{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,24]],"date-time":"2026-01-24T15:14:17Z","timestamp":1769267657414,"version":"3.49.0"},"reference-count":43,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2023YFE0118400"],"award-info":[{"award-number":["2023YFE0118400"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["22077016"],"award-info":[{"award-number":["22077016"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["32371312"],"award-info":[{"award-number":["32371312"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["32370990"],"award-info":[{"award-number":["32370990"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82070142"],"award-info":[{"award-number":["82070142"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003392","name":"Natural Science Foundation of Fujian Province","doi-asserted-by":"publisher","award":["2024J01237"],"award-info":[{"award-number":["2024J01237"]}],"id":[{"id":"10.13039\/501100003392","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003392","name":"Natural Science Foundation of Fujian Province","doi-asserted-by":"publisher","award":["2023Y4016"],"award-info":[{"award-number":["2023Y4016"]}],"id":[{"id":"10.13039\/501100003392","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Bioorganic Chemistry"],"published-print":{"date-parts":[[2025,11]]},"DOI":"10.1016\/j.bioorg.2025.109101","type":"journal-article","created":{"date-parts":[[2025,10,12]],"date-time":"2025-10-12T22:01:42Z","timestamp":1760306502000},"page":"109101","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"special_numbering":"C","title":["Amphiphilic fluorinated Aza-BODIPY alleviates hypoxia in solid tumors and enhances the photodynamic efficacy for breast cancer"],"prefix":"10.1016","volume":"166","author":[{"given":"Lina","family":"Deng","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gan","family":"Xu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jian-Yong","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mingdong","family":"Huang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"32","key":"10.1016\/j.bioorg.2025.109101_bb0005","doi-asserted-by":"crossref","DOI":"10.1002\/adma.201700996","article-title":"Emerging nanotechnology and advanced materials for Cancer radiation therapy","volume":"29","author":"Song","year":"2017","journal-title":"Adv. Mater."},{"issue":"7","key":"10.1016\/j.bioorg.2025.109101_bb0010","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1038\/nrc3958","article-title":"The tumour microenvironment after radiotherapy: mechanisms of resistance and recurrence","volume":"15","author":"Barker","year":"2015","journal-title":"Nat. Rev. Cancer"},{"issue":"27","key":"10.1016\/j.bioorg.2025.109101_bb0015","doi-asserted-by":"crossref","DOI":"10.1002\/adma.201904337","article-title":"Recent advances in Nanostrategies capable of overcoming biological barriers for tumor management","volume":"32","author":"Huo","year":"2020","journal-title":"Adv. Mater."},{"issue":"8","key":"10.1016\/j.bioorg.2025.109101_bb0020","doi-asserted-by":"crossref","DOI":"10.1002\/mabi.202100092","article-title":"Strategies of alleviating tumor hypoxia and enhancing tumor therapeutic effect by macromolecular nanomaterials","volume":"21","author":"Jin","year":"2021","journal-title":"Macromol. Biosci."},{"key":"10.1016\/j.bioorg.2025.109101_bb0025","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1016\/j.jconrel.2019.12.041","article-title":"Hypoxia-responsive nanoparticle based drug delivery systems in cancer therapy: an up-to-date review","volume":"319","author":"Kumari","year":"2020","journal-title":"J. Control. Release"},{"issue":"36","key":"10.1016\/j.bioorg.2025.109101_bb0030","doi-asserted-by":"crossref","first-page":"11522","DOI":"10.1002\/anie.201805138","article-title":"Innovative strategies for hypoxic-tumor photodynamic therapy","volume":"57","author":"Li","year":"2018","journal-title":"Angew. Chem. Int. Ed. Engl."},{"issue":"21","key":"10.1016\/j.bioorg.2025.109101_bb0035","doi-asserted-by":"crossref","first-page":"13454","DOI":"10.1021\/acs.chemrev.1c00381","article-title":"Recent strategies to develop innovative photosensitizers for enhanced photodynamic therapy","volume":"121","author":"Pham","year":"2021","journal-title":"Chem. Rev."