{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,19]],"date-time":"2026-01-19T01:39:37Z","timestamp":1768786777197,"version":"3.49.0"},"reference-count":53,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,2,1]],"date-time":"2025-02-01T00:00:00Z","timestamp":1738368000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,2,1]],"date-time":"2025-02-01T00:00:00Z","timestamp":1738368000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,2,1]],"date-time":"2025-02-01T00:00:00Z","timestamp":1738368000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,2,1]],"date-time":"2025-02-01T00:00:00Z","timestamp":1738368000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,2,1]],"date-time":"2025-02-01T00:00:00Z","timestamp":1738368000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,2,1]],"date-time":"2025-02-01T00:00:00Z","timestamp":1738368000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,2,1]],"date-time":"2025-02-01T00:00:00Z","timestamp":1738368000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100011238","name":"State Key Laboratory of Phytochemistry and Plant Resources in West China","doi-asserted-by":"publisher","award":["P2022-KF06"],"award-info":[{"award-number":["P2022-KF06"]}],"id":[{"id":"10.13039\/501100011238","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002367","name":"Chinese Academy of Sciences","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002367","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100013152","name":"Shanghai Institute of Materia Medica, Chinese Academy of Sciences","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100013152","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100011198","name":"State Key Laboratory of Drug Research","doi-asserted-by":"publisher","award":["SIMM2205KF-08"],"award-info":[{"award-number":["SIMM2205KF-08"]}],"id":[{"id":"10.13039\/501100011198","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Bioorganic Chemistry"],"published-print":{"date-parts":[[2025,2]]},"DOI":"10.1016\/j.bioorg.2025.108132","type":"journal-article","created":{"date-parts":[[2025,1,7]],"date-time":"2025-01-07T17:04:16Z","timestamp":1736269456000},"page":"108132","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":3,"special_numbering":"C","title":["Design, synthesis and biological evaluation of Alisol B derivatives for potential treatment of non-alcoholic steatohepatitis"],"prefix":"10.1016","volume":"155","author":[{"given":"Nai-Rong","family":"Yu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Suling","family":"Huang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhen-Tao","family":"Deng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiayue","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yu","family":"Shen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ying","family":"Leng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qin-Shi","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.bioorg.2025.108132_b0005","doi-asserted-by":"crossref","unstructured":"L. Rong, J. Zou, W. Ran, X. Qi, Y. Chen, H. Cui, J. Guo, Advancements in the treatment of non-alcoholic fatty liver disease (NAFLD), Front. Endocrinol. (Lausanne) 13 (2023) 1087260. https:\/\/doi.org\/ 10.3389\/fendo.2022.1087260.","DOI":"10.3389\/fendo.2022.1087260"},{"key":"10.1016\/j.bioorg.2025.108132_b0010","doi-asserted-by":"crossref","first-page":"2212","DOI":"10.1016\/S0140-6736(20)32511-3","article-title":"Non-alcoholic fatty liver disease","volume":"397","author":"Powell","year":"2021","journal-title":"Lancet"},{"key":"10.1016\/j.bioorg.2025.108132_b0015","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1016\/j.cld.2015.10.002","article-title":"The metabolic syndrome and its influence on nonalcoholic steatohepatitis","volume":"20","author":"Kanwar","year":"2016","journal-title":"Clin. Liver. Dis."},{"key":"10.1016\/j.bioorg.2025.108132_b0020","doi-asserted-by":"crossref","DOI":"10.1016\/j.drudis.2024.103910","article-title":"NAFLD and NASH: etiology, targets and emerging therapies","volume":"29","author":"Wei","year":"2024","journal-title":"Drug. Discov. Today."