{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,22]],"date-time":"2026-07-22T13:56:19Z","timestamp":1784728579692,"version":"3.55.0"},"reference-count":37,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100003399","name":"Science and Technology Commission of Shanghai Municipality","doi-asserted-by":"publisher","award":["22YF1449600"],"award-info":[{"award-number":["22YF1449600"]}],"id":[{"id":"10.13039\/501100003399","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82405136"],"award-info":[{"award-number":["82405136"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82404467"],"award-info":[{"award-number":["82404467"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82405514"],"award-info":[{"award-number":["82405514"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Bioorganic Chemistry"],"published-print":{"date-parts":[[2025,8]]},"DOI":"10.1016\/j.bioorg.2025.108642","type":"journal-article","created":{"date-parts":[[2025,5,28]],"date-time":"2025-05-28T19:02:55Z","timestamp":1748458975000},"page":"108642","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":3,"special_numbering":"C","title":["Quercetin-3-\u03b2-aminobutyrate (HPS-\u03b2) as a promising novel anti-inflammatory agent for the treatment of sepsis"],"prefix":"10.1016","volume":"163","author":[{"given":"Yuge","family":"Zhou","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yimin","family":"Ma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kaidi","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chang","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yali","family":"Sang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weifan","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiacheng","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiuhong","family":"Lu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoni","family":"Kong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bioorg.2025.108642_bb0005","series-title":"Michigan Medicine Clinical Care Guidelines [M]. Early Recognition and Initial Management of Sepsis in Adult Patients. Ann Arbor (MI); Michigan Medicine University of Michigan \u00a9 Regents of the University of Michigan","author":"King","year":"2023"},{"issue":"10219","key":"10.1016\/j.bioorg.2025.108642_bb0010","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1016\/S0140-6736(19)32989-7","article-title":"Global, regional, and national sepsis incidence and mortality, 1990-2017: analysis for the global burden of disease study [J]","volume":"395","author":"Rudd","year":"2020","journal-title":"Lancet (London, England)"},{"issue":"11","key":"10.1016\/j.bioorg.2025.108642_bb0015","doi-asserted-by":"crossref","first-page":"1180","DOI":"10.1016\/S1473-3099(17)30322-5","article-title":"The epidemiology of sepsis in Brazilian intensive care units (the Sepsis PREvalence assessment database, SPREAD): an observational study [J]","volume":"17","author":"Machado","year":"2017","journal-title":"Lancet Infect. Dis."},{"issue":"5","key":"10.1016\/j.bioorg.2025.108642_bb0020","doi-asserted-by":"crossref","first-page":"380","DOI":"10.1016\/S2213-2600(14)70061-X","article-title":"Assessment of the worldwide burden of critical illness: the intensive care over nations (ICON) audit [J]","volume":"2","author":"Vincent","year":"2014","journal-title":"Lancet Respir. Med."