{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T16:46:54Z","timestamp":1786985214032,"version":"build-2736575974"},"reference-count":31,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81991525"],"award-info":[{"award-number":["81991525"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["DY135-B-05"],"award-info":[{"award-number":["DY135-B-05"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["2022Z144"],"award-info":[{"award-number":["2022Z144"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["2021Z046"],"award-info":[{"award-number":["2021Z046"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Bioorganic Chemistry"],"published-print":{"date-parts":[[2025,1]]},"DOI":"10.1016\/j.bioorg.2024.108099","type":"journal-article","created":{"date-parts":[[2024,12,24]],"date-time":"2024-12-24T19:33:12Z","timestamp":1735068792000},"page":"108099","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":5,"special_numbering":"C","title":["Targeted isolation of diketopiperazines from a deep-sea derived fungus with anti-neuroinflammatory effects"],"prefix":"10.1016","volume":"154","author":[{"given":"Jingshuai","family":"Wu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying","family":"Kang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qinyu","family":"Meng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongli","family":"Jia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dong","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jian","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aili","family":"Fan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenhan","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bioorg.2024.108099_b0005","doi-asserted-by":"crossref","first-page":"6659","DOI":"10.1021\/acs.jafc.6b01772","article-title":"Structural diversity and biological activities of indole diketopiperazine alkaloids from fungi","volume":"64","author":"Ma","year":"2016","journal-title":"J. Agri. Food Chem."},{"key":"10.1016\/j.bioorg.2024.108099_b0010","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1007\/s42995-019-00023-0","article-title":"Chemical diversity and biological function of indolediketopiperazines from marine-derived fungi","volume":"2","author":"Cao","year":"2020","journal-title":"Mar. Life Sci. Technol."},{"key":"10.1016\/j.bioorg.2024.108099_b0015","doi-asserted-by":"crossref","first-page":"644","DOI":"10.1039\/c2969000644b","article-title":"The brevianamides: a new class of fungal alkaloid","volume":"12","author":"Birch","year":"1969","journal-title":"J. Chem. Soc. d: Chem. Commun."},{"key":"10.1016\/j.bioorg.2024.108099_b0020","doi-asserted-by":"crossref","first-page":"123","DOI":"10.2174\/0929867324666170724103410","article-title":"Fumitremorginsand relatives-from tremorgenic compounds to valuable anti-cancer drugs","volume":"25","author":"Abraham","year":"2018","journal-title":"Curr. Med. Chem."},{"key":"10.1016\/j.bioorg.2024.108099_b0025","doi-asserted-by":"crossref","first-page":"3331","DOI":"10.1016\/S0040-4039(01)97170-9","article-title":"Austamide, a new toxic metabolite from Aspergillus ustus","volume":"12","author":"Steyn","year":"1971","journal-title":"Tetrahedron Lett."},{"key":"10.1016\/j.bioorg.2024.108099_b0030","doi-asserted-by":"crossref","first-page":"2254","DOI":"10.1002\/anie.200604381","article-title":"Notoamides A-D: prenylated indole alkaloids isolated from a marine-derived fungus","volume":"46","author":"Kato","year":"2007","journal-title":"Aspergillus Sp. Angew. Chem. Inter. Ed."},{"key":"10.1016\/j.bioorg.2024.108099_b0035","doi-asserted-by":"crossref","first-page":"e54","DOI":"10.3390\/md21010054","article-title":"New marine fungal deoxy-14,15-dehydroisoaustamide resensitizes prostate cancer cells to enzalutamide","volume":"21","author":"Dyshlovoy","year":"2023","journal-title":"Mar. Drugs."},{"key":"10.1016\/j.bioorg.2024.108099_b0040","doi-asserted-by":"crossref","first-page":"1415","DOI":"10.1517\/13543776.2013.828036","article-title":"Developments around the bioactive diketopiperazines: a patent review","volume":"23","author":"Wang","year":"2013","journal-title":"Expert Opin. Ther. Pat."