},{"key":"10.1016\/j.bioorg.2025.108132_b0025","doi-asserted-by":"crossref","first-page":"908","DOI":"10.1038\/s41591-018-0104-9","article-title":"Mechanisms of NAFLD development and therapeutic strategies","volume":"24","author":"Friedman","year":"2018","journal-title":"Nat. Med."},{"key":"10.1016\/j.bioorg.2025.108132_b0030","doi-asserted-by":"crossref","first-page":"1453","DOI":"10.1172\/JCI134165","article-title":"Insulin resistance drives hepatic de novo lipogenesis in nonalcoholic fatty liver disease","volume":"130","author":"Smith","year":"2020","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.bioorg.2025.108132_b0035","doi-asserted-by":"crossref","first-page":"21833","DOI":"10.3390\/ijms141121833","article-title":"Rodent models of nonalcoholic fatty liver disease\/nonalcoholic steatohepatitis","volume":"14","author":"Imajo","year":"2013","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.bioorg.2025.108132_b0040","doi-asserted-by":"crossref","unstructured":"S. Raza, S. Rajak, A. Upadhyay, A. Tewari, R. Anthony Sinha, Current treatment paradigms and emerging therapies for NAFLD\/NASH, Front. Biosci. (Landmark Ed) 26 (2021) 206-237. https:\/\/doi.org\/10.2741\/4892.","DOI":"10.2741\/4892"},{"key":"10.1016\/j.bioorg.2025.108132_b0045","doi-asserted-by":"crossref","first-page":"956","DOI":"10.1016\/S0140-6736(14)61933-4","article-title":"NASH Clinical Research Network, Farnesoid X nuclear receptor ligand obeticholic acid for non-cirrhotic, non-alcoholic steatohepatitis (FLINT): a multicentre, randomised, placebo-controlled trial","volume":"385","author":"Neuschwander-Tetri","year":"2015","journal-title":"Lancet"},{"key":"10.1016\/j.bioorg.2025.108132_b0050","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1056\/NEJMoa2309000","article-title":"MAESTRO-NASH Investigators, A phase 3, randomized, controlled trial of resmetirom in NASH with liver fibrosis","volume":"390","author":"Harrison","year":"2024","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.bioorg.2025.108132_b0055","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1016\/j.jhep.2018.09.024","article-title":"Longitudinal correlations between MRE, MRI-PDFF, and liver histology in patients with non-alcoholic steatohepatitis: analysis of data from a phase II trial of selonsertib","volume":"70","author":"Jayakumar","year":"2019","journal-title":"J. Hepatol."},{"key":"10.1016\/j.bioorg.2025.108132_b0060","doi-asserted-by":"crossref","first-page":"878","DOI":"10.1002\/jcph.2427","article-title":"Pharmacokinetics and safety of firsocostat, an acetyl\u2010coenzyme a carboxylase inhibitor, in participants with mild, moderate, and severe hepatic impairment","volume":"64","author":"Younis","year":"2024","journal-title":"J. Clin. Pharmacol."},{"key":"10.1016\/j.bioorg.2025.108132_b0065","doi-asserted-by":"crossref","first-page":"729","DOI":"10.1007\/s40265-024-02045-0","article-title":"Resmetirom: first approval","volume":"84","author":"Keam","year":"2024","journal-title":"Drugs"},{"key":"10.1016\/j.bioorg.2025.108132_b0070","doi-asserted-by":"crossref","first-page":"15489","DOI":"10.3390\/ijms232415489","article-title":"Non-alcoholic fatty liver disease (NAFLD) pathogenesis and natural products for prevention and treatment","volume":"23","author":"Guo","year":"2022","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.bioorg.2025.108132_b0075","doi-asserted-by":"crossref","DOI":"10.1002\/cbdv.201700452","article-title":"Protostane\u2010type triterpenoids from Alisma orientale","volume":"14","author":"Li","year":"2017","journal-title":"Chem. Biodivers."},{"key":"10.1016\/j.bioorg.2025.108132_b0080","doi-asserted-by":"crossref","unstructured":"H.-G. Jin, Q. Jin, A. Ryun Kim, H. Choi, J.H. Lee, Y.S. Kim, D.G. Lee, E.-R. Woo, A new triterpenoid from Alisma orientale and their antibacterial effect, Arch. Pharm. Res. 35 (2012) 1919-1926. https:\/\/doi.org\/10.1007\/s12272-012-1108-5.","DOI":"10.1007\/s12272-012-1108-5"},{"key":"10.1016\/j.bioorg.2025.108132_b0085","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1016\/j.phytochem.2007.06.014","article-title":"Alisolide, alisols O and P from the rhizome of Alisma orientale","volume":"69","author":"Zhao","year":"2008","journal-title":"Phytochemistry"},{"key":"10.1016\/j.bioorg.2025.108132_b0090","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejmech.2019.111652","article-title":"Highly potent non-steroidal FXR agonists protostane-type triterpenoids: structure-activity relationship and mechanism","volume":"182","author":"Luan","year":"2019","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.bioorg.2025.108132_b0095","doi-asserted-by":"crossref","first-page":"1391","DOI":"10.1211\/jpp.57.10.0013","article-title":"Protective effects of the Alisma orientalis extract on the experimental nonalcoholic fatty liver disease","volume":"58","author":"Hong","year":"2006","journal-title":"J. Pharm. Pharmacol."