{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,20]],"date-time":"2026-07-20T15:46:44Z","timestamp":1784562404732,"version":"3.55.0"},"reference-count":29,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100003399","name":"Science and Technology Commission of Shanghai Municipality","doi-asserted-by":"publisher","award":["24ZR1404700"],"award-info":[{"award-number":["24ZR1404700"]}],"id":[{"id":"10.13039\/501100003399","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003395","name":"Shanghai Municipal Education Commission","doi-asserted-by":"publisher","award":["24KXZNB09"],"award-info":[{"award-number":["24KXZNB09"]}],"id":[{"id":"10.13039\/501100003395","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Bioorganic Chemistry"],"published-print":{"date-parts":[[2025,7]]},"DOI":"10.1016\/j.bioorg.2025.108496","type":"journal-article","created":{"date-parts":[[2025,4,21]],"date-time":"2025-04-21T19:05:03Z","timestamp":1745262303000},"page":"108496","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":4,"special_numbering":"C","title":["Identification of CH2-linker modified desfluoroquinolone-aminopyrimidine hybrids to combat antibiotic-resistant gram-positive bacteria"],"prefix":"10.1016","volume":"161","author":[{"given":"Yue","family":"Hu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinghua","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiayi","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tao","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peng","family":"Cui","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Renhua","family":"Fan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiuqin","family":"He","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bioorg.2025.108496_bb0005","doi-asserted-by":"crossref","DOI":"10.1111\/1751-7915.14510","article-title":"The antibiotic resistance crisis and the development of new antibiotics","volume":"17","author":"Br\u00fcssow","year":"2024","journal-title":"Microb. Biotechnol."},{"key":"10.1016\/j.bioorg.2025.108496_bb0010","doi-asserted-by":"crossref","first-page":"18033","DOI":"10.1038\/nrdp.2018.33","article-title":"Methicillin-resistant Staphylococcus aureus","volume":"4","author":"Lee","year":"2018","journal-title":"Nat. Rev. Dis. Primers"},{"key":"10.1016\/j.bioorg.2025.108496_bb0015","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1136\/jcp.14.4.385","article-title":"Methicillin-resistant staphylococci","volume":"14","author":"Barber","year":"1961","journal-title":"J. Clin. Pathol."},{"key":"10.1016\/j.bioorg.2025.108496_bb0020","doi-asserted-by":"crossref","first-page":"S5","DOI":"10.1086\/491709","article-title":"Vancomycin: a history","volume":"42","author":"Levine","year":"2006","journal-title":"Clin. Infect. Dis."},{"key":"10.1016\/j.bioorg.2025.108496_bb0025","doi-asserted-by":"crossref","first-page":"4425","DOI":"10.2174\/0109298673249381231130111352","article-title":"Treatment of MRSA infection: where are we?","volume":"31","author":"Ni","year":"2024","journal-title":"Curr. Med. Chem."},{"key":"10.1016\/j.bioorg.2025.108496_bb0030","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1093\/ofid\/ofac137","article-title":"Approaching 65 years: is it time to consider retirement of vancomycin for treating methicillin-resistant Staphylococcus aureus endovascular infections?","volume":"9","author":"Rose","year":"2022","journal-title":"Open Forum Infect. Diseases"},{"key":"10.1016\/j.bioorg.2025.108496_bb0035","doi-asserted-by":"crossref","DOI":"10.1371\/journal.ppat.1012422","article-title":"Vancomycin-resistant Staphylococcus aureus (VRSA) can overcome the cost of antibiotic resistance and may threaten vancomycin\u2019s clinical durability","volume":"20","author":"Blechman","year":"2024","journal-title":"PLoS Pathog."