{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T03:09:29Z","timestamp":1792724969247,"version":"4.5.0"},"reference-count":66,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Bioorganic Chemistry"],"published-print":{"date-parts":[[2025,9]]},"DOI":"10.1016\/j.bioorg.2025.108869","type":"journal-article","created":{"date-parts":[[2025,8,15]],"date-time":"2025-08-15T05:43:40Z","timestamp":1755236620000},"page":"108869","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":15,"special_numbering":"C","title":["Novel thiazolidinedione hybrids as cholinesterase inhibitors and targeting neuroblastoma: design, synthesis, in vitro and in silico biological evaluations"],"prefix":"10.1016","volume":"164","author":[{"given":"Gurbet \u00c7elik","family":"Turgut","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Furkan","family":"\u00c7ak\u0131r","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alaattin","family":"\u015een","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Feyzi Sinan","family":"Tokal\u0131","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Halil","family":"\u015eenol","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"4","key":"10.1016\/j.bioorg.2025.108869_bb0005","doi-asserted-by":"crossref","first-page":"335","DOI":"10.2967\/jnmt.118.218057","article-title":"Effects of Alzheimer disease on patients and their family","volume":"46","author":"Grabher","year":"2018","journal-title":"J. Nucl. Med. Technol."},{"key":"10.1016\/j.bioorg.2025.108869_bb0010","doi-asserted-by":"crossref","first-page":"1524292","DOI":"10.3389\/fpsyg.2025.1524292","article-title":"Effects of an interdisciplinary programme on psychoemotional factors in informal caregivers of people with Alzheimer\u2019s disease","volume":"16","author":"Mu\u00f1oz-Bermejo","year":"2025","journal-title":"Front. Psychol."},{"key":"10.1016\/j.bioorg.2025.108869_bb0015","doi-asserted-by":"crossref","DOI":"10.1016\/j.eclinm.2022.101580","article-title":"Global and regional projections of the economic burden of Alzheimer\u2019s disease and related dementias from 2019 to 2050: a value of statistical life approach","volume":"51","author":"Nandi","year":"2022","journal-title":"EClinicalMedicine"},{"issue":"4","key":"10.1016\/j.bioorg.2025.108869_bb0020","doi-asserted-by":"crossref","first-page":"2200554","DOI":"10.1002\/ardp.202200554","article-title":"Enzyme inhibition, molecular docking, and density functional theory studies of new thiosemicarbazones incorporating the 4-hydroxy-3,5-dimethoxy benzaldehyde motif","volume":"356","author":"Demir","year":"2023","journal-title":"Arch. Pharm."},{"key":"10.1016\/j.bioorg.2025.108869_bb0025","doi-asserted-by":"crossref","DOI":"10.1016\/j.molliq.2024.125558","article-title":"Bioactivity, cytotoxicity, and molecular modeling studies of novel sulfonamides as dual inhibitors of carbonic anhydrases and acetylcholinesterase","volume":"410","author":"G\u00fcle\u00e7","year":"2024","journal-title":"J. Mol. Liq."},{"key":"10.1016\/j.bioorg.2025.108869_bb0030","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejmcr.2024.100154","article-title":"Natural acetylcholinesterase inhibitors: a multi-targeted therapeutic potential in Alzheimer\u2019s disease","volume":"11","author":"Gajendra","year":"2024","journal-title":"European Journal of Medicinal Chemistry Reports"},{"issue":"4","key":"10.1016\/j.bioorg.2025.108869_bb0035","doi-asserted-by":"crossref","DOI":"10.1002\/ardp.202000375","article-title":"Synthesis and in vitro carbonic anhydrases and acetylcholinesterase inhibitory activities of novel imidazolinone-based benzenesulfonamides","volume":"354","author":"Tugrak","year":"2021","journal-title":"Arch. Pharm."