{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T22:58:10Z","timestamp":1791500290661,"version":"4.3.4"},"reference-count":65,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,10,24]],"date-time":"2025-10-24T00:00:00Z","timestamp":1761264000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100002809","name":"Generalitat de Catalunya","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100011033","name":"Agencia Estatal de Investigaci\u00f3n","doi-asserted-by":"publisher","award":["PID2021-127187OB-C21"],"award-info":[{"award-number":["PID2021-127187OB-C21"]}],"id":[{"id":"10.13039\/501100011033","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100011033","name":"Agencia Estatal de Investigaci\u00f3n","doi-asserted-by":"publisher","award":["IFUdG2020"],"award-info":[{"award-number":["IFUdG2020"]}],"id":[{"id":"10.13039\/501100011033","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100011033","name":"Agencia Estatal de Investigaci\u00f3n","doi-asserted-by":"publisher","award":["PID2021-127187OB-C22\/ MCIN\/ AEI \/ 10.13039\/501100011033\/FEDER"],"award-info":[{"award-number":["PID2021-127187OB-C22\/ MCIN\/ AEI \/ 10.13039\/501100011033\/FEDER"]}],"id":[{"id":"10.13039\/501100011033","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005855","name":"Universidade Nova de Lisboa","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100005855","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004837","name":"Ministerio de Ciencia e Innovaci\u00f3n","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004837","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100008722","name":"University of Girona","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008722","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003030","name":"Government of Catalonia Agency for Administration of University and Research Grants","doi-asserted-by":"publisher","award":["2021 FI_B 01036"],"award-info":[{"award-number":["2021 FI_B 01036"]}],"id":[{"id":"10.13039\/501100003030","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Bioorganic Chemistry"],"published-print":{"date-parts":[[2025,11]]},"DOI":"10.1016\/j.bioorg.2025.109142","type":"journal-article","created":{"date-parts":[[2025,10,24]],"date-time":"2025-10-24T20:59:54Z","timestamp":1761339594000},"page":"109142","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":3,"special_numbering":"C","title":["Photoinduced electron transfer enhances the tumor-targeted photodynamic activity of bombesin metallopeptides incorporating an Ir(III) complex and carboxyfluorescein"],"prefix":"10.1016","volume":"166","author":[{"given":"Elisenda","family":"Zafon","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gerard","family":"Riesco-Llach","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Igor","family":"Echevarr\u00eda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marta","family":"Mart\u00ednez-Alonso","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marta","family":"Planas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lidia","family":"Feliu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gustavo","family":"Espino","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Massaguer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bioorg.2025.109142_bb0005","doi-asserted-by":"crossref","first-page":"657","DOI":"10.1038\/s41571-020-0410-2","article-title":"Clinical development and potential of photothermal and photodynamic therapies for cancer","volume":"17","author":"Li","year":"2020","journal-title":"Nat. Rev. Clin. Oncol."},{"key":"10.1016\/j.bioorg.2025.109142_bb0010","article-title":"Activatable photosensitizers: agents for selective photodynamic therapy","volume":"27","author":"Li","year":"2017","journal-title":"Adv. Funct. Mater."},{"key":"10.1016\/j.bioorg.2025.109142_bb0015","doi-asserted-by":"crossref","first-page":"1098","DOI":"10.1016\/j.biopha.2018.07.049","article-title":"Photodynamic therapy \u2013 mechanisms, photosensitizers and combinations","volume":"106","author":"Kwiatkowski","year":"2018","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.bioorg.2025.109142_bb0020","first-page":"1","article-title":"Photoredox catalysis may be a general mechanism in photodynamic therapy","volume":"119","author":"Li","year":"2022","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.bioorg.2025.109142_bb0025","doi-asserted-by":"crossref","DOI":"10.1002\/adhm.201900132","article-title":"Photosensitizers for photodynamic therapy","volume":"8","author":"Lan","year":"2019","journal-title":"Adv. Healthc. Mater."