},{"key":"10.1016\/j.bioorg.2025.108132_b0100","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1186\/s12906-016-1181-2","article-title":"Anti-lipoapoptotic effects of Alisma orientalis extract on non-esterified fatty acid-induced HepG2 cells","volume":"16","author":"Jeong","year":"2016","journal-title":"BMC Complement. Altern. Med."},{"key":"10.1016\/j.bioorg.2025.108132_b0105","doi-asserted-by":"crossref","first-page":"5108","DOI":"10.1111\/jcmm.14380","article-title":"Alisol A attenuates high\u2010fat\u2010diet\u2010induced obesity and metabolic disorders via the AMPK\/ACC\/SREBP\u20101c pathway","volume":"23","author":"Ho","year":"2019","journal-title":"J. Cell. Mol. Med."},{"key":"10.1016\/j.bioorg.2025.108132_b0110","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1159\/000452560","article-title":"Alisol A 24-acetate prevents hepatic steatosis and metabolic disorders in HepG2 cells","volume":"40","author":"Zeng","year":"2016","journal-title":"Cell. Physiol. Biochem."},{"key":"10.1016\/j.bioorg.2025.108132_b0115","doi-asserted-by":"crossref","DOI":"10.1155\/2019\/2943162","article-title":"Pharmacological activities of Alisma orientale against nonalcoholic fatty liver disease and metabolic syndrome: literature review","author":"Choi","year":"2019","journal-title":"Evid. Based. Complement. Alternat. Med."},{"key":"10.1016\/j.bioorg.2025.108132_b0120","doi-asserted-by":"crossref","first-page":"294","DOI":"10.7150\/ijbs.78097","article-title":"Direct targeting of sEH with alisol B alleviated the apoptosis, inflammation, and oxidative stress in cisplatin-induced acute kidney injury","volume":"19","author":"Zhang","year":"2023","journal-title":"Int. J. Biol. Sci."},{"key":"10.1016\/j.bioorg.2025.108132_b0125","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2023.155313","article-title":"Alisol B regulates AMPK\/mTOR\/SREBPs via directly targeting VDAC1 to alleviate hyperlipidemia","volume":"128","author":"Gao","year":"2024","journal-title":"Phytomedicine"},{"key":"10.1016\/j.bioorg.2025.108132_b0130","doi-asserted-by":"crossref","first-page":"2372","DOI":"10.1021\/acs.jnatprod.5b00321","article-title":"Protostane triterpenoids from the rhizome of Alisma orientale exhibit inhibitory effects on human carboxylesterase 2","volume":"78","author":"Mai","year":"2015","journal-title":"J. Nat. Prod."},{"key":"10.1016\/j.bioorg.2025.108132_b0135","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1016\/j.apsb.2017.09.004","article-title":"Correlation analysis between the chemical contents and bioactivity for the quality control of Alismatis Rhizoma","volume":"8","author":"Gao","year":"2018","journal-title":"Acta. Pharm. Sin. b."},{"key":"10.1016\/j.bioorg.2025.108132_b0140","doi-asserted-by":"crossref","first-page":"2411","DOI":"10.3390\/nu14122411","article-title":"Alisol B alleviates hepatocyte lipid accumulation and lipotoxicity via regulating RAR\u03b1-PPAR\u03b3-CD36 cascade and attenuates non-alcoholic steatohepatitis in mice","volume":"14","author":"Zhao","year":"2022","journal-title":"Nutrients"},{"key":"10.1016\/j.bioorg.2025.108132_b0145","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1016\/j.bcp.2014.09.009","article-title":"Alisol B 23-acetate promotes liver regeneration in mice after partial hepatectomy via activating farnesoid X receptor","volume":"92","author":"Meng","year":"2014","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.bioorg.2025.108132_b0150","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2023.110768","article-title":"Farnesoid X receptor activation is required for the anti-inflammatory and anti-oxidative stress effects of alisol B 23-acetate in carbon tetrachloride-induced liver fibrosis in mice","volume":"123","author":"Zhang","year":"2023","journal-title":"Int. Immunopharmacol."