{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T12:10:05Z","timestamp":1790856605557,"version":"4.1.0"},"reference-count":32,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100002858","name":"China Postdoctoral Science Foundation","doi-asserted-by":"publisher","award":["2024M753800"],"award-info":[{"award-number":["2024M753800"]}],"id":[{"id":"10.13039\/501100002858","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002858","name":"China Postdoctoral Science Foundation","doi-asserted-by":"publisher","award":["JXSQ2023102240"],"award-info":[{"award-number":["JXSQ2023102240"]}],"id":[{"id":"10.13039\/501100002858","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003453","name":"Guangdong Provincial Natural Science Foundation","doi-asserted-by":"publisher","award":["2025A1515010564"],"award-info":[{"award-number":["2025A1515010564"]}],"id":[{"id":"10.13039\/501100003453","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003453","name":"Guangdong Provincial Natural Science Foundation","doi-asserted-by":"publisher","award":["2024A1515010169"],"award-info":[{"award-number":["2024A1515010169"]}],"id":[{"id":"10.13039\/501100003453","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82304322"],"award-info":[{"award-number":["82304322"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82273804"],"award-info":[{"award-number":["82273804"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["22407144"],"award-info":[{"award-number":["22407144"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82404454"],"award-info":[{"award-number":["82404454"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Bioorganic Chemistry"],"published-print":{"date-parts":[[2025,9]]},"DOI":"10.1016\/j.bioorg.2025.108820","type":"journal-article","created":{"date-parts":[[2025,7,31]],"date-time":"2025-07-31T15:50:04Z","timestamp":1753977004000},"page":"108820","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":3,"special_numbering":"C","title":["Daphnane diterpenoids for cancer therapy by suppressing ATR-mediated DNA damage response pathway"],"prefix":"10.1016","volume":"164","author":[{"given":"Shu-Qi","family":"Wu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lei-Ming","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fang-Yu","family":"Yuan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dong","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tao","family":"Yuan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhang-Hua","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gui-Hua","family":"Tang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jia-Luo","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sheng","family":"Yin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"3","key":"10.1016\/j.bioorg.2025.108820_bb0005","doi-asserted-by":"crossref","first-page":"229","DOI":"10.3322\/caac.21834","article-title":"Global cancer statistics 2022: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries","volume":"74","author":"Bray","year":"2024","journal-title":"CA-Cancer J. Clin."},{"issue":"9","key":"10.1016\/j.bioorg.2025.108820_bb0010","doi-asserted-by":"crossref","first-page":"624","DOI":"10.1038\/s41571-023-00798-3","article-title":"The global burden of lung cancer: current status and future trends","volume":"20","author":"Leiter","year":"2023","journal-title":"Nat. Rev. Clin. Oncol."},{"issue":"7689","key":"10.1016\/j.bioorg.2025.108820_bb0015","doi-asserted-by":"crossref","first-page":"446","DOI":"10.1038\/nature25183","article-title":"The biology and management of non-small cell lung cancer","volume":"553","author":"Herbst","year":"2018","journal-title":"Nature"},{"issue":"7","key":"10.1016\/j.bioorg.2025.108820_bb0020","doi-asserted-by":"crossref","first-page":"931","DOI":"10.1016\/j.jtho.2022.03.018","article-title":"The 2021 global lung cancer therapy landscape","volume":"17","author":"Deb","year":"2022","journal-title":"J. Thorac. Oncol."},{"issue":"10454","key":"10.1016\/j.bioorg.2025.108820_bb0025","doi-asserted-by":"crossref","first-page":"803","DOI":"10.1016\/S0140-6736(24)01029-8","article-title":"New promises and challenges in the treatment of advanced non-small-cell lung cancer","volume":"404","author":"Meyer","year":"2024","journal-title":"Lancet"},{"issue":"11","key":"10.1016\/j.bioorg.2025.108820_bb0030","doi-asserted-by":"crossref","first-page":"637","DOI":"10.1038\/nrc.2017.84","article-title":"Understanding and targeting resistance mechanisms in NSCLC","volume":"17","author":"Rotow","year":"2017","journal-title":"Nat. Rev. Cancer"},{"issue":"1","key":"10.1016\/j.bioorg.2025.108820_bb0035","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1186\/s12943-023-01740-y","article-title":"Lung cancer immunotherapy: progress, pitfalls, and promises","volume":"22","author":"Lahiri","year":"2023","journal-title":"Mol. Cancer"},{"issue":"3","key":"10.1016\/j.bioorg.2025.108820_bb0040","doi-asserted-by":"crossref","first-page":"770","DOI":"10.1021\/acs.jnatprod.9b01285","article-title":"Natural products as sources of new drugs over the nearly four decades from 01\/1981 to 09\/2019","volume":"83","author":"Newman","year":"2020","journal-title":"J. Nat. Prod."