},{"key":"10.1016\/j.bioorg.2025.109142_bb0030","doi-asserted-by":"crossref","DOI":"10.1002\/anie.202112236","article-title":"Clinical development of metal complexes as photosensitizers for photodynamic therapy of cancer","volume":"61","author":"Karges","year":"2022","journal-title":"Angew. Chem. Int. Ed."},{"key":"10.1016\/j.bioorg.2025.109142_bb0035","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1016\/j.ccr.2018.03.020","article-title":"Transition metal complexes as photosensitisers in one- and two-photon photodynamic therapy","volume":"379","author":"McKenzie","year":"2019","journal-title":"Coord. Chem. Rev."},{"key":"10.1016\/j.bioorg.2025.109142_bb0040","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1016\/j.ccr.2018.01.010","article-title":"Cyclometalated iridium(III) luminescent complexes in therapy and phototherapy","volume":"360","author":"Zamora","year":"2018","journal-title":"Coord. Chem. Rev."},{"key":"10.1016\/j.bioorg.2025.109142_bb0045","doi-asserted-by":"crossref","first-page":"1320","DOI":"10.1039\/D4DT03014A","article-title":"Breaking the deep-ted light absorption barrier of iridium(III)-based photosensitizers","volume":"54","author":"Vigueras","year":"2025","journal-title":"Dalton Trans."},{"key":"10.1016\/j.bioorg.2025.109142_bb0050","doi-asserted-by":"crossref","first-page":"3562","DOI":"10.1039\/D0DT00180E","article-title":"He Cyclometalated iridium(III) complexes for mitochondria-targeted combined chemo-photodynamic therapy","volume":"49","author":"Qin","year":"2020","journal-title":"Dalton Trans."},{"key":"10.1016\/j.bioorg.2025.109142_bb0055","doi-asserted-by":"crossref","first-page":"10968","DOI":"10.1021\/jacs.6b05302","article-title":"Endoplasmic reticulum-localized iridium(III) complexes as efficient photodynamic therapy agents via protein modifications","volume":"138","author":"Nam","year":"2016","journal-title":"J. Am. Chem. Soc."},{"key":"10.1016\/j.bioorg.2025.109142_bb0060","doi-asserted-by":"crossref","first-page":"5317","DOI":"10.3390\/molecules25225317","article-title":"Ligand-targeted delivery of photosensitizers for cancer treatment","volume":"25","author":"Gierlich","year":"2020","journal-title":"Molecules"},{"key":"10.1016\/j.bioorg.2025.109142_bb0065","doi-asserted-by":"crossref","DOI":"10.1016\/j.ccr.2020.213736","article-title":"Ruthenium polypyridyl complex-containing bioconjugates","volume":"434","author":"Mart\u00ednez-Alonso","year":"2021","journal-title":"Coord. Chem. Rev."},{"key":"10.1016\/j.bioorg.2025.109142_bb0070","doi-asserted-by":"crossref","first-page":"2992","DOI":"10.3390\/cancers13122992","article-title":"Photodynamic therapy: targeting cancer biomarkers for the treatment of cancers","volume":"13","author":"Wang","year":"2021","journal-title":"Cancers"},{"key":"10.1016\/j.bioorg.2025.109142_bb0075","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1186\/s40644-024-00658-y","article-title":"Advances of radiolabeled GRPR ligands for PET\/CT imaging of cancers","volume":"24","author":"Ma","year":"2024","journal-title":"Cancer Imaging"},{"key":"10.1016\/j.bioorg.2025.109142_bb0080","doi-asserted-by":"crossref","DOI":"10.3389\/fmed.2023.1250799","article-title":"GRPR-targeting radiotheranostics for breast cancer management","volume":"10","author":"D\u2019Onofrio","year":"2023","journal-title":"Front. Med."},{"key":"10.1016\/j.bioorg.2025.109142_bb0085","doi-asserted-by":"crossref","first-page":"3400","DOI":"10.3390\/ijms24043400","article-title":"Targeting the gastrin-releasing peptide receptor (GRP-R) in cancer therapy: development of bombesin-based peptide\u2013drug conjugates","volume":"24","author":"Gomena","year":"2023","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.bioorg.2025.109142_bb0090","doi-asserted-by":"crossref","first-page":"4287","DOI":"10.1039\/C3DT51817E","article-title":"Towards cancer cell-specific phototoxic organometallic rhenium(I) complexes","volume":"43","author":"Leonidova","year":"2014","journal-title":"Dalton Trans."