},{"issue":"15","key":"10.1016\/j.bioorg.2025.108642_bb0025","doi-asserted-by":"crossref","first-page":"1478","DOI":"10.1001\/jama.2020.2717","article-title":"Prevalence and outcomes of infection among patients in intensive care units in 2017 [J]","volume":"323","author":"Vincent","year":"2020","journal-title":"Jama"},{"issue":"1","key":"10.1016\/j.bioorg.2025.108642_bb0030","doi-asserted-by":"crossref","first-page":"392","DOI":"10.1186\/s13054-021-03804-1","article-title":"A systematic review and meta-analysis of enrollment into ARDS and sepsis trials published between 2009 and 2019 in major journals [J]","volume":"25","author":"Krutsinger","year":"2021","journal-title":"Crit. Care"},{"issue":"3","key":"10.1016\/j.bioorg.2025.108642_bb0035","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1177\/0884533617695243","article-title":"Sepsis: current definition, pathophysiology, diagnosis, and management [J]","volume":"32","author":"Taeb","year":"2017","journal-title":"Nut. Clin. Practice\u202f: Off. Publ. Am. Soc. Parent. Enteral Nut."},{"issue":"6","key":"10.1016\/j.bioorg.2025.108642_bb0040","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1631\/jzus.B2101075","article-title":"Roles of neutrophil reactive oxygen species (ROS) generation in organ function impairment in sepsis [J]","volume":"23","author":"Lu","year":"2022","journal-title":"J Zhejiang Univ Sci B"},{"issue":"10","key":"10.1016\/j.bioorg.2025.108642_bb0045","doi-asserted-by":"crossref","DOI":"10.3390\/vaccines10101575","article-title":"The interplay of oxidative stress and ROS scavenging: antioxidants as a therapeutic potential in Sepsis [J]","volume":"10","author":"Kumar","year":"2022","journal-title":"Vaccines"},{"key":"10.1016\/j.bioorg.2025.108642_bb0050","doi-asserted-by":"crossref","DOI":"10.1016\/j.cellsig.2022.110363","article-title":"Quercetin attenuates sepsis-induced acute lung injury via suppressing oxidative stress-mediated ER stress through activation of SIRT1\/AMPK pathways [J]","volume":"96","author":"Sang","year":"2022","journal-title":"Cell. Signal."},{"issue":"11","key":"10.1016\/j.bioorg.2025.108642_bb0055","doi-asserted-by":"crossref","first-page":"4999","DOI":"10.1002\/ptr.7966","article-title":"Advance in the pharmacological effects of quercetin in modulating oxidative stress and inflammation related disorders [J]","volume":"37","author":"Zhou","year":"2023","journal-title":"Phytother. Res.: PTR"},{"key":"10.1016\/j.bioorg.2025.108642_bb0060","series-title":"Therapeutic Detoxification of Quercetin for Aflatoxin B1-Related Toxicity: Roles of Oxidative Stress, Inflammation","volume":"345","author":"Dai","year":"2024"},{"key":"10.1016\/j.bioorg.2025.108642_bb0065","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejmech.2021.114068","article-title":"Quercetin derivatives: drug design, development, and biological activities, a review [J]","volume":"229","author":"Alizadeh","year":"2022","journal-title":"Eur. J. Med. Chem."},{"issue":"1","key":"10.1016\/j.bioorg.2025.108642_bb0070","doi-asserted-by":"crossref","first-page":"11","DOI":"10.4014\/jmb.1907.07003","article-title":"A review on structure, modifications and structure-activity relation of quercetin and its derivatives [J]","volume":"30","author":"Magar","year":"2020","journal-title":"J. Microbiol. Biotechnol."},{"issue":"3","key":"10.1016\/j.bioorg.2025.108642_bb0075","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1016\/S0006-2952(02)01510-1","article-title":"Metabolism of quercetin-7- and quercetin-3-glucuronides by an in vitro hepatic model: the role of human beta-glucuronidase, sulfotransferase, catechol-O-methyltransferase and multi-resistant protein 2 (MRP2) in flavonoid metabolism [J]","volume":"65","author":"O\u2019leary","year":"2003","journal-title":"Biochem. Pharmacol."},{"issue":"2","key":"10.1016\/j.bioorg.2025.108642_bb0080","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1023\/A:1008372017097","article-title":"Pre-clinical and clinical study of QC12, a water-soluble, pro-drug of quercetin [J]","volume":"12","author":"Mulholland","year":"2001","journal-title":"Annals Oncol.: off. J. Eur. Soc. Med. Oncol."},{"issue":"17","key":"10.1016\/j.bioorg.2025.108642_bb0085","doi-asserted-by":"crossref","first-page":"7216","DOI":"10.1021\/jm500290c","article-title":"Water-soluble and cleavable quercetin-amino acid conjugates as safe modulators for P-glycoprotein-based multidrug resistance [J]","volume":"57","author":"Kim","year":"2014","journal-title":"J. Med. Chem."