},{"key":"10.1016\/j.bioorg.2024.108099_b0045","doi-asserted-by":"crossref","DOI":"10.1016\/j.tiv.2020.104869","article-title":"In vitro protective effects of marine-derived Aspergillus puulaauensis TM124-S4 extract on H2O2-stressed primary human fibroblasts","volume":"66","author":"Letsiou","year":"2020","journal-title":"Toxicol. in Vitro"},{"key":"10.1016\/j.bioorg.2024.108099_b0050","doi-asserted-by":"crossref","first-page":"e228","DOI":"10.3390\/microorganisms10020228","article-title":"Garon, Cellular cytotoxicity and oxidative potential of recurrent molds of the genusAspergillusseriesVersicolores","volume":"10","author":"G\u00e9ry","year":"2022","journal-title":"Microorganisms"},{"key":"10.1016\/j.bioorg.2024.108099_b0055","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1021\/acs.jnatprod.0c00804","article-title":"Targeted isolation of asperheptatides from a coral-derived fungus using LC-MS\/MS-based molecular networking and antitubercular activities of modified cinnamate derivatives","volume":"84","author":"Chao","year":"2021","journal-title":"J. Nat. Prod."},{"key":"10.1016\/j.bioorg.2024.108099_b0060","doi-asserted-by":"crossref","first-page":"e157","DOI":"10.3390\/molecules28010157","article-title":"MS\/MS-basedmolecularnetworking: an efficient approach for natural products dereplication","volume":"28","author":"Qin","year":"2022","journal-title":"Molecules"},{"key":"10.1016\/j.bioorg.2024.108099_b0065","doi-asserted-by":"crossref","DOI":"10.1016\/j.phytochem.2022.113136","article-title":"MS\/MS-basedmolecularnetworkingaccelerated discovery of germacrane-type sesquiterpene lactones from Elephantopus scaber L","volume":"198","author":"Xu","year":"2022","journal-title":"Phytochemistry"},{"key":"10.1016\/j.bioorg.2024.108099_b0070","doi-asserted-by":"crossref","first-page":"19609","DOI":"10.1002\/anie.202103878","article-title":"Discovery of Neuritogenic securinega alkaloids from Flueggea suffruticosa by a building blocks-based molecular network strategy","volume":"60","author":"He","year":"2021","journal-title":"Angew. Chem. Int. Ed. Engl."},{"key":"10.1016\/j.bioorg.2024.108099_b0075","doi-asserted-by":"crossref","first-page":"2041","DOI":"10.1039\/D1NP00036E","article-title":"Metabolomics and genomics in natural products research: complementary tools for targeting new chemical entities","volume":"38","author":"Caesar","year":"2021","journal-title":"Nat. Prod. Rep."},{"key":"10.1016\/j.bioorg.2024.108099_b0080","doi-asserted-by":"crossref","first-page":"960","DOI":"10.1039\/C9NP00006B","article-title":"Natural products targeting strategies involving molecular networking: different manners, one goal","volume":"36","author":"Ramos","year":"2019","journal-title":"Nat. Prod. Rep."},{"key":"10.1016\/j.bioorg.2024.108099_b0085","doi-asserted-by":"crossref","first-page":"12733","DOI":"10.1021\/ja1049302","article-title":"Genome-based characterization of two prenylation steps in the assembly of the stephacidin and notoamide anticancer agents in a marine-derived Aspergillus sp","volume":"132","author":"Ding","year":"2010","journal-title":"J. Am. Chem. Soc."},{"key":"10.1016\/j.bioorg.2024.108099_b0090","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejmech.2024.116175","article-title":"OSMACstrategy: a promising way to explore microbial cyclic peptides","volume":"268","author":"Zhang","year":"2024","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.bioorg.2024.108099_b0095","doi-asserted-by":"crossref","first-page":"8514","DOI":"10.1021\/acs.analchem.2c01559","article-title":"Automatic MS\/MS data mining strategy for discovering target natural products: A case of lindenane sesquiterpenoids","volume":"94","author":"Li","year":"2022","journal-title":"Anal. Chem."},{"key":"10.1016\/j.bioorg.2024.108099_b0100","doi-asserted-by":"crossref","first-page":"2262","DOI":"10.1002\/anie.200604378","article-title":"A concise, biomimetic total synthesis of stephacidin A and notoamide B","volume":"46","author":"Greshock","year":"2007","journal-title":"Angew. Chem., Int. Ed."},{"key":"10.1016\/j.bioorg.2024.108099_b0105","doi-asserted-by":"crossref","first-page":"7895","DOI":"10.1021\/jo5010179","article-title":"Prenylated indole diketopiperazines from the marine-derived fungus Aspergillus versicolor","volume":"79","author":"Peng","year":"2014","journal-title":"J. Org. Chem."