{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T01:44:02Z","timestamp":1789436642888,"version":"build-2803163510"},"reference-count":84,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100004748","name":"Mashhad University of Medical Sciences","doi-asserted-by":"publisher","award":["980933"],"award-info":[{"award-number":["980933"]}],"id":[{"id":"10.13039\/501100004748","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Bioorganic Chemistry"],"published-print":{"date-parts":[[2025,1]]},"DOI":"10.1016\/j.bioorg.2024.108098","type":"journal-article","created":{"date-parts":[[2024,12,25]],"date-time":"2024-12-25T01:13:48Z","timestamp":1735089228000},"page":"108098","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":7,"special_numbering":"C","title":["Design, synthesis, biological evaluation and multi spectroscopic studies of novel 2-styrylquinoline-carboxamide derivatives as potential DNA intercalating anticancer agents"],"prefix":"10.1016","volume":"154","author":[{"given":"Negar","family":"Omidkhah","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amirhosein","family":"Gheisari","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sara Rahimzadeh","family":"Oskuei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jamshidkhan","family":"Chamani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Farzin","family":"Hadizadeh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amirhosein","family":"Atarodi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Razieh","family":"Ghodsi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"1","key":"10.1016\/j.bioorg.2024.108098_b0005","doi-asserted-by":"crossref","first-page":"17","DOI":"10.3322\/caac.21763","article-title":"Cancer statistics, 2023","volume":"73","author":"Siegel","year":"2023","journal-title":"CA Cancer J. Clin."},{"issue":"8","key":"10.1016\/j.bioorg.2024.108098_b0010","doi-asserted-by":"crossref","first-page":"1893","DOI":"10.1158\/1055-9965.EPI-10-0437","article-title":"Global patterns of cancer incidence and mortality rates and trends","volume":"19","author":"Jemal","year":"2010","journal-title":"Cancer Epidemiol. Biomark. Prev."},{"key":"10.1016\/j.bioorg.2024.108098_b0015","doi-asserted-by":"crossref","DOI":"10.1016\/j.molstruc.2023.136720","article-title":"A review of recent advances in quinoline\/isoquinoline based hybrids as microtubule targeted cancer therapeutics: Synthesis, binding mode, QSAR and docking studies","volume":"1295","author":"Nasehi","year":"2024","journal-title":"J. Mol. Struct."},{"key":"10.1016\/j.bioorg.2024.108098_b0020","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1016\/j.ejmech.2018.12.060","article-title":"Design, synthesis and biological evaluation of novel benzo-and tetrahydrobenzo-[h] quinoline derivatives as potential DNA-intercalating antitumor agents","volume":"164","author":"Jafari","year":"2019","journal-title":"Eur. J. Med. Chem."},{"issue":"4","key":"10.1016\/j.bioorg.2024.108098_b0025","doi-asserted-by":"crossref","first-page":"957","DOI":"10.1111\/cbdd.13154","article-title":"Design, synthesis, and cytotoxic evaluation of novel furo [2, 3\u2010b] quinoline derivatives","volume":"91","author":"Wang","year":"2018","journal-title":"Chem. Biol. Drug Des."