentials of synthetic indole derivatives","volume":"13","author":"Siddique","year":"2023","journal-title":"Scientific Reports."},{"issue":"270","key":"10.1016\/j.bioorg.2024.108092_b0590","article-title":"A series of indole-derived \u03b3-hydroxy propiolate esters as potent anti-inflammatory agents: Design, synthesis, in-vitro and in-vivo biological studies","volume":"15","author":"Akhtar","year":"2024","journal-title":"Eur. J. Med. Chem."},{"issue":"10","key":"10.1016\/j.bioorg.2024.108092_b0595","doi-asserted-by":"crossref","first-page":"12175","DOI":"10.1021\/acsomega.4c00026","article-title":"Design, Synthesis, and In Vivo Evaluation of a New Series of Indole-Chalcone Hybrids as Analgesic and Anti-Inflammatory Agents","volume":"9","author":"Baramaki","year":"2024","journal-title":"ACS Omega."},{"issue":"4","key":"10.1016\/j.bioorg.2024.108092_b0600","doi-asserted-by":"crossref","first-page":"410","DOI":"10.1007\/s10593-021-02917-3","article-title":"Recent advances on heterocyclic compounds with antiviral properties","volume":"57","author":"De","year":"2021","journal-title":"Chem Heterocycl Compd."},{"issue":"1","key":"10.1016\/j.bioorg.2024.108092_b0605","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1016\/j.bmc.2016.10.037","article-title":"Discovery of novel multi-target indole-based derivatives as potent and selective inhibitors of chikungunya virus replication","volume":"25","author":"Scuotto","year":"2017","journal-title":"Bioorg. Med. Chem."},{"issue":"9","key":"10.1016\/j.bioorg.2024.108092_b0610","doi-asserted-by":"crossref","first-page":"1856","DOI":"10.1039\/C7MD00319F","article-title":"Sugar modified pyrimido [4, 5-b] indole nucleosides: synthesis and antiviral activity","volume":"8","author":"Konc","year":"2017","journal-title":"Medchemcomm."},{"issue":"150","key":"10.1016\/j.bioorg.2024.108092_b0615","doi-asserted-by":"crossref","first-page":"1533","DOI":"10.1007\/s00706-019-02457-9","article-title":"Design, synthesis, antitubercular and antiviral properties of new spirocyclic indole derivatives","volume":"1","author":"Cihan-Ustundag","year":"2019","journal-title":"Monatsh.chem."},{"issue":"95","key":"10.1016\/j.bioorg.2024.108092_b0620","article-title":"Synthesis, molecular docking and biological evaluation of 2-(thiophen-2-yl)-1H-indoles as potent HIV-1 non-nucleoside reverse transcriptase inhibitors","volume":"1","author":"El-Hussieny","year":"2020","journal-title":"Bioorg Chem."},{"issue":"104","key":"10.1016\/j.bioorg.2024.108092_b0625","article-title":"Synthesis, molecular modeling and antiviral activity of novel 5-fluoro-1H-indole-2, 3-dione 3-thiosemicarbazones","volume":"1","author":"Sevin\u00e7li","year":"2020","journal-title":"Bioorg Chem."},{"issue":"46","key":"10.1016\/j.bioorg.2024.108092_b0630","article-title":"Synthesis and biological activity of conformationally restricted indole-based inhibitors of neurotropic alphavirus replication: Generation of a three-dimensional pharmacophore","volume":"15","author":"Barraza","year":"2021","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"10.1016\/j.bioorg.2024.108092_b0635","article-title":"A small molecule compound with an indole moiety inhibits the main protease of SARS-CoV-2 and blocks virus replication","volume":"28;12(1):668","author":"Hattori","year":"2021","journal-title":"Nat. Commun."},{"issue":"124","key":"10.1016\/j.bioorg.2024.108092_b0640","article-title":"TiO2 nanoparticle as catalyst for an efficient green one-pot synthesis of 1H-3-Indolyl Derivatives as significant antiviral activity","volume":"1","author":"Elsayed","year":"2022","journal-title":"Bioorg Chem."},{"key":"10.1016\/j.bioorg.2024.108092_b0645","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejmech.2019.111861","article-title":"Design and synthesis of 2-((1H-indol-3-yl) thio)-N-phenyl-acetamides as novel dual inhibitors of respiratory syncytial virus and influenza virus A","volume":"186","author":"Zhang","year":"2020","journal-title":"Eur. J. Med. Chem."