{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T16:46:56Z","timestamp":1786985216281,"version":"build-2736575974"},"reference-count":51,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100002383","name":"King Saud University","doi-asserted-by":"publisher","award":["RSP2025R349"],"award-info":[{"award-number":["RSP2025R349"]}],"id":[{"id":"10.13039\/501100002383","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Bioorganic Chemistry"],"published-print":{"date-parts":[[2025,7]]},"DOI":"10.1016\/j.bioorg.2025.108584","type":"journal-article","created":{"date-parts":[[2025,5,12]],"date-time":"2025-05-12T10:58:02Z","timestamp":1747047482000},"page":"108584","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":10,"special_numbering":"C","title":["Development and evaluation of chitosan conjugated Isatin-linked Pyrazole derivative to target anti-inflammatory and anti-fibrotic in ethanol induced liver fibrosis using an in-vivo zebra fish model"],"prefix":"10.1016","volume":"162","author":[{"given":"S.","family":"Madesh","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sanjay","family":"Gopi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karthikeyan","family":"Ramamurthy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mukil","family":"Srivasan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kathiravan Muthu","family":"Kumaradoss","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marapatla","family":"Shiny","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohamed Farouk","family":"Elsadek","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohamed S.","family":"Elshikh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Selvaraj","family":"Arokiyaraj","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vellapandian","family":"Chitra","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Girija Sastry","family":"Vedula","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jesu","family":"Arockiaraj","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bioorg.2025.108584_bb0005","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s41598-018-34351-5","article-title":"Mesenchymal stromal cells prevent progression of liver fibrosis in a novel zebrafish embryo model","volume":"8","author":"van der Helm","year":"2018","journal-title":"Sci. Rep."},{"key":"10.1016\/j.bioorg.2025.108584_bb0010","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1016\/j.jhep.2023.11.006","article-title":"Association between public health policies on alcohol and worldwide cancer, liver disease and cardiovascular disease outcomes","volume":"80","author":"D\u00edaz","year":"2024","journal-title":"J. Hepatol."},{"key":"10.1016\/j.bioorg.2025.108584_bb0015","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1089\/zeb.2014.1054","article-title":"Development of an animal model for alcoholic liver disease in zebrafish","volume":"12","author":"Lin","year":"2015","journal-title":"Zebrafish"},{"key":"10.1016\/j.bioorg.2025.108584_bb0020","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2019.109179","article-title":"Low dose of chronic ethanol exposure in adult zebrafish induces hepatic steatosis and injury","volume":"117","author":"Park","year":"2019","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.bioorg.2025.108584_bb0025","doi-asserted-by":"crossref","first-page":"418","DOI":"10.4254\/wjh.v9.i8.418","article-title":"Chronic exposure to ethanol causes steatosis and inflammation in zebrafish liver","volume":"9","author":"Schneider","year":"2017","journal-title":"World J. Hepatol."},{"key":"10.1016\/j.bioorg.2025.108584_bb0030","first-page":"1","article-title":"Using zebrafish as a disease model to study fibrotic disease","volume":"22","author":"Wang","year":"2021","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.bioorg.2025.108584_bb0035","article-title":"Anti-inflammatory and antinociceptive effects of the isatin derivative (Z)-2-(5-chloro-2-oxoindolin-3-ylidene)-N-phenyl-hydrazinecarbothioamide in mice, Brazilian J. Med","volume":"53","author":"Dantas","year":"2020","journal-title":"Biol. Res."