},{"key":"10.1016\/j.bioorg.2024.108098_b0030","article-title":"Cancer chemotherapy and beyond: Current status, drug candidates, associated risks and progress in targeted therapeutics","author":"Anand","year":"2022","journal-title":"Genes & Diseases"},{"key":"10.1016\/j.bioorg.2024.108098_b0035","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s12943-018-0804-2","article-title":"Kinase-targeted cancer therapies: progress, challenges and future directions","volume":"17","author":"Bhullar","year":"2018","journal-title":"Mol. Cancer"},{"key":"10.1016\/j.bioorg.2024.108098_b0040","doi-asserted-by":"crossref","DOI":"10.1038\/s41388-024-02976-8","article-title":"SIRT7: a novel molecular target for personalized cancer treatment?","author":"Ianni","year":"2024","journal-title":"Oncogene"},{"issue":"2","key":"10.1016\/j.bioorg.2024.108098_b0045","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1042\/BCJ20160583","article-title":"Topoisomerases as anticancer targets","volume":"475","author":"Delgado","year":"2018","journal-title":"Biochem. J"},{"key":"10.1016\/j.bioorg.2024.108098_b0050","doi-asserted-by":"crossref","DOI":"10.1016\/j.jpba.2022.115036","article-title":"Electrochemistry of chemotherapeutic alkylating agents and their interaction with DNA","volume":"222","author":"Chiorcea-Paquim","year":"2023","journal-title":"J. Pharm. Biomed. Anal."},{"issue":"6","key":"10.1016\/j.bioorg.2024.108098_b0055","doi-asserted-by":"crossref","first-page":"5602","DOI":"10.3390\/ijms24065602","article-title":"Phototoxic Potential of Different DNA Intercalators for Skin Cancer Therapy: In Vitro Screening","volume":"24","author":"Pivetta","year":"2023","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.bioorg.2024.108098_b0060","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/j.ejmech.2013.11.029","article-title":"Recent advances in small organic molecules as DNA intercalating agents: Synthesis, activity, and modeling","volume":"74","author":"Rescifina","year":"2014","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.bioorg.2024.108098_b0065","doi-asserted-by":"crossref","unstructured":"M.D. Tomczyk, K.Z. Walczak, l, 8-Naphthalimide based DNA intercalators and anticancer agents. A systematic review from 2007 to 2017, European journal of medicinal chemistry 159 (2018) 393-422.","DOI":"10.1016\/j.ejmech.2018.09.055"},{"issue":"6","key":"10.1016\/j.bioorg.2024.108098_b0070","doi-asserted-by":"crossref","first-page":"627","DOI":"10.2174\/138955707780859413","article-title":"DNA intercalators in cancer therapy: organic and inorganic drugs and their spectroscopic tools of analysis","volume":"7","author":"Wheate","year":"2007","journal-title":"Mini Rev Med Chem"},{"issue":"3","key":"10.1016\/j.bioorg.2024.108098_b0075","first-page":"811","article-title":"DNA intercalators and using them as anticancer drugs","volume":"2","author":"Goftar","year":"2014","journal-title":"Int. J. Adv. Biol. Biomed. Res"},{"key":"10.1016\/j.bioorg.2024.108098_b0080","doi-asserted-by":"crossref","DOI":"10.1016\/j.lfs.2021.119527","article-title":"A comprehensive review on time-tested anticancer drug doxorubicin","volume":"278","author":"Sritharan","year":"2021","journal-title":"Life Sci."},{"key":"10.1016\/j.bioorg.2024.108098_b0085","doi-asserted-by":"crossref","unstructured":"K.-W. Kim, J.K. Roh, H.-J. Wee, C. Kim, K.-W. Kim, J.K. Roh, H.-J. Wee, C. Kim, Natural product anticancer drugs, Cancer drug discovery: Science and history (2016) 113-134.","DOI":"10.1007\/978-94-024-0844-7_6"},{"issue":"15","key":"10.1016\/j.bioorg.2024.108098_b0090","doi-asserted-by":"crossref","first-page":"1498","DOI":"10.1200\/JCO.2017.76.4126","article-title":"Phase III intergroup trial of adjuvant androgen deprivation with or without mitoxantrone plus prednisone in patients with high-risk prostate cancer after radical prostatectomy: SWOG S9921","volume":"36","author":"Hussain","year":"2018","journal-title":"J. Clin. Oncol."},{"issue":"12","key":"10.1016\/j.bioorg.2024.108098_b0095","doi-asserted-by":"crossref","first-page":"879","DOI":"10.1038\/ja.2016.45","article-title":"Preclinical development of Ramizol, an antibiotic belonging to a new class, for the treatment of Clostridium difficile colitis","volume":"69","author":"Rao","year":"2016","journal-title":"J. Antibiot."