},{"issue":"23","key":"10.1016\/j.bioorg.2025.109101_bb0040","doi-asserted-by":"crossref","first-page":"6597","DOI":"10.1039\/C6CS00271D","article-title":"Reactive oxygen species generating systems meeting challenges of photodynamic cancer therapy","volume":"45","author":"Zhou","year":"2016","journal-title":"Chem. Soc. Rev."},{"issue":"1","key":"10.1016\/j.bioorg.2025.109101_bb0045","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1038\/s41392-023-01332-8","article-title":"Hypoxic microenvironment in cancer: molecular mechanisms and therapeutic interventions","volume":"8","author":"Chen","year":"2023","journal-title":"Signal Transduct. Target. Ther."},{"issue":"12","key":"10.1016\/j.bioorg.2025.109101_bb0050","first-page":"3316","article-title":"Oxygenation of human tumors: evaluation of tissue oxygen distribution in breast cancers by computerized O2 tension measurements","volume":"51","author":"Vaupel","year":"1991","journal-title":"Cancer Res."},{"issue":"5","key":"10.1016\/j.bioorg.2025.109101_bb0055","doi-asserted-by":"crossref","first-page":"937","DOI":"10.1016\/j.ccell.2025.02.015","article-title":"Hypoxia inducible factor-1alpha drives cancer resistance to cuproptosis","volume":"43","author":"Yang","year":"2025","journal-title":"Cancer Cell"},{"issue":"2 Pt A","key":"10.1016\/j.bioorg.2025.109101_bb0060","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1016\/j.canlet.2014.01.032","article-title":"Hypoxia and hypoxia inducible factors in tumor metabolism","volume":"356","author":"Zeng","year":"2015","journal-title":"Cancer Lett."},{"issue":"1","key":"10.1016\/j.bioorg.2025.109101_bb0065","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1038\/nrc3183","article-title":"HIF1alpha and HIF2alpha: sibling rivalry in hypoxic tumour growth and progression","volume":"12","author":"Keith","year":"2011","journal-title":"Nat. Rev. Cancer"},{"issue":"5","key":"10.1016\/j.bioorg.2025.109101_bb0070","doi-asserted-by":"crossref","first-page":"625","DOI":"10.1038\/onc.2009.441","article-title":"Defining the role of hypoxia-inducible factor 1 in cancer biology and therapeutics","volume":"29","author":"Semenza","year":"2010","journal-title":"Oncogene"},{"issue":"6282","key":"10.1016\/j.bioorg.2025.109101_bb0075","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1126\/science.aaf4405","article-title":"Hypoxic control of metastasis","volume":"352","author":"Rankin","year":"2016","journal-title":"Science"},{"key":"10.1016\/j.bioorg.2025.109101_bb0080","doi-asserted-by":"crossref","DOI":"10.1016\/j.ccr.2020.213604","article-title":"Enhanced photodynamic therapy for overcoming tumor hypoxia: from microenvironment regulation to photosensitizer innovation","volume":"427","author":"Du","year":"2021","journal-title":"Coord. Chem. Rev."},{"issue":"21","key":"10.1016\/j.bioorg.2025.109101_bb0085","doi-asserted-by":"crossref","DOI":"10.1002\/adhm.202300089","article-title":"Recent advances in Nanoplatform construction strategy for alleviating tumor hypoxia","volume":"12","author":"Shen","year":"2023","journal-title":"Adv. Healthc. Mater."},{"key":"10.1016\/j.bioorg.2025.109101_bb0090","doi-asserted-by":"crossref","unstructured":"C. Zhang, W.J. Qin, X.F. Bai, X.Z. Zhang, Nanomaterials to relieve tumor hypoxia for enhanced 2.9.photodynamic therapy, Nano Today 35 (2020). ARTN 100960 doi: https:\/\/doi.org\/10.1016\/j.nantod.2020.100960.","DOI":"10.1016\/j.nantod.2020.100960"},{"issue":"10","key":"10.1016\/j.bioorg.2025.109101_bb0095","doi-asserted-by":"crossref","first-page":"6145","DOI":"10.1021\/acs.nanolett.6b02365","article-title":"Ultrasound triggered tumor oxygenation with oxygen-shuttle Nanoperfluorocarbon to overcome hypoxia-associated resistance in Cancer therapies","volume":"16","author":"Song","year":"2016","journal-title":"Nano Lett."},{"key":"10.1016\/j.bioorg.2025.109101_bb0100","article-title":"Hyperoxia in the management of respiratory failure: a literature review","volume":"81","author":"Lius","year":"2022","journal-title":"Ann Med Surg (Lond)"},{"issue":"38","key":"10.1016\/j.bioorg.2025.109101_bb0105","article-title":"Cai Cancer cell membrane-biomimetic oxygen Nanocarrier for breaking hypoxia-induced Chemoresistance","volume":"27","author":"HZTLL","year":"2017","journal-title":"Adv. Funct. Mater."