{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,23]],"date-time":"2026-04-23T05:42:45Z","timestamp":1776922965161,"version":"3.51.2"},"reference-count":33,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["22177123"],"award-info":[{"award-number":["22177123"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82374108"],"award-info":[{"award-number":["82374108"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Bioorganic Chemistry"],"published-print":{"date-parts":[[2025,8]]},"DOI":"10.1016\/j.bioorg.2025.108663","type":"journal-article","created":{"date-parts":[[2025,6,3]],"date-time":"2025-06-03T19:27:19Z","timestamp":1748978839000},"page":"108663","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Immunosuppressive nitrogen-containing triterpenoid saponins from Mussaenda erosa and the therapeutic efficacy of heinsiagenin A in a murine lupus erythematosus model"],"prefix":"10.1016","volume":"163","author":[{"given":"Yidan","family":"Xu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mai","family":"Xiang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuan","family":"Chang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhenhua","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rujun","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fenghua","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaoqian","family":"Yang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaoyu","family":"Xiong","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jianping","family":"Zuo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zemin","family":"Lin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Weimin","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.bioorg.2025.108663_bb0005","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/j.cell.2020.03.007","article-title":"Challenges, progress, and prospects of developing therapies to treat autoimmune diseases","volume":"181","author":"Fugger","year":"2020","journal-title":"Cell"},{"key":"10.1016\/j.bioorg.2025.108663_bb0010","doi-asserted-by":"crossref","DOI":"10.1016\/j.coi.2022.102266","article-title":"The increasing prevalence of autoimmunity and autoimmune diseases: an urgent call to action for improved understanding, diagnosis, treatment, and prevention","volume":"80","author":"Miller","year":"2023","journal-title":"Curr. Opin. Immunol."},{"key":"10.1016\/j.bioorg.2025.108663_bb0015","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1038\/s41577-022-00787-0","article-title":"Neutrophil extracellular traps in systemic autoimmune and autoinflammatory diseases","volume":"23","author":"Wigerblad","year":"2023","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.bioorg.2025.108663_bb0020","doi-asserted-by":"crossref","first-page":"647","DOI":"10.1016\/j.autrev.2019.05.001","article-title":"Polyphenols in the treatment of autoimmune diseases","volume":"18","author":"Khan","year":"2019","journal-title":"Autoimmun. Rev."},{"key":"10.1016\/j.bioorg.2025.108663_bb0025","doi-asserted-by":"crossref","DOI":"10.1016\/j.autrev.2020.102743","article-title":"An updated advance of autoantibodies in autoimmune diseases","volume":"20","author":"Xiao","year":"2021","journal-title":"Autoimmun. Rev."},{"key":"10.1016\/j.bioorg.2025.108663_bb0030","article-title":"The prevalence of autoimmune disorders in women: a narrative review","volume":"12","author":"Angum","year":"2020","journal-title":"Cureus"},{"key":"10.1016\/j.bioorg.2025.108663_bb0035","doi-asserted-by":"crossref","first-page":"2326","DOI":"10.1016\/S0140-6736(24)00398-2","article-title":"Systemic lupus erythematosus","volume":"403","author":"Hoi","year":"2024","journal-title":"Lancet (London, England)"},{"key":"10.1016\/j.bioorg.2025.108663_bb0040","first-page":"583","article-title":"Systemic lupus erythematosus: one year in review","volume":"42","author":"Schilir\u00f2","year":"2024","journal-title":"Clin. Exp. Rheumatol."},{"key":"10.1016\/j.bioorg.2025.108663_bb0045","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1146\/annurev-med-043021-032611","article-title":"Systemic lupus erythematosus: new diagnostic and therapeutic approaches","volume":"74","author":"Lazar","year":"2023","journal-title":"Annu. Rev. Med."