{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T21:09:42Z","timestamp":1788901782395,"version":"build-2803163510"},"reference-count":50,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T00:00:00Z","timestamp":1743465600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T00:00:00Z","timestamp":1743465600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T00:00:00Z","timestamp":1743465600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T00:00:00Z","timestamp":1743465600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T00:00:00Z","timestamp":1743465600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T00:00:00Z","timestamp":1743465600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T00:00:00Z","timestamp":1743465600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100002855","name":"Ministry of Science and Technology of the People's Republic of China","doi-asserted-by":"publisher","award":["2019FY100700"],"award-info":[{"award-number":["2019FY100700"]}],"id":[{"id":"10.13039\/501100002855","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100018934","name":"Liaoning Provincial Department of Human Resources and Social Security","doi-asserted-by":"publisher","award":["XLYC1902072"],"award-info":[{"award-number":["XLYC1902072"]}],"id":[{"id":"10.13039\/100018934","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100018617","name":"Liaoning Revitalization Talents Program","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100018617","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100013099","name":"Scientific Research Fund of Liaoning Provincial Education Department","doi-asserted-by":"publisher","award":["JYTQN2023336"],"award-info":[{"award-number":["JYTQN2023336"]}],"id":[{"id":"10.13039\/501100013099","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100013806","name":"Shenyang Pharmaceutical University","doi-asserted-by":"publisher","award":["2311520035"],"award-info":[{"award-number":["2311520035"]}],"id":[{"id":"10.13039\/501100013806","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Bioorganic Chemistry"],"published-print":{"date-parts":[[2025,4]]},"DOI":"10.1016\/j.bioorg.2025.108309","type":"journal-article","created":{"date-parts":[[2025,2,22]],"date-time":"2025-02-22T10:54:39Z","timestamp":1740221679000},"page":"108309","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":5,"special_numbering":"C","title":["De novo-designed amphiphilic \u03b1-helical peptide Z2 exhibits broad-spectrum antimicrobial, anti-biofilm, and anti-inflammatory efficacy in acute Pseudomonas aeruginosa pneumonia"],"prefix":"10.1016","volume":"157","author":[{"given":"Meng-Yue","family":"Zhang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuang","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu-Ling","family":"Han","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi-Fan","family":"Shi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying-Ying","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan","family":"Cheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cai-Yun","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xun-Yong","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi-Xuan","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bioorg.2025.108309_bb0005","doi-asserted-by":"crossref","DOI":"10.1016\/j.drup.2023.100954","article-title":"Antimicrobial peptides for combating drug-resistant bacterial infections","volume":"68","author":"Xuan","year":"2023","journal-title":"Drug Resist. Updat."},{"key":"10.1016\/j.bioorg.2025.108309_bb0010","first-page":"1","article-title":"Anti-Pseudomonas aeruginosa activity of natural antimicrobial peptides when used alone or in combination with antibiotics","volume":"14","author":"Chen","year":"2023","journal-title":"Front. Microbiol."},{"issue":"47","key":"10.1016\/j.bioorg.2025.108309_bb0015","doi-asserted-by":"crossref","first-page":"12827","DOI":"10.1002\/anie.201409270","article-title":"Combining topology and sequence Design for the Discovery of potent antimicrobial peptide dendrimers against multidrug-resistant Pseudomonas aeruginosa","volume":"53","author":"Stach","year":"2014","journal-title":"Angew. Chem. Int. Ed. Eng."