{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,5]],"date-time":"2026-08-05T15:27:36Z","timestamp":1785943656366,"version":"3.56.0"},"reference-count":61,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T00:00:00Z","timestamp":1748736000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T00:00:00Z","timestamp":1748736000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T00:00:00Z","timestamp":1748736000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T00:00:00Z","timestamp":1748736000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T00:00:00Z","timestamp":1748736000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T00:00:00Z","timestamp":1748736000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T00:00:00Z","timestamp":1748736000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100003453","name":"Natural Science Foundation of Guangdong Province","doi-asserted-by":"publisher","award":["2020A1515010992"],"award-info":[{"award-number":["2020A1515010992"]}],"id":[{"id":"10.13039\/501100003453","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100015956","name":"Special Project for Research and Development in Key areas of Guangdong Province","doi-asserted-by":"publisher","award":["2020B1111100009"],"award-info":[{"award-number":["2020B1111100009"]}],"id":[{"id":"10.13039\/501100015956","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004863","name":"Zhejiang Chinese Medical University","doi-asserted-by":"publisher","award":["202,303\\u20130118"],"award-info":[{"award-number":["202,303\\u20130118"]}],"id":[{"id":"10.13039\/501100004863","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004863","name":"Zhejiang Chinese Medical University","doi-asserted-by":"publisher","award":["IACUC-20230306-13"],"award-info":[{"award-number":["IACUC-20230306-13"]}],"id":[{"id":"10.13039\/501100004863","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100013076","name":"National Major Science and Technology Projects of China","doi-asserted-by":"publisher","award":["2024ZD0528105"],"award-info":[{"award-number":["2024ZD0528105"]}],"id":[{"id":"10.13039\/501100013076","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100013076","name":"National Major Science and Technology Projects of China","doi-asserted-by":"publisher","award":["2024ZD0528100"],"award-info":[{"award-number":["2024ZD0528100"]}],"id":[{"id":"10.13039\/501100013076","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81974559"],"award-info":[{"award-number":["81974559"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Bioorganic Chemistry"],"published-print":{"date-parts":[[2025,6]]},"DOI":"10.1016\/j.bioorg.2025.108493","type":"journal-article","created":{"date-parts":[[2025,4,19]],"date-time":"2025-04-19T15:04:18Z","timestamp":1745075058000},"page":"108493","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":3,"special_numbering":"C","title":["Ginsenoside Rd and chrysophanol: Modulating the serine-glycine-one-carbon pathway to enhance neuroprotection in intracerebral hemorrhage"],"prefix":"10.1016","volume":"160","author":[{"given":"Xingping","family":"Zhao","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huifen","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhiyong","family":"Pan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"JianWen","family":"Guo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiehong","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"HaiTong","family":"Wan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bioorg.2025.108493_bb0005","doi-asserted-by":"crossref","first-page":"2192","DOI":"10.1161\/STROKEAHA.123.040806","article-title":"Role of brain imaging in the prediction of intracerebral hemorrhage following endovascular therapy for acute stroke","volume":"54","author":"Seners","year":"2023","journal-title":"Stroke"},{"key":"10.1016\/j.bioorg.2025.108493_bb0010","doi-asserted-by":"crossref","first-page":"e794","DOI":"10.1212\/WNL.0000000000207510","article-title":"Association of the Presence and Pattern of MRI markers of cerebral small vessel disease with recurrent intracerebral hemorrhage","volume":"101","author":"Fandler-H\u00f6fler","year":"2023","journal-title":"Neurology"},{"key":"10.1016\/j.bioorg.2025.108493_bb0015","doi-asserted-by":"crossref","DOI":"10.1016\/j.expneurol.2022.114302","article-title":"Downregulation of mitochondrial calcium uptake family 3 attenuates secondary brain injury after intracerebral hemorrhage in rats","volume":"361","author":"Wang","year":"2023","journal-title":"Exp. Neurol."