},{"issue":"3","key":"10.1016\/j.bioorg.2025.109101_bb0110","doi-asserted-by":"crossref","first-page":"3414","DOI":"10.1021\/acsnano.9b09426","article-title":"Enhanced Ferroptosis by oxygen-boosted phototherapy based on a 2-in-1 Nanoplatform of ferrous hemoglobin for tumor synergistic therapy","volume":"14","author":"Xu","year":"2020","journal-title":"ACS Nano"},{"issue":"5","key":"10.1016\/j.bioorg.2025.109101_bb0115","doi-asserted-by":"crossref","first-page":"5901","DOI":"10.1021\/acsnano.0c01059","article-title":"Black phosphorus-loaded separable microneedles as responsive oxygen delivery carriers for wound healing","volume":"14","author":"Zhang","year":"2020","journal-title":"ACS Nano"},{"issue":"1S Suppl 1","key":"10.1016\/j.bioorg.2025.109101_bb0120","doi-asserted-by":"crossref","first-page":"S48","DOI":"10.1097\/TA.0000000000002250","article-title":"Artificial oxygen carriers and red blood cell substitutes: a historic overview and recent developments toward military and clinical relevance","volume":"87","author":"Bialas","year":"2019","journal-title":"J. Trauma Acute Care Surg."},{"issue":"34","key":"10.1016\/j.bioorg.2025.109101_bb0125","doi-asserted-by":"crossref","DOI":"10.1002\/smll.202101015","article-title":"Tumor microenvironment modulation platform based on composite biodegradable bismuth-manganese Radiosensitizer for inhibiting Radioresistant hypoxic tumors","volume":"17","author":"Liu","year":"2021","journal-title":"Small"},{"issue":"30","key":"10.1016\/j.bioorg.2025.109101_bb0130","doi-asserted-by":"crossref","first-page":"5490","DOI":"10.1002\/adfm.201600676","article-title":"Modulation of hypoxia in solid tumor microenvironment with MnO2 nanoparticles to enhance photodynamic therapy","volume":"26","author":"Zhu","year":"2016","journal-title":"Adv. Funct. Mater."},{"issue":"17","key":"10.1016\/j.bioorg.2025.109101_bb0135","doi-asserted-by":"crossref","DOI":"10.1002\/advs.202200005","article-title":"Ultrathin-FeOOH-coated MnO2 Sonosensitizers with boosted reactive oxygen species yield and remodeled tumor microenvironment for efficient Cancer therapy","volume":"9","author":"Liu","year":"2022","journal-title":"Adv. Sci."},{"key":"10.1016\/j.bioorg.2025.109101_bb0140","doi-asserted-by":"crossref","DOI":"10.1016\/j.biomaterials.2022.121706","article-title":"MnO(2)-melittin nanoparticles serve as an effective anti-tumor immunotherapy by enhancing systemic immune response","volume":"288","author":"Tang","year":"2022","journal-title":"Biomaterials"},{"key":"10.1016\/j.bioorg.2025.109101_bb0145","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2025.103761","article-title":"The role and mechanism of the cGAS-STING pathway-mediated ROS in apoptosis and ferroptosis induced by manganese exposure","volume":"85","author":"Zhang","year":"2025","journal-title":"Redox Biol."},{"issue":"3","key":"10.1016\/j.bioorg.2025.109101_bb0150","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1038\/nri.2017.145","article-title":"Improving immune-vascular crosstalk for cancer immunotherapy","volume":"18","author":"Huang","year":"2018","journal-title":"Nat. Rev. Immunol."},{"issue":"8","key":"10.1016\/j.bioorg.2025.109101_bb0155","doi-asserted-by":"crossref","DOI":"10.1002\/adhm.202400596","article-title":"Natural MOF-like photocatalytic Nanozymes alleviate tumor pressure for enhanced Nanodrug penetration","volume":"14","author":"Li","year":"2025","journal-title":"Adv. Healthc. Mater."},{"issue":"6","key":"10.1016\/j.bioorg.2025.109101_bb0160","doi-asserted-by":"crossref","first-page":"3243","DOI":"10.1016\/j.apsb.2025.04.007","article-title":"A photodynamic nanohybrid system reverses hypoxia and augment anti-primary and metastatic tumor efficacy of immunotherapy","volume":"15","author":"Yuan","year":"2025","journal-title":"Acta Pharm. Sin. B"},{"key":"10.1016\/j.bioorg.2025.109101_bb0165","doi-asserted-by":"crossref","DOI":"10.1016\/j.biomaterials.2024.123073","article-title":"Visualizing enterohepatic circulation in vivo by sensitive (19)F MRI with a fluorinated ferrous chelate-based small molecule probe","volume":"317","author":"Li","year":"2025","journal-title":"Biomaterials"},{"issue":"19","key":"10.1016\/j.bioorg.2025.109101_bb0170","doi-asserted-by":"crossref","DOI":"10.1002\/adhm.202203209","article-title":"Outersphere approach to increasing the Persistance of oxygen-sensitive europium(II)-containing contrast agents for magnetic resonance imaging with perfluorocarbon Nanoemulsions toward imaging of hypoxia","volume":"12","author":"Lutter","year":"2023","journal-title":"Adv. Healthc. Mater."