},{"issue":"11","key":"10.1016\/j.bioorg.2025.108309_bb0020","doi-asserted-by":"crossref","first-page":"9451","DOI":"10.3390\/ijms24119451","article-title":"Creation of new antimicrobial peptides","volume":"24","author":"Galzitskaya","year":"2023","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.bioorg.2025.108309_bb0025","doi-asserted-by":"crossref","DOI":"10.1016\/j.bioorg.2019.103038","article-title":"Repurposing the scorpion venom peptide VmCT1 into an active peptide against gram-negative ESKAPE pathogens","volume":"90","author":"Pedron","year":"2019","journal-title":"Bioorg. Chem."},{"key":"10.1016\/j.bioorg.2025.108309_bb0030","first-page":"305","article-title":"Specifically targeted antimicrobial peptides synergize with bacterial-entrapping peptide against systemic MRSA infections","volume":"67","author":"Xu","year":"2024","journal-title":"J. Adv. Res."},{"key":"10.1016\/j.bioorg.2025.108309_bb0035","doi-asserted-by":"crossref","DOI":"10.1016\/j.bioorg.2024.107821","article-title":"Impact of lipidation site on the activity of \u03b1-helical antimicrobial peptides","volume":"153","author":"Makowska","year":"2024","journal-title":"Bioorg. Chem."},{"issue":"9","key":"10.1016\/j.bioorg.2025.108309_bb0040","doi-asserted-by":"crossref","first-page":"2278","DOI":"10.3390\/pharmaceutics15092278","article-title":"The contribution of antimicrobial peptides to immune cell function: a review of recent advances","volume":"15","author":"Li","year":"2023","journal-title":"Pharmaceutics"},{"key":"10.1016\/j.bioorg.2025.108309_bb0045","doi-asserted-by":"crossref","DOI":"10.1016\/j.bioorg.2024.107239","article-title":"Hydrocarbon stapled temporin-L analogue as potential antibacterial and antiendotoxin agents with enhanced protease stability","volume":"145","author":"Mahto","year":"2024","journal-title":"Bioorg. Chem."},{"key":"10.1016\/j.bioorg.2025.108309_bb0050","doi-asserted-by":"crossref","DOI":"10.1016\/j.bioorg.2024.107151","article-title":"Recent advances in antimicrobial peptide-based therapy","volume":"145","author":"Mulukutla","year":"2024","journal-title":"Bioorg. Chem."},{"issue":"5","key":"10.1016\/j.bioorg.2025.108309_bb0055","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1038\/s41573-019-0058-8","article-title":"Antimicrobial host defence peptides: functions and clinical potential","volume":"19","author":"Mookherjee","year":"2020","journal-title":"Nat. Rev. Drug Discov."},{"issue":"16","key":"10.1016\/j.bioorg.2025.108309_bb0060","doi-asserted-by":"crossref","first-page":"6382","DOI":"10.1073\/pnas.1219059110","article-title":"Common mechanism unites membrane poration by amyloid and antimicrobial peptides","volume":"110","author":"Last","year":"2013","journal-title":"Proc. Natl. Acad. Sci. USA"},{"issue":"1","key":"10.1016\/j.bioorg.2025.108309_bb0065","doi-asserted-by":"crossref","first-page":"7170","DOI":"10.1038\/s41467-023-42374-4","article-title":"Targeting nucleic acid phase transitions as a mechanism of action for antimicrobial peptides","volume":"14","author":"Sneideris","year":"2023","journal-title":"Nat. Commun."},{"issue":"2","key":"10.1016\/j.bioorg.2025.108309_bb0070","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1515\/pac-2018-0704","article-title":"Using chemical synthesis to optimise antimicrobial peptides in the fight against antimicrobial resistance","volume":"91","author":"Li","year":"2019","journal-title":"Pure Appl. Chem."},{"issue":"1","key":"10.1016\/j.bioorg.2025.108309_bb0075","doi-asserted-by":"crossref","first-page":"244","DOI":"10.1016\/j.actbio.2013.08.043","article-title":"Design of imperfectly amphipathic \u03b1-helical antimicrobial peptides with enhanced cell selectivity","volume":"10","author":"Zhu","year":"2014","journal-title":"Acta Biomater."},{"key":"10.1016\/j.bioorg.2025.108309_bb0080","doi-asserted-by":"crossref","DOI":"10.1016\/j.bioorg.2022.106251","article-title":"C-terminal modification of a<i> de<\/i><i> novo<\/i> designed antimicrobial peptide via capping of macrolactam rings","volume":"130","author":"Zeng","year":"2023","journal-title":"Bioorg. Chem."