},{"issue":"7","key":"10.1016\/j.bioorg.2025.108642_bb0090","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1016\/j.addr.2007.05.010","article-title":"Salt formation to improve drug solubility [J]","volume":"59","author":"Serajuddin","year":"2007","journal-title":"Adv. Drug Deliv. Rev."},{"issue":"3","key":"10.1016\/j.bioorg.2025.108642_bb0095","article-title":"Conjugation as a tool in therapeutics: role of amino acids\/peptides-bioactive (including heterocycles) hybrid molecules in treating infectious diseases [J]","volume":"vol. 12","author":"Gattu","year":"2023","journal-title":"Antibiotics(Basel, Switzerland)"},{"key":"10.1016\/j.bioorg.2025.108642_bb0100","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1016\/j.ejmech.2018.09.068","article-title":"Development of 2-amino-4-phenylthiazole analogues to disrupt myeloid differentiation factor 88 and prevent inflammatory responses in acute lung injury [J]","volume":"161","author":"Chen","year":"2019","journal-title":"Eur. J. Med. Chem."},{"issue":"10","key":"10.1016\/j.bioorg.2025.108642_bb0105","doi-asserted-by":"crossref","DOI":"10.3390\/molecules21101317","article-title":"A potential mechanism for the anti-apoptotic property of koumine involving mitochondrial pathway in LPS-Mediated RAW 264.7 macrophages [J]","volume":"vol. 21","author":"Yuan","year":"2016","journal-title":"Molecules (Basel, Switzerland)"},{"key":"10.1016\/j.bioorg.2025.108642_bb0110","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2024.103194","article-title":"Histone lactylation-regulated METTL3 promotes ferroptosis via m6A-modification on ACSL4 in sepsis-associated lung injury [J]","volume":"74","author":"Wu","year":"2024","journal-title":"Redox Biol."},{"key":"10.1016\/j.bioorg.2025.108642_bb0115","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2023.102655","article-title":"miR-125b-5p in adipose derived stem cells exosome alleviates pulmonary microvascular endothelial cells ferroptosis via Keap1\/Nrf2\/GPX4 in sepsis lung injury [J]","volume":"62","author":"Shen","year":"2023","journal-title":"Redox Biol."},{"issue":"Pt 2","key":"10.1016\/j.bioorg.2025.108642_bb0120","article-title":"Immunologic role of macrophages in sepsis-induced acute liver injury [J]","volume":"143","author":"Xu","year":"2024","journal-title":"Int. Immunopharmacol."},{"issue":"4","key":"10.1016\/j.bioorg.2025.108642_bb0125","first-page":"629","article-title":"Organ dysfunction in Sepsis: an ominous trajectory from infection to death [J]","volume":"92","author":"Caraballo","year":"2019","journal-title":"Yale J. Biol. Med."},{"issue":"3","key":"10.1016\/j.bioorg.2025.108642_bb0130","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1111\/j.1872-034X.2012.01069.x","article-title":"Sepsis-associated liver injury: incidence, classification and the clinical significance [J]","volume":"43","author":"Kobashi","year":"2013","journal-title":"Hepatol. Res."},{"issue":"5","key":"10.1016\/j.bioorg.2025.108642_bb0135","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0303469","article-title":"An interpretable machine learning model for predicting 28-day mortality in patients with sepsis-associated liver injury [J]","volume":"19","author":"Wen","year":"2024","journal-title":"PLoS One"},{"key":"10.1016\/j.bioorg.2025.108642_bb0140","doi-asserted-by":"crossref","DOI":"10.1016\/j.gene.2024.149137","article-title":"Transcriptomic analysis of key genes and signaling pathways in sepsis-associated intestinal mucosal barrier damage [J]","volume":"936","author":"Gao","year":"2025","journal-title":"Gene"},{"issue":"1","key":"10.1016\/j.bioorg.2025.108642_bb0145","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1186\/s13054-023-04780-4","article-title":"Gut mycobiome dysbiosis after sepsis and trauma [J]","volume":"28","author":"Park","year":"2024","journal-title":"Crit. Care"},{"issue":"91","key":"10.1016\/j.bioorg.2025.108642_bb0150","doi-asserted-by":"crossref","first-page":"eadi0672","DOI":"10.1126\/sciimmunol.adi0672","article-title":"A dynamic atlas of immunocyte migration from the gut [J]","volume":"9","author":"Galv\u00e1n-Pe\u00f1a","year":"2024","journal-title":"Sci. Immun."