},{"key":"10.1016\/j.bioorg.2025.108493_bb0020","doi-asserted-by":"crossref","first-page":"948","DOI":"10.4103\/1673-5374.250568","article-title":"Nicotinamide adenine dinucleotide phosphate oxidase activation and neuronal death after ischemic stroke","volume":"14","author":"Shen","year":"2019","journal-title":"Neural Regen. Res."},{"key":"10.1016\/j.bioorg.2025.108493_bb0025","doi-asserted-by":"crossref","first-page":"199","DOI":"10.33549\/physiolres.934802","article-title":"Brain fluid channels for metabolite removal","volume":"71","author":"Malovesk\u00e1","year":"2022","journal-title":"Physiol. Res."},{"key":"10.1016\/j.bioorg.2025.108493_bb0030","doi-asserted-by":"crossref","first-page":"1269","DOI":"10.1093\/neuros\/nyy179","article-title":"Persistent metabolic disturbance in the Perihemorrhagic zone despite a normalized cerebral blood flow following surgery for intracerebral hemorrhage","volume":"84","author":"Tobieson","year":"2019","journal-title":"Neurosurgery"},{"key":"10.1016\/j.bioorg.2025.108493_bb0035","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1093\/intimm\/dxx063","article-title":"Lysosome biogenesis regulated by the amino-acid transporter SLC15A4 is critical for functional integrity of mast cells","volume":"29","author":"Kobayashi","year":"2017","journal-title":"Int. Immunol."},{"key":"10.1016\/j.bioorg.2025.108493_bb0040","doi-asserted-by":"crossref","first-page":"1179","DOI":"10.1001\/jamaneurol.2021.2956","article-title":"Effects of antiplatelet therapy after stroke caused by intracerebral hemorrhage: extended follow-up of the RESTART randomized clinical trial","volume":"78","author":"Al-Shahi Salman","year":"2021","journal-title":"JAMA Neurol."},{"key":"10.1016\/j.bioorg.2025.108493_bb0045","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1136\/svn-2021-001101","article-title":"Initial antihypertensive agent effects on acute blood pressure after intracerebral haemorrhage","volume":"7","author":"Ng","year":"2022","journal-title":"Stroke Vascular Neurol."},{"key":"10.1016\/j.bioorg.2025.108493_bb0050","doi-asserted-by":"crossref","first-page":"1204","DOI":"10.1161\/CIRCRESAHA.121.319949","article-title":"Cerebral hemorrhage: pathophysiology, treatment, and future directions","volume":"130","author":"Magid-Bernstein","year":"2022","journal-title":"Circ. Res."},{"key":"10.1016\/j.bioorg.2025.108493_bb0055","doi-asserted-by":"crossref","DOI":"10.1016\/j.phrs.2022.106200","article-title":"Traditional Chinese medicine use in the pathophysiological processes of intracerebral hemorrhage and comparison with conventional therapy","volume":"179","author":"Duan","year":"2022","journal-title":"Pharmacol. Res."},{"key":"10.1016\/j.bioorg.2025.108493_bb0060","doi-asserted-by":"crossref","first-page":"3431","DOI":"10.1007\/s43032-021-00692-2","article-title":"Ginsenoside Rg2 ameliorates brain injury after intracerebral hemorrhage in a rat model of preeclampsia","volume":"28","author":"Cai","year":"2021","journal-title":"Reprod. Sci."},{"key":"10.1016\/j.bioorg.2025.108493_bb0065","doi-asserted-by":"crossref","first-page":"244","DOI":"10.1016\/j.jep.2018.11.032","article-title":"iTRAQ-based quantitative proteomics reveals the neuroprotection of rhubarb in experimental intracerebral hemorrhage","volume":"232","author":"Liu","year":"2019","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.bioorg.2025.108493_bb0070","article-title":"Combination of Radix Astragali and safflower promotes angiogenesis in rats with ischemic stroke via silencing PTGS2","volume":"24","author":"Xu","year":"2023","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.bioorg.2025.108493_bb0075","doi-asserted-by":"crossref","DOI":"10.1016\/j.bioorg.2022.105975","article-title":"Investigation on the potential targets of Astragaloside IV against intracerebral hemorrhage based on network pharmacology and experimental validation","volume":"127","author":"Zheng","year":"2022","journal-title":"Bioorg. Chem."