},{"key":"10.1016\/j.bioorg.2025.108584_bb0040","article-title":"A survey of isatin hybrids and their biological properties","author":"Shu","year":"2024","journal-title":"Mol. Divers."},{"key":"10.1016\/j.bioorg.2025.108584_bb0045","first-page":"156","article-title":"Synthesis and optimization of chitosan nanoparticles: potential applications in nanomedicine and biomedical engineering","volume":"5","author":"Ghadi","year":"2014","journal-title":"Casp. J. Intern. Med."},{"key":"10.1016\/j.bioorg.2025.108584_bb0050","doi-asserted-by":"crossref","first-page":"2173","DOI":"10.1002\/app.38354","article-title":"Encapsulation and release of cladribine from chitosan nanoparticles","volume":"128","author":"Domaratzki","year":"2013","journal-title":"J. Appl. Polym. Sci."},{"key":"10.1016\/j.bioorg.2025.108584_bb0055","doi-asserted-by":"crossref","first-page":"756","DOI":"10.1208\/aapsj080485","article-title":"In vitro evaluation of chitosan-EDTA conjugate polyplexes as a nanoparticulate gene delivery system","volume":"8","author":"Loretz","year":"2006","journal-title":"AAPS J."},{"key":"10.1016\/j.bioorg.2025.108584_bb0060","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2024.113206","article-title":"COX-2 targeted therapy for diabetic foot ulcers using T7-enhanced CS-PVA membranes","volume":"143","author":"Murugan","year":"2024","journal-title":"Int. Immunopharmacol."},{"key":"10.1016\/j.bioorg.2025.108584_bb0065","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijbiomac.2024.137599","article-title":"1,5- diaryl pyrazole-loaded chitosan nanoparticles as COX-2 inhibitors, mitigate neoplastic growth by regulating NF-\u03baB pathway in-vivo zebrafish model","volume":"283","author":"Murugan","year":"2024","journal-title":"Int. J. Biol. Macromol."},{"key":"10.1016\/j.bioorg.2025.108584_bb0070","doi-asserted-by":"crossref","DOI":"10.1016\/j.micpath.2023.106123","article-title":"Luteolin, a promising quorum quencher mitigates virulence factors production in Pseudomonas aeruginosa - in vitro and in vivoapproach","volume":"180","author":"Nayak","year":"2023","journal-title":"Microb. Pathog."},{"key":"10.1016\/j.bioorg.2025.108584_bb0075","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1016\/j.procbio.2024.04.012","article-title":"Furan-based chalcone protects \u03b2-cell damage and improves glucose uptake in alloxan-induced zebrafish diabetic model via influencing peroxisome proliferator-activated receptor agonists (PPAR-\u03b3) signaling","volume":"142","author":"Nayak","year":"2024","journal-title":"Process Biochem."},{"key":"10.1016\/j.bioorg.2025.108584_bb0080","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejphar.2023.175994","article-title":"Furan based synthetic chalcone derivative functions against gut inflammation and oxidative stress demonstrated in in-vivo zebrafish model","volume":"957","author":"Nayak","year":"2023","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.bioorg.2025.108584_bb0085","doi-asserted-by":"crossref","DOI":"10.1016\/j.scitotenv.2024.175319","article-title":"Parental (F0) exposure to cadmium and Ketoprofen induces developmental deformities in offspring (F1): a transgenerational toxicity assessment in zebrafish model","volume":"950","author":"Madesh","year":"2024","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.bioorg.2025.108584_bb0090","first-page":"1","article-title":"Cadmium and ketoprofen accumulation influences aquatic ecosystem demonstrated using in-vivo zebrafish model","author":"Madesh","year":"2024","journal-title":"Drug Chem. Toxicol."