},{"key":"10.1016\/j.bioorg.2025.108869_bb0040","doi-asserted-by":"crossref","DOI":"10.1016\/j.molstruc.2023.137365","article-title":"New naphthoquinone thiazole hybrids as carbonic anhydrase and cholinesterase inhibitors: synthesis, crystal structure, molecular docking, and acid dissociation constant","volume":"1301","author":"Efeoglu","year":"2024","journal-title":"J. Mol. Struct."},{"issue":"1","key":"10.1016\/j.bioorg.2025.108869_bb0045","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1080\/10942912.2019.1597882","article-title":"Anticholinergic and antidiabetic effects of isoeugenol from clove (Eugenia caryophylata) oil","volume":"22","author":"Topal","year":"2019","journal-title":"Int. J. Food Prop."},{"issue":"9","key":"10.1016\/j.bioorg.2025.108869_bb0050","doi-asserted-by":"crossref","DOI":"10.3390\/molecules26092469","article-title":"LC-HRMS profiling and antidiabetic, anticholinergic, and antioxidant activities of aerial parts of K\u0131nkor (Ferulago stellata)","volume":"26","author":"K\u0131z\u0131lta\u015f","year":"2021","journal-title":"Molecules"},{"issue":"1","key":"10.1016\/j.bioorg.2025.108869_bb0055","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1038\/s41392-024-01911-3","article-title":"Recent advances in Alzheimer's disease: mechanisms, clinical trials and new drug development strategies","volume":"9","author":"Zhang","year":"2024","journal-title":"Signal Transduct. Target. Ther."},{"issue":"2","key":"10.1016\/j.bioorg.2025.108869_bb0060","doi-asserted-by":"crossref","DOI":"10.1002\/prp2.70088","article-title":"Sulfonamide-Bearing Pyrazolone Derivatives as Multitarget Therapeutic Agents: Design, Synthesis, Characterization, Biological Evaluation, In Silico ADME\/T Profiling and Molecular Docking Study","volume":"13","author":"Lolak","year":"2025","journal-title":"Pharmacol. Res. Perspect."},{"issue":"9","key":"10.1016\/j.bioorg.2025.108869_bb0065","doi-asserted-by":"crossref","DOI":"10.1002\/slct.202405876","article-title":"Discovery of dual-inhibitor acyl hydrazones for acetylcholinesterase and carbonic anhydrase I\/II: a mechanistic insight into Alzheimer's disease","volume":"10","author":"Dincel","year":"2025","journal-title":"ChemistrySelect"},{"issue":"6","key":"10.1016\/j.bioorg.2025.108869_bb0070","doi-asserted-by":"crossref","DOI":"10.3390\/chemosensors12060100","article-title":"Improved affinity: a customized fluorescent probe for the rapid detection of Butyrylcholinesterase","volume":"12","author":"Wang","year":"2024","journal-title":"Chemosensors"},{"issue":"19","key":"10.1016\/j.bioorg.2025.108869_bb0075","doi-asserted-by":"crossref","first-page":"8752","DOI":"10.1080\/07391102.2021.1916599","article-title":"Novel inhibitors with sulfamethazine backbone: synthesis and biological study of multi-target cholinesterases and \u03b1-glucosidase inhibitors","volume":"40","author":"T\u00fcrke\u015f","year":"2022","journal-title":"J. Biomol. Struct. Dyn."},{"issue":"4","key":"10.1016\/j.bioorg.2025.108869_bb0080","doi-asserted-by":"crossref","DOI":"10.1002\/cbdv.202000958","article-title":"Synthesis, characterization, and inhibition study of novel substituted Phenylureido Sulfaguanidine derivatives as \u03b1-glycosidase and cholinesterase inhibitors","volume":"18","author":"Akocak","year":"2021","journal-title":"Chem. Biodivers."},{"key":"10.1016\/j.bioorg.2025.108869_bb0085","doi-asserted-by":"crossref","DOI":"10.1016\/j.molstruc.2024.139472","article-title":"Synthesis, biological evaluation and molecular docking of novel pyrazole derivatives as multitarget acetylcholinesterase and carbonic anhydrase inhibitors","volume":"1319","author":"Mert","year":"2025","journal-title":"J. Mol. Struct."