},{"key":"10.1016\/j.bioorg.2025.108493_bb0080","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1159\/000477814","article-title":"Chrysophanol suppressed glutamate-induced hippocampal neuronal cell death via regulation of dynamin-related protein 1-dependent mitochondrial fission","volume":"100","author":"Chae","year":"2017","journal-title":"Pharmacology"},{"key":"10.1016\/j.bioorg.2025.108493_bb0085","article-title":"Ginsenoside Rd: a promising natural neuroprotective agent","volume":"95","author":"Chen","year":"2022","journal-title":"Phytomed\u202f: Int. J. phytotherapy Phytopharmacol."},{"key":"10.1016\/j.bioorg.2025.108493_bb0090","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2022.109220","article-title":"Chrysophanol facilitates long-term neurological recovery through limiting microglia-mediated neuroinflammation after ischemic stroke in mice","volume":"112","author":"Liu","year":"2022","journal-title":"Int. Immunopharmacol."},{"key":"10.1016\/j.bioorg.2025.108493_bb0095","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1016\/j.jgr.2015.02.002","article-title":"Ginsenoside Rd and ischemic stroke; a short review of literatures","volume":"39","author":"Nabavi","year":"2015","journal-title":"J. Ginseng Res."},{"key":"10.1016\/j.bioorg.2025.108493_bb0100","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2021.113997","article-title":"Ginsenoside Rh2 alleviates ulcerative colitis by regulating the STAT3\/miR-214 signaling pathway","volume":"274","author":"Chen","year":"2021","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.bioorg.2025.108493_bb0105","doi-asserted-by":"crossref","first-page":"1475","DOI":"10.1111\/jphp.13143","article-title":"Chrysophanol: a review of its pharmacology, toxicity and pharmacokinetics","volume":"71","author":"Xie","year":"2019","journal-title":"J. Pharm. Pharmacol."},{"key":"10.1016\/j.bioorg.2025.108493_bb0110","doi-asserted-by":"crossref","first-page":"1031","DOI":"10.1007\/s12272-020-01279-2","article-title":"Mitochondrial connection to ginsenosides","volume":"43","author":"Wang","year":"2020","journal-title":"Arch. Pharm. Res."},{"key":"10.1016\/j.bioorg.2025.108493_bb0115","doi-asserted-by":"crossref","first-page":"1139","DOI":"10.1142\/S0192415X09007454","article-title":"Regulation on energy metabolism and protection on mitochondria of Panax ginseng polysaccharide","volume":"37","author":"Li","year":"2009","journal-title":"Am. J. Chin. Med."},{"key":"10.1016\/j.bioorg.2025.108493_bb0120","series-title":"Ginseng(\u00ae) Alleviates Malathion-Induced Hepatorenal Injury through Modulation of the Biochemical, Antioxidant, Anti-Apoptotic, and Anti-Inflammatory Markers in Male Rats","volume":"vol. 12","author":"Ghamry","year":"2022"},{"key":"10.1016\/j.bioorg.2025.108493_bb0125","doi-asserted-by":"crossref","first-page":"369","DOI":"10.55782\/ane-2006-1625","article-title":"Neuroprotective effects of ginsenosides","volume":"66","author":"Rausch","year":"2006","journal-title":"Acta Neurobiol. Exp."},{"key":"10.1016\/j.bioorg.2025.108493_bb0130","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1007\/s11596-022-2496-x","article-title":"Neuroprotective effect of Chrysophanol as a PI3K\/AKT\/mTOR signaling inhibitor in an experimental model of autologous blood-induced intracerebral hemorrhage","volume":"42","author":"Jadaun","year":"2022","journal-title":"Curr. Med. Sci."},{"key":"10.1016\/j.bioorg.2025.108493_bb0135","doi-asserted-by":"crossref","DOI":"10.1016\/j.expneurol.2020.113386","article-title":"Activated WNK3 induced by intracerebral hemorrhage deteriorates brain injury maybe via WNK3\/SPAK\/NKCC1 pathway","volume":"332","author":"Wu","year":"2020","journal-title":"Exp. Neurol."