},{"key":"10.1016\/j.bioorg.2025.108496_bb0040","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejmech.2024.116399","article-title":"Identification of CH2-linked quinolone-aminopyrimidine hybrids as potent anti-MRSA agents: low resistance potential and lack of cross-resistance with fluoroquinolone antibiotics","volume":"271","author":"Dai","year":"2024","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.bioorg.2025.108496_bb0045","doi-asserted-by":"crossref","DOI":"10.1016\/j.bioorg.2024.107773","article-title":"Fluoroquinolones tackling antimicrobial resistance: rational design, mechanistic insights and comparative analysis of norfloxacin vs ciprofloxacin derivatives","volume":"153","author":"Khanna","year":"2024","journal-title":"Bioorg. Chem."},{"key":"10.1016\/j.bioorg.2025.108496_bb0050","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejmech.2024.116630","article-title":"Design, synthesis and structure-activity relationships of novel non-ketolides: 9-oxime clarithromycin featured with seven-to thirteen-atom-length diamine linkers at 3-OH","volume":"276","author":"Ma","year":"2024","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.bioorg.2025.108496_bb0055","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejmech.2024.116626","article-title":"Synthesis and antibacterial medicinal evaluation of carbothioamido hydrazonyl thiazolylquinolone with multitargeting antimicrobial potential to combat increasingly global resistance","volume":"275","author":"Zang","year":"2024","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.bioorg.2025.108496_bb0060","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejmech.2024.116215","article-title":"Effective ciprofloxacin cationic antibacterial agent against persister bacteria with low hemolytic toxicity","volume":"267","author":"Gao","year":"2024","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.bioorg.2025.108496_bb0065","article-title":"Design and structure-activity relationships of ether-linked alkylides: hybrids of 3-O-descladinosyl macrolides and quinolone motifs","volume":"151","author":"Zhang","year":"2024","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.bioorg.2025.108496_bb0070","doi-asserted-by":"crossref","first-page":"9465","DOI":"10.1021\/acs.jmedchem.4c00558","article-title":"Discovery and structure\u2013activity relationship of cadazolid: a first-in-class quinoxolidinone antibiotic for the treatment of clostridioides difficile infection","volume":"67","author":"Rueedi","year":"2024","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.bioorg.2025.108496_bb0075","doi-asserted-by":"crossref","first-page":"2169","DOI":"10.1021\/acs.jmedchem.2c02044","article-title":"Design and synthesis of 3-hydroxy-pyridin-4(1H)-ones\u2013ciprofloxacin conjugates as dual antibacterial and antibiofilm agents against Pseudomonas aeruginosa","volume":"66","author":"Wang","year":"2023","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.bioorg.2025.108496_bb0080","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejmech.2022.115026","article-title":"Current scenario of quinolone hybrids with potential antibacterial activity against ESKAPE pathogens","volume":"247","author":"Gao","year":"2023","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.bioorg.2025.108496_bb0085","doi-asserted-by":"crossref","first-page":"555","DOI":"10.4155\/fmc-2023-0002","article-title":"Recent advances in quinolone hybrids with potential antibacterial activity against drug-resistant bacteria","volume":"15","author":"Wang","year":"2023","journal-title":"Future Med. Chem."},{"key":"10.1016\/j.bioorg.2025.108496_bb0090","doi-asserted-by":"crossref","first-page":"2725","DOI":"10.1021\/acsomega.1c05303","article-title":"Ciprofloxacin-tethered 1,2,3-triazole conjugates: new quinolone family compounds to upgrade our antiquated approach against bacterial infections","volume":"7","author":"Agarwal","year":"2022","journal-title":"ACS Omega"},{"key":"10.1016\/j.bioorg.2025.108496_bb0095","doi-asserted-by":"crossref","DOI":"10.1016\/j.bioorg.2020.104176","article-title":"Design and synthesis of novel desfluoroquinolone-aminopyrimidine hybrids as potent anti-MRSA agents with low hERG activity","volume":"103","author":"Song","year":"2020","journal-title":"Bioorg. Chem."