},{"key":"10.1016\/j.bioorg.2025.108132_b0155","doi-asserted-by":"crossref","first-page":"608","DOI":"10.1007\/BF02976929","article-title":"Chemical modification of alisol B 23-acetate and their cytotoxic activity","volume":"25","author":"Lee","year":"2002","journal-title":"Arch. Pharm. Res."},{"key":"10.1016\/j.bioorg.2025.108132_b0160","doi-asserted-by":"crossref","first-page":"4181","DOI":"10.2174\/0929867330666221128142730","article-title":"Recent advances in biological active sulfonamide based hybrid compounds part C: multicomponent sulfonamide hybrids","volume":"30","author":"Ghomashi","year":"2023","journal-title":"Curr. Med. Chem."},{"key":"10.1016\/j.bioorg.2025.108132_b0165","doi-asserted-by":"crossref","first-page":"2042","DOI":"10.1016\/j.bmcl.2019.06.041","article-title":"Sulfonamide derivatives as multi-target agents for complex diseases","volume":"29","author":"Apayd\u0131n","year":"2019","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"10.1016\/j.bioorg.2025.108132_b0170","doi-asserted-by":"crossref","first-page":"1115","DOI":"10.1080\/14756366.2021.1890066","article-title":"Application of triazoles in the structural modification of natural products","volume":"36","author":"Guo","year":"2021","journal-title":"J. Enzyme. Inhib. Med. Chem."},{"key":"10.1016\/j.bioorg.2025.108132_b0175","doi-asserted-by":"crossref","first-page":"7788","DOI":"10.1021\/acs.jmedchem.4c00652","article-title":"Triazoles in medicinal chemistry: physicochemical properties, bioisosterism, and application","volume":"67","author":"Guan","year":"2024","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.bioorg.2025.108132_b0180","doi-asserted-by":"crossref","first-page":"570","DOI":"10.1039\/b408974j","article-title":"An economical and green approach for the oxidation of olefins to enones","volume":"6","author":"Marwah","year":"2004","journal-title":"Green. Chem."},{"key":"10.1016\/j.bioorg.2025.108132_b0185","doi-asserted-by":"crossref","first-page":"4540","DOI":"10.1021\/ja070571s","article-title":"A diosphenol-based strategy for the total synthesis of (-)-terpestacin","volume":"129","author":"Trost","year":"2007","journal-title":"J. Am. Chem. Soc."},{"key":"10.1016\/j.bioorg.2025.108132_b0190","doi-asserted-by":"crossref","DOI":"10.1016\/j.steroids.2021.108931","article-title":"Synthesis and biological evaluation of novel steroidal pyrazole amides as highly potent anticancer agents","volume":"176","author":"Huo","year":"2021","journal-title":"Steroids"},{"key":"10.1016\/j.bioorg.2025.108132_b0195","doi-asserted-by":"crossref","unstructured":"C.T. Supuran, A. Casini, A. Scozzafava, protease inhibitors of the sulfonamide type: anticancer, antiinflammatory, and antiviral agents, Med. Res. Rev. 23 (2003) 535-558. https:\/\/doi.org\/0.1002\/med.10047.","DOI":"10.1002\/med.10047"},{"key":"10.1016\/j.bioorg.2025.108132_b0200","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1080\/13543776.2018.1487400","article-title":"Sulfonamide inhibitors: a patent review 2013-present","volume":"28","author":"Gul\u00e7in","year":"2018","journal-title":"Expert. Opin. Ther. Pat."},{"key":"10.1016\/j.bioorg.2025.108132_b0205","doi-asserted-by":"crossref","first-page":"3511","DOI":"10.1016\/j.bmc.2019.07.005","article-title":"1,2,3-Triazole-containing hybrids as leads in medicinal chemistry: a recent overview","volume":"27","author":"Bozorov","year":"2019","journal-title":"Bioorg. Med. Chem."},{"key":"10.1016\/j.bioorg.2025.108132_b0210","doi-asserted-by":"crossref","first-page":"1572","DOI":"10.1016\/j.drudis.2017.05.014","article-title":"The 1,2,3-triazole ring as a bioisostere in medicinal chemistry","volume":"22","author":"Bonandi","year":"2017","journal-title":"Drug. Discov. Today."},{"key":"10.1016\/j.bioorg.2025.108132_b0215","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1002\/tcr.201600093","article-title":"Click chemistry route to the synthesis of unusual amino acids, peptides, triazole-fused heterocycles and pseudodisaccharides","volume":"17","author":"Chandrasekaran","year":"2017","journal-title":"Chem. Rec."