{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T04:18:07Z","timestamp":1789705087134,"version":"4.0.1"},"reference-count":54,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Bioorganic Chemistry"],"published-print":{"date-parts":[[2025,8]]},"DOI":"10.1016\/j.bioorg.2025.108719","type":"journal-article","created":{"date-parts":[[2025,7,2]],"date-time":"2025-07-02T11:56:58Z","timestamp":1751457418000},"page":"108719","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":16,"special_numbering":"C","title":["Design, synthesis, and antimicrobial activity of new thiourea-uracil derivatives: Anti-biofilm, ROS, DHFR, computational and SAR studies"],"prefix":"10.1016","volume":"163","author":[{"given":"Farid M.","family":"Sroor","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ahmed F.","family":"El-Sayed","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohamed","family":"Abdelraof","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bioorg.2025.108719_bb0005","doi-asserted-by":"crossref","first-page":"1075","DOI":"10.1016\/j.bbamem.2015.01.004","article-title":"Structure-activity analysis of thiourea analogs as inhibitors of UT-A and UT-B urea transporters","volume":"1848","author":"Esteva-Font","year":"2015","journal-title":"Biochim. Biophys. Acta Biomembr."},{"key":"10.1016\/j.bioorg.2025.108719_bb0010","doi-asserted-by":"crossref","DOI":"10.1016\/j.bioorg.2025.108319","article-title":"Thiourea compounds as multifaceted bioactive agents in medicinal chemistry","volume":"158","author":"Khan","year":"2025","journal-title":"Bioorg.Chem."},{"key":"10.1016\/j.bioorg.2025.108719_bb0015","doi-asserted-by":"crossref","first-page":"5513","DOI":"10.1039\/D0OB00595A","article-title":"Recent applications of thiourea-based organocatalysts in asymmetric multicomponent reactions (AMCRs)","volume":"18","author":"Parvin","year":"2020","journal-title":"Org. Biomol. Chem."},{"key":"10.1016\/j.bioorg.2025.108719_bb0020","doi-asserted-by":"crossref","first-page":"33235","DOI":"10.1039\/D4RA05799F","article-title":"Novel pyrimidine linked acyl thiourea derivatives as potent \u03b1-amylase and proteinase K inhibitors: design, synthesis, molecular docking and ADME studies","volume":"14","author":"Zaman","year":"2024","journal-title":"RSC Adv."},{"key":"10.1016\/j.bioorg.2025.108719_bb0025","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1021\/cr50001a005","article-title":"Thioureas","volume":"55","author":"Schroeder","year":"2002","journal-title":"Chem. Rev."},{"key":"10.1016\/j.bioorg.2025.108719_bb0030","first-page":"10","article-title":"Thiourea derivatives in drug design and medicinal chemistry: a short review","volume":"2","author":"Shakeel","year":"2016","journal-title":"Journal of Drug Des. Med. Chem."},{"key":"10.1016\/j.bioorg.2025.108719_bb0035","doi-asserted-by":"crossref","first-page":"1046","DOI":"10.1039\/D1MD00058F","article-title":"Recent advances in urea- and thiourea-containing compounds: focus on innovative approaches in medicinal chemistry and organic synthesis","volume":"12","author":"Ronchetti","year":"2021","journal-title":"RSC Med. Chem."},{"key":"10.1016\/j.bioorg.2025.108719_bb0040","doi-asserted-by":"crossref","first-page":"883","DOI":"10.1111\/cbdd.13009","article-title":"New thiourea and 1,3-thiazolidin-4-one derivatives effective on the HIV-1 virus","volume":"90","author":"Bielenica","year":"2017","journal-title":"Chem. Bio. Drug Des."},{"key":"10.1016\/j.bioorg.2025.108719_bb0045","doi-asserted-by":"crossref","first-page":"1323","DOI":"10.1016\/j.ejmech.2009.12.016","article-title":"Synthesis, characterization and biological evaluation of some thiourea derivatives bearing benzothiazole moiety as potential antimicrobial and anticancer agents","volume":"45","author":"Saeed","year":"2010","journal-title":"Eur. J. Med.Chem."