},{"key":"10.1016\/j.bioorg.2025.108493_bb0140","doi-asserted-by":"crossref","first-page":"4999","DOI":"10.1007\/s12035-021-02468-w","article-title":"Loss of MIC60 aggravates neuronal death by inducing mitochondrial dysfunction in a rat model of intracerebral hemorrhage","volume":"58","author":"Deng","year":"2021","journal-title":"Mol. Neurobiol."},{"key":"10.1016\/j.bioorg.2025.108493_bb0145","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1093\/toxsci\/52.2.141","article-title":"Ethical review of regulatory toxicology guidelines involving experiments on animals: the example of endocrine disrupters","volume":"52","author":"Purchase","year":"1999","journal-title":"Toxicol. Sci.: Official J. Society Toxicol."},{"key":"10.1016\/j.bioorg.2025.108493_bb0150","doi-asserted-by":"crossref","first-page":"1795","DOI":"10.4103\/1673-5374.332157","article-title":"Oxidized low-density lipoprotein receptor 1: a novel potential therapeutic target for intracerebral hemorrhage","volume":"17","author":"Zhang","year":"2022","journal-title":"Neural Regen. Res."},{"key":"10.1016\/j.bioorg.2025.108493_bb0155","doi-asserted-by":"crossref","DOI":"10.1161\/JAHA.117.006042","article-title":"CM352 reduces brain damage and improves functional recovery in a rat model of intracerebral hemorrhage","volume":"6","author":"Rodr\u00edguez","year":"2017","journal-title":"J. Am. Heart Assoc."},{"key":"10.1016\/j.bioorg.2025.108493_bb0160","doi-asserted-by":"crossref","DOI":"10.3390\/ijms20184331","article-title":"Molecular docking: shifting paradigms in drug discovery","volume":"20","author":"Pinzi","year":"2019","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.bioorg.2025.108493_bb0165","doi-asserted-by":"crossref","first-page":"S88","DOI":"10.1161\/STROKEAHA.108.533281","article-title":"Thrombin and brain recovery after intracerebral hemorrhage","volume":"40","author":"Hua","year":"2009","journal-title":"Stroke"},{"key":"10.1016\/j.bioorg.2025.108493_bb0170","doi-asserted-by":"crossref","DOI":"10.1155\/2014\/495817","article-title":"Necrostatin-1 reduces neurovascular injury after intracerebral hemorrhage","volume":"2014","author":"King","year":"2014","journal-title":"Int. J. cell Biol."},{"key":"10.1016\/j.bioorg.2025.108493_bb0175","doi-asserted-by":"crossref","DOI":"10.1002\/jbt.23702","article-title":"Protective effects of esculetin against doxorubicin-induced toxicity correlated with oxidative stress in rat liver: in vivo and in silico studies","volume":"38","author":"K\u00f6ro\u011flu","year":"2024","journal-title":"J. Biochem. Mol. Toxicol."},{"key":"10.1016\/j.bioorg.2025.108493_bb0180","doi-asserted-by":"crossref","DOI":"10.1016\/j.expneurol.2022.114197","article-title":"Chrysophanol postconditioning attenuated cerebral ischemia-reperfusion injury induced NLRP3-related pyroptosis in a TRAF6-dependent manner","volume":"357","author":"Xia","year":"2022","journal-title":"Exp. Neurol."},{"key":"10.1016\/j.bioorg.2025.108493_bb0185","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2022.154434","article-title":"Magnolol effectively ameliorates diabetic peripheral neuropathy in mice","volume":"107","author":"Yang","year":"2022","journal-title":"Phytomedicine : Int. J. phytotherapy Phytopharmacol."},{"key":"10.1016\/j.bioorg.2025.108493_bb0190","doi-asserted-by":"crossref","first-page":"1036313","DOI":"10.3389\/fncel.2022.1036313","article-title":"Autophagy regulates inflammation in intracerebral hemorrhage: enemy or friend?","volume":"16","author":"Fu","year":"2022","journal-title":"Front. Cell. Neurosci."},{"key":"10.1016\/j.bioorg.2025.108493_bb0195","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1101\/gad.351428.123","article-title":"Psat1-generated \u03b1-ketoglutarate and glutamine promote muscle stem cell activation and regeneration","volume":"38","author":"Ciuffoli","year":"2024","journal-title":"Genes Dev."