{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,25]],"date-time":"2026-06-25T11:06:39Z","timestamp":1782385599251,"version":"3.54.5"},"reference-count":61,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100012249","name":"Jiangxi University of Traditional Chinese Medicine","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100012249","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100011833","name":"Guangxi University of Chinese Medicine","doi-asserted-by":"publisher","award":["2024BSZR003"],"award-info":[{"award-number":["2024BSZR003"]}],"id":[{"id":"10.13039\/501100011833","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Bioorganic Chemistry"],"published-print":{"date-parts":[[2025,7]]},"DOI":"10.1016\/j.bioorg.2025.108478","type":"journal-article","created":{"date-parts":[[2025,4,17]],"date-time":"2025-04-17T12:57:34Z","timestamp":1744894654000},"page":"108478","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"special_numbering":"C","title":["Design, synthesis and evaluation of novel L-tryptophan derivatives as multifunctional agents with cholinesterase inhibition, anti-\u03b2-amyloid aggregation, anti-inflammatory, antioxidant and neuroprotection properties against Alzheimer's disease"],"prefix":"10.1016","volume":"161","author":[{"given":"Haiyang","family":"Yu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yinfang","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huizhen","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhiqiang","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yushun","family":"Cui","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shan","family":"Han","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yaru","family":"Cui","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xianghao","family":"Zeng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shaobing","family":"Cheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yulin","family":"Feng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"24","key":"10.1016\/j.bioorg.2025.108478_bb0005","doi-asserted-by":"crossref","first-page":"5789","DOI":"10.3390\/molecules25245789","article-title":"Comprehensive review on Alzheimer\u2019s disease: causes and treatment","volume":"25","author":"Breijyeh","year":"2020","journal-title":"Molecules"},{"issue":"11","key":"10.1016\/j.bioorg.2025.108478_bb0010","doi-asserted-by":"crossref","first-page":"1106","DOI":"10.2174\/1570159X18666200528142429","article-title":"Recent advancements in pathogenesis, diagnostics and treatment of Alzheimer\u2019s disease","volume":"18","author":"Khan","year":"2020","journal-title":"Curr. Neuropharmacol."},{"issue":"3","key":"10.1016\/j.bioorg.2025.108478_bb0015","doi-asserted-by":"crossref","first-page":"903","DOI":"10.1093\/brain\/awx356","article-title":"Effect of cholinergic treatment depends on cholinergic integrity in early Alzheimer\u2019s disease","volume":"141","author":"Richter","year":"2018","journal-title":"Brain"},{"issue":"7","key":"10.1016\/j.bioorg.2025.108478_bb0020","doi-asserted-by":"crossref","first-page":"1917","DOI":"10.1093\/brain\/awy132","article-title":"The cholinergic system in the pathophysiology and treatment of Alzheimer\u2019s disease","volume":"141","author":"Hampel","year":"2018","journal-title":"Brain"},{"issue":"5","key":"10.1016\/j.bioorg.2025.108478_bb0025","doi-asserted-by":"crossref","first-page":"2283","DOI":"10.3390\/ijms22052283","article-title":"Involvement of cholinergic, adrenergic, and glutamatergic network modulation with cognitive dysfunction in Alzheimer\u2019s disease","volume":"22","author":"Cheng","year":"2021","journal-title":"Int. J. Mol. Sci."