},{"key":"10.1016\/j.bioorg.2025.108719_bb0050","doi-asserted-by":"crossref","first-page":"3591","DOI":"10.1016\/j.ejmech.2009.02.030","article-title":"Faruk Bayrak, synthesis, antiviral and anticancer activity of some novel thioureas derivedfrom N-(4-nitro-2-phenoxyphenyl)-methanesulfonamide","volume":"44","author":"Karaku\u015f","year":"2009","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.bioorg.2025.108719_bb0055","doi-asserted-by":"crossref","first-page":"75","DOI":"10.3109\/14756366.2013.879656","article-title":"Synthesis and biological activity of novel thiourea derivatives as carbonic anhydrase inhibitors","volume":"30","author":"Korkmaz","year":"2014","journal-title":"J. Enz. Inhibi. Med. Chem."},{"key":"10.1016\/j.bioorg.2025.108719_bb0060","doi-asserted-by":"crossref","first-page":"15441","DOI":"10.1038\/s41598-024-65308-6","article-title":"Green, facile synthesis and evaluation of unsymmetrical carbamide derivatives as antimicrobial and anticancer agents with mechanistic insights","volume":"14","author":"Sroor","year":"2024","journal-title":"Sci. Rep."},{"key":"10.1016\/j.bioorg.2025.108719_bb0065","article-title":"A preclinical study on 4-methyl-N-((4-(trifluoromethoxy)phenyl) carbamoyl)-benzenesulfonamide as a potent chemotherapeutic agent against liver and pancreatic carcinogenesis in rats: Immunohistochemical and histopathological studies","volume":"20","author":"Sroor","year":"2024","journal-title":"Med. Chem."},{"key":"10.1016\/j.bioorg.2025.108719_bb0070","doi-asserted-by":"crossref","first-page":"17560","DOI":"10.1038\/s41598-023-44753-9","article-title":"Impact of trifluoromethyl and sulfonyl groups on the biological activity of novel aryl-urea derivatives: synthesis, in-vitro, in-silico and SAR studies","volume":"13","author":"Sroor","year":"2023","journal-title":"Sci. Rep."},{"key":"10.1016\/j.bioorg.2025.108719_bb0075","doi-asserted-by":"crossref","first-page":"400","DOI":"10.1007\/s00044-022-02849-3","article-title":"Anticancer and antimicrobial activities of new thiazolyl-urea derivatives: gene expression, DNA damage, DNA fragmentation and SAR studies","volume":"31","author":"Sroor","year":"2022","journal-title":"Med. Chem. Res."},{"key":"10.1016\/j.bioorg.2025.108719_bb0080","doi-asserted-by":"crossref","first-page":"1018","DOI":"10.1039\/D3RA06812A","article-title":"Novel pyrazoline linked acyl thiourea pharmacophores as antimicrobial, urease, amylase and \u03b1-glucosidase inhibitors: design, synthesis, SAR and molecular docking studies","volume":"14","author":"Saeed","year":"2024","journal-title":"RSC Adv."},{"key":"10.1016\/j.bioorg.2025.108719_bb0085","doi-asserted-by":"crossref","first-page":"314","DOI":"10.1007\/s00044-010-9315-4","article-title":"Screening and evaluation of thiourea derivatives for their HIV capsid and human cyclophilin a inhibitory activity","volume":"20","author":"Tan","year":"2010","journal-title":"Med. Chem. Res."},{"key":"10.1016\/j.bioorg.2025.108719_bb0090","doi-asserted-by":"crossref","first-page":"3053","DOI":"10.1007\/s11164-016-2811-5","article-title":"Recent developments in chemistry, coordination, structure and biological aspects of 1-(acyl\/aroyl)-3-(substituted) thioureas","volume":"43","author":"Saeed","year":"2016","journal-title":"Res. Chem. Intermed."},{"key":"10.1016\/j.bioorg.2025.108719_bb0095","doi-asserted-by":"crossref","first-page":"18011","DOI":"10.1039\/D4RA02567A","article-title":"Exploring the latest trends in chemistry, structure, coordination, and diverse applications of 1-acyl-3-substituted thioureas: a comprehensive review","volume":"14","author":"Ullah","year":"2024","journal-title":"RSC Adv."},{"key":"10.1016\/j.bioorg.2025.108719_bb0100","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1016\/j.ejmech.2015.06.027","article-title":"Synthesis, cytotoxicity and antimicrobial activity of thiourea derivatives incorporating 3-(trifluoromethyl)phenyl moiety","volume":"101","author":"Bielenica","year":"2015","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.bioorg.2025.108719_bb0105","doi-asserted-by":"crossref","first-page":"1383","DOI":"10.1021\/jf803215t","article-title":"Synthesis and antiviral activities of chiral Thiourea derivatives containing an \u03b1-Aminophosphonate moiety","volume":"57","author":"Chen","year":"2009","journal-title":"J. Agric. Food Chem."