{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,20]],"date-time":"2026-07-20T11:42:58Z","timestamp":1784547778972,"version":"3.55.0"},"reference-count":79,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T00:00:00Z","timestamp":1748736000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T00:00:00Z","timestamp":1748736000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T00:00:00Z","timestamp":1748736000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T00:00:00Z","timestamp":1748736000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T00:00:00Z","timestamp":1748736000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T00:00:00Z","timestamp":1748736000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T00:00:00Z","timestamp":1748736000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Bioorganic Chemistry"],"published-print":{"date-parts":[[2025,6]]},"DOI":"10.1016\/j.bioorg.2025.108335","type":"journal-article","created":{"date-parts":[[2025,3,6]],"date-time":"2025-03-06T00:08:56Z","timestamp":1741219736000},"page":"108335","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":5,"special_numbering":"C","title":["Development of novel amino-benzenesulfonamide derivatives and their analogues as carbonic anhydrase inhibitors: Design, synthesis, anticancer activity assessment, and pharmacokinetic studies using UPLC-MS\/MS"],"prefix":"10.1016","volume":"159","author":[{"given":"Khaled A.","family":"Elsayad","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ghada F.","family":"Elmasry","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sally T.","family":"Mahmoud","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fadi M.","family":"Awadallah","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simone","family":"Giovannuzzi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudiu T.","family":"Supuran","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bioorg.2025.108335_bb0005","series-title":"The Carbonic Anhydrases in Health and Disease, the Carbonic Anhydrases: Current and Emerging Therapeutic Targets","first-page":"1","author":"Chegwidden","year":"2021"},{"key":"10.1016\/j.bioorg.2025.108335_bb0010","doi-asserted-by":"crossref","DOI":"10.1039\/D4CC05003G","article-title":"Implications of non-native metal substitution in carbonic anhydrase-engineered enzymes and models","author":"Bhandary","year":"2025","journal-title":"Chem. Commun."},{"key":"10.1016\/j.bioorg.2025.108335_bb0015","doi-asserted-by":"crossref","first-page":"107409","DOI":"10.1016\/j.bioorg.2024.107409","article-title":"Sulfonamides as anticancer agents: a brief review on sulfonamide derivatives as inhibitors of various proteins overexpressed in cancer","author":"Elsayad","year":"2024","journal-title":"Bioorg. Chem."},{"key":"10.1016\/j.bioorg.2025.108335_bb0020","first-page":"139","article-title":"Carbonic anhydrases, in metalloenzymes","author":"Supuran","year":"2024","journal-title":"Elsiever"},{"key":"10.1016\/j.bioorg.2025.108335_bb0025","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1186\/s13058-023-01644-1","article-title":"Carbonic anhydrases reduce the acidity of the tumor microenvironment, promote immune infiltration, decelerate tumor growth, and improve survival in ErbB2\/HER2-enriched breast cancer","volume":"25","author":"Lee","year":"2023","journal-title":"Breast Cancer Res."},{"key":"10.1016\/j.bioorg.2025.108335_bb0030","doi-asserted-by":"crossref","first-page":"1834","DOI":"10.1080\/14756366.2020.1826942","article-title":"Sulphonamide inhibition profile of Staphylococcus aureus \u03b2-carbonic anhydrase","volume":"35","author":"Urbanski","year":"2020","journal-title":"J. Enzyme Inhib. Med. Chem."},{"key":"10.1016\/j.bioorg.2025.108335_bb0035","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1186\/s12915-021-01039-8","article-title":"Characterization of a novel type of carbonic anhydrase that acts without metal cofactors","volume":"19","author":"Hirakawa","year":"2021","journal-title":"BMC Biol."