},{"issue":"4","key":"10.1016\/j.bioorg.2025.108478_bb0030","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1097\/00008571-200304000-00008","article-title":"Regulation of attention and response to therapy in dementia by butyrylcholinesterase","volume":"13","author":"O\u2019Brien","year":"2003","journal-title":"Pharmacogenetics"},{"issue":"1","key":"10.1016\/j.bioorg.2025.108478_bb0035","doi-asserted-by":"crossref","first-page":"294","DOI":"10.1016\/j.ejmech.2017.03.062","article-title":"Recent progress in the identification of selective butyrylcholinesterase inhibitors for Alzheimer\u2019s disease","volume":"132","author":"Li","year":"2017","journal-title":"Eur. J. Med. Chem."},{"issue":"1","key":"10.1016\/j.bioorg.2025.108478_bb0040","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/S0165-3806(02)00367-X","article-title":"Rescue of the acetylcholinesterase knockout mouse by feeding a liquid diet; phenotype of the adult acetylcholinesterase deficient mouse","volume":"137","author":"Duysen","year":"2002","journal-title":"Dev. Brain Res."},{"issue":"1\u20132","key":"10.1016\/j.bioorg.2025.108478_bb0045","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1016\/j.cca.2006.11.005","article-title":"A medical health report on individuals with silent butyrylcholinesterase in the Vysya community of India","volume":"378","author":"Manoharan","year":"2007","journal-title":"Clin. Chim. Acta"},{"issue":"4","key":"10.1016\/j.bioorg.2025.108478_bb0050","doi-asserted-by":"crossref","first-page":"1105","DOI":"10.3233\/JAD-161088","article-title":"Oxidative stress, synaptic dysfunction, and Alzheimer\u2019s disease","volume":"57","author":"T\u00f6nnies","year":"2017","journal-title":"J. Alzheimers Dis."},{"issue":"8","key":"10.1016\/j.bioorg.2025.108478_bb0055","doi-asserted-by":"crossref","DOI":"10.3390\/molecules23082010","article-title":"A bifunctional anti-amyloid blocks oxidative stress and the accumulation of intraneuronal amyloid- beta","volume":"23","author":"Hilt","year":"2018","journal-title":"Molecules"},{"issue":"9","key":"10.1016\/j.bioorg.2025.108478_bb0060","doi-asserted-by":"crossref","first-page":"768","DOI":"10.1016\/j.tips.2016.06.007","article-title":"Targeting oxidative stress in central nervous system disorders","volume":"37","author":"Patel","year":"2016","journal-title":"Trends Pharmacol. Sci."},{"issue":"3","key":"10.1016\/j.bioorg.2025.108478_bb0065","doi-asserted-by":"crossref","first-page":"538","DOI":"10.1523\/JNEUROSCI.0295-20.2020","article-title":"Oxidative damage and antioxidant response in frontal cortex of demented and nondemented individuals with Alzheimer's neuropathology","volume":"41","author":"Fracassi","year":"2021","journal-title":"J. Neurosci."},{"issue":"1","key":"10.1016\/j.bioorg.2025.108478_bb0070","doi-asserted-by":"crossref","first-page":"598","DOI":"10.1016\/j.ejmech.2018.07.033","article-title":"Multi-target-directed ligands for treating Alzheimer\u2019s disease: Butyrylcholinesterase inhibitors displaying antioxidant and neuroprotective activities","volume":"156","author":"Knez","year":"2018","journal-title":"Eur. J. Med. Chem."},{"issue":"3","key":"10.1016\/j.bioorg.2025.108478_bb0075","doi-asserted-by":"crossref","first-page":"952","DOI":"10.3390\/ijms21030952","article-title":"Protofibrils of amyloid-\u03b2 are important targets of a disease-modifying approach for Alzheimer\u2019s disease","volume":"21","author":"Ono","year":"2020","journal-title":"Int. J. Mol. Sci."},{"issue":"1","key":"10.1016\/j.bioorg.2025.108478_bb0080","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1124\/jpet.114.219352","article-title":"Complex disposition of methylthioninium redox forms determines efficacy in tau aggregation inhibitor therapy for Alzheimer\u2019s disease","volume":"352","author":"Baddeley","year":"2015","journal-title":"J. Pharmacol. Exp. Ther."