},{"key":"10.1016\/j.bioorg.2025.109142_bb0095","doi-asserted-by":"crossref","first-page":"17897","DOI":"10.1002\/anie.202007920","article-title":"Peptide-conjugated long-lived theranostic imaging for targeting GRPr in cancer and immune cells","volume":"59","author":"Wang","year":"2020","journal-title":"Angew. Chem. Int. Ed."},{"key":"10.1016\/j.bioorg.2025.109142_bb0100","doi-asserted-by":"crossref","DOI":"10.1016\/j.biocel.2019.105567","article-title":"Bombesin receptors as potential targets for anticancer drug delivery and imaging","volume":"114","author":"Pooja","year":"2019","journal-title":"Int. J. Biochem. Cell Biol."},{"key":"10.1016\/j.bioorg.2025.109142_bb0105","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1021\/bc980096a","article-title":"99m Tc-labeling and in vivo studies of a bombesin analogue with a novel water-soluble dithiadiphosphine-based bifunctional chelating agent","volume":"10","author":"Karra","year":"1999","journal-title":"Bioconjug. Chem."},{"key":"10.1016\/j.bioorg.2025.109142_bb0110","doi-asserted-by":"crossref","first-page":"1694","DOI":"10.1007\/s002590000355","article-title":"Technetium-99m RP527, a GRP analogue for visualisation of GRP receptor-expressing malignancies: a feasibility study","volume":"27","author":"Van de Wiele","year":"2000","journal-title":"Eur. J. Nucl. Med."},{"key":"10.1016\/j.bioorg.2025.109142_bb0115","doi-asserted-by":"crossref","first-page":"5766","DOI":"10.3390\/cancers13225766","article-title":"Radiolabeled bombesin analogs","volume":"13","author":"Mansi","year":"2021","journal-title":"Cancers"},{"key":"10.1016\/j.bioorg.2025.109142_bb0120","doi-asserted-by":"crossref","first-page":"888","DOI":"10.1007\/s11307-014-0754-z","article-title":"GRP receptor imaging of prostate cancer using [99mTc]demobesin 4: a first-in-man study","volume":"16","author":"Mather","year":"2014","journal-title":"Mol. Imaging Biol."},{"key":"10.1016\/j.bioorg.2025.109142_bb0125","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1002\/cbic.202200647","article-title":"Towards selective delivery of a ruthenium(II) polypyridyl complex-containing bombesin conjugate into cancer cells","volume":"24","author":"Silva","year":"2023","journal-title":"ChemBioChem"},{"key":"10.1016\/j.bioorg.2025.109142_bb0130","doi-asserted-by":"crossref","first-page":"2424","DOI":"10.1016\/j.bmcl.2008.02.051","article-title":"Targeting gastrin-releasing peptide receptors of prostate cancer cells for photodynamic therapy with a phthalocyanine\u2013bombesin conjugate","volume":"18","author":"Dubuc","year":"2008","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"10.1016\/j.bioorg.2025.109142_bb0135","doi-asserted-by":"crossref","DOI":"10.1016\/j.jinorgbio.2020.111214","article-title":"A nucleus-directed bombesin derivative for targeted delivery of metallodrugs to cancer cells","volume":"212","author":"Barrab\u00e9s","year":"2020","journal-title":"J. Inorg. Biochem."},{"key":"10.1016\/j.bioorg.2025.109142_bb0140","doi-asserted-by":"crossref","first-page":"19140","DOI":"10.1021\/acs.inorgchem.4c02583","article-title":"Bombesin-targeted delivery of \u03b2-carboline-based Ir(III) and Ru(II) photosensitizers for a selective photodynamic therapy of prostate cancer","volume":"63","author":"Sanz-Villafruela","year":"2024","journal-title":"Inorg. Chem."},{"key":"10.1016\/j.bioorg.2025.109142_bb0150","doi-asserted-by":"crossref","DOI":"10.1002\/ejic.202300519","article-title":"Synthetic approaches towards peptide-conjugates of Pt(II) compounds with an (O,S) chelating moiety","volume":"26","author":"M\u00fcgge","year":"2023","journal-title":"Eur. J. Inorg. Chem."},{"key":"10.1016\/j.bioorg.2025.109142_bb0155","doi-asserted-by":"crossref","first-page":"12099","DOI":"10.1039\/C9NJ05685H","article-title":"Synthesis, characterization and in vitro anticancer activity of thiabendazole-derived 1,2,3-triazole derivatives","volume":"44","author":"El Bourakadi","year":"2020","journal-title":"New J. Chem."