},{"key":"10.1016\/j.bioorg.2024.108098_b0100","series-title":"Medicinal chemistry of anticancer drugs","author":"Avenda\u00f1o","year":"2015"},{"issue":"2","key":"10.1016\/j.bioorg.2024.108098_b0105","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1093\/nar\/23.2.223","article-title":"Base sequence determinants of amonafide stimulation of topoisomerase II DNA clevage","volume":"23","author":"De Isabella","year":"1995","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.bioorg.2024.108098_b0110","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1016\/j.ejmech.2019.05.088","article-title":"Design, synthesis and biological evaluation of new quinoline derivatives as potential antitumor agents","volume":"178","author":"Su","year":"2019","journal-title":"Eur. J. Med. Chem."},{"issue":"3","key":"10.1016\/j.bioorg.2024.108098_b0115","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1515\/acph-2015-0030","article-title":"Anti-breast cancer activity of some novel quinoline derivatives","volume":"65","author":"Ghorab","year":"2015","journal-title":"Acta Pharm."},{"key":"10.1016\/j.bioorg.2024.108098_b0120","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s12885-015-1970-x","article-title":"BPIQ, a novel synthetic quinoline derivative, inhibits growth and induces mitochondrial apoptosis of lung cancer cells in vitro and in zebrafish xenograft model","volume":"15","author":"Chiu","year":"2015","journal-title":"BMC Cancer"},{"key":"10.1016\/j.bioorg.2024.108098_b0125","doi-asserted-by":"crossref","first-page":"871","DOI":"10.1016\/j.ejmech.2014.07.044","article-title":"A review on anticancer potential of bioactive heterocycle quinoline","volume":"97","author":"Afzal","year":"2015","journal-title":"Eur. J. Med. Chem."},{"issue":"11","key":"10.1016\/j.bioorg.2024.108098_b0130","doi-asserted-by":"crossref","DOI":"10.1016\/j.arabjc.2022.104168","article-title":"Review on recent development of quinoline for anticancer activities","volume":"15","author":"Ilakiyalakshmi","year":"2022","journal-title":"Arab. J. Chem."},{"issue":"4","key":"10.1016\/j.bioorg.2024.108098_b0135","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0010186","article-title":"Voreloxin is an anticancer quinolone derivative that intercalates DNA and poisons topoisomerase II","volume":"5","author":"Hawtin","year":"2010","journal-title":"PLoS One"},{"issue":"18","key":"10.1016\/j.bioorg.2024.108098_b0140","doi-asserted-by":"crossref","first-page":"1655","DOI":"10.2174\/0929867023369277","article-title":"Acridine derivatives as chemotherapeutic agents","volume":"9","author":"Denny","year":"2002","journal-title":"Curr. Med. Chem."},{"issue":"9","key":"10.1016\/j.bioorg.2024.108098_b0145","doi-asserted-by":"crossref","first-page":"2741","DOI":"10.1002\/slct.201803785","article-title":"Design, synthesis, DNA binding, cytotoxicity, and molecular docking studies of amonafide\u2010linked \u03b2\u2010lactam","volume":"4","author":"Rad","year":"2019","journal-title":"ChemistrySelect"},{"issue":"18","key":"10.1016\/j.bioorg.2024.108098_b0150","doi-asserted-by":"crossref","first-page":"8440","DOI":"10.1016\/j.bmc.2008.08.027","article-title":"Design, synthesis, and biological evaluation of new mitonafide derivatives as potential antitumor drugs","volume":"16","author":"Antonini","year":"2008","journal-title":"Bioorg. Med. Chem."},{"issue":"8","key":"10.1016\/j.bioorg.2024.108098_b0155","doi-asserted-by":"crossref","first-page":"4348","DOI":"10.1016\/j.arabjc.2016.06.014","article-title":"Design, synthesis and biological evaluation of tetracyclic azafluorenone derivatives with topoisomerase I inhibitory properties as potential anticancer agents","volume":"12","author":"Chen","year":"2019","journal-title":"Arab. J. Chem."