},{"issue":"1","key":"10.1016\/j.bioorg.2025.108478_bb0085","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1186\/s40035-022-00292-3","article-title":"Immunotherapy for Alzheimer's disease: targeting \u03b2-amyloid and beyond","volume":"11","author":"Song","year":"2022","journal-title":"Transl Neurodegener"},{"issue":"7","key":"10.1016\/j.bioorg.2025.108478_bb0090","doi-asserted-by":"crossref","first-page":"2294","DOI":"10.1016\/j.ymthe.2021.02.026","article-title":"Gene therapy using a\u03b2 variants for amyloid reduction","volume":"29","author":"Park","year":"2021","journal-title":"Mol. Ther."},{"issue":"10","key":"10.1016\/j.bioorg.2025.108478_bb0095","doi-asserted-by":"crossref","first-page":"7032","DOI":"10.1007\/s12035-019-1563-9","article-title":"Molecular targets in Alzheimer's disease","volume":"56","author":"Bj\u00f8rklund","year":"2019","journal-title":"Mol. Neurobiol."},{"issue":"14","key":"10.1016\/j.bioorg.2025.108478_bb0100","doi-asserted-by":"crossref","first-page":"2545","DOI":"10.1021\/acschemneuro.4c00246","article-title":"Harnessing the therapeutic potential of peptides for synergistic treatment of Alzheimer\u2019s disease by targeting a\u03b2 aggregation, metal-mediated a\u03b2 aggregation, cholinesterase, tau degradation, and oxidative stress","volume":"15","author":"Singh","year":"2024","journal-title":"ACS Chem. Neurosci."},{"key":"10.1016\/j.bioorg.2025.108478_bb0105","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejmech.2022.114464","article-title":"Alzheimer\u2019s disease: updated multi-targets therapeutics are in clinical and in progress","volume":"238","author":"Sang","year":"2022","journal-title":"Eur. J. Med. Chem."},{"issue":"1","key":"10.1016\/j.bioorg.2025.108478_bb0110","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1016\/j.bbr.2015.08.026","article-title":"Learning performances and vulnerability to amyloid toxicity in the butyrylcholinesterase knockout mouse","volume":"296","author":"Maurice","year":"2016","journal-title":"Behav. Brain Res."},{"key":"10.1016\/j.bioorg.2025.108478_bb0115","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejmech.2024.116569","article-title":"New insights into butyrylcholinesterase: pharmaceutical applications, selective inhibitors and multitarget-directed ligands","volume":"275","author":"Sun","year":"2024","journal-title":"Eur. J. Med. Chem."},{"issue":"18","key":"10.1016\/j.bioorg.2025.108478_bb0120","doi-asserted-by":"crossref","first-page":"12292","DOI":"10.1021\/acs.jmedchem.2c01003","article-title":"Discovery of potent cholinesterase inhibition-based multi-target-directed lead compounds for synaptoprotection in Alzheimer\u2019s disease","volume":"65","author":"Turgutalp","year":"2022","journal-title":"J. Med. Chem."},{"issue":"1","key":"10.1016\/j.bioorg.2025.108478_bb0125","article-title":"Tryptophan metabolites modify brain a\u03b2 peptide degradation: A role in Alzheimer\u2019s disease?","volume":"190","author":"Maitre","year":"2020","journal-title":"Prog. Neurobiol."},{"issue":"37","key":"10.1016\/j.bioorg.2025.108478_bb0130","doi-asserted-by":"crossref","first-page":"6363","DOI":"10.1016\/j.tet.2014.05.089","article-title":"Controlling bacterial behavior with indole-containing natural products and derivatives","volume":"70","author":"Melander","year":"2014","journal-title":"Tetrahedron"},{"issue":"1","key":"10.1016\/j.bioorg.2025.108478_bb0135","article-title":"The role of the indoles in microbiota-gut-brain axis and potential therapeutic targets: A focus on human neurological and neuropsychiatric diseases","volume":"239","author":"Hou","year":"2023","journal-title":"Neuropharmacology"},{"issue":"4","key":"10.1016\/j.bioorg.2025.108478_bb0140","first-page":"1969","article-title":"P2Y1R silencing in astrocytes protected neuroinflammation and cognitive decline in a mouse model of Alzheimer's disease","volume":"15","author":"Luo","year":"2024","journal-title":"Aging Dis."},{"issue":"26","key":"10.1016\/j.bioorg.2025.108478_bb0145","doi-asserted-by":"crossref","first-page":"3765","DOI":"10.1039\/C9CC01330J","article-title":"Tryptophan-derived butyrylcholinesterase inhibitors as promising leads against Alzheimer\u2019s disease","volume":"55","author":"Meden","year":"2019","journal-title":"Chem. Commun. (Camb.)"