{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,22]],"date-time":"2025-11-22T21:36:22Z","timestamp":1763847382904,"version":"3.45.0"},"reference-count":33,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T00:00:00Z","timestamp":1743465600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T00:00:00Z","timestamp":1743465600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T00:00:00Z","timestamp":1743465600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T00:00:00Z","timestamp":1743465600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T00:00:00Z","timestamp":1743465600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T00:00:00Z","timestamp":1743465600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T00:00:00Z","timestamp":1743465600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["U22A20582","42306138","32070054"],"award-info":[{"award-number":["U22A20582","42306138","32070054"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007128","name":"Natural Science Foundation of Shaanxi Province","doi-asserted-by":"publisher","award":["2023-JC-QN-0160"],"award-info":[{"award-number":["2023-JC-QN-0160"]}],"id":[{"id":"10.13039\/501100007128","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007548","name":"Northwest A and F University","doi-asserted-by":"publisher","award":["2452022163","2452023025"],"award-info":[{"award-number":["2452022163","2452023025"]}],"id":[{"id":"10.13039\/501100007548","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Bioorganic Chemistry"],"published-print":{"date-parts":[[2025,4]]},"DOI":"10.1016\/j.bioorg.2025.108268","type":"journal-article","created":{"date-parts":[[2025,2,17]],"date-time":"2025-02-17T19:04:01Z","timestamp":1739819041000},"page":"108268","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":2,"special_numbering":"C","title":["Targeted discovery of diterpene compounds ostamycins with anti-influenza a viral activity from a deepsea-derived Streptomyces strain"],"prefix":"10.1016","volume":"157","author":[{"given":"Lukuan","family":"Hou","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shuyao","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuanhang","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xue","family":"Yang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zihui","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuxuan","family":"Gao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wenli","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"10","key":"10.1016\/j.bioorg.2025.108268_bb0005","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1016\/j.micres.2012.06.005","article-title":"Marine actinomycetes: an ongoing source of novel bioactive metabolites","volume":"167","author":"Subramani","year":"2012","journal-title":"Microbiol. Res."},{"key":"10.1016\/j.bioorg.2025.108268_bb0010","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1016\/j.biopha.2016.12.086","article-title":"Marine actinobacteria as a drug treasure house","volume":"87","author":"Ul Hassan","year":"2017","journal-title":"Biomed. Pharmacother."},{"issue":"7917","key":"10.1016\/j.bioorg.2025.108268_bb0015","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1038\/s41586-022-04862-3","article-title":"Biosynthetic potential of the global ocean microbiome","volume":"607","author":"Paoli","year":"2022","journal-title":"Nature"},{"issue":"8029","key":"10.1016\/j.bioorg.2025.108268_bb0020","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1038\/s41586-024-07891-2","article-title":"Global marine microbial diversity and its potential in bioprospecting","volume":"633","author":"Chen","year":"2024","journal-title":"Nature"},{"issue":"1","key":"10.1016\/j.bioorg.2025.108268_bb0025","doi-asserted-by":"crossref","first-page":"763","DOI":"10.1146\/annurev-biochem-081420-102432","article-title":"A natural product chemist\u2019s guide to unlocking silent biosynthetic gene clusters","volume":"90","author":"Covington","year":"2021","journal-title":"Annu. Rev. Biochem."},{"issue":"17","key":"10.1016\/j.bioorg.2025.108268_bb0030","doi-asserted-by":"crossref","first-page":"11570","DOI":"10.1021\/acs.chemrev.7b00287","article-title":"Structural and chemical biology of terpenoid cyclases","volume":"117","author":"Christianson","year":"2017","journal-title":"Chem. Rev."