},{"key":"10.1016\/j.bioorg.2025.108663_bb0050","doi-asserted-by":"crossref","DOI":"10.1016\/j.phrs.2021.106000","article-title":"Elucidation of the anti-inflammatory mechanism of Er Miao san by integrative approach of network pharmacology and experimental verification","volume":"175","author":"Guo","year":"2022","journal-title":"Pharmacol. Res."},{"key":"10.1016\/j.bioorg.2025.108663_bb0055","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2021.114368","article-title":"Traditional herbal medicine: therapeutic potential in rheumatoid arthritis","volume":"279","author":"Wang","year":"2021","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.bioorg.2025.108663_bb0060","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1007\/s12016-012-8332-0","article-title":"Traditional chinese medicine and immune regulation","volume":"44","author":"Ma","year":"2013","journal-title":"Clin. Rev. Allergy Immunol."},{"key":"10.1016\/j.bioorg.2025.108663_bb0065","doi-asserted-by":"crossref","first-page":"1024955","DOI":"10.3389\/fphar.2022.1024955","article-title":"The therapeutic potential of triptolide and celastrol in neurological diseases","volume":"13","author":"Cui","year":"2022","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.bioorg.2025.108663_bb0070","doi-asserted-by":"crossref","first-page":"843","DOI":"10.1039\/D0NP00054J","article-title":"Triptolide: reflections on two decades of research and prospects for the future","volume":"38","author":"Tong","year":"2021","journal-title":"Nat. Prod. Rep."},{"key":"10.1016\/j.bioorg.2025.108663_bb0075","doi-asserted-by":"crossref","first-page":"1432625","DOI":"10.3389\/fimmu.2024.1432625","article-title":"Advances in the study of artemisinin and its derivatives for the treatment of rheumatic skeletal disorders, autoimmune inflammatory diseases, and autoimmune disorders: a comprehensive review","volume":"15","author":"Long","year":"2024","journal-title":"Front. Immunol."},{"key":"10.1016\/j.bioorg.2025.108663_bb0080","article-title":"Artemisinin and its derivatives as promising therapies for autoimmune diseases","volume":"10","author":"Xie","year":"2024","journal-title":"Heliyon"},{"key":"10.1016\/j.bioorg.2025.108663_bb0085","doi-asserted-by":"crossref","first-page":"867","DOI":"10.1002\/med.22001","article-title":"Artemisinins: promising drug candidates for the treatment of autoimmune diseases","volume":"44","author":"Gao","year":"2024","journal-title":"Med. Res. Rev."},{"key":"10.1016\/j.bioorg.2025.108663_bb0090","series-title":"Flora of China","author":"Editorial Committee of Flora of China","year":"1997"},{"key":"10.1016\/j.bioorg.2025.108663_bb0095","doi-asserted-by":"crossref","first-page":"718","DOI":"10.1002\/ptr.1518","article-title":"Antiviral activities of medicinal herbs traditionally used in southern mainland China","volume":"18","author":"Li","year":"2004","journal-title":"Phytother. Res."},{"key":"10.1016\/j.bioorg.2025.108663_bb0100","doi-asserted-by":"crossref","first-page":"2303","DOI":"10.1080\/14786419.2022.2039137","article-title":"Recurvataside, a new saponin from aerial parts of Mussaenda recurvata","volume":"37","author":"Tri","year":"2023","journal-title":"Nat. Prod. Res."},{"key":"10.1016\/j.bioorg.2025.108663_bb0105","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1076\/phbi.37.3.202.6300","article-title":"Pharmacological properties of seven medicinal plants of the Rubiaceae from Mauritius","volume":"37","author":"Pedersen","year":"1999","journal-title":"Pharm. Biol."},{"key":"10.1016\/j.bioorg.2025.108663_bb0110","first-page":"1788","article-title":"Isolation and structural elucidation of chemical constituents of Mussaenda Hainanensis Merr","volume":"5","author":"Li","year":"2011","journal-title":"J. Med. Plants Res."},{"key":"10.1016\/j.bioorg.2025.108663_bb0115","doi-asserted-by":"crossref","first-page":"779","DOI":"10.1021\/np020400v","article-title":"Isolation and structures of avicins D and G: in vitro tumor-inhibitory saponins derived from Acacia victoriae","volume":"66","author":"Jayatilake","year":"2003","journal-title":"J. Nat. Prod."