},{"issue":"1","key":"10.1016\/j.bioorg.2024.108098_b0160","doi-asserted-by":"crossref","first-page":"1051","DOI":"10.3762\/bjoc.14.93","article-title":"An overview of recent advances in duplex DNA recognition by small molecules","volume":"14","author":"Bhaduri","year":"2018","journal-title":"Beilstein J. Org. Chem."},{"key":"10.1016\/j.bioorg.2024.108098_b0165","doi-asserted-by":"crossref","DOI":"10.1155\/2016\/3128951","article-title":"Role of natural stilbenes in the prevention of cancer","volume":"2016","author":"Sirerol","year":"2016","journal-title":"Oxid. Med. Cell. Longev."},{"key":"10.1016\/j.bioorg.2024.108098_b0170","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1016\/j.phrs.2017.08.002","article-title":"Anti-inflammatory activity of natural stilbenoids: A review","volume":"124","author":"Dvorakova","year":"2017","journal-title":"Pharmacol. Res."},{"issue":"3","key":"10.1016\/j.bioorg.2024.108098_b0175","doi-asserted-by":"crossref","first-page":"506","DOI":"10.1007\/s00044-023-03018-w","article-title":"Synthesis, cytotoxicity, Pan-HDAC inhibitory activity and docking study of new N-(2-aminophenyl)-2-methylquinoline-4-carboxamide and (E)-N-(2-aminophenyl)-2-styrylquinoline-4-carboxamide derivatives as anticancer agents","volume":"32","author":"Omidkhah","year":"2023","journal-title":"Med. Chem. Res."},{"issue":"9","key":"10.1016\/j.bioorg.2024.108098_b0180","doi-asserted-by":"crossref","first-page":"4062","DOI":"10.1021\/acs.jmedchem.7b00376","article-title":"Neuroprotective and antineuroinflammatory effects of hydroxyl-functionalized stilbenes and 2-arylbenzo [b] furans","volume":"60","author":"Chen","year":"2017","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.bioorg.2024.108098_b0185","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/j.taap.2019.01.025","article-title":"Antibacterial activity of resveratrol structural analogues: A mechanistic evaluation of the structure-activity relationship","volume":"367","author":"Singh","year":"2019","journal-title":"Toxicol. Appl. Pharmacol."},{"issue":"3","key":"10.1016\/j.bioorg.2024.108098_b0190","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1002\/ddr.21525","article-title":"Stilbene derivatives as new perspective in antifungal medicinal chemistry","volume":"80","author":"De Filippis","year":"2019","journal-title":"Drug Dev. Res."},{"issue":"28","key":"10.1016\/j.bioorg.2024.108098_b0195","doi-asserted-by":"crossref","first-page":"6224","DOI":"10.1002\/chem.201905753","article-title":"Stiff\u2010stilbene ligands target G\u2010quadruplex DNA and exhibit selective anticancer and antiparasitic activity, Chemistry\u2013A","volume":"26","author":"O'Hagan","year":"2020","journal-title":"European Journal"},{"issue":"13","key":"10.1016\/j.bioorg.2024.108098_b0200","doi-asserted-by":"crossref","first-page":"3976","DOI":"10.1021\/acs.jafc.0c00515","article-title":"Isorhapontigenin improves diabetes in mice via regulating the activity and stability of PPAR\u03b3 in adipocytes","volume":"68","author":"Chu","year":"2020","journal-title":"J. Agric. Food Chem."},{"key":"10.1016\/j.bioorg.2024.108098_b0205","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1007\/s40495-018-0134-5","article-title":"Stilbenes: chemistry and molecular mechanisms of anti-obesity","volume":"4","author":"Chou","year":"2018","journal-title":"Current Pharmacology Reports"},{"issue":"9","key":"10.1016\/j.bioorg.2024.108098_b0210","first-page":"3225","article-title":"Stilbene-based natural compounds as promising drug candidates against COVID-19","volume":"39","author":"Wahedi","year":"2021","journal-title":"J. Biomol. Struct. Dyn."