},{"key":"10.1016\/j.bioorg.2025.108584_bb0095","doi-asserted-by":"crossref","first-page":"5350","DOI":"10.3390\/molecules28145350","article-title":"Ophthalmic intervention of Naringenin decreases vascular endothelial growth factor by counteracting oxidative stress and cellular damage in in vivo zebrafish","volume":"28","author":"Sudhakaran","year":"2023","journal-title":"Molecules"},{"key":"10.1016\/j.bioorg.2025.108584_bb0100","article-title":"236: fish embryo acute toxicity (FET) test","author":"No","year":"2013","journal-title":"OECD"},{"key":"10.1016\/j.bioorg.2025.108584_bb0105","doi-asserted-by":"crossref","DOI":"10.1016\/j.scitotenv.2024.171706","article-title":"Mechanistic interplay of dual environmental stressors: bisphenol-a and cadmium-induced ovarian follicular damage and hepatocyte dysfunction in vivo","volume":"924","author":"Sudhakaran","year":"2024","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.bioorg.2025.108584_bb0110","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1093\/ajcp\/28.1.56","article-title":"A colorimetric method for the determination of serum glutamic Oxalacetic and glutamic pyruvic transaminases","volume":"28","author":"Reitman","year":"1957","journal-title":"Am. J. Clin. Pathol."},{"key":"10.1016\/j.bioorg.2025.108584_bb0115","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1016\/S0021-9258(18)43072-4","article-title":"A method for the rapid determination of alkaline phosphates with five cubic millimeters of serum","volume":"164","author":"Bessey","year":"1946","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bioorg.2025.108584_bb0120","doi-asserted-by":"crossref","first-page":"619","DOI":"10.1186\/s40064-015-1408-6","article-title":"Modulatory effect of protocatechuic acid on cadmium induced nephrotoxicity and hepatoxicity in rats in vivo","volume":"4","author":"Adefegha","year":"2015","journal-title":"Springerplus"},{"key":"10.1016\/j.bioorg.2025.108584_bb0125","doi-asserted-by":"crossref","first-page":"633","DOI":"10.1016\/j.carbpol.2009.04.033","article-title":"A simple method for hyaluronic acid quantification in culture broth","volume":"78","author":"Song","year":"2009","journal-title":"Carbohydr. Polym."},{"key":"10.1016\/j.bioorg.2025.108584_bb0130","first-page":"1","article-title":"Metabolomic characterizations of liver injury caused by acute arsenic toxicity in zebrafish","volume":"11","author":"Li","year":"2016","journal-title":"PLoS One"},{"key":"10.1016\/j.bioorg.2025.108584_bb0135","first-page":"1","article-title":"A zebrafish model for studying the mechanisms of newborn hyperbilirubinemia and bilirubin-induced neurological damage, front. Cell","volume":"11","author":"Guzelkaya","year":"2023","journal-title":"Dev. Biol."},{"key":"10.1016\/j.bioorg.2025.108584_bb0140","article-title":"Protective effect of sulfur-containing heterocyclic analogs against acrylamide-induced behavioral and biochemical alterations in zebrafish","author":"Haridevamuthu","year":"2024","journal-title":"Mol. Neurobiol."},{"key":"10.1016\/j.bioorg.2025.108584_bb0145","doi-asserted-by":"crossref","DOI":"10.1016\/j.cbpc.2023.109600","article-title":"Trihydroxy piperlongumine protects aluminium induced neurotoxicity in zebrafish: behavioral and biochemical approach","volume":"268","author":"Haridevamuthu","year":"2023","journal-title":"Comp. Biochem. Physiol. Part C Toxicol. Pharmacol."},{"key":"10.1016\/j.bioorg.2025.108584_bb0150","doi-asserted-by":"crossref","DOI":"10.1016\/j.jhazmat.2023.132524","article-title":"Synthetic azo-dye, Tartrazine induces neurodevelopmental toxicity via mitochondria-mediated apoptosis in zebrafish embryos","volume":"461","author":"Haridevamuthu","year":"2024","journal-title":"J. Hazard. Mater."