},{"issue":"1","key":"10.1016\/j.bioorg.2025.108309_bb0085","doi-asserted-by":"crossref","first-page":"7197","DOI":"10.1038\/s41467-023-42434-9","article-title":"Cell-free biosynthesis combined with deep learning accelerates de novo-development of antimicrobial peptides","volume":"14","author":"Pandi","year":"2023","journal-title":"Nat. Commun."},{"issue":"12","key":"10.1016\/j.bioorg.2025.108309_bb0090","doi-asserted-by":"crossref","first-page":"2632","DOI":"10.1021\/acsinfecdis.3c00468","article-title":"Establishing quantifiable guidelines for antimicrobial \u03b1\/\u03b2-peptide design: a partial least-squares approach to improve antimicrobial activity and reduce mammalian cell toxicity","volume":"9","author":"Chang","year":"2023","journal-title":"ACS Infect. Dis."},{"issue":"22","key":"10.1016\/j.bioorg.2025.108309_bb0095","doi-asserted-by":"crossref","first-page":"8624","DOI":"10.3390\/ijms21228624","article-title":"Effects of rationally designed Physico-chemical variants of the peptide PuroA on biocidal activity towards bacterial and mammalian cells","volume":"21","author":"Shagaghi","year":"2020","journal-title":"Int. J. Mol. Sci."},{"issue":"5","key":"10.1016\/j.bioorg.2025.108309_bb0100","doi-asserted-by":"crossref","first-page":"2727","DOI":"10.1021\/acs.jafc.3c08241","article-title":"Chickpea-derived modified antimicrobial peptides KTA and KTR inactivate Staphylococcus aureus via disrupting cell membrane and interfering with peptidoglycan synthesis","volume":"72","author":"Zhang","year":"2024","journal-title":"J. Agric. Food Chem."},{"issue":"9","key":"10.1016\/j.bioorg.2025.108309_bb0105","doi-asserted-by":"crossref","first-page":"1307","DOI":"10.1007\/s11426-013-4884-y","article-title":"Comparison on effect of hydrophobicity on the antibacterial and antifungal activities of \u03b1-helical antimicrobial peptides","volume":"56","author":"Zhao","year":"2013","journal-title":"Sci. China Chem."},{"issue":"3","key":"10.1016\/j.bioorg.2025.108309_bb0110","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1128\/CMR.00056-05","article-title":"Peptide antimicrobial agents","volume":"19","author":"Jenssen","year":"2006","journal-title":"Clin. Microbiol. Rev."},{"issue":"22","key":"10.1016\/j.bioorg.2025.108309_bb0115","doi-asserted-by":"crossref","first-page":"6483","DOI":"10.1111\/j.1742-4658.2009.07359.x","article-title":"Multifunctional host defense peptides: intracellular-targeting antimicrobial peptides","volume":"276","author":"Nicolas","year":"2009","journal-title":"FEBS J."},{"issue":"69","key":"10.1016\/j.bioorg.2025.108309_bb0120","doi-asserted-by":"crossref","first-page":"9631","DOI":"10.1039\/C8CC04407D","article-title":"Tuning of protease resistance in oligopeptides through N-alkylation","volume":"54","author":"Kaminker","year":"2018","journal-title":"Chem. Commun."},{"issue":"12","key":"10.1016\/j.bioorg.2025.108309_bb0125","doi-asserted-by":"crossref","first-page":"2065","DOI":"10.3390\/pharmaceutics13122065","article-title":"Protease-resistant peptides for targeting and intracellular delivery of therapeutics","volume":"13","author":"Lucana","year":"2021","journal-title":"Pharmaceutics"},{"key":"10.1016\/j.bioorg.2025.108309_bb0130","doi-asserted-by":"crossref","first-page":"2869","DOI":"10.3762\/bjoc.13.279","article-title":"Position-dependent impact of hexafluoroleucine and trifluoroisoleucine on protease digestion","volume":"13","author":"Huhmann","year":"2017","journal-title":"Beilstein J. Org. Chem."},{"key":"10.1016\/j.bioorg.2025.108309_bb0135","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1016\/j.actbio.2023.04.030","article-title":"Boosting stability and therapeutic potential of proteolysis-resistant antimicrobial peptides by end-tagging \u03b2-naphthylalanine","volume":"164","author":"He","year":"2023","journal-title":"Acta Biomater."},{"issue":"4","key":"10.1016\/j.bioorg.2025.108309_bb0140","doi-asserted-by":"crossref","first-page":"1470","DOI":"10.3390\/ijms21041470","article-title":"Hybridization with insect Cecropin a (1-8) improve the stability and selectivity of naturally occurring peptides","volume":"21","author":"Yang","year":"2020","journal-title":"Int. J. Mol. Sci."