},{"issue":"9","key":"10.1016\/j.bioorg.2024.108098_b0215","doi-asserted-by":"crossref","first-page":"1084","DOI":"10.1016\/j.ejmech.2006.03.024","article-title":"Synthesis of stilbene derivatives with inhibition of SARS coronavirus replication","volume":"41","author":"Li","year":"2006","journal-title":"Eur. J. Med. Chem."},{"issue":"10","key":"10.1016\/j.bioorg.2024.108098_b0220","doi-asserted-by":"crossref","first-page":"1664","DOI":"10.1002\/ijc.33919","article-title":"Comparison of adverse drug reactions between tamoxifen and toremifene in breast cancer patients with different CYP2D6 genotypes: A propensity\u2010score matched cohort study","volume":"150","author":"Zhou","year":"2022","journal-title":"Int. J. Cancer"},{"issue":"6","key":"10.1016\/j.bioorg.2024.108098_b0225","doi-asserted-by":"crossref","first-page":"798","DOI":"10.1007\/s11094-022-02713-z","article-title":"Synthesis and In-Vitro Evaluation of Raloxifene\u2013Oxalyl Chloride Conjugate Targeting Breast Cancer","volume":"56","author":"Bhatia","year":"2022","journal-title":"Pharm. Chem. J."},{"key":"10.1016\/j.bioorg.2024.108098_b0230","doi-asserted-by":"crossref","DOI":"10.2174\/1566524023666230525104730","article-title":"Hypothesizing the Green Synthesis of Tamoxifen Loaded Magnetic Nanoparticles for the Treatment of Breast Cancer","author":"Tyagi","year":"2024","journal-title":"Curr. Mol. Med."},{"issue":"8","key":"10.1016\/j.bioorg.2024.108098_b0235","doi-asserted-by":"crossref","first-page":"1111","DOI":"10.3390\/biom10081111","article-title":"More than resveratrol: New insights into stilbene-based compounds","volume":"10","author":"Pecyna","year":"2020","journal-title":"Biomolecules"},{"issue":"5","key":"10.1016\/j.bioorg.2024.108098_b0240","doi-asserted-by":"crossref","first-page":"5870","DOI":"10.3390\/molecules17055870","article-title":"Design, synthesis and antiproliferative activity of novel 2-substituted-4-amino-6-halogenquinolines","volume":"17","author":"Jiang","year":"2012","journal-title":"Molecules"},{"key":"10.1016\/j.bioorg.2024.108098_b0245","doi-asserted-by":"crossref","DOI":"10.1016\/j.bioorg.2020.103711","article-title":"Design, synthesis and biological evaluation of novel 5, 6, 7-trimethoxy-N-aryl-2-styrylquinolin-4-amines as potential anticancer agents and tubulin polymerization inhibitors","volume":"98","author":"Mirzaei","year":"2020","journal-title":"Bioorg. Chem."},{"key":"10.1016\/j.bioorg.2024.108098_b0250","doi-asserted-by":"crossref","DOI":"10.1016\/j.molstruc.2022.133599","article-title":"Synthesis, structure activity relationship and biological evaluation of a novel series of quinoline\u2013based benzamide derivatives as anticancer agents and histone deacetylase (HDAC) inhibitors","volume":"1267","author":"Omidkhah","year":"2022","journal-title":"J. Mol. Struct."},{"issue":"29","key":"10.1016\/j.bioorg.2024.108098_b0255","doi-asserted-by":"crossref","DOI":"10.1002\/slct.202201239","article-title":"Synthesis, cytotoxicity, Pan\u2010hdac inhibitory activity and docking study of N\u2010(2\u2010Aminophenyl)\u20102\u2010arylquinoline\u20104\u2010and N\u2010(2\u2010Aminophenyl)\u20102\u2010arylbenzo [h] quinoline\u20104\u2010carboxamides","volume":"7","author":"Omidkhah","year":"2022","journal-title":"ChemistrySelect"},{"key":"10.1016\/j.bioorg.2024.108098_b0260","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1515\/9783110573138-004","article-title":"4 Resonance light scattering spectroscopy","author":"Ling","year":"2018","journal-title":"Elastic Light Scattering Spectrometry"},{"key":"10.1016\/j.bioorg.2024.108098_b0265","doi-asserted-by":"crossref","DOI":"10.1016\/j.saa.2023.122398","article-title":"Optimization of aflatoxin B1 removal efficiency of DNA by resonance light scattering spectroscopy","volume":"292","author":"Li","year":"2023","journal-title":"Spectrochim. Acta A Mol. Biomol. Spectrosc."