},{"key":"10.1016\/j.bioorg.2025.108719_bb0110","doi-asserted-by":"crossref","first-page":"282","DOI":"10.1016\/j.ejmech.2019.03.047","article-title":"Design, synthesis and biological evaluation of novel uracil derivatives bearing 1, 2, 3-triazole moiety as thymidylate synthase (TS) inhibitors and as potential antitumor drugs","volume":"171","author":"Lu","year":"2019","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.bioorg.2025.108719_bb0115","doi-asserted-by":"crossref","first-page":"966","DOI":"10.3390\/ph16070966","article-title":"Discovery of new uracil and Thiouracil derivatives as potential HDAC inhibitors","volume":"16","author":"Elbatrawy","year":"2023","journal-title":"Pharmaceuticals"},{"key":"10.1016\/j.bioorg.2025.108719_bb0120","doi-asserted-by":"crossref","DOI":"10.1186\/s13065-023-01106-x","article-title":"Synthesis, design, biological evaluation, and computational analysis of some novel uracil-azole derivatives as cytotoxic agents","volume":"18","author":"Emami","year":"2024","journal-title":"BMC Chem."},{"key":"10.1016\/j.bioorg.2025.108719_bb0125","doi-asserted-by":"crossref","DOI":"10.1016\/j.bcp.2024.116559","article-title":"Design, synthesis and biological evaluation of novel curcumin-fluorouracil hybrids as potential anti-cancer agents","volume":"230","author":"Wang","year":"2024","journal-title":"Biochem.Pharmaco."},{"key":"10.1016\/j.bioorg.2025.108719_bb0130","doi-asserted-by":"crossref","first-page":"582","DOI":"10.1016\/j.ejmech.2014.10.008","article-title":"In search of uracil derivatives as bioactive agents. Uracils and fused uracils: synthesis, biological activity and applications","volume":"97","author":"Pa\u0142asz","year":"2015","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.bioorg.2025.108719_bb0135","doi-asserted-by":"crossref","DOI":"10.3389\/fonc.2021.658636","article-title":"5-fluorouracil: a narrative review on the role of regulatory mechanisms in driving resistance to this chemotherapeutic agent","volume":"11","author":"Ghafouri-Fard","year":"2021","journal-title":"Front. Oncol."},{"key":"10.1016\/j.bioorg.2025.108719_bb0140","doi-asserted-by":"crossref","first-page":"2335","DOI":"10.1056\/NEJMoa032691","article-title":"Bevacizumab plus irinotecan, fluorouracil, and Leucovorin for metastatic colorectal Cancer","volume":"350","author":"Hurwitz","year":"2004","journal-title":"New Eng. J. Med."},{"key":"10.1016\/j.bioorg.2025.108719_bb0145","doi-asserted-by":"crossref","first-page":"663","DOI":"10.1038\/179663a0","article-title":"Fluorinated pyrimidines, A New Class of Tumour-Inhibitory Compounds","volume":"179","author":"Heidelberger","year":"1957","journal-title":"Nat"},{"key":"10.1016\/j.bioorg.2025.108719_bb0150","doi-asserted-by":"crossref","DOI":"10.1016\/j.bioorg.2024.107944","article-title":"Novel 5-fluorouracil analogues versus perfluorophenyl ureas as potent anti-breast cancer agents: design, robust synthesis, in vitro, molecular docking, pharmacokinetics ADMET analysis and dynamic simulations","volume":"153","author":"Sroor","year":"2024","journal-title":"Bioorg. Chem."},{"key":"10.1016\/j.bioorg.2025.108719_bb0155","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1179\/2047773215Y.0000000030","article-title":"Antimicrobial resistance: a global multifaceted phenomenon","volume":"109","author":"Prestinaci","year":"2015","journal-title":"Pathog. Glob. Health"},{"key":"10.1016\/j.bioorg.2025.108719_bb0160","doi-asserted-by":"crossref","DOI":"10.1016\/j.glmedi.2024.100081","article-title":"Antimicrobial resistance: impacts, challenges, and future prospects","volume":"2","author":"Ahmed","year":"2024","journal-title":"J. Med. Surg. Public Health."},{"key":"10.1016\/j.bioorg.2025.108719_bb0165","doi-asserted-by":"crossref","first-page":"616","DOI":"10.3390\/molecules27030616","article-title":"Multidrug resistance (MDR): a widespread phenomenon in pharmacological therapies","volume":"27","author":"Catalano","year":"2022","journal-title":"Molecules"},{"key":"10.1016\/j.bioorg.2025.108719_bb0170","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1111\/j.1469-0691.2011.03570.x","article-title":"Multidrug-resistant, extensively drug-resistant and pandrug-resistant bacteria: an international expert proposal for interim standard definitions for acquired resistance","volume":"18","author":"Magiorakos","year":"2012","journal-title":"Clin. Microbiol. Infect."