{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T00:43:06Z","timestamp":1790728986912,"version":"4.1.0"},"reference-count":39,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82474517"],"award-info":[{"award-number":["82474517"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007129","name":"Shandong Province Natural Science Foundation","doi-asserted-by":"publisher","award":["ZR2024MH060"],"award-info":[{"award-number":["ZR2024MH060"]}],"id":[{"id":"10.13039\/501100007129","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Bioorganic Chemistry"],"published-print":{"date-parts":[[2025,8]]},"DOI":"10.1016\/j.bioorg.2025.108711","type":"journal-article","created":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T11:53:10Z","timestamp":1751370790000},"page":"108711","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":7,"special_numbering":"C","title":["Benzoylpaeoniflorin alleviates psoriasis-like inflammation by modulating immune balance and inhibiting NF-\u03baB signaling pathway"],"prefix":"10.1016","volume":"163","author":[{"given":"Jingjing","family":"Wei","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mingming","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lingyun","family":"Du","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shanrong","family":"Lv","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi","family":"Leng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoke","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kemei","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qingqing","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chunhong","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"10281","key":"10.1016\/j.bioorg.2025.108711_bb0005","doi-asserted-by":"crossref","first-page":"1301","DOI":"10.1016\/S0140-6736(20)32549-6","volume":"397","author":"Griffiths","year":"2021","journal-title":"Psoriasis. Lancet."},{"issue":"Suppl. 2","key":"10.1016\/j.bioorg.2025.108711_bb0010","article-title":"Psoriasis: epidemiology, clinical features, and quality of life","volume":"64","author":"Langley","year":"2005","journal-title":"Ann. Rheum. Dis."},{"issue":"18","key":"10.1016\/j.bioorg.2025.108711_bb0015","doi-asserted-by":"crossref","DOI":"10.3390\/ijms20184347","article-title":"Risk factors for the development of psoriasis","volume":"20","author":"Kamiya","year":"2019","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.bioorg.2025.108711_bb0020","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.coi.2017.07.007","article-title":"Psoriasis: a mixed autoimmune and autoinflammatory disease","volume":"49","author":"Liang","year":"2017","journal-title":"Curr. Opin. Immunol."},{"issue":"6","key":"10.1016\/j.bioorg.2025.108711_bb0025","doi-asserted-by":"crossref","DOI":"10.3390\/ijms20061475","article-title":"Psoriasis pathogenesis and treatment","volume":"20","author":"Rendon","year":"2019","journal-title":"Int. J. Mol. Sci."},{"issue":"14","key":"10.1016\/j.bioorg.2025.108711_bb0030","article-title":"Th17 cells and the IL-23\/IL-17 Axis in the pathogenesis of periodontitis and immune-mediated inflammatory diseases","volume":"20","author":"Bunte","year":"2019","journal-title":"Int. J. Mol. Sci."},{"issue":"5","key":"10.1016\/j.bioorg.2025.108711_bb0035","doi-asserted-by":"crossref","DOI":"10.3390\/ijms24054901","article-title":"Psoriatic arthritis: pathogenesis and targeted therapies","volume":"24","author":"Azuaga","year":"2023","journal-title":"Int. J. Mol. Sci."},{"issue":"17","key":"10.1016\/j.bioorg.2025.108711_bb0040","doi-asserted-by":"crossref","DOI":"10.3390\/ijms241713313","article-title":"Challenges and future trends in the treatment of psoriasis","volume":"24","author":"Lee","year":"2023","journal-title":"Int. J. Mol. Sci."