},{"key":"10.1016\/j.bioorg.2025.108335_bb0040","article-title":"Carbonic anhydrase isoforms of pyropia yezoensis: intracellular location and expression profiles in response to inorganic carbon concentration and life stage","author":"Zhang","year":"2021","journal-title":"Res. Sq."},{"issue":"2","key":"10.1016\/j.bioorg.2025.108335_bb0045","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1113\/JP283579","article-title":"Mitochondrial carbonic anhydrase VA and VB: properties and roles in health and disease","volume":"601","author":"Aspatwar","year":"2023","journal-title":"J. Physiol."},{"issue":"2","key":"10.1016\/j.bioorg.2025.108335_bb0050","doi-asserted-by":"crossref","first-page":"25","DOI":"10.3390\/metabo8020025","article-title":"Carbonic anhydrases and metabolism","volume":"8","author":"Supuran","year":"2018","journal-title":"Metabolites"},{"key":"10.1016\/j.bioorg.2025.108335_bb0055","first-page":"18","article-title":"Prediction of activity and selectivity profiles of human carbonic anhydrase inhibitors using machine learning classification models","volume":"13","author":"Tinivella","year":"2021","journal-title":"J. Chemother."},{"key":"10.1016\/j.bioorg.2025.108335_bb0060","doi-asserted-by":"crossref","first-page":"4595","DOI":"10.3390\/ijms24054595","article-title":"Expression dynamics of CA IX epitope in cancer cells under intermittent hypoxia correlates with extracellular pH drop and cell killing by ureido-sulfonamide CA IX inhibitors","volume":"24","author":"Sufian","year":"2023","journal-title":"IInt. J. Mol. Sci."},{"key":"10.1016\/j.bioorg.2025.108335_bb0065","doi-asserted-by":"crossref","DOI":"10.3389\/fnagi.2021.772278","article-title":"Carbonic anhydrases as potential targets against neurovascular unit dysfunction in Alzheimer\u2019s disease and stroke","volume":"13","author":"Lemon","year":"2021","journal-title":"Front. Aging Neurosci."},{"key":"10.1016\/j.bioorg.2025.108335_bb0070","doi-asserted-by":"crossref","first-page":"14115","DOI":"10.3390\/ijms232214115","article-title":"Benzenesulfonamides incorporating hydantoin moieties effectively inhibit eukaryotic and human carbonic anhydrases","volume":"23","author":"Abdoli","year":"2022","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.bioorg.2025.108335_bb0075","first-page":"543","article-title":"Post-Translational Modifications in Tumor-Associated Carbonic Anhydrases","volume":"54","author":"Fiore","year":"2022"},{"key":"10.1016\/j.bioorg.2025.108335_bb0080","doi-asserted-by":"crossref","first-page":"701","DOI":"10.1080\/13543776.2023.2245971","article-title":"Targeting carbonic anhydrases for the management of hypoxic metastatic tumors","volume":"33","author":"Supuran","year":"2023","journal-title":"Expert Opin. Ther. Pat."},{"key":"10.1016\/j.bioorg.2025.108335_bb0085","doi-asserted-by":"crossref","DOI":"10.1080\/14756366.2023.2270180","article-title":"Design, synthesis, and biological investigation of selective human carbonic anhydrase II, IX, and XII inhibitors using 7-aryl\/heteroaryl triazolopyrimidines bearing a sulfanilamide scaffold","volume":"38","author":"Romagnoli","year":"2023","journal-title":"J. Enzyme Inhib. Med. Chem."},{"key":"10.1016\/j.bioorg.2025.108335_bb0090","doi-asserted-by":"crossref","first-page":"12291","DOI":"10.3390\/ijms252212291","article-title":"Sulfonamide-based inhibition of the \u03b2-carbonic anhydrase from a. baumannii, a multidrug-resistant bacterium","volume":"25","author":"Luca","year":"2024","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.bioorg.2025.108335_bb0095","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1007\/s10555-019-09799-0","article-title":"The role of carbonic anhydrase IX in cancer development: links to hypoxia, acidosis, and beyond","volume":"38","author":"Pastorekova","year":"2019","journal-title":"Cancer Metastasis Rev."},{"key":"10.1016\/j.bioorg.2025.108335_bb0100","doi-asserted-by":"crossref","first-page":"13405","DOI":"10.3390\/ijms222413405","article-title":"Carbonic anhydrase IX inhibitors as candidates for combination therapy of solid tumors","volume":"22","author":"Kalinin","year":"2021","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.bioorg.2025.108335_bb0105","first-page":"65","article-title":"Benzenesulfonamide based 1, 3, 4-oxadiazole derivatives: synthesis, pharmacokinetic property prediction, bovine carbonic anhydrase activity and molecular docking studies","author":"Alp\u0131nar","year":"2023","journal-title":"J. Sulfur Chem."