},{"issue":"7328","key":"10.1016\/j.bioorg.2025.108268_bb0035","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1038\/nature09628","article-title":"Taxadiene synthase structure and evolution of modular architecture in terpene biosynthesis","volume":"469","author":"K\u00f6ksal","year":"2011","journal-title":"Nature"},{"key":"10.1016\/j.bioorg.2025.108268_bb0040","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2022.830103","article-title":"Biological activities of meroterpenoids isolated from different sources","volume":"13","author":"Fuloria","year":"2022","journal-title":"Front. Pharmacol."},{"issue":"1","key":"10.1016\/j.bioorg.2025.108268_bb0045","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1021\/np50055a002","article-title":"Polygodial, an antifungal potentiator","volume":"51","author":"Kubo","year":"1988","journal-title":"J. Nat. Prod."},{"key":"10.1016\/j.bioorg.2025.108268_bb0050","doi-asserted-by":"crossref","DOI":"10.1016\/j.pharmthera.2020.107658","article-title":"The birth of artemisinin","volume":"216","author":"Ma","year":"2020","journal-title":"Pharmacol. Ther."},{"issue":"11","key":"10.1016\/j.bioorg.2025.108268_bb0055","doi-asserted-by":"crossref","first-page":"1521","DOI":"10.1039\/c0np00019a","article-title":"Two rings in them all: the labdane-related diterpenoids","volume":"27","author":"Peters","year":"2010","journal-title":"Nat. Prod. Rep."},{"key":"10.1016\/j.bioorg.2025.108268_bb0060","doi-asserted-by":"crossref","first-page":"10402","DOI":"10.1039\/D4SC01381F","article-title":"Structural-model-based genome mining can efficiently discover novel non-canonical terpene synthases hidden in genomes of diverse species","volume":"15","author":"Abe","year":"2024","journal-title":"Chem. Sci."},{"issue":"16","key":"10.1016\/j.bioorg.2025.108268_bb0065","doi-asserted-by":"crossref","first-page":"1727","DOI":"10.1002\/cbic.201800285","article-title":"Discovery of the tiancilactone antibiotics by genome mining of atypical bacterial type II diterpene synthases","volume":"19","author":"Dong","year":"2018","journal-title":"ChemBioChem"},{"issue":"4","key":"10.1016\/j.bioorg.2025.108268_bb0070","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1016\/j.chembiol.2006.01.011","article-title":"Biosynthesis of the terpene phenalinolactone in Streptomyces sp. T\u00fc6071: analysis of the gene cluster and generation of derivatives","volume":"13","author":"D\u00fcrr","year":"2006","journal-title":"Chem. Biol."},{"issue":"10","key":"10.1016\/j.bioorg.2025.108268_bb0075","doi-asserted-by":"crossref","first-page":"1010","DOI":"10.1039\/D4CB00138A","article-title":"Early-stage biosynthesis of phenalinolactone diterpenoids involves sequential prenylation, epoxidation, and cyclization","volume":"5","author":"Alsup","year":"2024","journal-title":"RSC Chem. Biol."},{"issue":"2","key":"10.1016\/j.bioorg.2025.108268_bb0080","doi-asserted-by":"crossref","DOI":"10.1002\/biot.201700527","article-title":"The immunosuppressant brasilicardin: determination of the biosynthetic gene cluster in the heterologous host Amycolatopsis japonicum","volume":"13","author":"Schwarz","year":"2018","journal-title":"Biotechnol. J."},{"year":"1989","series-title":"Molecular Cloning: A Laboratory Manual","author":"Sambrook","key":"10.1016\/j.bioorg.2025.108268_bb0085"},{"issue":"1","key":"10.1016\/j.bioorg.2025.108268_bb0090","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1128\/JB.181.1.204-211.1999","article-title":"Evidence that the extracytoplasmic function sigma factor \u03c3E is required for normal cell wall structure in Streptomyces coelicolor A3(2)","volume":"181","author":"Paget","year":"1999","journal-title":"J. Bacteriol."},{"issue":"2","key":"10.1016\/j.bioorg.2025.108268_bb0095","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1111\/j.1751-7915.2010.00219.x","article-title":"Engineering Streptomyces coelicolor for heterologous expression of secondary metabolite gene clusters","volume":"4","author":"Gomez-Escribano","year":"2011","journal-title":"J. Microbial. Biotechnol."},{"issue":"W1","key":"10.1016\/j.bioorg.2025.108268_bb0100","doi-asserted-by":"crossref","first-page":"W46","DOI":"10.1093\/nar\/gkad344","article-title":"antiSMASH 7.0: new and improved predictions for detection, regulation, chemical structures and visualisation","volume":"51","author":"Blin","year":"2023","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.bioorg.2025.108268_bb0105","doi-asserted-by":"crossref","first-page":"3389","DOI":"10.1093\/nar\/25.17.3389","article-title":"Gapped BLAST and PSI-BLAST: a new generation of protein database search programs","volume":"25","author":"Altschul","year":"1997","journal-title":"Nucleic Acids Res."