},{"issue":"D1","key":"10.1016\/j.bioorg.2025.108711_bb0045","doi-asserted-by":"crossref","first-page":"D1373","DOI":"10.1093\/nar\/gkac956","article-title":"PubChem 2023 update","volume":"51","author":"Kim","year":"2023","journal-title":"Nucleic Acids Res."},{"issue":"21","key":"10.1016\/j.bioorg.2025.108711_bb0050","doi-asserted-by":"crossref","DOI":"10.3390\/ijms232113130","article-title":"Benzoylpaeoniflorin activates anti-inflammatory mechanisms to mitigate Sepsis in cell-culture and mouse Sepsis models","volume":"23","author":"Kim","year":"2022","journal-title":"Int. J. Mol. Sci."},{"issue":"11","key":"10.1016\/j.bioorg.2025.108711_bb0055","first-page":"825","article-title":"Anti-anaphylactic potential of benzoylpaeoniflorin through inhibiting HDC and MAPKs from Paeonia lactiflora","volume":"19","author":"Zhong","year":"2021","journal-title":"Chin. J. Nat. Med."},{"issue":"1","key":"10.1016\/j.bioorg.2025.108711_bb0060","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1021\/acs.jnatprod.2c00927","article-title":"Selective inhibition of organic cation transporter 1 by Benzoylpaeoniflorin attenuates hepatic lipid accumulation through AMPK activation","volume":"86","author":"Bi","year":"2023","journal-title":"J. Nat. Prod."},{"issue":"9","key":"10.1016\/j.bioorg.2025.108711_bb0065","first-page":"1500","article-title":"Exploration of formulation regularity and mechanism of action of renowned traditional Chinese medicine physicians in treating psoriasis with heat-clearing and blood-cooling drugs based on data mining and network pharmacology","volume":"29","author":"Chen","year":"2023","journal-title":"J Basic Chin Med."},{"issue":"15","key":"10.1016\/j.bioorg.2025.108711_bb0070","first-page":"2097","article-title":"Absorption and transport characteristics of paeoniflorin and its derivatives in a Caco-2 cell monolayer model","volume":"44","author":"Yang","year":"2013","journal-title":"Chin. Tradit. Herb. Drug"},{"issue":"29","key":"10.1016\/j.bioorg.2025.108711_bb0075","doi-asserted-by":"crossref","first-page":"17595","DOI":"10.1016\/S0021-9258(18)71533-0","article-title":"The structure of tumor necrosis factor-alpha at 2.6 a resolution. Implications for receptor binding","volume":"264","author":"Eck","year":"1989","journal-title":"J. Biol. Chem."},{"issue":"12","key":"10.1016\/j.bioorg.2025.108711_bb0080","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pcbi.1004586","article-title":"AutoDockFR: advances in protein-ligand docking with explicitly specified binding site flexibility","volume":"11","author":"Ravindranath","year":"2015","journal-title":"PLoS Comput. Biol."},{"issue":"8","key":"10.1016\/j.bioorg.2025.108711_bb0085","doi-asserted-by":"crossref","first-page":"3891","DOI":"10.1021\/acs.jcim.1c00203","article-title":"AutoDock Vina 1.2.0: new docking methods, expanded force field, and Python bindings","volume":"61","author":"Eberhardt","year":"2021","journal-title":"J. Chem. Inf. Model."},{"issue":"11","key":"10.1016\/j.bioorg.2025.108711_bb0090","doi-asserted-by":"crossref","DOI":"10.1002\/pro.4792","article-title":"UCSF ChimeraX: tools for structure building and analysis","volume":"32","author":"Meng","year":"2023","journal-title":"Protein Sci."},{"issue":"3","key":"10.1016\/j.bioorg.2025.108711_bb0095","doi-asserted-by":"crossref","first-page":"1566","DOI":"10.3892\/mmr.2014.2914","article-title":"Ki67 is a promising molecular target in the diagnosis of cancer (review)","volume":"11","author":"Li","year":"2015","journal-title":"Mol. Med. Rep."