},{"key":"10.1016\/j.bioorg.2025.108335_bb0110","series-title":"Carbonic anhydrase inhibitors: designing isozyme-specific inhibitors as therapeutic agents, in the carbonic anhydrases: current and emerging therapeutic targets","first-page":"221","author":"Supuran","year":"2021"},{"key":"10.1016\/j.bioorg.2025.108335_bb0115","doi-asserted-by":"crossref","DOI":"10.1002\/ardp.202400073","article-title":"Chemistry of heterocycles as carbonic anhydrase inhibitors: a pathway to novel research in medicinal chemistry review","author":"Bendi","year":"2024","journal-title":"Arch. Pharm."},{"key":"10.1016\/j.bioorg.2025.108335_bb0120","doi-asserted-by":"crossref","first-page":"3220","DOI":"10.3390\/molecules28073220","article-title":"Five-membered heterocyclic sulfonamides as carbonic anhydrase inhibitors","volume":"28","author":"Angeli","year":"2023","journal-title":"Mol"},{"key":"10.1016\/j.bioorg.2025.108335_bb0125","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1080\/13543784.2024.2334714","article-title":"Novel carbonic anhydrase inhibitors for the treatment of helicobacter pylori infection","volume":"33","author":"Supuran","year":"2024","journal-title":"Expert Opin. Investig. Drugs"},{"key":"10.1016\/j.bioorg.2025.108335_bb0130","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1080\/17425255.2024.2328152","article-title":"Drug interactions of carbonic anhydrase inhibitors and activators","volume":"20","author":"Supuran","year":"2024","journal-title":"Expert Opin. Drug Metab. Toxicol."},{"key":"10.1016\/j.bioorg.2025.108335_bb0135","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejmech.2021.114004","article-title":"Application of the dual-tail approach for the design and synthesis of novel thiopyrimidine\u2013benzenesulfonamide hybrids as selective carbonic anhydrase inhibitors","volume":"228","author":"Abdel-Mohsen","year":"2022","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.bioorg.2025.108335_bb0140","doi-asserted-by":"crossref","DOI":"10.1016\/j.bioorg.2022.105920","article-title":"A decade of tail-approach based design of selective as well as potent tumor associated carbonic anhydrase inhibitors","volume":"126","author":"Kumar","year":"2022","journal-title":"Bioorg. Chem."},{"key":"10.1016\/j.bioorg.2025.108335_bb0145","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejmech.2020.112112","article-title":"Inclusion of a 5-fluorouracil moiety in nitrogenous bases derivatives as human carbonic anhydrase IX and XII inhibitors produced a targeted action against MDA-MB-231 and T47D breast cancer cells","volume":"190","author":"Petreni","year":"2020","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.bioorg.2025.108335_bb0150","doi-asserted-by":"crossref","DOI":"10.1016\/j.bmc.2024.117933","article-title":"Carbonic anhydrases: moiety appended derivatives, medicinal and pharmacological implications","volume":"114","author":"Jaitak","year":"2024","journal-title":"Bioorg. Med. Chem."},{"key":"10.1016\/j.bioorg.2025.108335_bb0155","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejmech.2022.114412","article-title":"Mohamed Fares, development of 4-((3-oxo-3-phenylpropyl) amino) benzenesulfonamide derivatives utilizing tail\/dual-tail approaches as novel carbonic anhydrase inhibitors","volume":"238","author":"Elbadawi","year":"2022","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.bioorg.2025.108335_bb0160","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejmech.2022.114190","article-title":"Discovery of new carbonic anhydrase IX inhibitors as anticancer agents by toning the hydrophobic and hydrophilic rims of the active site to encounter the dual-tail approach","volume":"232","author":"Tawfik","year":"2022","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.bioorg.2025.108335_bb0165","doi-asserted-by":"crossref","first-page":"7666","DOI":"10.1021\/acsomega.2c07285","article-title":"Terminators