{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,26]],"date-time":"2026-06-26T15:50:46Z","timestamp":1782489046051,"version":"3.54.5"},"reference-count":37,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100007620","name":"Liaoning Province Educational Department","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100007620","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Bioorganic Chemistry"],"published-print":{"date-parts":[[2025,10]]},"DOI":"10.1016\/j.bioorg.2025.109059","type":"journal-article","created":{"date-parts":[[2025,9,30]],"date-time":"2025-09-30T16:15:09Z","timestamp":1759248909000},"page":"109059","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":2,"special_numbering":"C","title":["Sesquiterpenoids from Eupatorium chinense L. induce G0\/G1 cell cycle arrest and apoptosis in AGS cell via DNA-PK\/AKT\/p53 pathway"],"prefix":"10.1016","volume":"165","author":[{"given":"Han-Chuan","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu-Qi","family":"Shi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bing-Hang","family":"Ji","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhu-Ling-Zhi","family":"Kuang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ce","family":"Song","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wen-Zhuo","family":"Ming","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu-Meng","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Da-Li","family":"Meng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"16","key":"10.1016\/j.bioorg.2025.109059_bb0005","doi-asserted-by":"crossref","first-page":"2452","DOI":"10.3748\/wjg.v29.i16.2452","article-title":"Updates on global epidemiology, risk and prognostic factors of gastric cancer","volume":"29","author":"Yang","year":"2023","journal-title":"World J. Gastroenterol."},{"issue":"11","key":"10.1016\/j.bioorg.2025.109059_bb0010","doi-asserted-by":"crossref","first-page":"4012","DOI":"10.3390\/ijms21114012","article-title":"Gastric Cancer: epidemiology, risk factors, classification, genomic characteristics and treatment strategies","volume":"21","author":"Machlowska","year":"2020","journal-title":"Int. J. Mol. Sci."},{"issue":"1","key":"10.1016\/j.bioorg.2025.109059_bb0015","doi-asserted-by":"crossref","first-page":"1331","DOI":"10.1080\/13696998.2024.2412946","article-title":"Gastric cancer in Spain: evaluating productivity loss and economic impact","volume":"27","author":"Darb\u00e0","year":"2024","journal-title":"J. Med. Econ."},{"key":"10.1016\/j.bioorg.2025.109059_bb0020","article-title":"Trends of gastric cancer burdens attributable to risk factors in China from 2000 to 2050","volume":"44","author":"He","year":"2024","journal-title":"Lancet Reg. Health West Pac."},{"issue":"10251","key":"10.1016\/j.bioorg.2025.109059_bb0025","doi-asserted-by":"crossref","first-page":"635","DOI":"10.1016\/S0140-6736(20)31288-5","article-title":"Gastric cancer","volume":"396","author":"Smyth","year":"2020","journal-title":"Lancet (London, England)"},{"issue":"1","key":"10.1016\/j.bioorg.2025.109059_bb0030","first-page":"1383697","article-title":"Han Lee, Apoptotic and anti-inflammatory effects of Eupatorium japonicum Thunb. In rheumatoid arthritis fibroblast-like Synoviocytes","volume":"2018","author":"Shin","year":"2018","journal-title":"Biomed. Res. Int."},{"issue":"3\u20134","key":"10.1016\/j.bioorg.2025.109059_bb0035","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1142\/S0192415X89000255","article-title":"A comparative study on the hepatic toxicity and metabolism of Crotalaria assamica and Eupatorium species","volume":"17","author":"Chan","year":"1989","journal-title":"Am. J. Chinese Med."