{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T17:39:28Z","timestamp":1793381968107,"version":"4.5.0"},"reference-count":44,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100003443","name":"Ministry of Science and Higher Education of the Russian Federation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003443","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100016971","name":"Lomonosov Moscow State University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100016971","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012190","name":"Ministry of Science and Higher Education of the Russian Federation","doi-asserted-by":"publisher","award":["075\\u201315\\u20132024-539"],"award-info":[{"award-number":["075\\u201315\\u20132024-539"]}],"id":[{"id":"10.13039\/501100012190","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Bioorganic Chemistry"],"published-print":{"date-parts":[[2025,7]]},"DOI":"10.1016\/j.bioorg.2025.108588","type":"journal-article","created":{"date-parts":[[2025,5,13]],"date-time":"2025-05-13T14:59:52Z","timestamp":1747148392000},"page":"108588","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":7,"special_numbering":"C","title":["AMPK-specific autophagy activator based on 1,3-diaza-2-oxophenoxazine"],"prefix":"10.1016","volume":"162","author":[{"given":"Ekaterina A.","family":"Guseva","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrey G.","family":"Tereshchenkov","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Polina N.","family":"Kamzeeva","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Boris P.","family":"Myasnikov","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Georgy K.","family":"Slushko","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Evgeny S.","family":"Belyaev","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sofya Y.","family":"Sokolskaya","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julia A.","family":"Golubeva","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria P.","family":"Rubtsova","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Petr V.","family":"Sergiev","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrey V.","family":"Aralov","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bioorg.2025.108588_bb0005","doi-asserted-by":"crossref","DOI":"10.1016\/j.arr.2021.101468","article-title":"Autophagy and the hallmarks of aging","volume":"72","author":"Kaushik","year":"2021","journal-title":"Ageing Res. Rev."},{"key":"10.1016\/j.bioorg.2025.108588_bb0010","doi-asserted-by":"crossref","DOI":"10.15252\/embj.2020104705","article-title":"Molecular mechanisms and physiological functions of mitophagy","volume":"40","author":"Onishi","year":"2021","journal-title":"EMBO J."},{"key":"10.1016\/j.bioorg.2025.108588_bb0015","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1038\/s41556-017-0007-x","article-title":"Systematic analysis of ribophagy in human cells reveals bystander flux during selective autophagy","volume":"20","author":"An","year":"2018","journal-title":"Nat. Cell Biol."},{"key":"10.1016\/j.bioorg.2025.108588_bb0020","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1038\/s41419-022-04593-3","article-title":"The regulation, function, and role of lipophagy, a form of selective autophagy, in metabolic disorders","volume":"13","author":"Zhang","year":"2022","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.bioorg.2025.108588_bb0025","doi-asserted-by":"crossref","first-page":"879","DOI":"10.1038\/nm.4132","article-title":"Urolithin a induces mitophagy and prolongs lifespan in C. Elegans and increases muscle function in rodents","volume":"22","author":"Ryu","year":"2016","journal-title":"Nat. Med."},{"key":"10.1016\/j.bioorg.2025.108588_bb0030","doi-asserted-by":"crossref","first-page":"491","DOI":"10.3389\/fnins.2019.00491","article-title":"Insulin and autophagy in neurodegeneration","volume":"13","author":"De Mello","year":"2019","journal-title":"Front. Neurosci."