},{"key":"10.1016\/j.bioorg.2025.109142_bb0160","doi-asserted-by":"crossref","DOI":"10.1016\/j.jinorgbio.2022.111790","article-title":"Rational design of mitochondria targeted thiabendazole-based Ir(III) biscyclometalated complexes for a multimodal photodynamic therapy of cancer","volume":"231","author":"Echevarr\u00eda","year":"2022","journal-title":"J. Inorg. Biochem."},{"key":"10.1016\/j.bioorg.2025.109142_bb0165","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1039\/D1DT03080A","article-title":"Photodynamic therapy with mitochondria-targeted biscyclometallated Ir(III) complexes. Multi-action mechanism and strong influence of the cyclometallating ligand","volume":"51","author":"Zafon","year":"2022","journal-title":"Dalton Trans."},{"key":"10.1016\/j.bioorg.2025.109142_bb0170","doi-asserted-by":"crossref","first-page":"8864","DOI":"10.1039\/D0DT01877E","article-title":"[Ru(Phen)2podppz]2+ significantly inhibits glioblastoma growth in vitro and vivo with fewer side-effects than cisplatin","volume":"49","author":"Li","year":"2020","journal-title":"Dalton Trans."},{"key":"10.1016\/j.bioorg.2025.109142_bb0175","doi-asserted-by":"crossref","first-page":"6193","DOI":"10.1021\/acs.inorgchem.2c00358","article-title":"Photocatalytic aerobic dehydrogenation of N-heterocycles with Ir(III) photosensitizers bearing the 2(2\u2032-pyridyl)benzimidazole scaffold","volume":"61","author":"Echevarr\u00eda","year":"2022","journal-title":"Inorg. Chem."},{"key":"10.1016\/j.bioorg.2025.109142_bb0180","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1016\/j.ejmech.2018.07.065","article-title":"Thiabendazole-based Rh(III) and Ir(III) biscyclometallated complexes with mitochondria-targeted anticancer activity and metal-sensitive photodynamic activity","volume":"157","author":"P\u00e9rez-Arnaiz","year":"2018","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.bioorg.2025.109142_bb0185","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1111\/php.13749","article-title":"Recent photosensitizer developments, delivery strategies and combination-based approaches for photodynamic therapy","volume":"99","author":"Mari\u00f1o-Ocampo","year":"2023","journal-title":"Photochem. Photobiol."},{"key":"10.1016\/j.bioorg.2025.109142_bb0190","doi-asserted-by":"crossref","first-page":"8178","DOI":"10.1002\/anie.201201471","article-title":"Luminescent ionic transition-metal complexes for light-emitting electrochemical cells","volume":"51","author":"Costa","year":"2012","journal-title":"Angew. Chem. Int. Ed."},{"key":"10.1016\/j.bioorg.2025.109142_bb0195","doi-asserted-by":"crossref","first-page":"4843","DOI":"10.1039\/D1BM00128K","article-title":"A new near-infrared phosphorescent iridium(III) complex conjugated to a xanthene dye for mitochondria-targeted photodynamic therapy","volume":"9","author":"Wu","year":"2021","journal-title":"Biomater. Sci."},{"key":"10.1016\/j.bioorg.2025.109142_bb0200","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1063\/1.555934","article-title":"Quantum yields for the photosensitized formation of the lowest electronically excited singlet state of molecular oxygen in solution","volume":"22","author":"Wilkinson","year":"1993","journal-title":"J. Phys. Chem. Ref. Data Monogr."},{"key":"10.1016\/j.bioorg.2025.109142_bb0205","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1016\/j.jphotochem.2019.04.029","article-title":"Singlet oxygen quantum yields determined by oxygen consumption","volume":"378","author":"Lutkus","year":"2019","journal-title":"J Photochem Photobiol A Chem"},{"key":"10.1016\/j.bioorg.2025.109142_bb0210","doi-asserted-by":"crossref","first-page":"8174","DOI":"10.1002\/anie.202014959","article-title":"Ferroptosis photoinduced by new cyclometalated iridium(III) complexes and its synergism with apoptosis in tumor cell inhibition","volume":"60","author":"Yuan","year":"2021","journal-title":"Angew. Chem. Int. Ed."