},{"issue":"1","key":"10.1016\/j.bioorg.2024.108092_b0650","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1038\/s41420-022-01280-2","article-title":"Indole-3-carbinol in vitro antiviral activity against SARS-Cov-2 virus and in vivo toxicity","volume":"8","author":"Centofanti","year":"2022","journal-title":"Cell Death Discov."},{"key":"10.1016\/j.bioorg.2024.108092_b0655","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejmech.2021.113767","article-title":"Synthesis, structure-activity relationship and antiviral activity of indole-containing inhibitors of Flavivirus NS2B-NS3 protease","volume":"225","author":"Nie","year":"2021","journal-title":"Eur. J. Med. Chem."},{"issue":"8","key":"10.1016\/j.bioorg.2024.108092_b0660","doi-asserted-by":"crossref","first-page":"1433","DOI":"10.3390\/v13081433","article-title":"3-Indoleacetonitrile is highly effective in treating influenza a virus infection in vitro and in vivo","volume":"13","author":"Zhao","year":"2021","journal-title":"Viruses."},{"issue":"8","key":"10.1016\/j.bioorg.2024.108092_b0665","doi-asserted-by":"crossref","first-page":"1238","DOI":"10.3390\/v16081238","article-title":"Novel Pyrazino [1, 2-a] indole-1, 3 (2 H, 4 H)-dione Derivatives Targeting the Replication of Flaviviridae Viruses: Structural and Mechanistic Insights","volume":"16","author":"Giannakopoulou","year":"2024","journal-title":"Viruses."},{"issue":"10","key":"10.1016\/j.bioorg.2024.108092_b0670","doi-asserted-by":"crossref","first-page":"2000143","DOI":"10.1002\/ardp.202000143","article-title":"Indole\/isatin\u2010containing hybrids as potential antibacterial agents","volume":"353","author":"Song","year":"2020","journal-title":"Archiv Der Pharmazie."},{"issue":"11","key":"10.1016\/j.bioorg.2024.108092_b0675","doi-asserted-by":"crossref","first-page":"1958","DOI":"10.3390\/molecules22111958","article-title":"Synthesis, spectroscopic characterization and antimicrobial potential of certain new isatin-indole molecular hybrids","volume":"22","author":"Al-Wabli","year":"2017","journal-title":"Molecules."},{"issue":"160","key":"10.1016\/j.bioorg.2024.108092_b0680","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/j.ejmech.2018.10.008","article-title":"Novel indole-thiazolidinone conjugates: Design, synthesis and whole-cell phenotypic evaluation as a novel class of antimicrobial agents","volume":"5","author":"Abo-Ashour","year":"2018","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.bioorg.2024.108092_b0685","article-title":"Synthesis and biological evaluation of novel indole-derived thioureas","volume":"7;23(10):2554","author":"Sanna","year":"2018","journal-title":"Molecules."},{"key":"10.1016\/j.bioorg.2024.108092_b0690","doi-asserted-by":"crossref","first-page":"2283","DOI":"10.2147\/IDR.S208757","article-title":"Indole-core-based novel antibacterial agent targeting FtsZ","volume":"24","author":"Yuan","year":"2019","journal-title":"Infect Drug Resist."},{"issue":"99","key":"10.1016\/j.bioorg.2024.108092_b0695","article-title":"Discovery of novel multi-substituted benzo-indole pyrazole schiff base derivatives with antibacterial activity targeting DNA gyrase","volume":"1","author":"Liu","year":"2020","journal-title":"Bioorg Chem."},{"key":"10.1016\/j.bioorg.2024.108092_b0700","first-page":"7157281","article-title":"Indole\u20103\u2010carbaldehyde Semicarbazone Derivatives: Synthesis, Characterization, and Antibacterial Activities","volume":"1","author":"Carrasco","year":"2020","journal-title":"J. Chem."},{"key":"10.1016\/j.bioorg.2024.108092_b0705","doi-asserted-by":"crossref","DOI":"10.1016\/j.molstruc.2020.127982","article-title":"5-Fluoro-1H-indole-2, 3-dione-triazoles-synthesis, biological activity, molecular docking, and DFT study","volume":"1209","author":"Deswal","year":"2020","journal-title":"J.mol.struct."},{"key":"10.1016\/j.bioorg.2024.108092_b0710","first-page":"4358453","article-title":"Synthesis and Evaluation of Antimicrobial Activities of Novel N\u2010Substituted Indole Derivatives","volume":"1","author":"MahamadAlli Shaikh","year":"2020","journal-title":"J. Chem."