},{"key":"10.1016\/j.bioorg.2025.108588_bb0035","doi-asserted-by":"crossref","DOI":"10.3389\/fcell.2021.651021","article-title":"From metabolic syndrome to neurological diseases: role of autophagy","volume":"9","author":"Maiuolo","year":"2021","journal-title":"Front. Cell Dev. Biol."},{"key":"10.1016\/j.bioorg.2025.108588_bb0040","doi-asserted-by":"crossref","first-page":"3374","DOI":"10.1073\/pnas.0712145105","article-title":"A role for the NAD-dependent deacetylase Sirt1 in the regulation of autophagy","volume":"105","author":"Lee","year":"2008","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.bioorg.2025.108588_bb0045","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1016\/j.cell.2010.01.028","article-title":"Methods in mammalian autophagy research","volume":"140","author":"Mizushima","year":"2010","journal-title":"Cell"},{"key":"10.1016\/j.bioorg.2025.108588_bb0050","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1146\/annurev-genet-102808-114910","article-title":"Regulation mechanisms and signaling pathways of autophagy","volume":"43","author":"He","year":"2009","journal-title":"Annu. Rev. Genet."},{"key":"10.1016\/j.bioorg.2025.108588_bb0055","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1038\/ncb2152","article-title":"AMPK and mTOR regulate autophagy through direct phosphorylation of Ulk1","volume":"13","author":"Kim","year":"2011","journal-title":"Nat. Cell Biol."},{"key":"10.1016\/j.bioorg.2025.108588_bb0060","doi-asserted-by":"crossref","first-page":"1015500","DOI":"10.3389\/fphys.2022.1015500","article-title":"Role of AMPK in autophagy","volume":"13","author":"Wang","year":"2022","journal-title":"Front. Physiol."},{"key":"10.1016\/j.bioorg.2025.108588_bb0065","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1134\/S0006297924010024","article-title":"Synthetic activators of autophagy","volume":"89","author":"Guseva","year":"2024","journal-title":"Biochem. Mosc."},{"key":"10.1016\/j.bioorg.2025.108588_bb0070","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1134\/S0006297924010012","article-title":"Natural activators of autophagy","volume":"89","author":"Pavlova","year":"2024","journal-title":"Biochem. Mosc."},{"key":"10.1016\/j.bioorg.2025.108588_bb0075","doi-asserted-by":"crossref","first-page":"16982","DOI":"10.1073\/pnas.1004498107","article-title":"A small-molecule scaffold induces autophagy in primary neurons and protects against toxicity in a Huntington disease model","volume":"107","author":"Tsvetkov","year":"2010","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.bioorg.2025.108588_bb0080","doi-asserted-by":"crossref","first-page":"115","DOI":"10.2174\/1871520616666160624091519","article-title":"Induction of Autophagic cell death in apoptosis-resistant pancreatic Cancer cells using benzo[\u03b1]phenoxazines derivatives, 10-methyl-benzo[\u03b1]phenoxazine-5-one and benzo[\u03b1]phenoxazine-5-one","volume":"17","author":"Pal","year":"2017","journal-title":"ACAMC"},{"key":"10.1016\/j.bioorg.2025.108588_bb0085","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1016\/j.antiviral.2019.01.010","article-title":"Antiviral activity spectrum of phenoxazine nucleoside derivatives","volume":"163","author":"Kozlovskaya","year":"2019","journal-title":"Antivir. Res."},{"key":"10.1016\/j.bioorg.2025.108588_bb0090","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejmech.2021.113467","article-title":"Phenoxazine nucleoside derivatives with a multiple activity against RNA and DNA viruses","volume":"220","author":"Kozlovskaya","year":"2021","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.bioorg.2025.108588_bb0095","doi-asserted-by":"crossref","DOI":"10.1016\/j.bmcl.2024.129980","article-title":"Modified (2\u2032-deoxy)adenosines activate autophagy primarily through AMPK\/ULK1-dependent pathway","volume":"113","author":"Guseva","year":"2024","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"10.1016\/j.bioorg.2025.108588_bb0100","doi-asserted-by":"crossref","first-page":"3817","DOI":"10.1083\/jcb.201804132","article-title":"Genome-wide CRISPR screen identifies TMEM41B as a gene required for autophagosome formation","volume":"217","author":"Morita","year":"2018","journal-title":"J. Cell Biol."