},{"key":"10.1016\/j.bioorg.2025.108663_bb0120","doi-asserted-by":"crossref","DOI":"10.1016\/j.bioorg.2024.107351","article-title":"N-containing triterpenoid saponins from Mussaenda densiflora and identification of heinsiagenin A as a potent immunosuppressant","volume":"147","author":"Du","year":"2024","journal-title":"Bioorg. Chem."},{"key":"10.1016\/j.bioorg.2025.108663_bb0125","doi-asserted-by":"crossref","first-page":"834","DOI":"10.1055\/s-0031-1298432","article-title":"Simultaneous determination of the absolute configuration of twelve monosaccharide enantiomers from natural products in a single injection by a UPLC-UV\/MS method","volume":"78","author":"Wang","year":"2012","journal-title":"Planta Med."},{"key":"10.1016\/j.bioorg.2025.108663_bb0130","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1021\/acs.joc.2c02442","article-title":"Baccaramiones A-D, four highly oxygenated and rearranged trinorditerpenoids from Baccaurea ramiflora","volume":"88","author":"Chen","year":"2023","journal-title":"J. Org. Chem."},{"key":"10.1016\/j.bioorg.2025.108663_bb0135","doi-asserted-by":"crossref","first-page":"1212","DOI":"10.1139\/v75-168","article-title":"Further studies on assignment of signals in 13C magnetic resonance spectra of aldoses and derived methyl glycosides","volume":"53","author":"Gorin","year":"1975","journal-title":"Can. J. Chem."},{"key":"10.1016\/j.bioorg.2025.108663_bb0140","doi-asserted-by":"crossref","first-page":"1613","DOI":"10.1021\/np50114a001","article-title":"New triterpenoid saponins from Mussaenda pubescens","volume":"57","author":"Zhao","year":"1994","journal-title":"J. Nat. Prod."},{"key":"10.1016\/j.bioorg.2025.108663_bb0145","doi-asserted-by":"crossref","first-page":"827","DOI":"10.1016\/0031-9422(95)00028-3","article-title":"Saponins from Mussaenda pubescens","volume":"42","author":"Zhao","year":"1996","journal-title":"Phytochemistry"},{"key":"10.1016\/j.bioorg.2025.108663_bb0150","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1016\/j.fitote.2015.10.011","article-title":"Potent antitrypanosomal triterpenoid saponins from Mussaenda luteola","volume":"107","author":"Mohamed","year":"2015","journal-title":"Fitoterapia"},{"key":"10.1016\/j.bioorg.2025.108663_bb0155","doi-asserted-by":"crossref","first-page":"1131","DOI":"10.1016\/0031-9422(96)00086-6","article-title":"Saponins from Mussaenda pubescens","volume":"42","author":"Zhao","year":"1996","journal-title":"Phytochemistry"},{"key":"10.1016\/j.bioorg.2025.108663_bb0160","doi-asserted-by":"crossref","first-page":"1073","DOI":"10.1016\/S0031-9422(97)00089-7","article-title":"Triterpenes and triterpenoid saponins from Mussaenda pubescens","volume":"45","author":"Zhao","year":"1997","journal-title":"Phytochemistry"},{"key":"10.1016\/j.bioorg.2025.108663_bb0165","doi-asserted-by":"crossref","first-page":"4126","DOI":"10.1080\/14786419.2020.1737059","article-title":"Iridoids and cycloartane saponins from Mussaenda pilosissima valeton and their inhibitory NO production in BV2 cells","volume":"35","author":"Thu","year":"2021","journal-title":"Nat. Prod. Res."}],"container-title":["Bioorganic Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0045206825005437?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0045206825005437?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,4,23]],"date-time":"2026-04-23T04:54:34Z","timestamp":1776920074000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0045206825005437"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,8]]},"references-count":33,"alternative-id":["S0045206825005437"],"URL":"https:\/\/doi.org\/10.1016\/j.bioorg.2025.108663","relation":{},"ISSN":["0045-2068"],"issn-type":[{"value":"0045-2068","type":"print"}],"subject":[],"published":{"date-parts":[[2025,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Immunosuppressive nitrogen-containing triterpenoid saponins from Mussaenda erosa and the therapeutic efficacy of heinsiagenin A in a murine lupus erythematosus model","name":"articletitle","label":"Article Title"},{"value":"Bioorganic Chemistry","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bioorg.2025.108663","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"108663"}}