},{"key":"10.1016\/j.bioorg.2025.108719_bb0175","article-title":"Retrospective analysis of drug resistance characteristics and infection related risk factors of multidrug-resistant organisms (MDROs) isolated from the orthopedics department of a tertiary hospital","volume":"13","author":"Yang","year":"2023","journal-title":"Sci. Rep."},{"key":"10.1016\/j.bioorg.2025.108719_bb0180","doi-asserted-by":"crossref","DOI":"10.1002\/ardp.202300738","article-title":"Design, synthesis, structure elucidation, antimicrobial, molecular docking, and SAR studies of novel urea derivatives bearing tricyclic aromatic hydrocarbon rings","volume":"357","author":"Sroor","year":"2024","journal-title":"Arch. Pharm."},{"key":"10.1016\/j.bioorg.2025.108719_bb0185","doi-asserted-by":"crossref","first-page":"12","DOI":"10.18231\/j.ijcaap.2022.003","article-title":"Basics, types and applications of molecular docking: a review","volume":"7","author":"Raval","year":"2022","journal-title":"IP Int. J. Compr. Adv. Pharmacol."},{"key":"10.1016\/j.bioorg.2025.108719_bb0190","doi-asserted-by":"crossref","first-page":"6737","DOI":"10.1039\/D5RA00909J","article-title":"Three-step process for the synthesis of 10,11-dihydro-5H-dibenzo[b,f]azepin-10-ol derivatives","volume":"15","author":"Sroor","year":"2025","journal-title":"RSC Adv."},{"key":"10.1016\/j.bioorg.2025.108719_bb0195","doi-asserted-by":"crossref","DOI":"10.1016\/j.molstruc.2024.140001","article-title":"New cyano-acrylamide derivatives incorporating the thiophene moiety: synthesis, anti-cancer, gene expression, DNA fragmentation, DNA damage, and in silico studies","volume":"1321","author":"Sroor","year":"2025","journal-title":"J. Mol. Struct."},{"key":"10.1016\/j.bioorg.2025.108719_bb0200","doi-asserted-by":"crossref","first-page":"6015","DOI":"10.1039\/D4RA08958H","article-title":"Utility of 6-aza-2-thiothymine in the synthesis of novel [1,2,4]triazolo[4,3-b][1,2,4]triazin-7-one derivatives: synthesis, structure elucidation, molecular docking and in vitro anti-lung cancer activity","volume":"15","author":"Kamel","year":"2025","journal-title":"RSC Adv."},{"key":"10.1016\/j.bioorg.2025.108719_bb0205","doi-asserted-by":"crossref","first-page":"21859","DOI":"10.1039\/D4RA03375B","article-title":"Synthesis, anticancer evaluation of novel hybrid pyrazole-based chalcones, molecular docking, DNA fragmentation, and gene expression: in vitro studies","volume":"14","author":"Yasser","year":"2024","journal-title":"RSC Adv."},{"key":"10.1016\/j.bioorg.2025.108719_bb0210","doi-asserted-by":"crossref","first-page":"26954","DOI":"10.1039\/D4RA03005B","article-title":"Design, synthesis and potent anti-pancreatic cancer activity of new pyrazole derivatives bearing chalcone, thiazole and thiadiazole moieties: gene expression, DNA fragmentation, cell cycle arrest and SAR","volume":"14","author":"Kamel","year":"2024","journal-title":"RSC Adv."},{"key":"10.1016\/j.bioorg.2025.108719_bb0215","first-page":"1","article-title":"Synthesis and structural characterization of divalent transition metal Alkynylamidinate complexes","volume":"26","author":"Wang","year":"2023","journal-title":"Eur. J. Inorg. Chem."},{"key":"10.1016\/j.bioorg.2025.108719_bb0220","doi-asserted-by":"crossref","DOI":"10.1016\/j.molstruc.2023.136516","article-title":"New 2,4-diaryl-3-azabicyclo[3.3.1]nonan-9-one derivatives as antimicrobial and anti-cancer agents: synthesis, in-vitro and SAR studies","volume":"1294","author":"Sroor","year":"2023","journal-title":"J. Mol. Struct."},{"key":"10.1016\/j.bioorg.2025.108719_bb0225","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1007\/s00044-021-02829-z","article-title":"Design, synthesis and SAR of novel sulfonylurea derivatives for the treatment of diabetes mellitus in rats","volume":"31","author":"Sroor","year":"2022","journal-title":"Med. Chem. Res."