},{"key":"10.1016\/j.bioorg.2025.108588_bb0105","doi-asserted-by":"crossref","first-page":"9106","DOI":"10.3390\/ijms24109106","article-title":"Kidney-related function of mitochondrial protein Mitoregulin","volume":"24","author":"Averina","year":"2023","journal-title":"IJMS"},{"key":"10.1016\/j.bioorg.2025.108588_bb0110","doi-asserted-by":"crossref","first-page":"3891","DOI":"10.1021\/acs.jcim.1c00203","article-title":"AutoDock Vina 1.2.0: new docking methods, expanded force field, and Python bindings","volume":"61","author":"Eberhardt","year":"2021","journal-title":"J. Chem. Inf. Model."},{"key":"10.1016\/j.bioorg.2025.108588_bb0115","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1002\/jcc.21334","article-title":"AutoDock Vina: improving the speed and accuracy of docking with a new scoring function, efficient optimization, and multithreading","volume":"31","author":"Trott","year":"2010","journal-title":"J. Comput. Chem."},{"key":"10.1016\/j.bioorg.2025.108588_bb0120","series-title":"Direct \u03b21\/ \u03b22 AMPK Activation Reduces Liver Steatosis but Not Fibrosis in a Mouse Model of Non-alcoholic Steatohepatitis","author":"Mather","year":"2024"},{"key":"10.1016\/j.bioorg.2025.108588_bb0125","first-page":"17","article-title":"Avogadro: an advanced semantic chemical editor, visualization, and analysis platform","volume":"4","author":"Hanwell","year":"2012","journal-title":"J. Chemother."},{"key":"10.1016\/j.bioorg.2025.108588_bb0130","first-page":"33","article-title":"Open babel: An open chemical toolbox","volume":"3","author":"O\u2019Boyle","year":"2011","journal-title":"J. Chemother."},{"key":"10.1016\/j.bioorg.2025.108588_bb0135","doi-asserted-by":"crossref","first-page":"3873","DOI":"10.1021\/ja00118a026","article-title":"Tricyclic 2\u2019-deoxycytidine analogs: syntheses and incorporation into Oligodeoxynucleotides which have enhanced binding to complementary RNA","volume":"117","author":"Lin","year":"1995","journal-title":"J. Am. Chem. Soc."},{"key":"10.1016\/j.bioorg.2025.108588_bb0140","doi-asserted-by":"crossref","first-page":"1249","DOI":"10.1002\/chem.201803653","article-title":"Electronic modifications of fluorescent cytidine analogues control Photophysics and fluorescent responses to base stacking and pairing","volume":"25","author":"Teppang","year":"2019","journal-title":"Chem. A Eur. J."},{"key":"10.1016\/j.bioorg.2025.108588_bb0145","doi-asserted-by":"crossref","DOI":"10.1016\/j.snb.2024.135747","article-title":"Diversifying i-motif-based pH sensors: labeling patterns tune the intracellular localization","volume":"411","author":"Shtork","year":"2024","journal-title":"Sensors Actuators B Chem."},{"key":"10.1016\/j.bioorg.2025.108588_bb0150","doi-asserted-by":"crossref","first-page":"6147","DOI":"10.1039\/D0OB00983K","article-title":"Phenoxazine-based scaffold for designing G4-interacting agents","volume":"18","author":"Tsvetkov","year":"2020","journal-title":"Org. Biomol. Chem."},{"key":"10.1016\/j.bioorg.2025.108588_bb0155","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/j.biochi.2022.07.001","article-title":"Anticancer activity of G4-targeting phenoxazine derivatives in vitro","volume":"201","author":"Lizunova","year":"2022","journal-title":"Biochimie"},{"key":"10.1016\/j.bioorg.2025.108588_bb0160","doi-asserted-by":"crossref","first-page":"1090","DOI":"10.4161\/auto.6.8.13426","article-title":"p62\/SQSTM1 is required for Parkin-induced mitochondrial clustering but not mitophagy; VDAC1 is dispensable for both","volume":"6","author":"Narendra","year":"2010","journal-title":"Autophagy"},{"key":"10.1016\/j.bioorg.2025.108588_bb0165","doi-asserted-by":"crossref","first-page":"795","DOI":"10.1083\/jcb.200809125","article-title":"Parkin is recruited selectively to impaired mitochondria and promotes their autophagy","volume":"183","author":"Narendra","year":"2008","journal-title":"J. Cell Biol."},{"key":"10.1016\/j.bioorg.2025.108588_bb0170","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1186\/s11658-016-0031-z","article-title":"p62 links the autophagy pathway and the ubiqutin\u2013proteasome system upon ubiquitinated protein degradation","volume":"21","author":"Liu","year":"2016","journal-title":"Cell. Mol. Biol. Lett."