},{"issue":"1","key":"10.1016\/j.bioorg.2025.108869_bb0090","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1080\/14756366.2016.1243534","article-title":"Tertiary amine derivatives of chlorochalcone as acetylcholinesterase (AChE) and buthylcholinesterase (BuChE) inhibitors: the influence of chlorine, alkyl amine side chain and \u03b1,\u03b2-unsaturated ketone group","volume":"32","author":"Gao","year":"2017","journal-title":"J. Enzyme Inhib. Med. Chem."},{"key":"10.1016\/j.bioorg.2025.108869_bb0095","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejmech.2022.114248","article-title":"From tryptophan-based amides to tertiary amines: optimization of a butyrylcholinesterase inhibitor series","volume":"234","author":"Meden","year":"2022","journal-title":"Eur. J. Med. Chem."},{"issue":"4","key":"10.1016\/j.bioorg.2025.108869_bb0100","doi-asserted-by":"crossref","first-page":"893","DOI":"10.1007\/s11030-018-9839-y","article-title":"Structure\u2013activity relationship investigation of coumarin\u2013chalcone hybrids with diverse side-chains as acetylcholinesterase and butyrylcholinesterase inhibitors","volume":"22","author":"Kang","year":"2018","journal-title":"Mol. Divers."},{"key":"10.1016\/j.bioorg.2025.108869_bb0105","doi-asserted-by":"crossref","first-page":"671","DOI":"10.1007\/s11030-024-10828-6","article-title":"Structure-based inhibition of acetylcholinesterase and butyrylcholinesterase with 2-aryl-6-carboxamide benzoxazole derivatives: synthesis, enzymatic assay, and in silico studies","volume":"29","author":"Kuzu","year":"2024","journal-title":"Mol. Divers."},{"issue":"3","key":"10.1016\/j.bioorg.2025.108869_bb0110","doi-asserted-by":"crossref","first-page":"2005","DOI":"10.1007\/s11696-025-03947-3","article-title":"Imidazo[1,2-a]pyridine mannich bases: synthesis, anticholinesterase evaluation, and in silico studies","volume":"79","author":"Kuzu","year":"2025","journal-title":"Chem. Pap."},{"key":"10.1016\/j.bioorg.2025.108869_bb0115","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1016\/j.ejmech.2013.02.014","article-title":"Synthesis and evaluation of 7,8-dehydrorutaecarpine derivatives as potential multifunctional agents for the treatment of Alzheimer\u2019s disease","volume":"63","author":"He","year":"2013","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.bioorg.2025.108869_bb0120","article-title":"Novel ferulic amide derivatives with tertiary amine side chain as acetylcholinesterase and butyrylcholinesterase inhibitors: the influence of carbon spacer length, alkylamine and aromatic group","volume":"126","author":"Liu","year":"2016","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.bioorg.2025.108869_bb0125","doi-asserted-by":"crossref","DOI":"10.1016\/j.abb.2025.110450","article-title":"Design, synthesis, and biological studies of isoniazid-based hydrazone derivatives: antibacterial, anticancer, and enzyme inhibitory properties","volume":"770","author":"Kalay","year":"2025","journal-title":"Arch. Biochem. Biophys."},{"issue":"10","key":"10.1016\/j.bioorg.2025.108869_bb0130","doi-asserted-by":"crossref","DOI":"10.1002\/slct.202205039","article-title":"New diacetic acids containing Quinazolin-4(3H)-one: synthesis, characterization, anticholinergic properties, DFT analysis and molecular docking studies","volume":"8","author":"Tokal\u0131","year":"2023","journal-title":"Chemistryselect"},{"issue":"7","key":"10.1016\/j.bioorg.2025.108869_bb0135","doi-asserted-by":"crossref","first-page":"735","DOI":"10.2174\/1573406418666211220124119","article-title":"Mannich bases: centrality in cytotoxic drug design","volume":"18","author":"Bhilare","year":"2022","journal-title":"Med. Chem."