},{"issue":"7","key":"10.1016\/j.bioorg.2025.108820_bb0045","doi-asserted-by":"crossref","first-page":"3012","DOI":"10.1021\/cr900019j","article-title":"Impact of natural products on developing new anti-cancer agents","volume":"109","author":"Cragg","year":"2009","journal-title":"Chem. Rev."},{"issue":"38","key":"10.1016\/j.bioorg.2025.108820_bb0050","doi-asserted-by":"crossref","first-page":"17522","DOI":"10.1021\/jacs.2c06449","article-title":"Discovery of highly potent daphnane diterpenoids uncovers importin-\u03b21 as a druggable vulnerability in castration-resistant prostate cancer","volume":"144","author":"Huang","year":"2022","journal-title":"J. Am. Chem. Soc."},{"issue":"12","key":"10.1016\/j.bioorg.2025.108820_bb0055","doi-asserted-by":"crossref","first-page":"4934","DOI":"10.1016\/j.apsb.2023.07.017","article-title":"Discovery of a highly potent and orally available importin-\u03b21 inhibitor that overcomes enzalutamide-resistance in advanced prostate cancer","volume":"13","author":"Huang","year":"2023","journal-title":"Acta Pharm. Sin. B"},{"key":"10.1016\/j.bioorg.2025.108820_bb0060","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/j.canlet.2021.03.030","article-title":"Jolkinolide B targets thioredoxin and glutathione systems to induce ROS-mediated paraptosis and apoptosis in bladder cancer cells","volume":"509","author":"Sang","year":"2021","journal-title":"Cancer Lett."},{"key":"10.1016\/j.bioorg.2025.108820_bb0065","doi-asserted-by":"crossref","first-page":"352","DOI":"10.1016\/j.canlet.2021.11.014","article-title":"Jolkinolide B sensitizes bladder cancer to mTOR inhibitors via dual inhibition of Akt signaling and autophagy","volume":"526","author":"Sang","year":"2022","journal-title":"Cancer Lett."},{"issue":"14","key":"10.1016\/j.bioorg.2025.108820_bb0070","doi-asserted-by":"crossref","first-page":"9926","DOI":"10.1021\/acs.jmedchem.1c00166","article-title":"Discovery of 8,9-seco-ent-kaurane diterpenoids as potential leads for the treatment of triple-negative breast cancer","volume":"64","author":"Fan","year":"2021","journal-title":"J. Med. Chem."},{"issue":"1","key":"10.1016\/j.bioorg.2025.108820_bb0075","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1021\/acs.orglett.9b03539","article-title":"Daphneodorins A\u2212C, anti-HIV gnidimacrin related macrocyclic daphnane orthoesters from Daphne odora","volume":"22","author":"Otsuki","year":"2020","journal-title":"Org. Lett."},{"issue":"11","key":"10.1016\/j.bioorg.2025.108820_bb0080","doi-asserted-by":"crossref","first-page":"3270","DOI":"10.1021\/acs.jnatprod.0c00540","article-title":"Isolation, structural elucidation, and anti-HIV activity of daphnane diterpenoids from Daphne odora","volume":"83","author":"Otsuki","year":"2020","journal-title":"J. Nat. Prod."},{"issue":"10","key":"10.1016\/j.bioorg.2025.108820_bb0085","first-page":"2605","article-title":"Resiniferonol-related diterpene esters from Daphne odora Thunb. and their ornithine decarboxylase-inducing activity in mouse skin","volume":"46","author":"Ohigashi","year":"1982","journal-title":"Agric. Biol. Chem."},{"issue":"8","key":"10.1016\/j.bioorg.2025.108820_bb0090","doi-asserted-by":"crossref","first-page":"5839","DOI":"10.1021\/acs.jmedchem.3c00067","article-title":"Discovery of the first raptor (regulatory-associated protein of mTOR) inhibitor as a new type of antiadipogenic agent","volume":"66","author":"Yan","year":"2023","journal-title":"J. Med. Chem."},{"issue":"4","key":"10.1016\/j.bioorg.2025.108820_bb0095","doi-asserted-by":"crossref","first-page":"1238","DOI":"10.1021\/acs.jnatprod.0c00003","article-title":"Daphnane diterpenoids from Daphne genkwa inhibit PI3K\/Akt\/mTOR signaling and induce cell cycle arrest and apoptosis in human colon cancer cells","volume":"83","author":"Pan","year":"2020","journal-title":"J. Nat. Prod."},{"issue":"6","key":"10.1016\/j.bioorg.2025.108820_bb0100","doi-asserted-by":"crossref","first-page":"1514","DOI":"10.1021\/acs.jnatprod.5c00390","article-title":"Daphnane diterpenoids from Daphne retusa with antiadipogenic activity: concurrent suppression of lipid biosynthesis and enhancement of metabolic pathways","volume":"88","author":"Song","year":"2025","journal-title":"J. Nat. Prod."