},{"issue":"2","key":"10.1016\/j.bioorg.2025.108478_bb0150","doi-asserted-by":"crossref","first-page":"292","DOI":"10.3390\/brainsci13020292","article-title":"The role of tryptophan metabolism in Alzheimer\u2019s disease","volume":"13","author":"Savonije","year":"2023","journal-title":"Brain Sci."},{"key":"10.1016\/j.bioorg.2025.108478_bb0155","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/j.smrv.2014.03.007","article-title":"Sleep and Alzheimer\u2019s disease","volume":"19","author":"Peter-Derex","year":"2015","journal-title":"Sleep Med. Rev."},{"key":"10.1016\/j.bioorg.2025.108478_bb0160","doi-asserted-by":"crossref","DOI":"10.1016\/j.pneurobio.2020.101902","article-title":"Sleep and its regulation: an emerging pathogenic and treatment frontier in Alzheimer\u2019s disease","volume":"197","author":"Kent","year":"2021","journal-title":"Prog. Neurobiol."},{"key":"10.1016\/j.bioorg.2025.108478_bb0165","article-title":"A tau pathogenesis-based network pharmacology approach for exploring the protections of chuanxiong rhizoma in Alzheimer\u2019s disease","volume":"13","author":"Zeng","year":"2022","journal-title":"Front. Pharmacol."},{"issue":"4","key":"10.1016\/j.bioorg.2025.108478_bb0170","doi-asserted-by":"crossref","first-page":"756","DOI":"10.3390\/nu11040756","article-title":"Polyphenols modulate Alzheimer\u2019s amyloid beta aggregation in a structure-dependent manner","volume":"11","author":"Phan","year":"2019","journal-title":"Nutrients"},{"issue":"5","key":"10.1016\/j.bioorg.2025.108478_bb0175","doi-asserted-by":"crossref","DOI":"10.1002\/ardp.202300603","article-title":"Design, synthesis, and activity evaluation of novel multitargeted L-tryptophan derivatives with powerful antioxidant activity against Alzheimer's disease","volume":"357","author":"Zeng","year":"2024","journal-title":"Arch Pharm (Weinheim)"},{"issue":"2","key":"10.1016\/j.bioorg.2025.108478_bb0180","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1016\/0006-2952(61)90145-9","article-title":"A new and rapid colorimetric determination of acetylcholinesterase activity","volume":"7","author":"Ellman","year":"1961","journal-title":"Biochem. Pharmacol."},{"issue":"16","key":"10.1016\/j.bioorg.2025.108478_bb0185","doi-asserted-by":"crossref","first-page":"11365","DOI":"10.1021\/acs.jmedchem.2c00944","article-title":"N-benzyl benzamide derivatives as selective sub-nanomolar butyrylcholinesterase inhibitors for possible treatment in advanced Alzheimer\u2019s disease","volume":"65","author":"Du","year":"2022","journal-title":"J. Med. Chem."},{"issue":"8","key":"10.1016\/j.bioorg.2025.108478_bb0190","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1038\/d41573-024-00116-1","article-title":"FDA approves third anti-amyloid antibody for Alzheimer disease","volume":"23","author":"Mullard","year":"2024","journal-title":"Nat. Rev. Drug Discov."},{"key":"10.1016\/j.bioorg.2025.108478_bb0195","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/bs.pbr.2019.03.001","article-title":"Nanomedicine in Alzheimer\u2019s disease: amyloid beta targeting strategy","volume":"245","author":"Tosi","year":"2019","journal-title":"Prog. Brain Res."},{"issue":"12","key":"10.1016\/j.bioorg.2025.108478_bb0200","doi-asserted-by":"crossref","first-page":"739","DOI":"10.1016\/j.neurol.2014.10.003","article-title":"Amyloid beta peptide immunotherapy in Alzheimer disease","volume":"170","author":"Delrieu","year":"2014","journal-title":"Rev. Neurol. (Paris)"},{"issue":"16","key":"10.1016\/j.bioorg.2025.108478_bb0205","doi-asserted-by":"crossref","first-page":"4437","DOI":"10.1021\/jf0201529","article-title":"High-throughput assay of oxygen radical absorbance capacity (ORAC) using a multichannel liquid handling system coupled with a microplate fluorescence reader in 96-well format","volume":"50","author":"Huang","year":"2002","journal-title":"J. Agric. Food Chem."