},{"issue":"3","key":"10.1016\/j.bioorg.2025.108711_bb0100","doi-asserted-by":"crossref","first-page":"334","DOI":"10.1111\/imm.12469","article-title":"Human spleen microanatomy: why mice do not suffice","volume":"145","author":"Steiniger","year":"2015","journal-title":"Immunology"},{"issue":"9","key":"10.1016\/j.bioorg.2025.108711_bb0105","doi-asserted-by":"crossref","first-page":"5836","DOI":"10.4049\/jimmunol.0802999","article-title":"Imiquimod-induced psoriasis-like skin inflammation in mice is mediated via the IL-23\/IL-17 axis","volume":"182","author":"van der Fits","year":"2009","journal-title":"J. Immunol."},{"issue":"4","key":"10.1016\/j.bioorg.2025.108711_bb0110","doi-asserted-by":"crossref","DOI":"10.3390\/cancers15041189","article-title":"Modulating T cell responses by targeting CD3","volume":"15","author":"Menon","year":"2023","journal-title":"Cancers (Basel)"},{"issue":"5","key":"10.1016\/j.bioorg.2025.108711_bb0115","doi-asserted-by":"crossref","DOI":"10.3390\/ijms21051690","article-title":"Efficacy and safety of biologics for psoriasis and psoriatic arthritis and their impact on comorbidities: a literature review","volume":"21","author":"Kamata","year":"2020","journal-title":"Int. J. Mol. Sci."},{"issue":"1","key":"10.1016\/j.bioorg.2025.108711_bb0120","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1186\/s12895-018-0074-0","article-title":"Persistence rates and medical costs of biological therapies for psoriasis treatment in Japan: a real-world data study using a claims database","volume":"18","author":"Sruamsiri","year":"2018","journal-title":"BMC Dermatol."},{"issue":"4","key":"10.1016\/j.bioorg.2025.108711_bb0125","doi-asserted-by":"crossref","DOI":"10.3390\/ijms19041188","article-title":"Sympathetic nerve hyperactivity in the spleen: causal for nonpathogenic-driven chronic immune-mediated inflammatory diseases (IMIDs)?","volume":"19","author":"Bellinger","year":"2018","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.bioorg.2025.108711_bb0130","doi-asserted-by":"crossref","first-page":"1449657","DOI":"10.3389\/fimmu.2024.1449657","article-title":"The anti-inflammatory and tolerogenic potential of small spleen peptides","volume":"15","author":"Wixler","year":"2024","journal-title":"Front. Immunol."},{"issue":"1","key":"10.1016\/j.bioorg.2025.108711_bb0135","doi-asserted-by":"crossref","first-page":"14738","DOI":"10.1038\/s41598-022-18900-7","article-title":"Effects of splenectomy on skin inflammation and psoriasis-like phenotype of imiquimod-treated mice","volume":"12","author":"Shinno-Hashimoto","year":"2022","journal-title":"Sci. Rep."},{"key":"10.1016\/j.bioorg.2025.108711_bb0140","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1016\/j.biopha.2018.12.060","article-title":"Inhibition of spleen tyrosine kinase attenuates psoriasis-like inflammation in mice through blockade of dendritic cell-Th17 inflammation axis","volume":"111","author":"Alzahrani","year":"2019","journal-title":"Biomed. Pharmacother."},{"issue":"9","key":"10.1016\/j.bioorg.2025.108711_bb0145","doi-asserted-by":"crossref","first-page":"1749","DOI":"10.1016\/j.jid.2016.04.029","article-title":"Expanding the list of dysregulated immunosuppressive cells in psoriasis","volume":"136","author":"Soler","year":"2016","journal-title":"J. Invest. Dermatol."},{"issue":"25","key":"10.1016\/j.bioorg.2025.108711_bb0150","doi-asserted-by":"crossref","first-page":"2920","DOI":"10.2174\/0929867322666150729115553","article-title":"Small molecules as anti-TNF drugs","volume":"22","author":"Richmond","year":"2015","journal-title":"Curr. Med. Chem."