},{"issue":"1","key":"10.1016\/j.bioorg.2025.108309_bb0145","doi-asserted-by":"crossref","first-page":"738","DOI":"10.1021\/acs.molpharmaceut.2c00918","article-title":"Peptide stability is important but not a general requirement for antimicrobial and Antibiofilm activity in vitro and in vivo","volume":"20","author":"Decker","year":"2023","journal-title":"Mol. Pharm."},{"issue":"1","key":"10.1016\/j.bioorg.2025.108309_bb0150","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1111\/bcp.12706","article-title":"The law of mass action and the pharmacological concentration-effect curve: resolving the paradox of apparently non-dose-related adverse drug reactions","volume":"81","author":"Aronson","year":"2016","journal-title":"Br. J. Clin. Pharmacol."},{"issue":"3","key":"10.1016\/j.bioorg.2025.108309_bb0155","doi-asserted-by":"crossref","first-page":"672","DOI":"10.1021\/acsinfecdis.0c00871","article-title":"Random peptide mixtures as safe and effective antimicrobials against Pseudomonas aeruginosa and MRSA in mouse models of bacteremia and pneumonia","volume":"7","author":"Bennett","year":"2021","journal-title":"ACS Infect. Dis."},{"issue":"12","key":"10.1016\/j.bioorg.2025.108309_bb0160","doi-asserted-by":"crossref","first-page":"1057","DOI":"10.1016\/S1473-3099(13)70318-9","article-title":"Antibiotic resistance-the need for global solutions","volume":"13","author":"Laxminarayan","year":"2013","journal-title":"Lancet Infect. Dis."},{"key":"10.1016\/j.bioorg.2025.108309_bb0165","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/j.actbio.2017.04.032","article-title":"Disruption of drug-resistant biofilms using de novo designed short \u03b1-helical antimicrobial peptides with idealized facial amphiphilicity","volume":"57","author":"Khara","year":"2017","journal-title":"Acta Biomater."},{"issue":"12","key":"10.1016\/j.bioorg.2025.108309_bb0170","doi-asserted-by":"crossref","first-page":"1551","DOI":"10.1038\/nbt1267","article-title":"Antimicrobial and host-defense peptides as new anti-infective therapeutic strategies","volume":"24","author":"Hancock","year":"2006","journal-title":"Nat. Biotechnol."},{"issue":"10","key":"10.1016\/j.bioorg.2025.108309_bb0175","doi-asserted-by":"crossref","first-page":"1186","DOI":"10.1038\/s41587-019-0222-z","article-title":"Design of stapled antimicrobial peptides that are stable, nontoxic and kill antibiotic-resistant bacteria in mice","volume":"37","author":"Mourtada","year":"2019","journal-title":"Nat. Biotechnol."},{"issue":"1","key":"10.1016\/j.bioorg.2025.108309_bb0180","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1038\/nrd3591","article-title":"Designing antimicrobial peptides: form follows function","volume":"11","author":"Fjell","year":"2012","journal-title":"Nat. Rev. Drug Discov."},{"key":"10.1016\/j.bioorg.2025.108309_bb0185","doi-asserted-by":"crossref","first-page":"2263","DOI":"10.1038\/s41467-017-02475-3","article-title":"Antimicrobial peptide capsids of de novo design","volume":"8","author":"De Santis","year":"2017","journal-title":"Nat. Commun."},{"issue":"3","key":"10.1016\/j.bioorg.2025.108309_bb0190","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1007\/s11426-016-0415-6","article-title":"Effects of chain length and hydrophobicity\/charge ratio of AMP on its antimicrobial activity","volume":"60","author":"Yu","year":"2017","journal-title":"Sci. China Chem."},{"issue":"5","key":"10.1016\/j.bioorg.2025.108309_bb0195","doi-asserted-by":"crossref","first-page":"1220","DOI":"10.3390\/molecules23051220","article-title":"Broad-Spectrum antimicrobial activity and low cytotoxicity against human cells of a peptide derived from bovine \u03b1S1-casein","volume":"23","author":"Hou","year":"2018","journal-title":"Molecules"},{"issue":"4","key":"10.1016\/j.bioorg.2025.108309_bb0200","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1038\/s41579-019-0158-9","article-title":"Bacteria and archaea on earth and their abundance in biofilms","volume":"17","author":"Flemming","year":"2019","journal-title":"Nat. Rev. Microbiol."},{"issue":"1","key":"10.1016\/j.bioorg.2025.108309_bb0205","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1080\/14787210.2018.1417036","article-title":"Biofilm-related disease","volume":"16","author":"Luis Del Pozo","year":"2018","journal-title":"Expert Rev. Anti-Infect. Ther."