},{"key":"10.1016\/j.bioorg.2025.108132_b0220","doi-asserted-by":"crossref","first-page":"726","DOI":"10.1053\/j.gastro.2013.11.049","article-title":"Increased de novo lipogenesis is a distinct characteristic of individuals with nonalcoholic fatty liver disease","volume":"146","author":"Lambert","year":"2014","journal-title":"Gastroenterology"},{"key":"10.1016\/j.bioorg.2025.108132_b0225","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1111\/joim.13531","article-title":"Current treatment of non\u2010alcoholic fatty liver disease","volume":"292","author":"Paternostro","year":"2022","journal-title":"J. Intern. Med."},{"key":"10.1016\/j.bioorg.2025.108132_b0230","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/j.mam.2018.09.002","article-title":"Liver fibrosis: pathophysiology, pathogenetic targets and clinical issues","volume":"65","author":"Parola","year":"2019","journal-title":"Mol. Aspects. Med."},{"key":"10.1016\/j.bioorg.2025.108132_b0235","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1369\/0022155415627681","article-title":"TGF-\u03b2\/SMAD pathway and its regulation in hepatic fibrosis","volume":"64","author":"Xu","year":"2016","journal-title":"J. Histochem. Cytochem."},{"key":"10.1016\/j.bioorg.2025.108132_b0240","doi-asserted-by":"crossref","first-page":"422","DOI":"10.1111\/1440-1681.12102","article-title":"A high-fat diet and multiple administration of carbon tetrachloride induces liver injury and pathological features associated with non-alcoholic steatohepatitis in mice","volume":"40","author":"Kubota","year":"2013","journal-title":"Clin. Exp. Pharmacol. Physiol."},{"key":"10.1016\/j.bioorg.2025.108132_b0245","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1016\/j.jhep.2018.03.011","article-title":"A simple diet- and chemical-induced murine NASH model with rapid progression of steatohepatitis, fibrosis and liver cancer","volume":"69","author":"Tsuchida","year":"2018","journal-title":"J. Hepatol."},{"key":"10.1016\/j.bioorg.2025.108132_b0250","doi-asserted-by":"crossref","first-page":"2184","DOI":"10.1016\/S0140-6736(19)33041-7","article-title":"REGENERATE Study Investigators, Obeticholic acid for the treatment of non-alcoholic steatohepatitis: interim analysis from a multicentre, randomised, placebo-controlled phase 3 trial","volume":"394","author":"Younossi","year":"2019","journal-title":"Lancet"},{"key":"10.1016\/j.bioorg.2025.108132_b0255","first-page":"711","article-title":"Liver enzymes, metabolomics and genome-wide association studies: from systems biology to the personalized medicine, World","volume":"21","author":"Sookoian","year":"2015","journal-title":"J. Gastroenterol."},{"key":"10.1016\/j.bioorg.2025.108132_b0260","article-title":"Lipid alterations in chronic liver disease and liver cancer","volume":"4","author":"Paul","year":"2022","journal-title":"JHEP Rep."},{"key":"10.1016\/j.bioorg.2025.108132_b0265","doi-asserted-by":"crossref","first-page":"1313","DOI":"10.1002\/hep.20701","article-title":"Nonalcoholic Steatohepatitis Clinical Research Network, Design and validation of a histological scoring system for nonalcoholic fatty liver disease","volume":"41","author":"Kleiner","year":"2005","journal-title":"Hepatology"}],"container-title":["Bioorganic Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0045206825000124?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0045206825000124?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,2,24]],"date-time":"2025-02-24T05:37:22Z","timestamp":1740375442000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0045206825000124"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,2]]},"references-count":53,"alternative-id":["S0045206825000124"],"URL":"https:\/\/doi.org\/10.1016\/j.bioorg.2025.108132","relation":{},"ISSN":["0045-2068"],"issn-type":[{"value":"0045-2068","type":"print"}],"subject":[],"published":{"date-parts":[[2025,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Design, synthesis and biological evaluation of Alisol B derivatives for potential treatment of non-alcoholic steatohepatitis","name":"articletitle","label":"Article Title"},{"value":"Bioorganic Chemistry","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bioorg.2025.108132","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"108132"}}