},{"key":"10.1016\/j.bioorg.2025.108584_bb0155","doi-asserted-by":"crossref","DOI":"10.1016\/j.bcp.2024.116601","article-title":"Protective role of 2-aminothiazole derivative against ethanol-induced teratogenic effects in-vivo zebrafish","volume":"230","author":"Madesh","year":"2024","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.bioorg.2025.108584_bb0160","doi-asserted-by":"crossref","first-page":"973","DOI":"10.7150\/ijbs.30013","article-title":"A comprehensive study of high cholesterol diet-induced larval zebrafish model: a short-time in vivo screening method for non-alcoholic fatty liver disease drugs","volume":"15","author":"Ma","year":"2019","journal-title":"Int. J. Biol. Sci."},{"key":"10.1016\/j.bioorg.2025.108584_bb0165","first-page":"1","article-title":"Development of an ethanol-induced fibrotic liver model in zebrafish to study progenitor cell-mediated hepatocyte regeneration","volume":"2016","author":"Huang","year":"2016","journal-title":"J. Vis. Exp."},{"key":"10.1016\/j.bioorg.2025.108584_bb0170","article-title":"Preparation of Phillygenin-hyaluronic acid composite milk-derived exosomes and its anti-hepatic fibrosis effect","volume":"23","author":"Gong","year":"2023","journal-title":"Mater. Today Bio"},{"key":"10.1016\/j.bioorg.2025.108584_bb0175","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3390\/nano9010122","article-title":"Impaired liver size and compromised neurobehavioral activity are elicited by chitosan nanoparticles in the zebrafish embryo model","volume":"9","author":"Abou-Saleh","year":"2019","journal-title":"Nanomaterials"},{"key":"10.1016\/j.bioorg.2025.108584_bb0180","first-page":"506","article-title":"Hepatoprotective effects of chitosan and chitosan nanoparticles against biochemical, genetic, and histological disorders induced by the toxicity of Emamectin benzoate, reports Biochem","volume":"10","author":"Fathalla Dawoud","year":"2021","journal-title":"Mol. Biol."},{"key":"10.1016\/j.bioorg.2025.108584_bb0185","doi-asserted-by":"crossref","first-page":"870","DOI":"10.3390\/nano10050870","article-title":"Chitosan nanoparticles for therapy and Theranostics of hepatocellular carcinoma (HCC) and liver-targeting","volume":"10","author":"Bonferoni","year":"2020","journal-title":"Nanomaterials"},{"key":"10.1016\/j.bioorg.2025.108584_bb0190","doi-asserted-by":"crossref","first-page":"364","DOI":"10.1016\/j.jddst.2019.03.019","article-title":"Preparation, toxicity analysis and in vivo protective effect of phyllanthin-loaded PLGA nanoparticles against CCl 4 -induced hepatic fibrosis","volume":"51","author":"Krithika","year":"2019","journal-title":"J. Drug Deliv. Sci. Technol."},{"key":"10.1016\/j.bioorg.2025.108584_bb0195","doi-asserted-by":"crossref","DOI":"10.1242\/dmm.031575","article-title":"Inorganic arsenic causes fatty liver and interacts with ethanol to cause alcoholic liver disease in zebrafish","volume":"11","author":"Bambino","year":"2018","journal-title":"Dis. Model. Mech."},{"key":"10.1016\/j.bioorg.2025.108584_bb0200","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2019.01594","article-title":"P-Hydroxyacetophenone ameliorates alcohol-induced steatosis and oxidative stress via the NF-\u03baB signaling pathway in zebrafish and hepatocytes","volume":"10","author":"Huang","year":"2020","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.bioorg.2025.108584_bb0205","doi-asserted-by":"crossref","first-page":"7813","DOI":"10.1038\/s41598-024-58043-5","article-title":"Hepatic extracellular ATP\/adenosine dynamics in zebrafish models of alcoholic and metabolic steatotic liver disease","volume":"14","author":"Tokumaru","year":"2024","journal-title":"Sci. Rep."