},{"key":"10.1016\/j.bioorg.2025.108869_bb0140","doi-asserted-by":"crossref","first-page":"743","DOI":"10.1016\/j.ejmech.2014.10.076","article-title":"Mannich bases in medicinal chemistry and drug design","volume":"89","author":"Roman","year":"2015","journal-title":"Eur. J. Med. Chem."},{"issue":"18","key":"10.1016\/j.bioorg.2025.108869_bb0145","doi-asserted-by":"crossref","first-page":"2265","DOI":"10.2174\/156802611797183230","article-title":"Prodrugs - an efficient way to breach delivery and targeting barriers","volume":"11","author":"Huttunen","year":"2011","journal-title":"Curr. Top. Med. Chem."},{"issue":"6","key":"10.1016\/j.bioorg.2025.108869_bb0150","doi-asserted-by":"crossref","DOI":"10.1016\/j.bbagen.2024.130599","article-title":"New thiazolidine-2,4-diones as potential anticancer agents and apoptotic inducers targeting VEGFR-2 kinase: design, synthesis, in silico and in vitro studies","volume":"1868","author":"Elkady","year":"2024","journal-title":"Biochim. Biophys. Acta Gen. Subj."},{"issue":"7","key":"10.1016\/j.bioorg.2025.108869_bb0155","doi-asserted-by":"crossref","DOI":"10.3390\/ph16070946","article-title":"Novel Thiazolidine-2,4-dione-trimethoxybenzene-thiazole hybrids as human topoisomerases inhibitors","volume":"16","author":"Sinicropi","year":"2023","journal-title":"Pharmaceuticals"},{"key":"10.1016\/j.bioorg.2025.108869_bb0160","doi-asserted-by":"crossref","DOI":"10.1016\/j.bioorg.2020.103569","article-title":"Synthesis of a novel series of (Z)-3,5-disubstituted thiazolidine-2,4-diones as promising anti-breast cancer agents","volume":"96","author":"El-Kashef","year":"2020","journal-title":"Bioorg. Chem."},{"issue":"1","key":"10.1016\/j.bioorg.2025.108869_bb0165","doi-asserted-by":"crossref","first-page":"1903","DOI":"10.1080\/14756366.2022.2085693","article-title":"Design and synthesis of thiazolidine-2,4-diones hybrids with 1,2-dihydroquinolones and 2-oxindoles as potential VEGFR-2 inhibitors: in-vitro anticancer evaluation and in-silico studies","volume":"37","author":"Taghour","year":"2022","journal-title":"J. Enzyme Inhib. Med. Chem."},{"key":"10.1016\/j.bioorg.2025.108869_bb0170","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1016\/j.neuro.2022.07.008","article-title":"The SH-SY5Y human neuroblastoma cell line, a relevant in vitro cell model for investigating neurotoxicology in human: focus on organic pollutants","volume":"92","author":"Lopez-Suarez","year":"2022","journal-title":"Neurotoxicology"},{"issue":"5","key":"10.1016\/j.bioorg.2025.108869_bb0175","doi-asserted-by":"crossref","DOI":"10.3390\/ph18050629","article-title":"Neuroprotective potential of Tetraselmis chuii compounds: insights into blood-brain barrier permeability and intestinal transport","volume":"18","author":"Cokdinleyen","year":"2025","journal-title":"Pharmaceuticals (Basel)"},{"key":"10.1016\/j.bioorg.2025.108869_bb0180","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.neuro.2022.02.006","article-title":"Butyrylcholinesterase in SH-SY5Y human neuroblastoma cells","volume":"90","author":"Onder","year":"2022","journal-title":"NeuroToxicology"},{"issue":"12","key":"10.1016\/j.bioorg.2025.108869_bb0185","doi-asserted-by":"crossref","first-page":"3046","DOI":"10.1002\/etc.5490","article-title":"Validation of an SH-SY5Y cell\u2013based acetylcholinesterase inhibition assay for water quality assessment","volume":"41","author":"Lee","year":"2022","journal-title":"Environ. Toxicol. Chem."