},{"issue":"12","key":"10.1016\/j.bioorg.2025.109059_bb0040","first-page":"2893","article-title":"Coumarin and Euponin, two inhibitors for insect development from leaves of Eupatorium japonicum","volume":"44","author":"Nakajima","year":"1980","journal-title":"Agric. Biol. Chem."},{"issue":"1","key":"10.1016\/j.bioorg.2025.109059_bb0045","doi-asserted-by":"crossref","first-page":"117","DOI":"10.3987\/S-1978-01-0117","article-title":"Euponin: a new epoxy Sesquiterpene lactone inhibiting insect development from Eupatorium japonicum","volume":"10","author":"Kazuyoshi","year":"1978","journal-title":"Heterocycles"},{"key":"10.1016\/j.bioorg.2025.109059_bb0050","doi-asserted-by":"crossref","DOI":"10.1016\/j.bioorg.2023.106841","article-title":"Monoterpenoid indole alkaloid dimers from the Melodinus axillaris induce G2\/M phase arrest and apoptosis via p38 MAPK activation in HCT116 cells","volume":"140","author":"Du","year":"2023","journal-title":"Bioorg. Chem."},{"key":"10.1016\/j.bioorg.2025.109059_bb0055","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2024.117771","article-title":"Monoterpenoid indole alkaloids from Melodinus axillaris W.T.Wang exhibit anti-inflammatory activities by inhibiting the NF-\u03baB signaling pathways","volume":"324","author":"Du","year":"2024","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.bioorg.2025.109059_bb0060","doi-asserted-by":"crossref","DOI":"10.1016\/j.phytochem.2022.113382","article-title":"Diterpene glycosides, acetophenone glycosides and tannins from polar extracts of the root of Euphorbia fischeriana with cytotoxicity and antibacterial activities","volume":"203","author":"Du","year":"2022","journal-title":"Phytochemistry"},{"key":"10.1016\/j.bioorg.2025.109059_bb0065","doi-asserted-by":"crossref","DOI":"10.1016\/j.phytochem.2022.113240","article-title":"Isoquinoline alkaloids from the Corydalis tomentella with potential anti-hepatoma and antibacterial activities","volume":"200","author":"Du","year":"2022","journal-title":"Phytochemistry"},{"key":"10.1016\/j.bioorg.2025.109059_bb0070","doi-asserted-by":"crossref","DOI":"10.1016\/j.phytochem.2022.113430","article-title":"Barrigenol-like triterpenoid saponins from the husks of Xanthoceras sorbifolia bunge and their anti-inflammatory activity by inhibiting COX-2 and iNOS expression","volume":"204","author":"Zhao","year":"2022","journal-title":"Phytochemistry"},{"issue":"5","key":"10.1016\/j.bioorg.2025.109059_bb0075","doi-asserted-by":"crossref","first-page":"973","DOI":"10.1002\/ejoc.201301445","article-title":"Sesquiterpenes from Artemisia argyi: absolute configurations and biological activities","volume":"2014","author":"Wang","year":"2014","journal-title":"Eur. J. Org. Chem."},{"issue":"4","key":"10.1016\/j.bioorg.2025.109059_bb0080","doi-asserted-by":"crossref","first-page":"638","DOI":"10.1021\/np0304159","article-title":"Cytotoxic sesquiterpenoids from Eupatorium chinense","volume":"67","author":"Yang Sheng","year":"2004","journal-title":"J. Nat. Prod."},{"issue":"5","key":"10.1016\/j.bioorg.2025.109059_bb0085","doi-asserted-by":"crossref","first-page":"795","DOI":"10.1021\/np060056s","article-title":"Sesquiterpene lactones as allelochemicals","volume":"69","author":"Macias","year":"2006","journal-title":"J. Nat. Prod."},{"key":"10.1016\/j.bioorg.2025.109059_bb0090","doi-asserted-by":"crossref","DOI":"10.3389\/fchem.2021.698700","article-title":"Guaianolide Sesquiterpenes with significant Antiproliferative activities from the leaves of Artemisia argyi","volume":"9","author":"Ming","year":"2021","journal-title":"Front. Chem."