},{"key":"10.1016\/j.bioorg.2025.108493_bb0200","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2023.116298","article-title":"Annao Pingchong decoction alleviate the neurological impairment by attenuating neuroinflammation and apoptosis in intracerebral hemorrhage rats","volume":"310","author":"Guo","year":"2023","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.bioorg.2025.108493_bb0205","doi-asserted-by":"crossref","first-page":"1280792","DOI":"10.3389\/fphar.2024.1280792","article-title":"Progress of Ginsenoside Rb1 in neurological disorders","volume":"15","author":"Ling","year":"2024","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.bioorg.2025.108493_bb0210","doi-asserted-by":"crossref","first-page":"1376601","DOI":"10.3389\/fncel.2024.1376601","article-title":"Engineered exosomes enriched with select microRNAs amplify their therapeutic efficacy for traumatic brain injury and stroke","volume":"18","author":"Chen","year":"2024","journal-title":"Front. Cell. Neurosci."},{"key":"10.1016\/j.bioorg.2025.108493_bb0215","doi-asserted-by":"crossref","first-page":"881","DOI":"10.1016\/S0028-3908(99)00248-8","article-title":"Enhanced neuroprotection and reduced hemorrhagic incidence in focal cerebral ischemia of rat by low dose combination therapy of urokinase and topiramate","volume":"39","author":"Yang","year":"2000","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.bioorg.2025.108493_bb0220","article-title":"The dipeptide Gly-pro (GP), derived from Hibiscus sabdariffa, exhibits potent Antifibrotic effects by regulating the TGF-\u03b21-ATF4-serine\/Glycine biosynthesis pathway","volume":"24","author":"Kim","year":"2023","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.bioorg.2025.108493_bb0225","doi-asserted-by":"crossref","first-page":"3296","DOI":"10.1093\/hmg\/ddaa214","article-title":"Coenzyme Q10 modulates sulfide metabolism and links the mitochondrial respiratory chain to pathways associated to one carbon metabolism","volume":"29","author":"Gonz\u00e1lez-Garc\u00eda","year":"2020","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.bioorg.2025.108493_bb0230","doi-asserted-by":"crossref","first-page":"23955","DOI":"10.18632\/oncotarget.15053","article-title":"One-carbon metabolism and nucleotide biosynthesis as attractive targets for anticancer therapy","volume":"8","author":"Shuvalov","year":"2017","journal-title":"Oncotarget"},{"key":"10.1016\/j.bioorg.2025.108493_bb0235","doi-asserted-by":"crossref","DOI":"10.1016\/j.bioorg.2024.107416","article-title":"Synergistic promotion of angiogenesis after intracerebral hemorrhage by ginsenoside Rh2 and chrysophanol in rats","volume":"147","author":"Li","year":"2024","journal-title":"Bioorg. Chem."},{"key":"10.1016\/j.bioorg.2025.108493_bb0240","doi-asserted-by":"crossref","first-page":"729","DOI":"10.1016\/j.neuroscience.2006.08.050","article-title":"Glutamate reduces secretion of l-serine in astrocytes isolated from stroke-prone spontaneously hypertensive rats","volume":"143","author":"Yamagata","year":"2006","journal-title":"Neuroscience"},{"key":"10.1016\/j.bioorg.2025.108493_bb0245","doi-asserted-by":"crossref","first-page":"1690","DOI":"10.1038\/s41598-025-85900-8","article-title":"Integrative bioinformatics approach identifies novel drug targets for hyperaldosteronism, with a focus on SHMT1 as a promising therapeutic candidate","volume":"15","author":"Jia","year":"2025","journal-title":"Sci. Rep."},{"key":"10.1016\/j.bioorg.2025.108493_bb0250","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1016\/j.mam.2016.11.005","article-title":"Targeting nuclear thymidylate biosynthesis","volume":"53","author":"Chon","year":"2017","journal-title":"Mol. Asp. Med."},{"key":"10.1016\/j.bioorg.2025.108493_bb0255","doi-asserted-by":"crossref","first-page":"366","DOI":"10.1038\/s41467-020-20223-y","article-title":"Serine synthesis pathway inhibition cooperates with dietary serine and glycine limitation for cancer therapy","volume":"12","author":"Tajan","year":"2021","journal-title":"Nat. Commun."