},{"issue":"1","key":"10.1016\/j.bioorg.2025.108869_bb0190","article-title":"New resveratrol derivatives exhibit acetylcholinesterase inhibitory properties and decrease reactive oxygen species production in the SH-SY5Y human neuroblastoma cell line","volume":"21","author":"Donozo","year":"2023","journal-title":"Med. Sci. Forum"},{"issue":"4","key":"10.1016\/j.bioorg.2025.108869_bb0195","doi-asserted-by":"crossref","first-page":"578","DOI":"10.1016\/j.ipha.2024.01.010","article-title":"The importance of in-silico studies in drug discovery","volume":"2","author":"Roney","year":"2024","journal-title":"Intelligent Pharmacy"},{"issue":"30","key":"10.1016\/j.bioorg.2025.108869_bb0200","doi-asserted-by":"crossref","DOI":"10.1002\/slct.202402129","article-title":"Exploring the inhibitory effects of quinolone medications on carbonic anhydrase enzyme activity: in vitro and in silico investigation","volume":"9","author":"Demir","year":"2024","journal-title":"ChemistrySelect"},{"issue":"3","key":"10.1016\/j.bioorg.2025.108869_bb0205","first-page":"8","article-title":"Meta-analysis and review of in silico methods in drug discovery - part 1: technological evolution and trends from big data to chemical space","volume":"25","author":"Uzundurukan","year":"2025","journal-title":"Pharm. J."},{"issue":"5","key":"10.1016\/j.bioorg.2025.108869_bb0210","doi-asserted-by":"crossref","first-page":"628","DOI":"10.1002\/ddr.21667","article-title":"Naphthoquinones, benzoquinones, and anthraquinones: molecular docking, ADME and inhibition studies on human serum paraoxonase-1 associated with cardiovascular diseases","volume":"81","author":"Demir","year":"2020","journal-title":"Drug Dev. Res."},{"issue":"22","key":"10.1016\/j.bioorg.2025.108869_bb0215","doi-asserted-by":"crossref","first-page":"12008","DOI":"10.1080\/07391102.2021.1967195","article-title":"Molecular docking and inhibition studies of vulpinic, carnosic and usnic acids on polyol pathway enzymes","volume":"40","author":"Demir","year":"2022","journal-title":"J. Biomol. Struct. Dyn."},{"issue":"9","key":"10.1016\/j.bioorg.2025.108869_bb0220","doi-asserted-by":"crossref","first-page":"4035","DOI":"10.1021\/acs.jmedchem.5b01684","article-title":"Role of molecular dynamics and related methods in drug discovery","volume":"59","author":"De Vivo","year":"2016","journal-title":"J. Med. Chem."},{"issue":"1","key":"10.1016\/j.bioorg.2025.108869_bb0225","doi-asserted-by":"crossref","first-page":"71","DOI":"10.3390\/pr9010071","article-title":"Molecular dynamics simulations in drug discovery and pharmaceutical development","volume":"9","author":"Salo-Ahen","year":"2021","journal-title":"Processes"},{"key":"10.1016\/j.bioorg.2025.108869_bb0230","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/j.bioorg.2014.05.006","article-title":"Design, synthesis and glucose uptake activity of some novel glitazones","volume":"56","author":"Kar","year":"2014","journal-title":"Bioorg. Chem."},{"issue":"2","key":"10.1016\/j.bioorg.2025.108869_bb0235","doi-asserted-by":"crossref","first-page":"563","DOI":"10.1007\/s13738-021-02331-8","article-title":"Novel phenolic Mannich base derivatives: synthesis, bioactivity, molecular docking, and ADME-Tox studies","volume":"19","author":"Tokal\u0131","year":"2022","journal-title":"J. Iran. Chem. Soc."},{"key":"10.1016\/j.bioorg.2025.108869_bb0240","doi-asserted-by":"crossref","DOI":"10.1016\/j.molliq.2025.127487","article-title":"Aldose reductase inhibition properties of novel thiazolidin-2,4-diones: in vitro and in silico approach for the treatment of diabetes-related complications","volume":"426","author":"Tokal\u0131","year":"2025","journal-title":"J. Mol. Liq."},{"issue":"2","key":"10.1016\/j.bioorg.2025.108869_bb0245","doi-asserted-by":"crossref","first-page":"282","DOI":"10.1134\/S1068162024020109","article-title":"Synthesis of some new Coumarin-thiazolidine-2,4-dione-1,2,3-triazole hybrids as tubulin targeting anti-lung Cancer agents","volume":"50","author":"Ramakrishna","year":"2024","journal-title":"Russ. J. Bioorg. Chem."