},{"issue":"9","key":"10.1016\/j.bioorg.2025.109059_bb0095","doi-asserted-by":"crossref","first-page":"1959","DOI":"10.1016\/S0031-9422(00)84950-X","article-title":"Sesquiterpene lactones from a Texas population of Helianthus maximiliani","volume":"23","author":"Jonathan","year":"1984","journal-title":"Phytochemistry"},{"issue":"5","key":"10.1016\/j.bioorg.2025.109059_bb0100","doi-asserted-by":"crossref","first-page":"847","DOI":"10.1021\/np070252e","article-title":"Sesquiterpene lactones from Staehelina fruticosa","volume":"71","author":"Kotsos","year":"2008","journal-title":"J. Nat. Prod."},{"issue":"10","key":"10.1016\/j.bioorg.2025.109059_bb0105","doi-asserted-by":"crossref","first-page":"6927","DOI":"10.1021\/acs.joc.2c00318","article-title":"Liriogerphines A-D, a class of Sesquiterpene-alkaloid Hybridsfrom the rare Chinese tulip tree plant","volume":"87","author":"He","year":"2022","journal-title":"J. Org. Chem."},{"issue":"6","key":"10.1016\/j.bioorg.2025.109059_bb0110","doi-asserted-by":"crossref","first-page":"1909","DOI":"10.1021\/acs.jnatprod.0c00115","article-title":"Cytotoxic activity of Germacrane-type Sesquiterpene lactones from Dimerostemma aspilioides","volume":"83","author":"Garc\u00eda Manzano","year":"2020","journal-title":"J. Nat. Prod."},{"issue":"11","key":"10.1016\/j.bioorg.2025.109059_bb0115","doi-asserted-by":"crossref","first-page":"2808","DOI":"10.1021\/acs.jnatprod.1c00416","article-title":"Sesquiterpene lactones from Sigesbeckia glabrescens possessing potent anti-inflammatory activity by directly binding to IKK\u03b1\/\u03b2","volume":"84","author":"Xiaoxu","year":"2021","journal-title":"J. Nat. Prod."},{"issue":"5","key":"10.1016\/j.bioorg.2025.109059_bb0120","doi-asserted-by":"crossref","first-page":"1369","DOI":"10.1016\/0031-9422(96)00108-2","article-title":"Sesquiterpene lactones from Stevia vaga","volume":"42","author":"Hern\u00e1ndez","year":"1996","journal-title":"Phytochemistry"},{"issue":"5","key":"10.1016\/j.bioorg.2025.109059_bb0125","doi-asserted-by":"crossref","first-page":"1122","DOI":"10.1590\/S0100-40422010000500022","article-title":"Blainvillea rhomboidea: constituintes qu\u00edmicos e atividade citot\u00f3xica","volume":"33","author":"Gomes","year":"2010","journal-title":"Qu\u00edm. Nova"},{"issue":"1","key":"10.1016\/j.bioorg.2025.109059_bb0130","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1021\/acs.jnatprod.7b00693","article-title":"Germacrane-type Sesquiterpenoids with Antiproliferative activities from Eupatorium chinense","volume":"81","author":"Xiaoqin","year":"2018","journal-title":"J. Nat. Prod."},{"issue":"6","key":"10.1016\/j.bioorg.2025.109059_bb0135","doi-asserted-by":"crossref","first-page":"1642","DOI":"10.1021\/np50078a024","article-title":"The revised structure of the cytotoxic Heliangolide Euparhombin","volume":"54","author":"Mart\u00ednez-V\u00e1zquez","year":"1991","journal-title":"J. Nat. Prod."},{"issue":"5","key":"10.1016\/j.bioorg.2025.109059_bb0140","doi-asserted-by":"crossref","first-page":"1069","DOI":"10.1016\/0031-9422(81)83029-4","article-title":"Germacranolides, a guaianolide with a \u03b2-lactone ring and further constituents from Grazielia species","volume":"20","author":"Bohlmann","year":"1981","journal-title":"Phytochemistry"},{"issue":"1","key":"10.1016\/j.bioorg.2025.109059_bb0145","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1016\/S0031-9422(99)00150-8","article-title":"Sesquiterpene lactones in Blainvillea rhomboidea","volume":"52","author":"Spring","year":"1999","journal-title":"Phytochemistry"},{"issue":"2","key":"10.1016\/j.bioorg.2025.109059_bb0150","doi-asserted-by":"crossref","first-page":"244","DOI":"10.1002\/cbdv.200590007","article-title":"New gemacranolides from Eupatorium hualienense","volume":"2","author":"Shen","year":"2005","journal-title":"Chem. Biodivers."