},{"key":"10.1016\/j.bioorg.2025.108820_bb0105","unstructured":"J. Zhu, Y. Li, C. Zhang, F. Li, X. Liu, Y. Nie, D. Guo, W. Guo, Y. Peng, Y. Wang, H. Lu, R. Xi, Extraction of daphnane type macrocyclic diterpenoids with 4,7-oxygen bridge structure for the treatment of melanoma, China Patent No. CN116789680A (2023) State Intellectual Property Office."},{"key":"10.1016\/j.bioorg.2025.108820_bb0110","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1016\/j.phytochem.2011.11.013","article-title":"Daphnane-type diterpene esters with cytotoxic and anti-HIV-1 activities from Daphne acutiloba Rehd","volume":"75","author":"Huang","year":"2012","journal-title":"Phytochemistry"},{"issue":"11","key":"10.1016\/j.bioorg.2025.108820_bb0115","doi-asserted-by":"crossref","first-page":"3888","DOI":"10.1016\/j.bmc.2006.01.055","article-title":"Preparation of yuanhuacine and relative daphne diterpene esters from Daphne genkwa and structure\u2013activity relationship of potent inhibitory activity against DNA topoisomerase I","volume":"14","author":"Zhang","year":"2006","journal-title":"Bioorg. Med. Chem."},{"issue":"6","key":"10.1016\/j.bioorg.2025.108820_bb0120","doi-asserted-by":"crossref","first-page":"1172","DOI":"10.1002\/hlca.200900359","article-title":"Daphnane-type diterpenoids from the flower buds of Daphne genkwa","volume":"93","author":"Li","year":"2010","journal-title":"Helv. Chim. Acta"},{"issue":"8","key":"10.1016\/j.bioorg.2025.108820_bb0125","first-page":"1073","article-title":"Daphnane diterpenoids from Daphne altaica","volume":"11","author":"Eko-Nugroho","year":"2016","journal-title":"Nat. Prod. Commun."},{"issue":"2","key":"10.1016\/j.bioorg.2025.108820_bb0130","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1002\/ptr.2650070221","article-title":"Oligo- and macrocyclic diterpenes in Thymelaeaceae and Euphorbiaceae occurring and utilized in Yunnan (Southwest China). 5. Daphnane-type diterpene 9,13,14-orthoesters from roots of Daphne papyracea","volume":"7","author":"Wu","year":"1993","journal-title":"Phytother. Res."},{"issue":"3","key":"10.1016\/j.bioorg.2025.108820_bb0135","doi-asserted-by":"crossref","first-page":"414","DOI":"10.1021\/np200855d","article-title":"Library-based discovery and characterization of daphnane diterpenes as potent and selective HIV inhibitors in Daphne gnidium","volume":"75","author":"Vidal","year":"2012","journal-title":"J. Nat. Prod."},{"issue":"1","key":"10.1016\/j.bioorg.2025.108820_bb0140","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1038\/ncb1337","article-title":"ATM- and cell cycle-dependent regulation of ATR in response to DNA double-strand breaks","volume":"8","author":"Jazayeri","year":"2006","journal-title":"Nat. Cell Biol."},{"issue":"8","key":"10.1016\/j.bioorg.2025.108820_bb0145","doi-asserted-by":"crossref","first-page":"616","DOI":"10.1038\/nrm2450","article-title":"ATR: an essential regulator of genome integrity","volume":"9","author":"Cimprich","year":"2008","journal-title":"Nat. Rev. Mol. Cell Biol."},{"issue":"3","key":"10.1016\/j.bioorg.2025.108820_bb0150","doi-asserted-by":"crossref","first-page":"1092","DOI":"10.1021\/cr0782832","article-title":"Plant orthoesters","volume":"109","author":"Liao","year":"2009","journal-title":"Chem. Rev."},{"key":"10.1016\/j.bioorg.2025.108820_bb0155","doi-asserted-by":"crossref","DOI":"10.1016\/j.coph.2024.102447","article-title":"Targeting TRP channels for pain relief: a review of current evidence from bench to bedside","volume":"75","author":"Koivisto","year":"2024","journal-title":"Curr. Opin. Pharmacol."},{"issue":"2","key":"10.1016\/j.bioorg.2025.108820_bb0160","doi-asserted-by":"crossref","first-page":"2650","DOI":"10.1021\/acs.chemrev.1c00324","article-title":"Advances in the E\u2192Z isomerization of alkenes using small molecule photocatalysts","volume":"122","author":"Nevesel\u00fd","year":"2022","journal-title":"Chem. Rev."}],"container-title":["Bioorganic Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S004520682500700X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S004520682500700X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,4]],"date-time":"2025-11-04T02:29:55Z","timestamp":1762223395000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S004520682500700X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,9]]},"references-count":32,"alternative-id":["S004520682500700X"],"URL":"https:\/\/doi.org\/10.1016\/j.bioorg.2025.108820","relation":{},"ISSN":["0045-2068"],"issn-type":[{"value":"0045-2068","type":"print"}],"subject":[],"published":{"date-parts":[[2025,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Daphnane diterpenoids for cancer therapy by suppressing ATR-mediated DNA damage response pathway","name":"articletitle","label":"Article Title"},{"value":"Bioorganic Chemistry","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bioorg.2025.108820","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"108820"}}