or guardians? Design, synthesis, and cytotoxicity profiling of chalcone-sulfonamide hybrids","volume":"8","author":"Aboukhatwa","year":"2023","journal-title":"ACS Omega"},{"key":"10.1016\/j.bioorg.2025.108335_bb0170","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejmech.2024.116527","article-title":"A new framework for novel analogues of pazopanib as potent and selective human carbonic anhydrase inhibitors: design, repurposing rational, synthesis, crystallographic, in vivo and in vitro biological assessments","author":"Hefny","year":"2024","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.bioorg.2025.108335_bb0175","doi-asserted-by":"crossref","first-page":"634","DOI":"10.3389\/fchem.2019.00634","article-title":"Biological activity evaluation of some new benzenesulphonamide derivatives","volume":"7","author":"Eze","year":"2019","journal-title":"Front. Chem."},{"key":"10.1016\/j.bioorg.2025.108335_bb0180","first-page":"301","article-title":"Synthesis of some novel dipeptides and their copper (II) complexes of (dibenzo [b, d] furan-2-ylsulfonyl) phenylalanine","author":"Moustafa","year":"2025","journal-title":"Bull. Chem. Soc. Ethiop."},{"key":"10.1016\/j.bioorg.2025.108335_bb0185","doi-asserted-by":"crossref","first-page":"721","DOI":"10.3390\/md20110721","article-title":"Carbonic anhydrase inhibitors from marine natural products","volume":"20","author":"Supuran","year":"2022","journal-title":"Mar. Drugs"},{"key":"10.1016\/j.bioorg.2025.108335_bb0190","doi-asserted-by":"crossref","DOI":"10.1016\/j.bmcl.2023.129411","article-title":"A simple yet multifaceted 90 years old, evergreen enzyme: carbonic anhydrase, its inhibition and activation","author":"Supuran","year":"2023","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"10.1016\/j.bioorg.2025.108335_bb0195","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1021\/acsmedchemlett.1c00644","article-title":"Interaction studies between carbonic anhydrase and a sulfonamide inhibitor by experimental and theoretical approaches","volume":"13","author":"Pagnozzi","year":"2022","journal-title":"ACS Med. Chem. Lett."},{"key":"10.1016\/j.bioorg.2025.108335_bb0200","doi-asserted-by":"crossref","first-page":"461","DOI":"10.3390\/ijms23010461","article-title":"Aromatic sulfonamides including a sulfonic acid tail: new membrane impermeant carbonic anhydrase inhibitors for targeting selectively the cancer-associated isoforms","volume":"23","author":"Giovannuzzi","year":"2021","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.bioorg.2025.108335_bb0205","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1080\/14756366.2022.2132485","article-title":"Design and synthesis of some new benzoylthioureido benzenesulfonamide derivatives and their analogues as carbonic anhydrase inhibitors","volume":"38","author":"Oudah","year":"2023","journal-title":"J. Enzyme Inhib. Med. Chem."},{"key":"10.1016\/j.bioorg.2025.108335_bb0210","doi-asserted-by":"crossref","first-page":"7422","DOI":"10.1021\/acs.jmedchem.0c00733","article-title":"Sulfonamide inhibitors of human carbonic anhydrases designed through a three-tails approach: improving ligand\/isoform matching and selectivity of action","volume":"63","author":"Bonardi","year":"2020","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.bioorg.2025.108335_bb0215","first-page":"12291","article-title":"Multi-and poly-pharmacology of carbonic anhydrase inhibitors","author":"Supuran","year":"2024","journal-title":"Pharmacol. Rev."},{"key":"10.1016\/j.bioorg.2025.108335_bb0220","article-title":"Carbonic anhydrase IX: an atypical target for innovative therapies in cancer","volume":"189120","author":"Ronca","year":"2024","journal-title":"BBA - Rev."