},{"year":"2000","series-title":"Practical Streptomyces Genetics","author":"Kieser","key":"10.1016\/j.bioorg.2025.108268_bb0110"},{"key":"10.1016\/j.bioorg.2025.108268_bb0115","doi-asserted-by":"crossref","DOI":"10.1016\/j.bioorg.2020.103954","article-title":"Targeted isolation of new polycyclic tetramate macrolactams from the deepsea-derived Streptomyces somaliensis SCSIO ZH66","volume":"101","author":"Hou","year":"2020","journal-title":"Bioorg. Chem."},{"key":"10.1016\/j.bioorg.2025.108268_bb0120","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1016\/j.antiviral.2017.04.007","article-title":"Inhibition effects of novel polyketide compound PPQ-B against influenza a virus replication by interfering with the cellular EGFR pathway","volume":"143","author":"Wang","year":"2017","journal-title":"Antiviral Res."},{"key":"10.1016\/j.bioorg.2025.108268_bb0125","article-title":"An optimized hemagglutination inhibition (HI) assay to quantify influenza-specific antibody titers","volume":"130","author":"Kaufmann","year":"2017","journal-title":"J. Vis. Exp."},{"issue":"13","key":"10.1016\/j.bioorg.2025.108268_bb0130","doi-asserted-by":"crossref","first-page":"3661","DOI":"10.1039\/D2SC06033G","article-title":"Building Streptomyces albus as a chassis for synthesis of bacterial terpenoids","volume":"14","author":"Hu","year":"2023","journal-title":"Chem. Sci."},{"key":"10.1016\/j.bioorg.2025.108268_bb0135","doi-asserted-by":"crossref","DOI":"10.1016\/j.carbpol.2022.119316","article-title":"The inhibition effects and mechanisms of sulfated chitooligosaccharides on influenza a virus in vitro and in vivo","volume":"286","author":"Wang","year":"2022","journal-title":"Carbohydr. Polym."},{"key":"10.1016\/j.bioorg.2025.108268_bb0140","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1016\/j.ejmech.2015.02.006","article-title":"Neoechinulin B and its analogues as potential entry inhibitors of influenza viruses, targeting viral hemagglutinin","volume":"93","author":"Chen","year":"2015","journal-title":"Eur. J. Med. Chem."},{"issue":"1","key":"10.1016\/j.bioorg.2025.108268_bb0145","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1016\/j.apsb.2022.07.001","article-title":"Vitisin B inhibits influenza a virus replication by multi-targeting neuraminidase and virus-induced oxidative stress","volume":"13","author":"Kwon","year":"2023","journal-title":"Acta Pharm. Sin. B"},{"key":"10.1016\/j.bioorg.2025.108268_bb0150","doi-asserted-by":"crossref","DOI":"10.1016\/j.bioorg.2022.106118","article-title":"Exploring the anti-influenza virus activity of novel triptolide derivatives targeting nucleoproteins","volume":"129","author":"Jiang","year":"2022","journal-title":"Bioorg. Chem."},{"issue":"5","key":"10.1016\/j.bioorg.2025.108268_bb0155","doi-asserted-by":"crossref","first-page":"530","DOI":"10.1038\/nsmb.1779","article-title":"Structures of influenza a proteins and insights into antiviral drug targets","volume":"17","author":"Das","year":"2010","journal-title":"Nat. Struct. Mol. Biol."},{"issue":"3","key":"10.1016\/j.bioorg.2025.108268_bb0160","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1038\/nbt0310-239","article-title":"Cellular targets for influenza drugs","volume":"28","author":"Min","year":"2010","journal-title":"Nat. Biotechnol."},{"key":"10.1016\/j.bioorg.2025.108268_bb0165","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s12985-019-1266-x","article-title":"Inhibition effects of patchouli alcohol against influenza a virus through targeting cellular PI3K\/Akt and ERK\/MAPK signaling pathways","volume":"16","author":"Yu","year":"2019","journal-title":"Virol. J."}],"container-title":["Bioorganic Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0045206825001488?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0045206825001488?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,22]],"date-time":"2025-11-22T21:31:51Z","timestamp":1763847111000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0045206825001488"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,4]]},"references-count":33,"alternative-id":["S0045206825001488"],"URL":"https:\/\/doi.org\/10.1016\/j.bioorg.2025.108268","relation":{},"ISSN":["0045-2068"],"issn-type":[{"type":"print","value":"0045-2068"}],"subject":[],"published":{"date-parts":[[2025,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Targeted discovery of diterpene compounds ostamycins with anti-influenza a viral activity from a deepsea-derived Streptomyces strain","name":"articletitle","label":"Article Title"},{"value":"Bioorganic Chemistry","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bioorg.2025.108268","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"108268"}}