},{"issue":"12","key":"10.1016\/j.bioorg.2025.108478_bb0210","doi-asserted-by":"crossref","first-page":"1550","DOI":"10.3109\/13880209.2014.908394","article-title":"Salvia and Stachys species protect neuronal cells against oxidative stress-induced apoptosis","volume":"52","author":"Tavakkoli","year":"2014","journal-title":"Pharm. Biol."},{"issue":"12","key":"10.1016\/j.bioorg.2025.108478_bb0215","doi-asserted-by":"crossref","first-page":"1451","DOI":"10.4155\/fmc.13.111","article-title":"Modulating nitric oxide signaling in the CNS for Alzheimer\u2019s disease therapy","volume":"5","author":"Zhihui","year":"2013","journal-title":"Future Med. Chem."},{"issue":"S1","key":"10.1016\/j.bioorg.2025.108478_bb0220","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1111\/jnc.13062","article-title":"Microglia and neuroprotection","volume":"136","author":"Chen","year":"2015","journal-title":"J. Neurochem."},{"issue":"10","key":"10.1016\/j.bioorg.2025.108478_bb0225","doi-asserted-by":"crossref","first-page":"2194","DOI":"10.1016\/j.immuni.2021.09.014","article-title":"Microglia: Immune and non-immune functions","volume":"54","author":"Borst","year":"2021","journal-title":"Immunity"},{"issue":"1","key":"10.1016\/j.bioorg.2025.108478_bb0230","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1186\/s12974-020-01820-6","article-title":"The relationships between neuroinflammation, beta-amyloid and tau deposition in Alzheimer\u2019s disease: a longitudinal PET study","volume":"17","author":"Ismail","year":"2020","journal-title":"J. Neuroinflammation"},{"issue":"8","key":"10.1016\/j.bioorg.2025.108478_bb0235","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1038\/s41577-019-0165-0","article-title":"The NLRP3 inflammasome: molecular activation and regulation to therapeutics","volume":"19","author":"Swanson","year":"2019","journal-title":"Nat. Rev. Immunol."},{"issue":"3","key":"10.1016\/j.bioorg.2025.108478_bb0240","doi-asserted-by":"crossref","first-page":"984","DOI":"10.1007\/s10753-018-0752-4","article-title":"Anti-inflammatory effects of hypophyllanthin and niranthin through downregulation of NF-\u03baB\/MAPKs\/PI3K-Akt signaling pathways","volume":"41","author":"Harikrishnan","year":"2018","journal-title":"Inflammation"},{"issue":"6513","key":"10.1016\/j.bioorg.2025.108478_bb0245","doi-asserted-by":"crossref","first-page":"eaay3302","DOI":"10.1126\/science.aay3302","article-title":"Coupling of NMDA receptors and TRPM4 guides discovery of unconventional neuroprotectants","volume":"370","author":"Yan","year":"2020","journal-title":"Science"},{"issue":"2","key":"10.1016\/j.bioorg.2025.108478_bb0250","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1113\/JP282389","article-title":"Ionotropic glutamate receptors: structure, function and dysfunction","volume":"600","author":"Wyllie","year":"2022","journal-title":"J. Physiol."},{"issue":"3","key":"10.1016\/j.bioorg.2025.108478_bb0255","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1016\/S0223-5234(03)00012-6","article-title":"High throughput artificial membrane permeability assay for blood-brain barrier","volume":"38","author":"Di","year":"2003","journal-title":"Eur. J. Med. Chem."},{"issue":"6","key":"10.1016\/j.bioorg.2025.108478_bb0260","doi-asserted-by":"crossref","first-page":"1142","DOI":"10.1038\/s41401-024-01240-9","article-title":"PHPB ameliorates memory deficits and reduces oxidative injury in Alzheimer\u2019s disease mouse model by activating Nrf2 signaling pathway","volume":"45","author":"Shang","year":"2024","journal-title":"Acta Pharmacol. Sin."},{"issue":"3","key":"10.1016\/j.bioorg.2025.108478_bb0265","doi-asserted-by":"crossref","first-page":"264","DOI":"10.1538\/expanim.21-0120","article-title":"Morris water maze: a versatile and pertinent tool for assessing spatial learning and memory","volume":"71","author":"Othman","year":"2022","journal-title":"Exp. Anim."