},{"issue":"224","key":"10.1016\/j.bioorg.2024.108092_b0715","article-title":"Modification of 5-methylphenanthridium from benzothiazoles to indoles as potent FtsZ inhibitors: Broadening the antibacterial spectrum toward vancomycin-resistant enterococci","volume":"15","author":"Zhang","year":"2021","journal-title":"Eur. J. Med. Chem."},{"issue":"12","key":"10.1016\/j.bioorg.2024.108092_b0720","doi-asserted-by":"crossref","first-page":"8644","DOI":"10.1021\/acs.jmedchem.1c00621","article-title":"Design, synthesis, and biological evaluation of novel pyrimido [4, 5-b] indole derivatives against gram-negative multidrug-resistant pathogens","volume":"64","author":"Kong","year":"2021","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.bioorg.2024.108092_b0725","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejmech.2021.113813","article-title":"Synthesis and biological evaluation of indole-based peptidomimetics as antibacterial agents against Gram-positive bacteria","volume":"226","author":"Chen","year":"2021","journal-title":"Eur. J. Med. Chem."},{"issue":"128","key":"10.1016\/j.bioorg.2024.108092_b0730","article-title":"Green synthesis and antibacterial evaluation of spiro fused tryptanthrin-thiopyrano [2, 3-b] indole hybrids targeting drug-resistant S. aureus","volume":"1","author":"Leena","year":"2022","journal-title":"Bioorg Chem."},{"issue":"18","key":"10.1016\/j.bioorg.2024.108092_b0735","doi-asserted-by":"crossref","first-page":"5781","DOI":"10.3390\/molecules27185781","article-title":"Isatin Bis-Indole and Bis-Imidazothiazole hybrids: synthesis and antimicrobial activity","volume":"27","author":"Bonvicini","year":"2022","journal-title":"Molecules."},{"key":"10.1016\/j.bioorg.2024.108092_b0740","doi-asserted-by":"crossref","DOI":"10.3389\/fmolb.2021.775013","article-title":"Synthesis, molecular docking analysis and in vitro biological evaluation of some new heterocyclic scaffolds-based indole moiety as possible antimicrobial agents","volume":"8","author":"Hassan","year":"2022","journal-title":"Front.mol.biosci."},{"issue":"1","key":"10.1016\/j.bioorg.2024.108092_b0745","first-page":"17","article-title":"Synthesis, biological activity of newly designed sulfonamide-based indole derivative as anti-microbial agent","volume":"9","author":"Agrawal","year":"2023","journal-title":"FJPS."},{"issue":"276","key":"10.1016\/j.bioorg.2024.108092_b0750","article-title":"Design and synthesis of unique indole-benzosulfonamide oleanolic acid derivatives as potent antibacterial agents against MRSA","volume":"5","author":"Li","year":"2024","journal-title":"Eur. J. Med. Chem."},{"issue":"147","key":"10.1016\/j.bioorg.2024.108092_b0755","article-title":"Dual site reactivity of indole-3-Schiff bases with S\/Se\/Cl substituted ketenes for stereoselective C-4 substituted indole-\u03b2-lactams, biological evaluations, magic chloro effect and molecular docking studies","volume":"1","author":"Sharma","year":"2024","journal-title":"Bioorg Chem."},{"issue":"1","key":"10.1016\/j.bioorg.2024.108092_b0760","doi-asserted-by":"crossref","first-page":"1489","DOI":"10.1038\/s42003-024-06996-8","article-title":"Synthetic indole derivatives as an antibacterial agent inhibiting respiratory metabolism of multidrug-resistant gram-positive bacteria","volume":"7","author":"Chandal","year":"2024","journal-title":"Commun.biol."},{"issue":"155","key":"10.1016\/j.bioorg.2024.108092_b0765","doi-asserted-by":"crossref","first-page":"764","DOI":"10.1016\/j.ejmech.2018.06.042","article-title":"Synthesis and antiplasmodial activity of glyco-conjugate hybrids of phenylhydrazono-indolinones and glycosylated 1, 2, 3-triazolyl-methyl-indoline-2, 3-diones","volume":"15","author":"Thakur","year":"2018","journal-title":"Eur. J. Med. Chem."