},{"key":"10.1016\/j.bioorg.2025.108869_bb0250","doi-asserted-by":"crossref","DOI":"10.1016\/j.bmc.2025.118264","article-title":"Development of phenolic Mannich bases as \u03b1-glucosidase and aldose reductase inhibitors: in vitro and in silico approaches for managing diabetes mellitus and its complications","volume":"128","author":"Tokal\u0131","year":"2025","journal-title":"Bioorg. Med. Chem."},{"issue":"AAM","key":"10.1016\/j.bioorg.2025.108869_bb0255","article-title":"Synthesis, characterization and in vitro & in silico biological evaluation of new mannich-based rhodanine and thiazolidine-2,4-dione derivatives as potential anti-lung cancer agents","volume":"0","author":"Ate\u015fo\u011flu","year":"2025","journal-title":"Synlett"},{"issue":"4","key":"10.1016\/j.bioorg.2025.108869_bb0260","doi-asserted-by":"crossref","first-page":"645","DOI":"10.1002\/jhet.4619","article-title":"Novel thiosemicarbazone and thiazolidin-4-one derivatives containing vanillin core: synthesis, characterization, and anticancer activity studies","volume":"60","author":"Tokal\u0131","year":"2023","journal-title":"J. Heterocyclic Chem."},{"issue":"4","key":"10.1016\/j.bioorg.2025.108869_bb0265","doi-asserted-by":"crossref","first-page":"2630","DOI":"10.1021\/acs.jctc.1c00136","article-title":"Reliable and accurate solution to the induced fit docking problem for protein-ligand binding","volume":"17","author":"Miller","year":"2021","journal-title":"J. Chem. Theory Comput."},{"issue":"6","key":"10.1016\/j.bioorg.2025.108869_bb0270","doi-asserted-by":"crossref","DOI":"10.1002\/ardp.70033","article-title":"Quinazolin-4(3H)-one-based new Glitazones as dual inhibitors of \u03b1-glucosidase and aldose reductase: comprehensive approaches for managing diabetes mellitus and its complications","volume":"358","author":"Tokal\u0131","year":"2025","journal-title":"Arch Pharm (Weinheim)"},{"key":"10.1016\/j.bioorg.2025.108869_bb0275","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejmech.2025.117915","article-title":"Synthesis, characterization, in vitro and in silico investigations of novel 1,2,3-triazole substituted salicylic acid phenolic hydrazones hybrids targeting TGF-\u03b22 expression in colorectal carcinoma","volume":"296","author":"Ay","year":"2025","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.bioorg.2025.108869_bb0280","doi-asserted-by":"crossref","DOI":"10.1016\/j.compbiolchem.2025.108486","article-title":"Synthesis and evaluation of aldose reductase inhibition of new thiazolidine-quinazoline hybrids through in vitro and in silico approaches","volume":"118","author":"\u015eenol","year":"2025","journal-title":"Comput. Biol. Chem."},{"key":"10.1016\/j.bioorg.2025.108869_bb0285","doi-asserted-by":"crossref","DOI":"10.1016\/j.bioorg.2025.108614","article-title":"Design, synthesis, and aldose reductase inhibition assessment of novel Quinazolin-4(3H)-one derivatives with 4-Bromo-2-Fluorobenzene functionality","volume":"162","author":"Tokal\u0131","year":"2025","journal-title":"Bioorg. Chem."},{"issue":"2","key":"10.1016\/j.bioorg.2025.108869_bb0290","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1016\/j.bmc.2016.11.015","article-title":"Computer design, synthesis, and bioactivity analyses of drugs like fingolimod used in the treatment of multiple sclerosis","volume":"25","author":"Turgut","year":"2017","journal-title":"Bioorg. Med. Chem."},{"issue":"n\/a","key":"10.1016\/j.bioorg.2025.108869_bb0295","article-title":"Therapeutic potential of nitrogen-substituted oleanolic acid derivatives in neuroinflammatory and cytokine pathways: insights from cell-based and computational models","volume":"n\/a","author":"Turgut","year":"2025","journal-title":"Chem. Biodivers."