{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,3]],"date-time":"2026-11-03T17:25:55Z","timestamp":1793726755862,"version":"4.6.1"},"reference-count":48,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82204438"],"award-info":[{"award-number":["82204438"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82160654"],"award-info":[{"award-number":["82160654"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100016079","name":"Science and Technology Department of Xinjiang Uygur Autonomous Region","doi-asserted-by":"publisher","award":["2024TSYCCX0079"],"award-info":[{"award-number":["2024TSYCCX0079"]}],"id":[{"id":"10.13039\/100016079","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004880","name":"Xinjiang Medical University","doi-asserted-by":"publisher","award":["XYD2024GR07"],"award-info":[{"award-number":["XYD2024GR07"]}],"id":[{"id":"10.13039\/501100004880","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Bioorganic Chemistry"],"published-print":{"date-parts":[[2025,10]]},"DOI":"10.1016\/j.bioorg.2025.109006","type":"journal-article","created":{"date-parts":[[2025,9,17]],"date-time":"2025-09-17T06:33:07Z","timestamp":1758090787000},"page":"109006","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":4,"special_numbering":"C","title":["Design and synthesis of novel quinoline-chalcone derivatives as dual inhibitors of tubulin polymerization and P-glycoprotein to overcome cisplatin resistance in cervical cancer"],"prefix":"10.1016","volume":"165","author":[{"given":"Tong","family":"Yan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miao Miao","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin Yi","family":"Deng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Madina","family":"Imam","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mourboul","family":"Ablise","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei Yi","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"1","key":"10.1016\/j.bioorg.2025.109006_bb0005","doi-asserted-by":"crossref","first-page":"4369","DOI":"10.1038\/s41467-024-48705-3","article-title":"Artificial intelligence enables precision diagnosis of cervical cytology grades and cervical cancer","volume":"15","author":"Wang","year":"2024","journal-title":"Nat. Commun."},{"issue":"3","key":"10.1016\/j.bioorg.2025.109006_bb0010","first-page":"229","article-title":"Global cancer statistics 2022: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries","volume":"74","author":"Bray","year":"2024","journal-title":"CA Cancer J. Clin."},{"issue":"2","key":"10.1016\/j.bioorg.2025.109006_bb0015","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1002\/cac2.12629","article-title":"Advances in cervical cancer: current insights and future directions","volume":"45","author":"Xu","year":"2025","journal-title":"Cancer Commun. (London)"},{"issue":"1","key":"10.1016\/j.bioorg.2025.109006_bb0020","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1056\/NEJMra2404457","article-title":"Cervical Cancer","volume":"392","author":"Tewari","year":"2025","journal-title":"N. Engl. J. Med."},{"issue":"20","key":"10.1016\/j.bioorg.2025.109006_bb0025","doi-asserted-by":"crossref","first-page":"1908","DOI":"10.1056\/NEJMsr2030640","article-title":"The IARC perspective on cervical Cancer screening","volume":"385","author":"Bouvard","year":"2021","journal-title":"N. Engl. J. Med."},{"issue":"3","key":"10.1016\/j.bioorg.2025.109006_bb0030","doi-asserted-by":"crossref","first-page":"394","DOI":"10.1136\/ijgc-2022-003703","article-title":"Updates on cervical cancer prevention","volume":"33","author":"Viveros-Carre\u00f1o","year":"2023","journal-title":"Int. J. Gynecol. Cancer"},{"issue":"5","key":"10.1016\/j.bioorg.2025.109006_bb0035","article-title":"Prophylactic vaccination against human papillomaviruses to prevent cervical cancer and its precursors","volume":"5","author":"Arbyn","year":"2018","journal-title":"Cochrane Database Syst. Rev."