},{"issue":"1","key":"10.1016\/j.bioorg.2025.108478_bb0270","doi-asserted-by":"crossref","first-page":"812","DOI":"10.1021\/acs.jmedchem.0c01775","article-title":"Discovery of a potent dual inhibitor of acetylcholinesterase and butyrylcholinesterase with antioxidant activity that alleviates Alzheimer-like pathology in old APP\/PS1 mice","volume":"64","author":"Viayna","year":"2021","journal-title":"J. Med. Chem."},{"issue":"1","key":"10.1016\/j.bioorg.2025.108478_bb0275","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1021\/acs.jmedchem.7b01086","article-title":"The magic of crystal sructure-based inhibitor optimization: development of a butyrylcholinesterase inhibitor with picomolar affinity and in vivo activity","volume":"61","author":"Ko\u0161ak","year":"2018","journal-title":"J. Med. Chem."},{"issue":"7","key":"10.1016\/j.bioorg.2025.108478_bb0280","first-page":"1154","article-title":"Discovery of sustainable drugs for Alzheimer\u2019s disease: cardanol-derived cholinesterase inhibitors with antioxidant and anti-amyloid properties. RSC","volume":"12","author":"de Andrade Ramos","year":"2021","journal-title":"Med. Chem."},{"issue":"1","key":"10.1016\/j.bioorg.2025.108478_bb0285","doi-asserted-by":"crossref","first-page":"18144","DOI":"10.1038\/s41598-020-74646-0","article-title":"Fenton reaction mechanism generating no OH radicals in Nafion membrane decomposition","volume":"10","author":"Tsuneda","year":"2020","journal-title":"Sci. Rep."},{"key":"10.1016\/j.bioorg.2025.108478_bb0290","doi-asserted-by":"crossref","first-page":"749","DOI":"10.1016\/j.foodchem.2015.07.119","article-title":"Antioxidant activity of protocatechuates evaluated by DPPH, ORAC, and CAT methods","volume":"194","author":"Grajeda-Iglesias","year":"2016","journal-title":"Food Chem."},{"issue":"5","key":"10.1016\/j.bioorg.2025.108478_bb0295","doi-asserted-by":"crossref","first-page":"645","DOI":"10.1016\/j.freeradbiomed.2007.04.026","article-title":"Methods to detect nitric oxide and its metabolites in biological samples","volume":"43","author":"Bryan","year":"2007","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.bioorg.2025.108478_bb0300","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1016\/j.ejps.2014.12.014","article-title":"Prediction of blood\u2013brain barrier permeation of \u03b1-adrenergic and imidazoline receptor ligands using PAMPA technique and quantitative-structure permeability relationship analysis","volume":"68","author":"Vucicevic","year":"2015","journal-title":"Eur. J. Pharm. Sci."},{"key":"10.1016\/j.bioorg.2025.108478_bb0305","unstructured":"ADMET Prediction Service. http:\/\/qsar. chem. msu. ru\/admet\/."}],"container-title":["Bioorganic Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S004520682500358X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S004520682500358X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,4]],"date-time":"2025-11-04T02:29:37Z","timestamp":1762223377000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S004520682500358X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,7]]},"references-count":61,"alternative-id":["S004520682500358X"],"URL":"https:\/\/doi.org\/10.1016\/j.bioorg.2025.108478","relation":{},"ISSN":["0045-2068"],"issn-type":[{"value":"0045-2068","type":"print"}],"subject":[],"published":{"date-parts":[[2025,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Design, synthesis and evaluation of novel L-tryptophan derivatives as multifunctional agents with cholinesterase inhibition, anti-\u03b2-amyloid aggregation, anti-inflammatory, antioxidant and neuroprotection properties against Alzheimer's disease","name":"articletitle","label":"Article Title"},{"value":"Bioorganic Chemistry","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bioorg.2025.108478","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"108478"}}