},{"key":"10.1016\/j.bioorg.2025.108493_bb0260","doi-asserted-by":"crossref","first-page":"9332","DOI":"10.1016\/j.biomaterials.2014.07.045","article-title":"Nucleotide biosynthesis arrest by silencing SHMT1 function via vitamin B6-coupled vector and effects on tumor growth inhibition","volume":"35","author":"Pandey","year":"2014","journal-title":"Biomaterials"},{"key":"10.1016\/j.bioorg.2025.108493_bb0265","doi-asserted-by":"crossref","DOI":"10.1016\/j.ecoenv.2023.115622","article-title":"Hexavalent chromium caused DNA damage repair and apoptosis via the PI3K\/AKT\/FOXO1 pathway triggered by oxidative stress in the lung of rat","volume":"267","author":"Zhang","year":"2023","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"10.1016\/j.bioorg.2025.108493_bb0270","doi-asserted-by":"crossref","first-page":"1212","DOI":"10.1159\/000492248","article-title":"Role of cytosolic serine Hydroxymethyl transferase 1 (SHMT1) in phosphate-induced vascular smooth muscle cell calcification","volume":"43","author":"Boehme","year":"2018","journal-title":"Kidney Blood Press. Res."},{"key":"10.1016\/j.bioorg.2025.108493_bb0275","doi-asserted-by":"crossref","first-page":"3837","DOI":"10.1158\/0008-5472.CAN-18-3541","article-title":"Metabolic reprogramming by MYCN confers dependence on the serine-Glycine-one-carbon biosynthetic pathway","volume":"79","author":"Xia","year":"2019","journal-title":"Cancer Res."},{"key":"10.1016\/j.bioorg.2025.108493_bb0280","doi-asserted-by":"crossref","first-page":"5381","DOI":"10.1021\/acs.jcim.4c00621","article-title":"DrugFlow: An AI-driven one-stop platform for innovative drug discovery","volume":"64","author":"Shen","year":"2024","journal-title":"J. Chem. Inf. Model."},{"key":"10.1016\/j.bioorg.2025.108493_bb0285","doi-asserted-by":"crossref","first-page":"689","DOI":"10.3340\/jkns.2020.0056","article-title":"Effect of pioglitazone on Perihematomal edema in intracerebral hemorrhage mouse model by regulating NLRP3 expression and energy metabolism","volume":"63","author":"Kim","year":"2020","journal-title":"J. Korean Neurosurgical Soc."},{"key":"10.1016\/j.bioorg.2025.108493_bb0290","doi-asserted-by":"crossref","first-page":"812","DOI":"10.1016\/j.nutres.2009.10.019","article-title":"Dietary n-3 polyunsaturated fatty acids increase oxidative stress in rats with intracerebral hemorrhagic stroke","volume":"29","author":"Park","year":"2009","journal-title":"Nutrition r Res. (New York, N.Y.)"},{"key":"10.1016\/j.bioorg.2025.108493_bb0295","article-title":"Biotransformation, pharmacokinetics, and pharmacological activities of Ginsenoside Rd against multiple diseases","volume":"13","author":"Li","year":"2022","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.bioorg.2025.108493_bb0300","doi-asserted-by":"crossref","first-page":"2687","DOI":"10.1158\/1078-0432.CCR-11-3165","article-title":"A phase I pharmacokinetic and pharmacodynamic study of CHR-3996, an oral class I selective histone deacetylase inhibitor in refractory solid tumors","volume":"18","author":"Banerji","year":"2012","journal-title":"Clinical Cancer Res\u202f: an Official J. Am Assoc. Cancer Res."},{"issue":"Suppl. 1","key":"10.1016\/j.bioorg.2025.108493_bb0305","first-page":"95","article-title":"Clinical chronopharmacokinetics","volume":"15","author":"Reinberg","year":"1984","journal-title":"Aust. J. Pharm."}],"container-title":["Bioorganic Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0045206825003736?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0045206825003736?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,5,26]],"date-time":"2025-05-26T04:19:22Z","timestamp":1748233162000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0045206825003736"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,6]]},"references-count":61,"alternative-id":["S0045206825003736"],"URL":"https:\/\/doi.org\/10.1016\/j.bioorg.2025.108493","relation":{},"ISSN":["0045-2068"],"issn-type":[{"value":"0045-2068","type":"print"}],"subject":[],"published":{"date-parts":[[2025,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Ginsenoside Rd and chrysophanol: Modulating the serine-glycine-one-carbon pathway to enhance neuroprotection in intracerebral hemorrhage","name":"articletitle","label":"Article Title"},{"value":"Bioorganic Chemistry","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bioorg.2025.108493","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"108493"}}