},{"issue":"87","key":"10.1016\/j.bioorg.2024.108092_b0770","doi-asserted-by":"crossref","first-page":"594","DOI":"10.1016\/j.bioorg.2019.03.042","article-title":"Design, synthesis and evaluation of 2-(indolylmethylidene)-2, 3-dihydro-1-benzofuran-3-one and 2-(indolyl)-4H-chromen-4-one derivatives as novel monoamine oxidases inhibitors","volume":"1","author":"Takao","year":"2019","journal-title":"Bioorg Chem."},{"issue":"97","key":"10.1016\/j.bioorg.2024.108092_b0775","article-title":"A multicomponent reaction to design antimalarial pyridyl-indole derivatives: Synthesis, biological activities and molecular docking","volume":"1","author":"Elshemy","year":"2020","journal-title":"Bioorg Chem."},{"issue":"65","key":"10.1016\/j.bioorg.2024.108092_b0780","article-title":"Design, synthesis and biological evaluation of novel pyridine derivatives as gut-selective NaPi2b inhibitors","volume":"1","author":"Ushiki","year":"2022","journal-title":"Bioorg. Med. Chem. Lett."},{"issue":"227","key":"10.1016\/j.bioorg.2024.108092_b0785","article-title":"Structural and PK-guided identification of indole-based non-acidic autotaxin (ATX) inhibitors exhibiting high in vivo anti-fibrosis efficacy in rodent model","volume":"5","author":"Lei","year":"2022","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.bioorg.2024.108092_b0790","doi-asserted-by":"crossref","DOI":"10.1016\/j.bmcl.2022.128826","article-title":"Discovery of novel indole and indoline derivatives against Candida albicans as potent antifungal agents","volume":"71","author":"Ma","year":"2022","journal-title":"Bioorg Med Chem Lett."},{"issue":"257","key":"10.1016\/j.bioorg.2024.108092_b0795","article-title":"Identification of 5-[5-cyano-1-(pyridin-2-ylmethyl)-1H-indole-3-carboxamido] thiazole-4-carboxylic acid as a promising dual inhibitor of urate transporter 1 and xanthine oxidase","volume":"5","author":"Lin","year":"2023","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.bioorg.2024.108092_b0800","doi-asserted-by":"crossref","DOI":"10.1016\/j.bmcl.2023.129349","article-title":"Design, synthesis and biological evaluation of novel indole-3-carboxylic acid derivatives with antihypertensive activity","volume":"90","author":"Danilenko","year":"2023","journal-title":"Bioorg Med Chem Lett."},{"issue":"146","key":"10.1016\/j.bioorg.2024.108092_b0805","article-title":"Synthesis, structure\u2013activity relationship and biological evaluation of indole derivatives as anti-Candida albicans agents","volume":"1","author":"Wu","year":"2024","journal-title":"Bioorg Chem."},{"key":"10.1016\/j.bioorg.2024.108092_bib806","first-page":"100151","article-title":"Design, synthesis of new 2, 4-thiazolidinediones: In-silico, in-vivo anti-diabetic and anti-inflammatory evaluation","volume":"11","author":"Gharge","year":"2024","journal-title":"EJMCR"},{"key":"10.1016\/j.bioorg.2024.108092_bib807","doi-asserted-by":"crossref","first-page":"3162","DOI":"10.1039\/D4MD00344F","article-title":"Quinoline-based Schiff bases as possible antidiabetic agents: ligand-based pharmacophore modeling, 3D QSAR, docking, and molecular dynamics simulations study","volume":"15","author":"Ranade","year":"2024","journal-title":"RSC Med. Chem."}],"container-title":["Bioorganic Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0045206824009970?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0045206824009970?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,1,9]],"date-time":"2025-01-09T21:05:09Z","timestamp":1736456709000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0045206824009970"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,1]]},"references-count":163,"alternative-id":["S0045206824009970"],"URL":"https:\/\/doi.org\/10.1016\/j.bioorg.2024.108092","relation":{},"ISSN":["0045-2068"],"issn-type":[{"value":"0045-2068","type":"print"}],"subject":[],"published":{"date-parts":[[2025,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Indoles as promising Therapeutics: A review of recent drug discovery efforts","name":"articletitle","label":"Article Title"},{"value":"Bioorganic Chemistry","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bioorg.2024.108092","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"108092"}}