},{"key":"10.1016\/j.bioorg.2025.108584_bb0210","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1080\/1354750X.2021.1874051","article-title":"Chronic exposure to ethanol alters the expression of miR-155, miR-122 and miR-217 in alcoholic liver disease in an adult zebrafish model","volume":"26","author":"Pasqualotto","year":"2021","journal-title":"Biomarkers"},{"key":"10.1016\/j.bioorg.2025.108584_bb0215","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0171898","article-title":"Hyaluronic acid synthesis is required for zebrafish tail fin regeneration","volume":"12","author":"Ouyang","year":"2017","journal-title":"PLoS One"},{"key":"10.1016\/j.bioorg.2025.108584_bb0220","doi-asserted-by":"crossref","DOI":"10.1096\/fj.202101686R","article-title":"Liver regeneration and ethanol detoxification: a new link in YAP regulation of ALDH1A1 during alcohol-related hepatocyte damage","volume":"36","author":"Zhou","year":"2022","journal-title":"FASEB J."},{"key":"10.1016\/j.bioorg.2025.108584_bb0225","doi-asserted-by":"crossref","first-page":"1258","DOI":"10.3390\/antiox11071258","article-title":"Ethanol metabolism in the liver, the induction of oxidant stress, and the antioxidant defense system","volume":"11","author":"Contreras-Zentella","year":"2022","journal-title":"Antioxidants"},{"key":"10.1016\/j.bioorg.2025.108584_bb0230","doi-asserted-by":"crossref","first-page":"5717","DOI":"10.3390\/ijms22115717","article-title":"Pathophysiological aspects of alcohol metabolism in the liver","volume":"22","author":"Hyun","year":"2021","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.bioorg.2025.108584_bb0235","doi-asserted-by":"crossref","first-page":"15","DOI":"10.21037\/dmr-21-91","article-title":"Narrative review on alcoholic liver disease: from fibrosis to cancer","volume":"5","author":"Seitz","year":"2022","journal-title":"Dig. Med. Res."},{"key":"10.1016\/j.bioorg.2025.108584_bb0240","doi-asserted-by":"crossref","first-page":"264","DOI":"10.1159\/000090174","article-title":"Molecular mechanisms of alcohol-induced hepatic fibrosis","volume":"23","author":"Siegmund","year":"2005","journal-title":"Dig. Dis."},{"key":"10.1016\/j.bioorg.2025.108584_bb0245","doi-asserted-by":"crossref","first-page":"14090","DOI":"10.1038\/s41598-018-32497-w","article-title":"Astaxanthin alleviated ethanol-induced liver injury by inhibition of oxidative stress and inflammatory responses via blocking of STAT3 activity","volume":"8","author":"Han","year":"2018","journal-title":"Sci. Rep."},{"key":"10.1016\/j.bioorg.2025.108584_bb0250","doi-asserted-by":"crossref","first-page":"14672","DOI":"10.3748\/wjg.v20.i40.14672","article-title":"Ethanol and liver: recent insights into the mechanisms of ethanol-induced fatty liver","volume":"20","author":"Liu","year":"2014","journal-title":"World J. Gastroenterol."},{"key":"10.1016\/j.bioorg.2025.108584_bb0255","doi-asserted-by":"crossref","first-page":"24424","DOI":"10.1007\/s11356-022-23789-w","article-title":"Protective efficacy of dietary natural antioxidants on microplastic particles-induced histopathological lesions in African catfish (Clarias gariepinus)","volume":"30","author":"Sayed","year":"2023","journal-title":"Environ. Sci. Pollut. Res."}],"container-title":["Bioorganic Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S004520682500464X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S004520682500464X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,6,3]],"date-time":"2025-06-03T14:05:10Z","timestamp":1748959510000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S004520682500464X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,7]]},"references-count":51,"alternative-id":["S004520682500464X"],"URL":"https:\/\/doi.org\/10.1016\/j.bioorg.2025.108584","relation":{},"ISSN":["0045-2068"],"issn-type":[{"value":"0045-2068","type":"print"}],"subject":[],"published":{"date-parts":[[2025,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Development and evaluation of chitosan conjugated Isatin-linked Pyrazole derivative to target anti-inflammatory and anti-fibrotic in ethanol induced liver fibrosis using an in-vivo zebra fish model","name":"articletitle","label":"Article Title"},{"value":"Bioorganic Chemistry","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bioorg.2025.108584","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"108584"}}