},{"key":"10.1016\/j.bioorg.2025.108335_bb0225","doi-asserted-by":"crossref","first-page":"20438","DOI":"10.1021\/acs.jmedchem.4c01894","article-title":"4-(Pyrazolyl) benzenesulfonamide Ureas as carbonic anhydrases inhibitors and hypoxia-mediated chemo-sensitizing agents in colorectal cancer cells","author":"Eldehna","year":"2024","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.bioorg.2025.108335_bb0230","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejmech.2023.115538","article-title":"Design and synthesis of 6-arylpyridine-tethered sulfonamides as novel selective inhibitors of carbonic anhydrase IX with promising antitumor features toward the human colorectal cancer","volume":"258","author":"Eldehna","year":"2023","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.bioorg.2025.108335_bb0235","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1080\/13543776.2024.2353625","article-title":"Anticancer drugs: where are we now?, expert Opin","author":"Simone","year":"2024","journal-title":"Ther. Pat."},{"key":"10.1016\/j.bioorg.2025.108335_bb0240","doi-asserted-by":"crossref","DOI":"10.3390\/ijms251810006","article-title":"Hydrogen sulfide-releasing carbonic anhydrase inhibitors effectively suppress cancer cell growth","volume":"25","author":"Bonardi","year":"2024","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.bioorg.2025.108335_bb0245","doi-asserted-by":"crossref","first-page":"26241","DOI":"10.1039\/D1RA05277B","article-title":"Design, synthesis and mechanistic study of new benzenesulfonamide derivatives as anticancer and antimicrobial agents via carbonic anhydrase IX inhibition","volume":"11","author":"Nemra","year":"2021","journal-title":"RSC Adv."},{"key":"10.1016\/j.bioorg.2025.108335_bb0250","doi-asserted-by":"crossref","first-page":"897","DOI":"10.1080\/14728222.2023.2263914","article-title":"An overview of novel antimicrobial carbonic anhydrase inhibitors","volume":"27","author":"Supuran","year":"2023","journal-title":"Expert Opin. Ther. Targets"},{"key":"10.1016\/j.bioorg.2025.108335_bb0255","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/B978-0-443-15635-9.00003-1","article-title":"Prodrugs: general concepts and prodrug design in medicinal chemistry","author":"Tanini","year":"2025","journal-title":"Adv. Prodrug."},{"key":"10.1016\/j.bioorg.2025.108335_bb0260","doi-asserted-by":"crossref","first-page":"1411","DOI":"10.1016\/j.tetlet.2006.12.101","article-title":"Photochemical \u03b1-bromination of ketones using N-bromosuccinimide: a simple, mild and efficient method","volume":"48","author":"Arbuj","year":"2007","journal-title":"Etrahedron Lett."},{"key":"10.1016\/j.bioorg.2025.108335_bb0265","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejmech.2023.115805","article-title":"Exploring novel anticancer pyrazole benzenesulfonamides featuring tail approach strategy as carbonic anhydrase inhibitors","volume":"261","author":"Ahmed","year":"2023","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.bioorg.2025.108335_bb0270","doi-asserted-by":"crossref","first-page":"1341","DOI":"10.1007\/s00109-017-1590-9","article-title":"Carbonic anhydrase IX inhibition affects viability of cancer cells adapted to extra cellular acidosis","author":"Andreucci","year":"2017","journal-title":"J. Mo.l Med. Berl."},{"key":"10.1016\/j.bioorg.2025.108335_bb0275","first-page":"117","article-title":"The carbonic anhydrase IX inhibitor SLC-0111 sensitises cancer cells to conventional chemotherapy","author":"Andreucci","year":"2018","journal-title":"J. Enzyme Inhib. Med. Chem."},{"key":"10.1016\/j.bioorg.2025.108335_bb0280","doi-asserted-by":"crossref","first-page":"1540174","DOI":"10.3389\/fchem.2025.1540174","article-title":"Antioxidant activity and selective cytotoxicity in HCT-116 and WI-38 cell lines of LC-MS\/MS profiled extract from Capparis spinosa L","volume":"13","author":"Oraibia","year":"2025","journal-title":"Front. Chem."},{"key":"10.1016\/j.bioorg.2025.108335_bb0285","article-title":"Green chemistry approach for the removal of Delafloxacin from aqueous solutions using calcinated layered double hydroxide: adsorption mechanism and material characterization","volume":"27","author":"Mahgoub","year":"2025","journal-title":"Sci. Afr."},{"key":"10.1016\/j.bioorg.2025.108335_bb0290","doi-asserted-by":"crossref","first-page":"4860","DOI":"10.1021\/acs.molpharmaceut.4c00786","article-title":"A perspective on the permeability of Cocrystals\/organic salts of Oral drugs","author":"Samie","year":"2024","journal-title":"Mol. Pharm."