},{"issue":"3","key":"10.1016\/j.bioorg.2025.109101_bb0175","doi-asserted-by":"crossref","first-page":"5405","DOI":"10.1021\/acsnano.1c00033","article-title":"Oxygen-delivering Polyfluorocarbon Nanovehicles improve tumor oxygenation and potentiate photodynamic-mediated antitumor immunity","volume":"15","author":"Wang","year":"2021","journal-title":"ACS Nano"},{"issue":"21","key":"10.1016\/j.bioorg.2025.109101_bb0180","doi-asserted-by":"crossref","DOI":"10.1002\/adma.201970155","article-title":"A versatile Theranostic Nanoemulsion for architecture-dependent multimodal imaging and dually augmented photodynamic therapy","volume":"31","author":"Zhang","year":"2019","journal-title":"Adv. Mater."},{"issue":"3730","key":"10.1016\/j.bioorg.2025.109101_bb0185","doi-asserted-by":"crossref","first-page":"1755","DOI":"10.1126\/science.152.3730.1755","article-title":"Survival of mammals breathing organic liquids equilibrated with oxygen at atmospheric pressure","volume":"152","author":"Clark","year":"1966","journal-title":"Science"},{"issue":"8","key":"10.1016\/j.bioorg.2025.109101_bb0190","doi-asserted-by":"crossref","first-page":"622","DOI":"10.1111\/j.1525-1594.2009.00944.x","article-title":"Perfluorocarbon-based oxygen carriers: review of products and trials","volume":"34","author":"Castro","year":"2010","journal-title":"Artif. Organs"},{"issue":"14","key":"10.1016\/j.bioorg.2025.109101_bb0195","doi-asserted-by":"crossref","first-page":"3846","DOI":"10.1039\/C6CS00200E","article-title":"Azadipyrromethenes: from traditional dye chemistry to leading edge applications","volume":"45","author":"Ge","year":"2016","journal-title":"Chem. Soc. Rev."},{"key":"10.1016\/j.bioorg.2025.109101_bb0200","doi-asserted-by":"crossref","DOI":"10.1016\/j.ccr.2023.215428","article-title":"Evolution of Aza-BODIPY dyes-a hot topic","volume":"498","author":"Kaur","year":"2024","journal-title":"Coord. Chem. Rev."},{"key":"10.1016\/j.bioorg.2025.109101_bb0205","doi-asserted-by":"crossref","DOI":"10.1016\/j.ccr.2022.214908","article-title":"Engineering of BODIPY-based theranostics for cancer therapy","volume":"476","author":"Mao","year":"2023","journal-title":"Coord. Chem. Rev."},{"issue":"21","key":"10.1016\/j.bioorg.2025.109101_bb0210","doi-asserted-by":"crossref","first-page":"7533","DOI":"10.1039\/D0CS00234H","article-title":"Bioapplications of small molecule Aza-BODIPY: from rational structural design to in vivo investigations","volume":"49","author":"Shi","year":"2020","journal-title":"Chem. Soc. Rev."},{"issue":"1","key":"10.1016\/j.bioorg.2025.109101_bb0215","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1063\/1.555934","article-title":"Quantum yields for the photosensitized formation of the lowest electronically excited singlet state of molecular oxygen in solution","volume":"22","author":"Wilkinson","year":"1993","journal-title":"J. Phys. Chem. Ref. Data Monogr."}],"container-title":["Bioorganic Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0045206825009812?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0045206825009812?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,20]],"date-time":"2025-11-20T19:11:02Z","timestamp":1763665862000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0045206825009812"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,11]]},"references-count":43,"alternative-id":["S0045206825009812"],"URL":"https:\/\/doi.org\/10.1016\/j.bioorg.2025.109101","relation":{},"ISSN":["0045-2068"],"issn-type":[{"value":"0045-2068","type":"print"}],"subject":[],"published":{"date-parts":[[2025,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Amphiphilic fluorinated Aza-BODIPY alleviates hypoxia in solid tumors and enhances the photodynamic efficacy for breast cancer","name":"articletitle","label":"Article Title"},{"value":"Bioorganic Chemistry","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bioorg.2025.109101","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"109101"}}