},{"issue":"5750","key":"10.1016\/j.bioorg.2025.108711_bb0155","doi-asserted-by":"crossref","first-page":"1022","DOI":"10.1126\/science.1116304","article-title":"Small-molecule inhibition of TNF-alpha","volume":"310","author":"He","year":"2005","journal-title":"Science"},{"issue":"9997","key":"10.1016\/j.bioorg.2025.108711_bb0160","doi-asserted-by":"crossref","first-page":"983","DOI":"10.1016\/S0140-6736(14)61909-7","volume":"386","author":"Boehncke","year":"2015","journal-title":"Psoriasis. Lancet."},{"issue":"1","key":"10.1016\/j.bioorg.2025.108711_bb0165","doi-asserted-by":"crossref","first-page":"4741","DOI":"10.1038\/s41467-021-25066-9","article-title":"Enhanced NF-\u03baB signaling in type-2 dendritic cells at baseline predicts non-response to adalimumab in psoriasis","volume":"12","author":"Andres-Ejarque","year":"2021","journal-title":"Nat. Commun."},{"issue":"7","key":"10.1016\/j.bioorg.2025.108711_bb0170","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0101937","article-title":"Inhibition of keratinocyte differentiation by the synergistic effect of IL-17A, IL-22, IL-1\u03b1, TNF\u03b1 and oncostatin M","volume":"9","author":"Rabeony","year":"2014","journal-title":"PloS One"},{"issue":"1","key":"10.1016\/j.bioorg.2025.108711_bb0175","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1016\/j.jid.2018.06.184","article-title":"Cornulin is induced in psoriasis lesions and promotes keratinocyte proliferation via phosphoinositide 3-kinase\/Akt pathways","volume":"139","author":"Li","year":"2019","journal-title":"J. Invest. Dermatol."},{"issue":"1","key":"10.1016\/j.bioorg.2025.108711_bb0180","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1038\/nrrheum.2015.169","article-title":"TNF biology, pathogenic mechanisms and emerging therapeutic strategies","volume":"12","author":"Kalliolias","year":"2016","journal-title":"Nat. Rev. Rheumatol."},{"issue":"11","key":"10.1016\/j.bioorg.2025.108711_bb0185","doi-asserted-by":"crossref","first-page":"913","DOI":"10.1080\/17425255.2019.1681969","article-title":"Pharmacodynamics OF TNF \u03b1 inhibitors for the treatment of psoriasis","volume":"15","author":"Campanati","year":"2019","journal-title":"Expert Opin. Drug Metab. Toxicol."},{"issue":"6","key":"10.1016\/j.bioorg.2025.108711_bb0190","doi-asserted-by":"crossref","DOI":"10.1101\/cshperspect.a001651","article-title":"The nuclear factor NF-kappaB pathway in inflammation","volume":"1","author":"Lawrence","year":"2009","journal-title":"Cold Spring Harb. Perspect. Biol."},{"issue":"2","key":"10.1016\/j.bioorg.2025.108711_bb0195","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/j.jdermsci.2012.11.002","article-title":"NF-\u03baB: an essential transcription factor in psoriasis","volume":"69","author":"Goldminz","year":"2013","journal-title":"J. Dermatol. Sci."}],"container-title":["Bioorganic Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0045206825005917?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0045206825005917?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,4,23]],"date-time":"2026-04-23T05:02:38Z","timestamp":1776920558000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0045206825005917"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,8]]},"references-count":39,"alternative-id":["S0045206825005917"],"URL":"https:\/\/doi.org\/10.1016\/j.bioorg.2025.108711","relation":{},"ISSN":["0045-2068"],"issn-type":[{"value":"0045-2068","type":"print"}],"subject":[],"published":{"date-parts":[[2025,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Benzoylpaeoniflorin alleviates psoriasis-like inflammation by modulating immune balance and inhibiting NF-\u03baB signaling pathway","name":"articletitle","label":"Article Title"},{"value":"Bioorganic Chemistry","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bioorg.2025.108711","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"108711"}}