},{"issue":"4","key":"10.1016\/j.bioorg.2025.109059_bb0155","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1021\/np050437q","article-title":"Sesquiterpene lactones from Inula britannica and their cytotoxic and apoptotic effects on human cancer cell lines","volume":"69","author":"Naisheng","year":"2006","journal-title":"J. Nat. Prod."},{"issue":"9","key":"10.1016\/j.bioorg.2025.109059_bb0160","doi-asserted-by":"crossref","first-page":"1250","DOI":"10.1248\/cpb.50.1250","article-title":"Seven germacranolides, eupaglehnins a, B, C, D, E, and F, and 2alpha-acetoxyepitulipinolide from Eupatorium glehni","volume":"50","author":"Motoo","year":"2002","journal-title":"Chem. Pharm. Bull."},{"issue":"6","key":"10.1016\/j.bioorg.2025.109059_bb0165","doi-asserted-by":"crossref","first-page":"1339","DOI":"10.1016\/0031-9422(81)80034-9","article-title":"Minor sesquiterpene lactones of helianthus pumilus","volume":"20","author":"Werner","year":"1981","journal-title":"Phytochemistry"},{"issue":"6","key":"10.1016\/j.bioorg.2025.109059_bb0170","doi-asserted-by":"crossref","first-page":"1003","DOI":"10.1016\/S0031-9422(00)91464-X","article-title":"Germacranolides in Helianthus mollis","volume":"18","author":"Nobuo","year":"1979","journal-title":"Phytochemistry"},{"issue":"1","key":"10.1016\/j.bioorg.2025.109059_bb0175","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1016\/S0031-9422(00)94521-7","article-title":"Sesquiterpene lactones and diterpene carboxylic acids from Helianthus divaricatus, H. resinosus and H. salicifolius","volume":"25","author":"John","year":"1985","journal-title":"Phytochemistry"},{"issue":"6","key":"10.1016\/j.bioorg.2025.109059_bb0180","doi-asserted-by":"crossref","first-page":"967","DOI":"10.1016\/S0031-9422(98)00648-7","article-title":"New sesquiterpene lactones from the Portuguese liverwort Targionia lorbeeriana","volume":"50","author":"Neves","year":"1999","journal-title":"Phytochemistry"},{"issue":"4","key":"10.1016\/j.bioorg.2025.109059_bb0185","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1080\/10286020600727673","article-title":"Cytotoxic sesquiterpene lactones from Eupatorium lindleyanum","volume":"9","author":"Yang","year":"2007","journal-title":"J. Asian Nat. Prod. Res."}],"container-title":["Bioorganic Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0045206825009393?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0045206825009393?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,15]],"date-time":"2025-10-15T20:37:30Z","timestamp":1760560650000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0045206825009393"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,10]]},"references-count":37,"alternative-id":["S0045206825009393"],"URL":"https:\/\/doi.org\/10.1016\/j.bioorg.2025.109059","relation":{},"ISSN":["0045-2068"],"issn-type":[{"value":"0045-2068","type":"print"}],"subject":[],"published":{"date-parts":[[2025,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Sesquiterpenoids from Eupatorium chinense L. induce G0\/G1 cell cycle arrest and apoptosis in AGS cell via DNA-PK\/AKT\/p53 pathway","name":"articletitle","label":"Article Title"},{"value":"Bioorganic Chemistry","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bioorg.2025.109059","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"109059"}}