},{"issue":"2","key":"10.1016\/j.bioorg.2025.108642_bb0155","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1016\/j.amjms.2019.10.006","article-title":"The prognostic value of Endotoxemia and intestinal barrier biomarker ZO-1 in Bacteremic Sepsis [J]","volume":"359","author":"Assimakopoulos","year":"2020","journal-title":"Am J Med Sci"},{"issue":"10","key":"10.1016\/j.bioorg.2025.108642_bb0160","doi-asserted-by":"crossref","first-page":"1848","DOI":"10.1136\/gutjnl-2022-327365","article-title":"A mechanism by which gut microbiota elevates permeability and inflammation in obese\/diabetic mice and human gut [J]","volume":"72","author":"Mishra","year":"2023","journal-title":"Gut"},{"issue":"2","key":"10.1016\/j.bioorg.2025.108642_bb0165","doi-asserted-by":"crossref","first-page":"392","DOI":"10.1007\/s13311-020-00862-1","article-title":"Septic-associated encephalopathy: a comprehensive review [J]","volume":"17","author":"Mazeraud","year":"2020","journal-title":"Neurother.:J. Am. Soc. Experimen. NeuroTher."},{"issue":"1","key":"10.1016\/j.bioorg.2025.108642_bb0170","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1038\/nrn2297","article-title":"From inflammation to sickness and depression: when the immune system subjugates the brain [J]","volume":"9","author":"Dantzer","year":"2008","journal-title":"Nat. Rev. Neurosci."},{"issue":"7","key":"10.1016\/j.bioorg.2025.108642_bb0175","doi-asserted-by":"crossref","first-page":"444","DOI":"10.1038\/s41577-021-00643-7","article-title":"Cerebral dysfunctions caused by sepsis during ageing [J]","volume":"22","author":"Manabe","year":"2022","journal-title":"Nat. Rev. Immunol."},{"issue":"6","key":"10.1016\/j.bioorg.2025.108642_bb0180","doi-asserted-by":"crossref","first-page":"2770","DOI":"10.1007\/s12035-021-02303-2","article-title":"Sepsis-associated encephalopathy: from pathophysiology to Progress in experimental studies [J]","volume":"58","author":"Catarina","year":"2021","journal-title":"Mol. Neurobiol."},{"key":"10.1016\/j.bioorg.2025.108642_bb0185","doi-asserted-by":"crossref","DOI":"10.1155\/2022\/1328729","article-title":"Sepsis-induced brain dysfunction: pathogenesis, diagnosis, and treatment [J]","volume":"2022","author":"Pan","year":"2022","journal-title":"Oxidative Med. Cell. Longev."}],"container-title":["Bioorganic Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S004520682500522X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S004520682500522X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,4,23]],"date-time":"2026-04-23T05:05:03Z","timestamp":1776920703000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S004520682500522X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,8]]},"references-count":37,"alternative-id":["S004520682500522X"],"URL":"https:\/\/doi.org\/10.1016\/j.bioorg.2025.108642","relation":{},"ISSN":["0045-2068"],"issn-type":[{"value":"0045-2068","type":"print"}],"subject":[],"published":{"date-parts":[[2025,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Quercetin-3-\u03b2-aminobutyrate (HPS-\u03b2) as a promising novel anti-inflammatory agent for the treatment of sepsis","name":"articletitle","label":"Article Title"},{"value":"Bioorganic Chemistry","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bioorg.2025.108642","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"108642"}}