},{"key":"10.1016\/j.bioorg.2025.108496_bb0100","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1099\/jmm.0.000873","article-title":"Mechanisms of ciprofloxacin resistance in Pseudomonas aeruginosa: new approaches to an old problem","volume":"68","author":"Rehman","year":"2019","journal-title":"J. Med. Microbiol."},{"key":"10.1016\/j.bioorg.2025.108496_bb0105","doi-asserted-by":"crossref","DOI":"10.3389\/fmicb.2020.598291","article-title":"Mechanisms for development of ciprofloxacin resistance in a clinical isolate of Pseudomonas aeruginosa","volume":"11","author":"Xu","year":"2021","journal-title":"Front. Microbiol."},{"key":"10.1016\/j.bioorg.2025.108496_bb0110","doi-asserted-by":"crossref","first-page":"535","DOI":"10.2165\/00003495-200868040-00011","article-title":"Levofloxacin: a review of its use as a high-dose, short-course treatment for bacterial infection","volume":"68","author":"Anderson","year":"2008","journal-title":"Drugs"},{"key":"10.1016\/j.bioorg.2025.108496_bb0115","doi-asserted-by":"crossref","first-page":"1049","DOI":"10.1016\/S0149-2918(98)80104-5","article-title":"Levofloxacin: a therapeutic review","volume":"20","author":"Wimer","year":"1998","journal-title":"Clin. Ther."},{"key":"10.1016\/j.bioorg.2025.108496_bb0120","doi-asserted-by":"crossref","first-page":"2321","DOI":"10.1128\/AAC.40.10.2321","article-title":"Involvement of topoisomerase IV and DNA gyrase as ciprofloxacin targets in Streptococcus pneumoniae","volume":"40","author":"Pan","year":"1996","journal-title":"Antimicrob. Agents Chemother."},{"key":"10.1016\/j.bioorg.2025.108496_bb0125","doi-asserted-by":"crossref","first-page":"35927","DOI":"10.1074\/jbc.274.50.35927","article-title":"Quinolones inhibit DNA religation mediated by Staphylococcus aureus topoisomerase IV. Changes in drug mechanism across evolutionary boundaries","volume":"274","author":"Anderson","year":"1999","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bioorg.2025.108496_bb0130","doi-asserted-by":"crossref","first-page":"2726","DOI":"10.1021\/bi992302n","article-title":"Action of quinolones against Staphylococcus aureus topoisomerase IV: basis for DNA cleavage enhancement","volume":"39","author":"Anderson","year":"2000","journal-title":"Biochem"},{"key":"10.1016\/j.bioorg.2025.108496_bb0135","doi-asserted-by":"crossref","first-page":"11861","DOI":"10.1039\/C4RA11682H","article-title":"Structure, antimicrobial activity, albumin- and DNA-binding of manganese(ii)\u2013sparfloxacinato complexes","volume":"5","author":"Zampakou","year":"2015","journal-title":"RSC Adv."},{"key":"10.1016\/j.bioorg.2025.108496_bb0140","doi-asserted-by":"crossref","first-page":"2291","DOI":"10.1021\/acsinfecdis.2c00365","article-title":"Discovery of new anti-MRSA agents based on phenoxyethanol and its mechanism","volume":"8","author":"Xie","year":"2022","journal-title":"ACS Infect. Dis."},{"key":"10.1016\/j.bioorg.2025.108496_bb0145","doi-asserted-by":"crossref","first-page":"9028","DOI":"10.1021\/acs.jmedchem.4c00238","article-title":"Cyanomethylquinolones as a new class of potential multitargeting broad-spectrum antibacterial agents","volume":"67","author":"Tan","year":"2024","journal-title":"J. Med. Chem."}],"container-title":["Bioorganic Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0045206825003761?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0045206825003761?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,7,25]],"date-time":"2025-07-25T13:05:53Z","timestamp":1753448753000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0045206825003761"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,7]]},"references-count":29,"alternative-id":["S0045206825003761"],"URL":"https:\/\/doi.org\/10.1016\/j.bioorg.2025.108496","relation":{},"ISSN":["0045-2068"],"issn-type":[{"value":"0045-2068","type":"print"}],"subject":[],"published":{"date-parts":[[2025,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Identification of CH2-linker modified desfluoroquinolone-aminopyrimidine hybrids to combat antibiotic-resistant gram-positive bacteria","name":"articletitle","label":"Article Title"},{"value":"Bioorganic Chemistry","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bioorg.2025.108496","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"108496"}}