},{"key":"10.1016\/j.bioorg.2025.109142_bb0215","doi-asserted-by":"crossref","first-page":"5488","DOI":"10.1039\/C7TB00731K","article-title":"Two-photon photodynamic ablation of tumor cells by mitochondria-targeted iridium(III) complexes in aggregate states","volume":"5","author":"Qiu","year":"2017","journal-title":"J. Mater. Chem. B"},{"key":"10.1016\/j.bioorg.2025.109142_bb0220","doi-asserted-by":"crossref","unstructured":"L.D. Zorova, V.A. Popkov, E.Y. Plotnikov, D.N. Silachev, I.B. Pevzner, S.S, Jankauskas, V.A. Babenko, S.D. Zorov, A.V. Balakireva, M. Juhaszova, S.J. Sollott, D.B. Zorov, Mitochondrial membrane potential, Anal. Biochem. 552 (2018) 50\u201359. Doi: https:\/\/doi.org\/10.1016\/j.ab.2017.07.009.","DOI":"10.1016\/j.ab.2017.07.009"},{"key":"10.1016\/j.bioorg.2025.109142_bb0225","doi-asserted-by":"crossref","first-page":"1478","DOI":"10.1038\/sj.cdd.4401682","article-title":"Mitochondrial permeability transition in apoptosis and necrosis","volume":"12","author":"Zamzami","year":"2005","journal-title":"Cell Death Differ."},{"key":"10.1016\/j.bioorg.2025.109142_bb0230","doi-asserted-by":"crossref","first-page":"364","DOI":"10.1016\/j.ejphar.2014.07.025","article-title":"Cisplatin in cancer therapy: molecular mechanisms of action","volume":"740","author":"Dasari","year":"2014","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.bioorg.2025.109142_bb0235","doi-asserted-by":"crossref","first-page":"900","DOI":"10.1002\/mc.21930","article-title":"Molecular imaging of P53 signal pathway in lung cancer cell cycle arrest induced by cisplatin","volume":"52","author":"Wang","year":"2013","journal-title":"Mol. Carcinog."},{"key":"10.1016\/j.bioorg.2025.109142_bb0240","doi-asserted-by":"crossref","DOI":"10.4061\/2010\/201367","article-title":"Cellular responses to cisplatin-induced DNA damage","volume":"2010","author":"Basu","year":"2010","journal-title":"J. Nucleic Acids"},{"key":"10.1016\/j.bioorg.2025.109142_bb0245","doi-asserted-by":"crossref","first-page":"1149","DOI":"10.1016\/S0959-8049(00)00071-X","article-title":"Altered cell cycle response of drug-resistant lung carcinoma cells to doxorubicin","volume":"36","author":"O\u2019Loughlin","year":"2000","journal-title":"Eur. J. Cancer"},{"key":"10.1016\/j.bioorg.2025.109142_bb0250","doi-asserted-by":"crossref","first-page":"6923","DOI":"10.3390\/ijms22136923","article-title":"The influence of cell cycle regulation on chemotherapy","volume":"22","author":"Sun","year":"2021","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.bioorg.2025.109142_bb0255","doi-asserted-by":"crossref","DOI":"10.3390\/ijms242316890","article-title":"Cellular mechanisms of singlet oxygen in photodynamic therapy","volume":"24","author":"Przygoda","year":"2023","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.bioorg.2025.109142_bb0260","doi-asserted-by":"crossref","first-page":"604","DOI":"10.1021\/bc300585h","article-title":"Cellular uptake and cytotoxicity of drug\u2013peptide conjugates regulated by conjugation site","volume":"24","author":"Zhang","year":"2013","journal-title":"Bioconjug. Chem."},{"key":"10.1016\/j.bioorg.2025.109142_bb0145","doi-asserted-by":"crossref","first-page":"1470","DOI":"10.1039\/C4OB01875C","article-title":"Enzyme-triggered delivery of chlorambucil from conjugates based on the cell-penetrating peptide BP16","volume":"13","author":"Soler","year":"2015","journal-title":"Org. Biomol. Chem."},{"key":"10.1016\/j.bioorg.2025.109142_bb0265","doi-asserted-by":"crossref","first-page":"1652","DOI":"10.1039\/C3OB42422G","article-title":"Identification of BP16 as a non-toxic cell-penetrating peptide with highly efficient drug delivery properties","volume":"12","author":"Soler","year":"2014","journal-title":"Org. Biomol. Chem."},{"key":"10.1016\/j.bioorg.2025.109142_bb0270","doi-asserted-by":"crossref","first-page":"653","DOI":"10.1021\/bc025658b","article-title":"Extending the applicability of carboxyfluorescein in solid-phase synthesis","volume":"14","author":"Fischer","year":"2003","journal-title":"Bioconjug. Chem."