},{"key":"10.1016\/j.bioorg.2025.108588_bb0175","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1038\/nrm3311","article-title":"AMPK: a nutrient and energy sensor that maintains energy homeostasis","volume":"13","author":"Hardie","year":"2012","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.bioorg.2025.108588_bb0180","doi-asserted-by":"crossref","first-page":"1016","DOI":"10.1038\/ncb2329","article-title":"The AMPK signalling pathway coordinates cell growth, autophagy and metabolism","volume":"13","author":"Mihaylova","year":"2011","journal-title":"Nat. Cell Biol."},{"key":"10.1016\/j.bioorg.2025.108588_bb0185","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1038\/cr.2014.163","article-title":"Choreography of AMPK activation","volume":"25","author":"Langendorf","year":"2015","journal-title":"Cell Res."},{"key":"10.1016\/j.bioorg.2025.108588_bb0190","doi-asserted-by":"crossref","first-page":"3017","DOI":"10.1038\/ncomms4017","article-title":"Structural basis of AMPK regulation by small molecule activators","volume":"4","author":"Xiao","year":"2013","journal-title":"Nat. Commun."},{"key":"10.1016\/j.bioorg.2025.108588_bb0195","doi-asserted-by":"crossref","first-page":"496","DOI":"10.1038\/nature06161","article-title":"Structural basis for AMP binding to mammalian AMP-activated protein kinase","volume":"449","author":"Xiao","year":"2007","journal-title":"Nature"},{"key":"10.1016\/j.bioorg.2025.108588_bb0200","doi-asserted-by":"crossref","first-page":"1161","DOI":"10.1016\/j.str.2014.06.009","article-title":"Structural basis for AMPK activation: natural and synthetic ligands regulate kinase activity from opposite poles by different molecular mechanisms","volume":"22","author":"Calabrese","year":"2014","journal-title":"Structure"},{"key":"10.1016\/j.bioorg.2025.108588_bb0205","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1172\/JCI19874","article-title":"CBS domains form energy-sensing modules whose binding of adenosine ligands is disrupted by disease mutations","volume":"113","author":"Scott","year":"2004","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.bioorg.2025.108588_bb0210","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1016\/j.tem.2011.12.006","article-title":"AMPK functions as an adenylate charge-regulated protein kinase","volume":"23","author":"Oakhill","year":"2012","journal-title":"Trends Endocrinol. Metab."},{"key":"10.1016\/j.bioorg.2025.108588_bb0215","doi-asserted-by":"crossref","first-page":"1237","DOI":"10.1038\/cr.2013.121","article-title":"Coordinated regulation of AMPK activity by multiple elements in the \u03b1-subunit","volume":"23","author":"Xin","year":"2013","journal-title":"Cell Res."},{"key":"10.1016\/j.bioorg.2025.108588_bb0220","doi-asserted-by":"crossref","first-page":"E8","DOI":"10.1038\/nature12189","article-title":"Conserved regulatory elements in AMPK","volume":"498","author":"Chen","year":"2013","journal-title":"Nature"}],"container-title":["Bioorganic Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0045206825004687?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0045206825004687?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,6,3]],"date-time":"2025-06-03T18:05:09Z","timestamp":1748973909000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0045206825004687"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,7]]},"references-count":44,"alternative-id":["S0045206825004687"],"URL":"https:\/\/doi.org\/10.1016\/j.bioorg.2025.108588","relation":{},"ISSN":["0045-2068"],"issn-type":[{"value":"0045-2068","type":"print"}],"subject":[],"published":{"date-parts":[[2025,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"AMPK-specific autophagy activator based on 1,3-diaza-2-oxophenoxazine","name":"articletitle","label":"Article Title"},{"value":"Bioorganic Chemistry","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bioorg.2025.108588","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"108588"}}