},{"key":"10.1016\/j.bioorg.2025.109006_bb0040","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejmech.2024.116425","article-title":"Design, synthesis, and biological evaluation of novel benzimidazole derivatives as anti-cervical cancer agents through PI3K\/Akt\/mTOR pathway and tubulin inhibition","volume":"271","author":"Li","year":"2024","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.bioorg.2025.109006_bb0045","doi-asserted-by":"crossref","first-page":"1885","DOI":"10.2147\/DDDT.S106412","article-title":"Molecular mechanisms of cisplatin resistance in cervical cancer","volume":"10","author":"Zhu","year":"2016","journal-title":"Drug Des. Devel. Ther."},{"issue":"2","key":"10.1016\/j.bioorg.2025.109006_bb0050","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1007\/s10637-019-00781-9","article-title":"Cardamonin, a natural chalcone, reduces 5-fluorouracil resistance of gastric cancer cells through targeting Wnt\/\u03b2-catenin signal pathway","volume":"38","author":"Hou","year":"2020","journal-title":"Invest. New Drugs"},{"key":"10.1016\/j.bioorg.2025.109006_bb0055","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.90174.3","article-title":"Tracing the substrate translocation mechanism in P-glycoprotein","volume":"12","author":"Gewering","year":"2024","journal-title":"Elife"},{"issue":"2","key":"10.1016\/j.bioorg.2025.109006_bb0060","doi-asserted-by":"crossref","first-page":"215","DOI":"10.3390\/antiox13020215","article-title":"Regulation of P-glycoprotein during oxidative stress","volume":"13","author":"Shchulkin","year":"2024","journal-title":"Antioxidants (Basel)"},{"key":"10.1016\/j.bioorg.2025.109006_bb0065","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejmech.2023.115150","article-title":"Design and evaluation of dibenzoazepine-tetrahydroisoquinoline hybrids as potential P-glycoprotein inhibitors against multidrug resistant K562\/A02 cells","volume":"249","author":"Jiang","year":"2023","journal-title":"Eur. J. Med. Chem."},{"issue":"5\u20136","key":"10.1016\/j.bioorg.2025.109006_bb0070","doi-asserted-by":"crossref","first-page":"943","DOI":"10.1016\/S0006-2952(02)01156-5","article-title":"Transcriptional regulators of the human multidrug resistance 1 gene: recent views","volume":"64","author":"Labialle","year":"2002","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.bioorg.2025.109006_bb0075","doi-asserted-by":"crossref","DOI":"10.1016\/j.bmc.2024.117944","article-title":"Synthesis and evaluation of novel tetrahydroisoquinoline-benzo[h]chromen-4-one conjugates as dual ABCB1\/CYP1B1 inhibitors for overcoming MDR in cancer","volume":"114","author":"Dong","year":"2024","journal-title":"Bioorg. Med. Chem."},{"issue":"11","key":"10.1016\/j.bioorg.2025.109006_bb0080","doi-asserted-by":"crossref","DOI":"10.1016\/j.drudis.2024.104161","article-title":"P-glycoprotein (P-gp)-driven cancer drug resistance: biological profile, non-coding RNAs, drugs and nanomodulators","volume":"29","author":"Guo","year":"2024","journal-title":"Drug Discov. Today"},{"issue":"5","key":"10.1016\/j.bioorg.2025.109006_bb0085","doi-asserted-by":"crossref","first-page":"119","DOI":"10.3892\/ijo.2023.5567","article-title":"Mechanism of multidrug resistance to chemotherapy mediated by P-glycoprotein (review)","volume":"63","author":"Tian","year":"2023","journal-title":"Int. J. Oncol."},{"key":"10.1016\/j.bioorg.2025.109006_bb0090","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejmech.2021.113930","article-title":"Identification and optimization of biphenyl derivatives as novel tubulin inhibitors targeting colchicine-binding site overcoming multidrug resistance","volume":"228","author":"Cheng","year":"2022","journal-title":"Eur. J. Med. Chem."