},{"key":"10.1016\/j.bioorg.2025.108335_bb0295","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1080\/13543776.2018.1473379","article-title":"Benzoxaborole compounds for therapeutic uses: a patent review (2010-2018)","volume":"28","author":"Nocentini","year":"2018","journal-title":"Expert Opin. Ther. Pat."},{"key":"10.1016\/j.bioorg.2025.108335_bb0300","first-page":"357","article-title":"Pharmacokinetics and pharmacodynamics: fundamentals and role (s) in drug discovery and development, recent Adv","author":"Mittal","year":"2023","journal-title":"Pharm. Innov. Res. Springer."},{"key":"10.1016\/j.bioorg.2025.108335_bb0305","doi-asserted-by":"crossref","DOI":"10.1016\/j.bioorg.2023.107009","article-title":"Novel indolinone-tethered benzothiophenes as anti-tubercular agents against MDR\/XDR M. Tuberculosis: design, synthesis, biological evaluation and in vivo pharmacokinetic study","volume":"143","author":"Eldehna","year":"2024","journal-title":"Bioorg. Chem."},{"key":"10.1016\/j.bioorg.2025.108335_bb0310","doi-asserted-by":"crossref","first-page":"1739","DOI":"10.1002\/ddr.21992","article-title":"Nonacidic thiophene-based derivatives as potential analgesic and design, synthesis, biological evaluation, and metabolic stability study","volume":"83","author":"Mikhail","year":"2022","journal-title":"Drug Dev. Res."},{"key":"10.1016\/j.bioorg.2025.108335_bb0315","doi-asserted-by":"crossref","DOI":"10.1016\/bs.enz.2024.05.006","article-title":"Challenges for developing bacterial CA inhibitors as novel antibiotics","volume":"55","author":"Supuran","year":"2024","journal-title":"Enzymes"},{"key":"10.1016\/j.bioorg.2025.108335_bb0320","doi-asserted-by":"crossref","DOI":"10.1016\/j.bioorg.2019.103239","article-title":"Design, synthesis and molecular docking of novel pyrazolo [1, 5-a][1, 3, 5] triazine derivatives as CDK2 inhibitors","volume":"92","author":"Oudah","year":"2019","journal-title":"Bioorg. Chem."},{"key":"10.1016\/j.bioorg.2025.108335_bb0325","doi-asserted-by":"crossref","first-page":"1775","DOI":"10.1007\/s11164-018-3702-8","article-title":"A magnetically recoverable copper\u2013salen complex as a nano-catalytic system for amine protection via acetylation using thioacetic acid","volume":"45","author":"Yazdani","year":"2019","journal-title":"Res. Chem. Intermed."},{"key":"10.1016\/j.bioorg.2025.108335_bb0330","doi-asserted-by":"crossref","DOI":"10.1080\/14756366.2023.2189126","article-title":"Synthesis, biological evaluation and theoretical studies of (E)-1-(4-sulfamoyl-phenylethyl)-3-arylidene-5-aryl-1H-pyrrol-2 (3H)-ones as human carbonic anhydrase inhibitors","author":"Ramzan","year":"2023","journal-title":"J. Enzym. Inhib."},{"key":"10.1016\/j.bioorg.2025.108335_bb0335","doi-asserted-by":"crossref","DOI":"10.1016\/j.bioorg.2023.107089","article-title":"Identification of thienopyrimidine derivatives tethered with sulfonamide and other moieties as carbonic anhydrase inhibitors: design, synthesis and anti-proliferative activity","volume":"144","author":"Higazy","year":"2024","journal-title":"Bioorg. Chem."},{"key":"10.1016\/j.bioorg.2025.108335_bb0340","doi-asserted-by":"crossref","DOI":"10.1080\/14756366.2023.2189126","article-title":"Synthesis, biological evaluation and theoretical studies of (E)-1-(4-sulfamoyl-phenylethyl)-3-arylidene-5-aryl-1H-pyrrol-2 (3H)-ones as human carbonic anhydrase inhibitors","volume":"38","author":"Ramzan","year":"2023","journal-title":"J. Enzyme Inhib. Med. Chem."},{"key":"10.1016\/j.bioorg.2025.108335_bb0345","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2023.1175503","article-title":"3D cancer models: one step closer to in vitro human studies","volume":"14","author":"Manduca","year":"2023","journal-title":"Front. Immunol."},{"key":"10.1016\/j.bioorg.2025.108335_bb0350","doi-asserted-by":"crossref","first-page":"3170","DOI":"10.1158\/0008-5472.CAN-23-2612","article-title":"The NCI-60 human tumor cell line screen: a catalyst for progressive evolution of models for discovery and development of cancer drugs","volume":"83","author":"Workman","year":"2023","journal-title":"Cancer Res."