},{"key":"10.1016\/j.bioorg.2025.108719_bb0230","doi-asserted-by":"crossref","first-page":"12587","DOI":"10.1039\/C8DT02257G","article-title":"Cyclooctatetraenyl calcium and strontium amido complexes","volume":"47","author":"Sroor","year":"2018","journal-title":"Dalton Trans."},{"key":"10.1016\/j.bioorg.2025.108719_bb0235","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1002\/ddr.70096","article-title":"Investigation of new biologically active benzo[4,5]imidazo[1,2-a]pyrimidine derivatives as broad-Spectrum antimicrobial agents: synthesis, anti-biofilm, ROS and in silico studies","volume":"86","author":"Sroor","year":"2025","journal-title":"Drug Dev. Res."},{"key":"10.1016\/j.bioorg.2025.108719_bb0240","doi-asserted-by":"crossref","DOI":"10.3389\/fchem.2022.1076383","article-title":"Design and synthesis of new thiazolidinone\/uracil derivatives as antiproliferative agents targeting EGFR and\/or BRAFV600E","volume":"10","author":"Alshammari","year":"2022","journal-title":"Front. Chem."},{"key":"10.1016\/j.bioorg.2025.108719_bb0245","doi-asserted-by":"crossref","DOI":"10.1016\/j.bmc.2021.116506","article-title":"Antimycobacterial and anti-inflammatory activities of thiourea derivatives focusing on treatment approaches for severe pulmonary tuberculosis","volume":"53","author":"Calixto","year":"2022","journal-title":"Bioorg. Med. Chem."},{"key":"10.1016\/j.bioorg.2025.108719_bb0250","doi-asserted-by":"crossref","first-page":"807","DOI":"10.3390\/antibiotics12050807","article-title":"New N-acyl Thiourea derivatives: synthesis, standardized quantification method and in vitro evaluation of potential biological activities","volume":"12","author":"Roman","year":"2023","journal-title":"Antibiotics"},{"key":"10.1016\/j.bioorg.2025.108719_bb0255","doi-asserted-by":"crossref","first-page":"2234","DOI":"10.1016\/j.bmcl.2016.11.060","article-title":"Design, synthesis and antibacterial activities of thiouracil derivatives containing acyl thiourea as SecA inhibitors","volume":"27","author":"Cui","year":"2017","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"10.1016\/j.bioorg.2025.108719_bb0260","doi-asserted-by":"crossref","DOI":"10.1016\/j.molstruc.2025.141520","article-title":"Synthesis, molecular docking and anti-biofilm activity of novel benzo[4,5]imidazo[2,1-a]quinazoline, 4H-chromene, and acridine derivatives as potent anti-candida agents","volume":"1331","author":"Sroor","year":"2025","journal-title":"J. Mol. Struct."},{"key":"10.1016\/j.bioorg.2025.108719_bb0265","doi-asserted-by":"crossref","first-page":"39250","DOI":"10.1021\/acsomega.3c04736","article-title":"New Thiophenyl-pyrazolyl-thiazole hybrids as DHFR inhibitors: design, synthesis, antimicrobial evaluation, molecular modeling, and biodistribution studies","volume":"8","author":"Dawood","year":"2023","journal-title":"ACS Omega"},{"key":"10.1016\/j.bioorg.2025.108719_bb0270","doi-asserted-by":"crossref","DOI":"10.1063\/5.0018516","article-title":"Heterogeneous parallelization and acceleration of molecular dynamics simulations in GROMACS","volume":"153","author":"P\u00e1ll","year":"2020","journal-title":"J. Chem. Phys."}],"container-title":["Bioorganic Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0045206825005991?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0045206825005991?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,4,23]],"date-time":"2026-04-23T05:03:55Z","timestamp":1776920635000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0045206825005991"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,8]]},"references-count":54,"alternative-id":["S0045206825005991"],"URL":"https:\/\/doi.org\/10.1016\/j.bioorg.2025.108719","relation":{},"ISSN":["0045-2068"],"issn-type":[{"value":"0045-2068","type":"print"}],"subject":[],"published":{"date-parts":[[2025,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Design, synthesis, and antimicrobial activity of new thiourea-uracil derivatives: Anti-biofilm, ROS, DHFR, computational and SAR studies","name":"articletitle","label":"Article Title"},{"value":"Bioorganic Chemistry","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bioorg.2025.108719","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"108719"}}