},{"issue":"3","key":"10.1016\/j.bioorg.2025.109006_bb0095","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1021\/np068054v","article-title":"Natural products as sources of new drugs over the last 25 years","volume":"70","author":"Newman","year":"2007","journal-title":"J. Nat. Prod."},{"issue":"6","key":"10.1016\/j.bioorg.2025.109006_bb0100","doi-asserted-by":"crossref","first-page":"894","DOI":"10.3390\/biom11060894","article-title":"Chalcone derivatives: role in anticancer therapy","volume":"11","author":"Ouyang","year":"2021","journal-title":"Biomolecules"},{"key":"10.1016\/j.bioorg.2025.109006_bb0105","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/j.ejmech.2015.05.004","article-title":"Anti-cancer chalcones: structural and molecular target perspectives","volume":"98","author":"Mahapatra","year":"2015","journal-title":"Eur. J. Med. Chem."},{"issue":"1","key":"10.1016\/j.bioorg.2025.109006_bb0110","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1080\/14756366.2020.1852556","article-title":"Discovery of orally active chalcones as histone lysine specific demethylase 1 inhibitors for the treatment of leukaemia","volume":"36","author":"Li","year":"2021","journal-title":"J. Enzyme Inhib. Med. Chem."},{"issue":"7","key":"10.1016\/j.bioorg.2025.109006_bb0115","doi-asserted-by":"crossref","first-page":"3447","DOI":"10.1021\/acs.jmedchem.8b01951","article-title":"Design, synthesis, and biological evaluation of novel allosteric protein Disulfide isomerase inhibitors","volume":"62","author":"Yang","year":"2019","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.bioorg.2025.109006_bb0120","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1016\/j.ejmech.2013.02.037","article-title":"Cytotoxic 3,4,5-trimethoxychalcones as mitotic arresters and cell migration inhibitors","volume":"63","author":"Salum","year":"2013","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.bioorg.2025.109006_bb0125","doi-asserted-by":"crossref","DOI":"10.1016\/j.molstruc.2025.141506","article-title":"Design and synthesis of new anti-cervical cancer compounds, including pyridines, indoles, naphthalenes, and pyrrolopyridines derived from chalcone derivatives","volume":"1330","author":"Wang","year":"2025","journal-title":"J. Mol. Struct."},{"key":"10.1016\/j.bioorg.2025.109006_bb0130","doi-asserted-by":"crossref","DOI":"10.1016\/j.bioorg.2024.107310","article-title":"Design and synthesis of novel imidazole-chalcone derivatives as microtubule protein polymerization inhibitors to treat cervical cancer and reverse cisplatin resistance","volume":"147","author":"Liu","year":"2024","journal-title":"Bioorg. Chem."},{"key":"10.1016\/j.bioorg.2025.109006_bb0135","doi-asserted-by":"crossref","DOI":"10.1016\/j.bioorg.2024.107498","article-title":"Design, synthesis, and ex vivo anti-drug resistant cervical cancer activity of novel molecularly targeted chalcone derivatives","volume":"149","author":"Yang","year":"2024","journal-title":"Bioorg. Chem."},{"issue":"52","key":"10.1016\/j.bioorg.2025.109006_bb0140","doi-asserted-by":"crossref","first-page":"18328","DOI":"10.1074\/jbc.RA120.015223","article-title":"Therapeutic targeting of pancreatic cancer stem cells by dexamethasone modulation of the MKP-1-JNK axis","volume":"295","author":"Suzuki","year":"2020","journal-title":"J. Biol. Chem."},{"issue":"8","key":"10.1016\/j.bioorg.2025.109006_bb0145","doi-asserted-by":"crossref","first-page":"4920","DOI":"10.1016\/j.arabjc.2016.10.009","article-title":"Comprehensive review on current developments of quinoline-based anticancer agents","volume":"12","author":"Jain","year":"2019","journal-title":"Arab. J. Chem."