},{"key":"10.1016\/j.bioorg.2025.108335_bb0355","article-title":"Cytotoxicity and cell viability assessment of biomaterials, cytotoxicity-cellular damage & response","author":"Sukumaran","year":"2023","journal-title":"IntechOpen"},{"key":"10.1016\/j.bioorg.2025.108335_bb0360","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1007\/978-1-0716-3052-5_18","article-title":"Optimization of cell viability assays for drug sensitivity screens","author":"Larsson","year":"2023","journal-title":"Cell Viability Assays: Methods Protoc."},{"key":"10.1016\/j.bioorg.2025.108335_bb0365","doi-asserted-by":"crossref","DOI":"10.1016\/j.bioorg.2024.107413","article-title":"Molecular docking approach for the design and synthesis of new pyrazolopyrimidine analogs of roscovitine as potential CDK2 inhibitors endowed with pronounced anticancer activity","volume":"147","author":"Hamed","year":"2024","journal-title":"Bioorg. Chem."},{"key":"10.1016\/j.bioorg.2025.108335_bb0370","doi-asserted-by":"crossref","first-page":"3891","DOI":"10.1021\/acs.jcim.1c00203","article-title":"AutoDock Vina 1.2. 0: new docking methods, expanded force field, and python bindings","volume":"61","author":"Eberhardt","year":"2021","journal-title":"J. Chem. Inf. Model."},{"key":"10.1016\/j.bioorg.2025.108335_bb0375","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejps.2023.106529","article-title":"Design, synthesis and biological evaluation of a novel bioactive indane scaffold 2-(diphenylmethylene) c-2, 3-dihydro-1H-inden-1-one with potential anticancer activity","volume":"188","author":"Zhang","year":"2023","journal-title":"Eur. J. Pharm. Sci."},{"issue":"1","key":"10.1016\/j.bioorg.2025.108335_bb0380","doi-asserted-by":"crossref","DOI":"10.1002\/ardp.202300449","article-title":"Identification of 3-(5-cyano-6-oxo-pyridin-2-yl) benzenesulfonamides as novel anticancer agents endowed with EGFR inhibitory activity","volume":"357","author":"Shaldam","year":"2024","journal-title":"Arch. Pharm."},{"key":"10.1016\/j.bioorg.2025.108335_bb0385","series-title":"Structures of Human Carbonic Anhydrases and their Complexes with Inhibitors, Carbonic Anhydrase as Drug Target: Thermodynamics and Structure of Inhibitor Binding","first-page":"179","author":"Smirnov","year":"2019"},{"key":"10.1016\/j.bioorg.2025.108335_bb0390","doi-asserted-by":"crossref","first-page":"19077","DOI":"10.1021\/acs.jmedchem.4c01555","article-title":"Inhibition of Pseudomonas aeruginosa carbonic anhydrases, exploring ciprofloxacin functionalization toward new antibacterial agents: an in-depth multidisciplinary study","author":"Marinacci","year":"2024","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.bioorg.2025.108335_bb0395","doi-asserted-by":"crossref","DOI":"10.1016\/j.bpc.2024.107179","article-title":"Insights into the structure-activity relationship of pyrimidine-sulfonamide analogues for targeting BRAF V600E protein","author":"Srisongkram","year":"2024","journal-title":"Biophys. Chem."}],"container-title":["Bioorganic Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0045206825002159?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0045206825002159?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,4,28]],"date-time":"2025-04-28T20:14:09Z","timestamp":1745871249000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0045206825002159"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,6]]},"references-count":79,"alternative-id":["S0045206825002159"],"URL":"https:\/\/doi.org\/10.1016\/j.bioorg.2025.108335","relation":{},"ISSN":["0045-2068"],"issn-type":[{"value":"0045-2068","type":"print"}],"subject":[],"published":{"date-parts":[[2025,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Development of novel amino-benzenesulfonamide derivatives and their analogues as carbonic anhydrase inhibitors: Design, synthesis, anticancer activity assessment, and pharmacokinetic studies using UPLC-MS\/MS","name":"articletitle","label":"Article Title"},{"value":"Bioorganic Chemistry","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bioorg.2025.108335","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"108335"}}