},{"key":"10.1016\/j.bioorg.2024.108098_b0270","doi-asserted-by":"crossref","unstructured":"J.R. Lakowicz, Principles of fluorescence spectroscopy, Kluwer Academic\/Plenum1999.","DOI":"10.1007\/978-1-4757-3061-6"},{"issue":"1","key":"10.1016\/j.bioorg.2024.108098_b0275","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1021\/jf048693g","article-title":"Interaction of flavonoids with bovine serum albumin: a fluorescence quenching study","volume":"53","author":"Papadopoulou","year":"2005","journal-title":"J. Agric. Food Chem."},{"key":"10.1016\/j.bioorg.2024.108098_b0280","doi-asserted-by":"crossref","first-page":"300","DOI":"10.1016\/j.ijbiomac.2018.02.098","article-title":"In vitro DNA binding studies of therapeutic and prophylactic drug citral","volume":"113","author":"Alam","year":"2018","journal-title":"Int. J. Biol. Macromol."},{"issue":"24","key":"10.1016\/j.bioorg.2024.108098_b0285","doi-asserted-by":"crossref","first-page":"6569","DOI":"10.1111\/febs.12558","article-title":"Naproxen intercalates with DNA and causes photocleavage through ROS generation","volume":"280","author":"Husain","year":"2013","journal-title":"FEBS J."},{"issue":"4","key":"10.1016\/j.bioorg.2024.108098_b0290","doi-asserted-by":"crossref","first-page":"991","DOI":"10.1021\/jf405085g","article-title":"Binding characteristics of sodium saccharin with calf thymus DNA in vitro","volume":"62","author":"Zhang","year":"2014","journal-title":"J. Agric. Food Chem."},{"key":"10.1016\/j.bioorg.2024.108098_b0295","doi-asserted-by":"crossref","DOI":"10.1016\/j.molstruc.2024.140334","article-title":"Synthesis, cytotoxicity, docking, MD simulation, drug-likeness, ADMET prediction and multi spectroscopic studies of some novel quinoline-4-carboxamide derivatives as DNA intercalating and anticancer agents","volume":"1322","author":"Omidkhah","year":"2025","journal-title":"J. Mol. Struct."},{"issue":"8","key":"10.1016\/j.bioorg.2024.108098_b0300","doi-asserted-by":"crossref","first-page":"1351","DOI":"10.1016\/j.biochi.2011.06.007","article-title":"A stabilizing and denaturing dual-effect for natural polyamines interacting with G-quadruplexes depending on concentration","volume":"93","author":"Sun","year":"2011","journal-title":"Biochimie"},{"key":"10.1016\/j.bioorg.2024.108098_b0305","doi-asserted-by":"crossref","DOI":"10.1016\/j.saa.2021.119952","article-title":"Exploring the binding mechanism of \u03b2-resorcylic acid with calf thymus DNA: Insights from multi-spectroscopic, thermodynamic and bioinformatics approaches","volume":"260","author":"Hussain","year":"2021","journal-title":"Spectrochim. Acta A Mol. Biomol. Spectrosc."},{"issue":"6","key":"10.1016\/j.bioorg.2024.108098_b0310","doi-asserted-by":"crossref","first-page":"29","DOI":"10.2174\/0115701638279362240223070810","article-title":"In silico Evaluation of NO-Sartans against SARS-CoV-2","volume":"21","author":"Omidkhah","year":"2024","journal-title":"Curr. Drug Discov. Technol."},{"issue":"8","key":"10.1016\/j.bioorg.2024.108098_b0315","doi-asserted-by":"crossref","first-page":"1947","DOI":"10.1016\/j.bios.2010.01.011","article-title":"Screening DNA-targeted anticancer drug in vitro based on the drug-conjugated DNA by resonance light scattering technique","volume":"25","author":"Chen","year":"2010","journal-title":"Biosens. Bioelectron."},{"issue":"5226","key":"10.1016\/j.bioorg.2024.108098_b0320","doi-asserted-by":"crossref","first-page":"935","DOI":"10.1126\/science.7638615","article-title":"Resonance light scattering: a new technique for studying chromophore aggregation","volume":"269","author":"Pasternack","year":"1995","journal-title":"Science"},{"key":"10.1016\/j.bioorg.2024.108098_b0325","doi-asserted-by":"crossref","first-page":"384","DOI":"10.1016\/j.saa.2017.11.042","article-title":"Spectroscopic profiling and computational study of the binding of tschimgine: A natural monoterpene derivative, with calf thymus DNA","volume":"192","author":"Khajeh","year":"2018","journal-title":"Spectrochim. Acta A Mol. Biomol. Spectrosc."