},{"key":"10.1016\/j.bioorg.2024.108099_b0110","doi-asserted-by":"crossref","first-page":"1107","DOI":"10.1093\/jnci\/82.13.1107","article-title":"Newcolorimetriccytotoxicityassayforanticancer-drugscreening","volume":"82","author":"Skehan","year":"1990","journal-title":"J. Natl. Cancer Inst."},{"key":"10.1016\/j.bioorg.2024.108099_b0115","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1016\/S0076-6879(02)59180-1","article-title":"Griess method for nitrite measurement of aqueous and protein-containing samples","volume":"359","author":"Kleinbongard","year":"2002","journal-title":"Methods Enzymol."},{"key":"10.1016\/j.bioorg.2024.108099_b0120","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1016\/j.cll.2019.07.001","article-title":"Antinuclear antibody tests","volume":"339","author":"Ling","year":"2019","journal-title":"Clin. Lab. Med."},{"key":"10.1016\/j.bioorg.2024.108099_b0125","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1007\/s00726-004-0118-0","article-title":"Marfey'sreagent for chiral amino acid analysis: a review","volume":"27","author":"Bhushan","year":"2004","journal-title":"Amino Acids"},{"key":"10.1016\/j.bioorg.2024.108099_b0130","doi-asserted-by":"crossref","unstructured":"L. Di Bari, G. Pescitelli,C. Pratelli,D. Pini,P. Salvadori, Determination of absolute configuration of acyclic 1, 2-diols with Mo2 (OAc)4. 1. Snatzke's method revisited. J. Org. Chem. 66 (2001) 4819-4825. doi: 10.1021\/jo010136v.","DOI":"10.1021\/jo010136v"},{"key":"10.1016\/j.bioorg.2024.108099_b0135","doi-asserted-by":"crossref","first-page":"408","DOI":"10.1016\/j.bbrc.2016.03.007","article-title":"Cornuside inhibits mast cell-mediated allergic response by down-regulating MAPK and NF-\u03baB signaling pathways","volume":"473","author":"Li","year":"2016","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.bioorg.2024.108099_b0140","doi-asserted-by":"crossref","first-page":"e36","DOI":"10.1186\/1471-2350-11-36","article-title":"Association of Nrf2-encoding NFE2L2 haplotypes with Parkinson\u2019s disease","volume":"11","author":"von Otter","year":"2010","journal-title":"BMC Med. Genet."},{"key":"10.1016\/j.bioorg.2024.108099_b0145","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1021\/acschemneuro.8b00243","article-title":"Discovery of a new pterocarpan-type antineuroinflammatory compound from Sophora tonkinensis through suppression of the TLR4\/NF-\u03baB\/MAPK signaling pathway with PU. 1 as a potential target","volume":"10","author":"Xia","year":"2019","journal-title":"ACS Chem. Neurosci."},{"key":"10.1016\/j.bioorg.2024.108099_b0150","doi-asserted-by":"crossref","first-page":"e1694","DOI":"10.21037\/atm-21-5752","article-title":"Salidroside inhibits NLRP3 inflammasome activation and apoptosis in microglia induced by cerebral ischemia\/reperfusion injury by inhibiting the TLR4\/NF-\u03baB signaling pathway","volume":"22","author":"Liu","year":"2021","journal-title":"Ann. Transl. Med."},{"key":"10.1016\/j.bioorg.2024.108099_b0155","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2021.153687","article-title":"Aesculin suppresses the NLRP3 inflammasome-mediated pyroptosis via the Akt\/GSK3\u03b2\/NF-\u03baB pathway to mitigate myocardial ischemia\/reperfusion injury","volume":"92","author":"Xu","year":"2021","journal-title":"Phytomedicine"}],"container-title":["Bioorganic Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0045206824010046?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0045206824010046?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T11:58:45Z","timestamp":1777463925000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0045206824010046"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,1]]},"references-count":31,"alternative-id":["S0045206824010046"],"URL":"https:\/\/doi.org\/10.1016\/j.bioorg.2024.108099","relation":{},"ISSN":["0045-2068"],"issn-type":[{"value":"0045-2068","type":"print"}],"subject":[],"published":{"date-parts":[[2025,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Targeted isolation of diketopiperazines from a deep-sea derived fungus with anti-neuroinflammatory effects","name":"articletitle","label":"Article Title"},{"value":"Bioorganic Chemistry","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bioorg.2024.108099","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"108099"}}