},{"issue":"2","key":"10.1016\/j.bioorg.2025.108309_bb0210","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1128\/CMR.15.2.167-193.2002","article-title":"Biofilms: survival mechanisms of clinically relevant microorganisms","volume":"15","author":"Donlan","year":"2002","journal-title":"Clin. Microbiol. Rev."},{"issue":"2","key":"10.1016\/j.bioorg.2025.108309_bb0215","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1016\/j.chom.2007.06.010","article-title":"Host-mediated inflammation disrupts the intestinal microbiota and promotes the overgrowth of Enterobacteriaceae","volume":"2","author":"Lupp","year":"2007","journal-title":"Cell Host Microbe"},{"issue":"6","key":"10.1016\/j.bioorg.2025.108309_bb0220","doi-asserted-by":"crossref","first-page":"504","DOI":"10.2174\/13892037113149990067","article-title":"Cathelicidins: peptides with antimicrobial, immunomodulatory, anti-inflammatory, Angiogenic, anticancer and Procancer activities","volume":"14","author":"Wong","year":"2013","journal-title":"Curr. Protein Pept. Sci."},{"issue":"1","key":"10.1016\/j.bioorg.2025.108309_bb0225","first-page":"14","article-title":"Aging as a risk factor on the Immunoexpression of pro-inflammatory IL-1\u03b2, IL-6 and TNF-\u03b1 cytokines in chronic apical periodontitis lesions","volume":"11","author":"Teixeira","year":"2022","journal-title":"Biology (Basel)"},{"key":"10.1016\/j.bioorg.2025.108309_bb0230","doi-asserted-by":"crossref","first-page":"212","DOI":"10.3389\/fphar.2018.00212","article-title":"Purinergic ligands as potential therapeutic tools for the treatment of inflammation-related intestinal diseases","volume":"9","author":"Dal Ben","year":"2018","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.bioorg.2025.108309_bb0235","doi-asserted-by":"crossref","DOI":"10.3389\/fbioe.2021.821288","article-title":"Reactive oxygen species-based biomaterials for regenerative medicine and tissue engineering applications","volume":"9","author":"Shafiq","year":"2021","journal-title":"Front. Bioeng. Biotechnol."},{"issue":"3","key":"10.1016\/j.bioorg.2025.108309_bb0240","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1023\/A:1015474228621","article-title":"Antimicrobial activity of myeloperoxidase from neutrophilic peroxisome","volume":"29","author":"But","year":"2002","journal-title":"Biol. Bull."},{"issue":"11","key":"10.1016\/j.bioorg.2025.108309_bb0245","doi-asserted-by":"crossref","first-page":"2302","DOI":"10.3390\/antiox11112302","article-title":"Myeloperoxidase: regulation of neutrophil function and target for therapy","volume":"11","author":"Rizo-T\u00e9llez","year":"2022","journal-title":"Antioxidants"},{"issue":"7","key":"10.1016\/j.bioorg.2025.108309_bb0250","doi-asserted-by":"crossref","first-page":"1094","DOI":"10.1111\/cmi.12263","article-title":"Pseudomonas aeruginosa homoserine lactone triggers apoptosis and Bak\/Bax-independent release of mitochondrial cytochrome C in fibroblasts","volume":"16","author":"Schwarzer","year":"2014","journal-title":"Cell. Microbiol."}],"container-title":["Bioorganic Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0045206825001890?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0045206825001890?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,22]],"date-time":"2025-11-22T21:38:21Z","timestamp":1763847501000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0045206825001890"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,4]]},"references-count":50,"alternative-id":["S0045206825001890"],"URL":"https:\/\/doi.org\/10.1016\/j.bioorg.2025.108309","relation":{},"ISSN":["0045-2068"],"issn-type":[{"value":"0045-2068","type":"print"}],"subject":[],"published":{"date-parts":[[2025,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"De novo-designed amphiphilic \u03b1-helical peptide Z2 exhibits broad-spectrum antimicrobial, anti-biofilm, and anti-inflammatory efficacy in acute Pseudomonas aeruginosa pneumonia","name":"articletitle","label":"Article Title"},{"value":"Bioorganic Chemistry","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bioorg.2025.108309","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"108309"}}