},{"issue":"2","key":"10.1016\/j.bioorg.2025.109006_bb0150","first-page":"65","article-title":"Anticancer mechanism of quinoline based compounds for cancer therapy","volume":"1","author":"Chawla","year":"2024","journal-title":"Int. J. Med. Pharmaceut. Health Sci."},{"key":"10.1016\/j.bioorg.2025.109006_bb0155","doi-asserted-by":"crossref","DOI":"10.3389\/fchem.2022.1040333","article-title":"Advances in antitumor research of CA-4 analogs carrying quinoline scaffold","volume":"10","author":"Wang","year":"2022","journal-title":"Front. Chem."},{"issue":"10","key":"10.1016\/j.bioorg.2025.109006_bb0160","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0007415","article-title":"NSC23925, identified in a high-throughput cell-based screen, reverses multidrug resistance","volume":"4","author":"Duan","year":"2009","journal-title":"PloS One"},{"issue":"1","key":"10.1016\/j.bioorg.2025.109006_bb0165","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1016\/j.ygyno.2015.02.002","article-title":"NSC23925 prevents the emergence of multidrug resistance in ovarian cancer in vitro and in vivo","volume":"137","author":"Yang","year":"2015","journal-title":"Gynecol. Oncol."},{"issue":"12","key":"10.1016\/j.bioorg.2025.109006_bb0170","doi-asserted-by":"crossref","first-page":"2896","DOI":"10.1038\/bjc.2014.254","article-title":"Prevention of multidrug resistance (MDR) in osteosarcoma by NSC23925","volume":"110","author":"Yang","year":"2014","journal-title":"Br. J. Cancer"},{"issue":"7","key":"10.1016\/j.bioorg.2025.109006_bb0175","doi-asserted-by":"crossref","first-page":"825","DOI":"10.2174\/1871520620666200516150345","article-title":"Recent Progress in the development of quinoline derivatives for the exploitation of anti-Cancer agents","volume":"21","author":"Man","year":"2021","journal-title":"Anticancer Agents Med Chem."},{"issue":"22","key":"10.1016\/j.bioorg.2025.109006_bb0180","doi-asserted-by":"crossref","DOI":"10.3390\/ijms232214125","article-title":"The impact of P-glycoprotein on opioid analgesics: what\u2019s the real meaning in pain management and palliative care?","volume":"23","author":"Coluzzi","year":"2022","journal-title":"Int. J. Mol. Sci."},{"issue":"6","key":"10.1016\/j.bioorg.2025.109006_bb0185","doi-asserted-by":"crossref","first-page":"1154","DOI":"10.1039\/c2ob06809e","article-title":"Towards dual photodynamic and antiangiogenic agents: design and synthesis of a phthalocyanine-chalcone conjugate","volume":"10","author":"Tuncel","year":"2012","journal-title":"Org. Biomol. Chem."},{"issue":"4","key":"10.1016\/j.bioorg.2025.109006_bb0190","doi-asserted-by":"crossref","first-page":"845","DOI":"10.1016\/j.bmc.2017.12.048","article-title":"Phenylquinoline transient receptor potential vanilloid 1 antagonists for the treatment of pain: discovery of 1-(2-phenylquinoline-4-carbonyl)-N-(4-(trifluoromethyl)phenyl)pyrrolidine-3-carboxamide","volume":"26","author":"Liao","year":"2018","journal-title":"Bioorg. Med. Chem."},{"key":"10.1016\/j.bioorg.2025.109006_bb0195","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/j.ejmech.2017.03.031","article-title":"Synthesis and biological evaluation of novel chalcone derivatives as a new class of microtubule destabilizing agents","volume":"132","author":"Huang","year":"2017","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.bioorg.2025.109006_bb0200","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejmech.2022.115085","article-title":"Discovery and biological evaluation of 4,6-pyrimidine analogues with potential anticancer agents as novel colchicine binding site inhibitors","volume":"248","author":"Zhang","year":"2023","journal-title":"Eur. J. Med. Chem."},{"issue":"8","key":"10.1016\/j.bioorg.2025.109006_bb0205","doi-asserted-by":"crossref","first-page":"4498","DOI":"10.1021\/acs.jmedchem.0c01837","article-title":"Discovery of novel benzimidazole and indazole analogues as tubulin polymerization inhibitors with potent anticancer activities","volume":"64","author":"Ren","year":"2021","journal-title":"J. Med. Chem."