},{"key":"10.1016\/j.bioorg.2025.109142_bb0275","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/j.peptides.2011.12.003","article-title":"Peptidotriazoles with antimicrobial activity against bacterial and fungal plant pathogens","volume":"33","author":"G\u00fcell","year":"2012","journal-title":"Peptides"},{"key":"10.1016\/j.bioorg.2025.109142_bb0280","doi-asserted-by":"crossref","first-page":"8760","DOI":"10.1073\/pnas.1002143107","article-title":"Bombesin functionalized gold nanoparticles show in vitro and in vivo cancer receptor specificity","volume":"107","author":"Chanda","year":"2010","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.bioorg.2025.109142_bb0285","doi-asserted-by":"crossref","DOI":"10.1016\/j.nantod.2020.100898","article-title":"Overcoming negatively charged tissue barriers: drug delivery using cationic peptides and proteins","volume":"34","author":"Vedadghavami","year":"2020","journal-title":"Nano Today"},{"key":"10.1016\/j.bioorg.2025.109142_bb0290","doi-asserted-by":"crossref","first-page":"3772","DOI":"10.1039\/D0TB00262C","article-title":"Fluorescence resonance energy transfer-based drug delivery systems for enhanced photodynamic therapy","volume":"8","author":"Huang","year":"2020","journal-title":"J. Mater. Chem. B"},{"key":"10.1016\/j.bioorg.2025.109142_bb0295","doi-asserted-by":"crossref","first-page":"2322","DOI":"10.1039\/D1CS01097B","article-title":"Photoinduced electron transfer (PeT) based fluorescent probes for cellular imaging and disease therapy","volume":"52","author":"Niu","year":"2023","journal-title":"Chem. Soc. Rev."},{"key":"10.1016\/j.bioorg.2025.109142_bb0300","doi-asserted-by":"crossref","first-page":"1389","DOI":"10.1002\/cphc.200900238","article-title":"Fluorescence quenching by photoinduced electron transfer: a reporter for conformational dynamics of macromolecules","volume":"10","author":"Doose","year":"2009","journal-title":"ChemPhysChem"},{"key":"10.1016\/j.bioorg.2025.109142_bb0305","doi-asserted-by":"crossref","DOI":"10.1002\/chem.202301077","article-title":"Investigating design rules for photoinduced electron transfer quenching in triangulenium probes","volume":"29","author":"Dahl Jensen","year":"2023","journal-title":"Chem. A Eur. J."},{"key":"10.1016\/j.bioorg.2025.109142_bb0310","doi-asserted-by":"crossref","first-page":"2581","DOI":"10.1039\/b301009k","article-title":"Quantum yields of singlet and triplet recombination products of singlet radical ion pairs","volume":"5","author":"Gladkikh","year":"2003","journal-title":"Phys. Chem. Chem. Phys."},{"key":"10.1016\/j.bioorg.2025.109142_bb0315","doi-asserted-by":"crossref","DOI":"10.1002\/chem.202201652","article-title":"A tumor-targeting dual-stimuli-activatable photodynamic molecular beacon for precise photodynamic therapy","volume":"28","author":"Tam","year":"2022","journal-title":"Chem. A Eur. J."},{"key":"10.1016\/j.bioorg.2025.109142_bb0320","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1016\/S0301-0104(98)00060-3","article-title":"Photochemical accumulation and recombination of ion pairs undergoing the singlet\u2013triplet conversion","volume":"235","author":"Burshtein","year":"1998","journal-title":"Chem. Phys."},{"key":"10.1016\/j.bioorg.2025.109142_bb0325","doi-asserted-by":"crossref","first-page":"666","DOI":"10.1038\/s41586-021-03840-5","article-title":"The role of charge recombination to triplet excitons in organic solar cells","volume":"597","author":"Gillett","year":"2021","journal-title":"Nature"}],"container-title":["Bioorganic Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0045206825010223?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0045206825010223?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T12:00:03Z","timestamp":1777464003000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0045206825010223"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,11]]},"references-count":65,"alternative-id":["S0045206825010223"],"URL":"https:\/\/doi.org\/10.1016\/j.bioorg.2025.109142","relation":{},"ISSN":["0045-2068"],"issn-type":[{"value":"0045-2068","type":"print"}],"subject":[],"published":{"date-parts":[[2025,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Photoinduced electron transfer enhances the tumor-targeted photodynamic activity of bombesin metallopeptides incorporating an Ir(III) complex and carboxyfluorescein","name":"articletitle","label":"Article Title"},{"value":"Bioorganic Chemistry","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bioorg.2025.109142","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Authors. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"109142"}}