},{"key":"10.1016\/j.bioorg.2024.108098_b0330","doi-asserted-by":"crossref","DOI":"10.1016\/j.saa.2020.118936","article-title":"Biophysical and theoretical studies of the interaction between a bioactive compound 3, 5-dimethoxy-4-hydroxycinnamic acid with calf thymus DNA","volume":"245","author":"Mondal","year":"2021","journal-title":"Spectrochim. Acta A Mol. Biomol. Spectrosc."},{"issue":"2","key":"10.1016\/j.bioorg.2024.108098_b0335","doi-asserted-by":"crossref","first-page":"799","DOI":"10.1016\/j.snb.2007.09.082","article-title":"Study on the interaction mechanism between DNA and the main active components in Scutellaria baicalensis Georgi","volume":"129","author":"Sun","year":"2008","journal-title":"Sens. Actuators B"},{"key":"10.1016\/j.bioorg.2024.108098_b0340","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1016\/j.molliq.2018.02.090","article-title":"Antiproliferative activities of procainamide and its binding with calf thymus DNA through multi-spectroscopic and computational approaches","volume":"258","author":"Ali","year":"2018","journal-title":"J. Mol. Liq."},{"key":"10.1016\/j.bioorg.2024.108098_b0345","article-title":"Groove binding between ferulic acid and calf thymus DNA: spectroscopic methodology combined with chemometrics and molecular docking studies","author":"Zhang","year":"2019","journal-title":"J. Biomol. Struct. Dyn."},{"issue":"16","key":"10.1016\/j.bioorg.2024.108098_b0350","doi-asserted-by":"crossref","first-page":"8944","DOI":"10.1021\/jf2019006","article-title":"Molecular spectroscopic studies of farrerol interaction with calf thymus DNA","volume":"59","author":"Zhang","year":"2011","journal-title":"J. Agric. Food Chem."},{"key":"10.1016\/j.bioorg.2024.108098_b0355","doi-asserted-by":"crossref","first-page":"623","DOI":"10.1134\/S0026893308040195","article-title":"Radius of gyration as an indicator of protein structure compactness","volume":"42","author":"Lobanov","year":"2008","journal-title":"Mol. Biol."},{"issue":"1","key":"10.1016\/j.bioorg.2024.108098_b0360","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1016\/j.drudis.2019.10.014","article-title":"A drug-likeness toolbox facilitates ADMET study in drug discovery","volume":"25","author":"Jia","year":"2020","journal-title":"Drug Discov. Today"},{"key":"10.1016\/j.bioorg.2024.108098_b0365","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1016\/j.addr.2015.01.009","article-title":"The application of in silico drug-likeness predictions in pharmaceutical research","volume":"86","author":"Tian","year":"2015","journal-title":"Adv. Drug Deliv. Rev."},{"issue":"23","key":"10.1016\/j.bioorg.2024.108098_b0370","doi-asserted-by":"crossref","first-page":"5262","DOI":"10.1093\/bioinformatics\/btac676","article-title":"Prediction of drug-likeness using graph convolutional attention network","volume":"38","author":"Sun","year":"2022","journal-title":"Bioinformatics"},{"key":"10.1016\/j.bioorg.2024.108098_b0375","doi-asserted-by":"crossref","unstructured":"F. Ndombera, G. Maiyoh, V. Tuei, Pharmacokinetic, physicochemical and medicinal properties of n-glycoside anti-cancer agent more potent than 2-deoxy-d-glucose in lung cancer cells, J. Pharm. Pharmacol. 7(4) (2019)165-176.","DOI":"10.17265\/2328-2150\/2019.04.003"},{"issue":"12","key":"10.1016\/j.bioorg.2024.108098_b0380","doi-asserted-by":"crossref","first-page":"2615","DOI":"10.1021\/jm020017n","article-title":"Molecular properties that influence the oral bioavailability of drug candidates","volume":"45","author":"Veber","year":"2002","journal-title":"J. Med. Chem."