},{"key":"10.1016\/j.bioorg.2025.108869_bb0300","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1016\/0006-2952(61)90145-9","volume":"7","author":"Ellman","year":"1961","journal-title":"Biochem. Pharmacol."},{"issue":"11","key":"10.1016\/j.bioorg.2025.108869_bb0305","doi-asserted-by":"crossref","DOI":"10.1002\/jbt.21973","article-title":"Synephrine and phenylephrine act as alpha-amylase, alpha-glycosidase, acetylcholinesterase, butyrylcholinesterase, and carbonic anhydrase enzymes inhibitors","volume":"31","author":"Taslimi","year":"2017","journal-title":"J. Biochem. Mol. Toxicol."},{"issue":"4","key":"10.1016\/j.bioorg.2025.108869_bb0310","doi-asserted-by":"crossref","first-page":"720","DOI":"10.1134\/S1068162022040124","article-title":"Identification of the inhibition effects of some natural antiproliferative agents on ca-i, ca-ii, and ache activities isolated from human erythrocytes by kinetic and molecular docking studies","volume":"48","author":"K\u0131l\u0131n\u00e7","year":"2022","journal-title":"Russ. J. Bioorg. Chem."},{"issue":"8","key":"10.1016\/j.bioorg.2025.108869_bb0315","doi-asserted-by":"crossref","DOI":"10.1002\/jbt.70412","article-title":"New quinazolin-4(3H)-one\u2013thiazolidine-2,4-dione hybrids as dual inhibitors of \u03b1-glycosidase and aldose reductase: the synthetic, in vitro, and in silico approaches","volume":"39","author":"Tokal\u0131","year":"2025","journal-title":"J. Biochem. Mol. Toxicol."},{"key":"10.1016\/j.bioorg.2025.108869_bb0320","doi-asserted-by":"crossref","DOI":"10.1016\/j.molliq.2024.125006","article-title":"New tetrahydro-isoquinoline derivatives as cholinesterase and \u03b1-glycosidase inhibitors: synthesis, characterization, molecular docking & dynamics, ADME prediction, in vitro cytotoxicity and enzyme inhibition studies","volume":"404","author":"Mamedov","year":"2024","journal-title":"J. Mol. Liq."},{"key":"10.1016\/j.bioorg.2025.108869_bb0325","doi-asserted-by":"crossref","DOI":"10.1016\/j.molstruc.2024.140153","article-title":"Synthesis, cytotoxic evaluation, and in silico studies of novel benzenesulfonamide-thiazolidinone derivatives against colorectal carcinoma","volume":"1321","author":"Zengin Kurt","year":"2025","journal-title":"J. Mol. Struct."},{"key":"10.1016\/j.bioorg.2025.108869_bb0330","doi-asserted-by":"crossref","first-page":"138998","DOI":"10.1016\/j.molstruc.2024.138998","article-title":"Synthesis of pyrrole-heterocyclic derivatives as anti-Alzheimer and antidiabetic candidates: an in vitro-in silico study","volume":"1315","author":"Petrova","year":"2024","journal-title":"J. Mol. Struct."}],"container-title":["Bioorganic Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0045206825007497?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0045206825007497?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,12]],"date-time":"2025-09-12T05:47:13Z","timestamp":1757656033000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0045206825007497"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,9]]},"references-count":66,"alternative-id":["S0045206825007497"],"URL":"https:\/\/doi.org\/10.1016\/j.bioorg.2025.108869","relation":{},"ISSN":["0045-2068"],"issn-type":[{"value":"0045-2068","type":"print"}],"subject":[],"published":{"date-parts":[[2025,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Novel thiazolidinedione hybrids as cholinesterase inhibitors and targeting neuroblastoma: design, synthesis, in vitro and in silico biological evaluations","name":"articletitle","label":"Article Title"},{"value":"Bioorganic Chemistry","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bioorg.2025.108869","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"108869"}}