},{"issue":"50","key":"10.1016\/j.bioorg.2025.109006_bb0210","doi-asserted-by":"crossref","first-page":"33533","DOI":"10.1074\/jbc.273.50.33533","article-title":"Importance of poly (ADP-ribose) polymerase and its cleavage in apoptosis. Lesson from an uncleavable mutant","volume":"273","author":"Oliver","year":"1998","journal-title":"J. Biol. Chem."},{"issue":"1","key":"10.1016\/j.bioorg.2025.109006_bb0215","doi-asserted-by":"crossref","first-page":"2004","DOI":"10.1080\/14756366.2022.2100366","article-title":"Discovery of benzochalcone derivative as a potential antigastric cancer agent targeting signal transducer and activator of transcription 3 (STAT3)","volume":"37","author":"Dong","year":"2022","journal-title":"J. Enzyme Inhib. Med. Chem."},{"issue":"1","key":"10.1016\/j.bioorg.2025.109006_bb0220","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1002\/mnfr.200700457","article-title":"From delocalized lipophilic cations to hypoxia: blocking tumor cell mitochondrial function leads to therapeutic gain with glycolytic inhibitors","volume":"53","author":"Kurtoglu","year":"2009","journal-title":"Mol. Nutr. Food Res."},{"issue":"2","key":"10.1016\/j.bioorg.2025.109006_bb0225","doi-asserted-by":"crossref","first-page":"12","DOI":"10.3390\/pharmaceutics8020012","article-title":"Evaluation of P-glycoprotein inhibitory potential using a rhodamine 123 accumulation assay","volume":"8","author":"Jouan","year":"2016","journal-title":"Pharmaceutics"},{"key":"10.1016\/j.bioorg.2025.109006_bb0230","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.pharmthera.2014.11.013","article-title":"Modulation of P-glycoprotein efflux pump: induction and activation as a therapeutic strategy","volume":"149","author":"Silva","year":"2015","journal-title":"Pharmacol. Ther."},{"issue":"22","key":"10.1016\/j.bioorg.2025.109006_bb0235","doi-asserted-by":"crossref","first-page":"7698","DOI":"10.1016\/j.bmc.2009.09.039","article-title":"Combretastatin-like chalcones as inhibitors of microtubule polymerization. Part 1: synthesis and biological evaluation of antivascular activity","volume":"17","author":"Ducki","year":"2009","journal-title":"Bioorg. Med. Chem."},{"issue":"22","key":"10.1016\/j.bioorg.2025.109006_bb0240","doi-asserted-by":"crossref","first-page":"3678","DOI":"10.3390\/cells11223678","article-title":"6-shogaol exhibits a promoting effect with tax via binding HSP60 in non-small-cell lung Cancer","volume":"11","author":"Mulati","year":"2022","journal-title":"Cells"}],"container-title":["Bioorganic Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0045206825008867?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0045206825008867?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,4]],"date-time":"2025-11-04T02:30:19Z","timestamp":1762223419000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0045206825008867"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,10]]},"references-count":48,"alternative-id":["S0045206825008867"],"URL":"https:\/\/doi.org\/10.1016\/j.bioorg.2025.109006","relation":{},"ISSN":["0045-2068"],"issn-type":[{"value":"0045-2068","type":"print"}],"subject":[],"published":{"date-parts":[[2025,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Design and synthesis of novel quinoline-chalcone derivatives as dual inhibitors of tubulin polymerization and P-glycoprotein to overcome cisplatin resistance in cervical cancer","name":"articletitle","label":"Article Title"},{"value":"Bioorganic Chemistry","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bioorg.2025.109006","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"109006"}}