},{"issue":"5","key":"10.1016\/j.bioorg.2024.108098_b0385","doi-asserted-by":"crossref","first-page":"2248","DOI":"10.1021\/acs.jcim.0c01227","article-title":"Toward an understanding of pan-assay interference compounds and promiscuity: a structural perspective on binding modes","volume":"61","author":"Bolz","year":"2021","journal-title":"J. Chem. Inf. Model."},{"issue":"25","key":"10.1016\/j.bioorg.2024.108098_b0390","doi-asserted-by":"crossref","first-page":"6470","DOI":"10.1021\/bi00076a022","article-title":"The nitrogen of the acetamido group of colchicine modulates P-glycoprotein-mediated multidrug resistance","volume":"32","author":"Tang-Wai","year":"1993","journal-title":"Biochemistry"},{"key":"10.1016\/j.bioorg.2024.108098_b0395","first-page":"151","article-title":"How does P-glycoprotein recognize its substrates?, Seminars in cancer biology","author":"Ueda","year":"1997","journal-title":"Elsevier"},{"key":"10.1016\/j.bioorg.2024.108098_b0400","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1016\/j.microc.2019.01.030","article-title":"The impact of lipophilicity on environmental processes, drug delivery and bioavailability of food components","volume":"146","author":"Chmiel","year":"2019","journal-title":"Microchem. J."},{"issue":"10","key":"10.1016\/j.bioorg.2024.108098_b0405","doi-asserted-by":"crossref","first-page":"863","DOI":"10.1517\/17460441.2012.714363","article-title":"The influence of lipophilicity in drug discovery and design","volume":"7","author":"Arnott","year":"2012","journal-title":"Expert Opin. Drug Discov."},{"issue":"15","key":"10.1016\/j.bioorg.2024.108098_b0410","doi-asserted-by":"crossref","first-page":"2922","DOI":"10.1021\/jm0000822","article-title":"ElogPoct: a tool for lipophilicity determination in drug discovery","volume":"43","author":"Lombardo","year":"2000","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.bioorg.2024.108098_b0415","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1016\/j.jpba.2017.01.042","article-title":"Evaluation of in silico pharmacokinetic properties and in vitro cytotoxic activity of selected newly synthesized N-succinimide derivatives","volume":"137","author":"Milosevic","year":"2017","journal-title":"J. Pharm. Biomed. Anal."},{"issue":"15","key":"10.1016\/j.bioorg.2024.108098_b0420","doi-asserted-by":"crossref","first-page":"5691","DOI":"10.1021\/acs.jmedchem.5b00201","article-title":"Volume of distribution in drug design: miniperspective","volume":"58","author":"Smith","year":"2015","journal-title":"J. Med. Chem."}],"container-title":["Bioorganic Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0045206824010034?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0045206824010034?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,2,23]],"date-time":"2025-02-23T18:33:09Z","timestamp":1740335589000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0045206824010034"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,1]]},"references-count":84,"alternative-id":["S0045206824010034"],"URL":"https:\/\/doi.org\/10.1016\/j.bioorg.2024.108098","relation":{},"ISSN":["0045-2068"],"issn-type":[{"value":"0045-2068","type":"print"}],"subject":[],"published":{"date-parts":[[2025,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Design, synthesis, biological evaluation and multi spectroscopic studies of novel 2-styrylquinoline-carboxamide derivatives as potential DNA intercalating anticancer agents","name":"articletitle","label":"Article Title"},{"value":"Bioorganic Chemistry","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bioorg.2024.108098","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"108098"}}