{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T04:03:28Z","timestamp":1793333008154,"version":"4.5.0"},"reference-count":60,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/100012899","name":"Lanzhou University","doi-asserted-by":"publisher","award":["20250260020"],"award-info":[{"award-number":["20250260020"]}],"id":[{"id":"10.13039\/100012899","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100012899","name":"Lanzhou University","doi-asserted-by":"publisher","award":["20250260016"],"award-info":[{"award-number":["20250260016"]}],"id":[{"id":"10.13039\/100012899","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100012899","name":"Lanzhou University","doi-asserted-by":"publisher","award":["20250260006"],"award-info":[{"award-number":["20250260006"]}],"id":[{"id":"10.13039\/100012899","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007764","name":"Lanzhou Science and Technology Bureau","doi-asserted-by":"publisher","award":["2025-2-100"],"award-info":[{"award-number":["2025-2-100"]}],"id":[{"id":"10.13039\/501100007764","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007764","name":"Lanzhou Science and Technology Bureau","doi-asserted-by":"publisher","award":["2024-4-2"],"award-info":[{"award-number":["2024-4-2"]}],"id":[{"id":"10.13039\/501100007764","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007764","name":"Lanzhou Science and Technology Bureau","doi-asserted-by":"publisher","award":["2025-2-103"],"award-info":[{"award-number":["2025-2-103"]}],"id":[{"id":"10.13039\/501100007764","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Bioorganic Chemistry"],"published-print":{"date-parts":[[2025,11]]},"DOI":"10.1016\/j.bioorg.2025.109171","type":"journal-article","created":{"date-parts":[[2025,10,28]],"date-time":"2025-10-28T17:18:46Z","timestamp":1761671926000},"page":"109171","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":2,"special_numbering":"C","title":["Camptothecin 20(S)-sulfonyl amidine derivative inhibits gastric cancer cell proliferation by targeting topoisomerase I to trigger the DNA damage-apoptosis cascade"],"prefix":"10.1016","volume":"166","author":[{"given":"Zhenzhen","family":"Si","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yunhao","family":"Ma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zeying","family":"Cheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Baizhuo","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mengyue","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chenranle","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yingjie","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hong","family":"Fang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yongyuan","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fanting","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yingqian","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peng","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"3","key":"10.1016\/j.bioorg.2025.109171_bb0005","first-page":"229","article-title":"Global cancer statistics 2022: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries","volume":"74","author":"Bray","year":"2024","journal-title":"CA Cancer J. Clin."},{"issue":"10494","key":"10.1016\/j.bioorg.2025.109171_bb0010","doi-asserted-by":"crossref","first-page":"2087","DOI":"10.1016\/S0140-6736(25)00052-2","article-title":"Gastric cancer","volume":"405","author":"Sundar","year":"2025","journal-title":"Lancet"},{"issue":"1","key":"10.1016\/j.bioorg.2025.109171_bb0015","first-page":"47","article-title":"Cancer incidence and mortality in China, 2022","volume":"4","author":"Han","year":"2024","journal-title":"J. Natl. Cancer Cent."},{"issue":"3","key":"10.1016\/j.bioorg.2025.109171_bb0020","doi-asserted-by":"crossref","DOI":"10.1016\/j.seminoncol.2025.152341","article-title":"Epidemiology and prevention of gastric cancer: a comprehensive review","volume":"52","author":"Pradhan","year":"2025","journal-title":"Semin. Oncol."},{"issue":"Suppl. 1","key":"10.1016\/j.bioorg.2025.109171_bb0025","first-page":"1","article-title":"Gastric cancer: Asia and the world","volume":"20","author":"Sano","year":"2017","journal-title":"Gastric cancer\u202f: official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association"},{"key":"10.1016\/j.bioorg.2025.109171_bb0030","doi-asserted-by":"crossref","DOI":"10.1016\/j.suronc.2025.102241","article-title":"Prognostic impact of conversion surgery in patients with stage IV gastric cancer: a multicenter population-based cohort study","volume":"61","author":"Kakinuma","year":"2025","journal-title":"Surg. Oncol."},{"issue":"7","key":"10.1016\/j.bioorg.2025.109171_bb0035","doi-asserted-by":"crossref","first-page":"1151","DOI":"10.1002\/jso.26834","article-title":"Systemic therapy for gastric cancer: perioperative strategies and beyond","volume":"125","author":"Cann","year":"2022","journal-title":"J. Surg. Oncol."},{"key":"10.1016\/j.bioorg.2025.109171_bb0040","doi-asserted-by":"crossref","DOI":"10.1016\/j.bpg.2021.101738","article-title":"Targeted and immunotherapy in the era of personalised gastric cancer treatment","volume":"50-51","author":"Catanese","year":"2021","journal-title":"Best Pract. Res. Clin. Gastroenterol."},{"key":"10.1016\/j.bioorg.2025.109171_bb0045","doi-asserted-by":"crossref","DOI":"10.1016\/j.critrevonc.2022.103841","article-title":"Characteristics of gastric cancer around the world","volume":"181","author":"L\u00f3pez","year":"2023","journal-title":"Crit. Rev. Oncol. Hematol."},{"key":"10.1016\/j.bioorg.2025.109171_bb0050","doi-asserted-by":"crossref","DOI":"10.1016\/j.jff.2025.106677","article-title":"Pre-clinical study of curcumin in the treatment of gastric Cancer","volume":"125","author":"Hao","year":"2025","journal-title":"J. Funct. Foods"},{"key":"10.1016\/j.bioorg.2025.109171_bb0055","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejmech.2025.117291","article-title":"The development of \u03b1, \u03b2-unsaturated lactam-based andrographolide derivatives as anti-gastric cancer agents with the ability of inhibiting the ERK\/c-Fos\/Jun pathway","volume":"286","author":"Zhang","year":"2025","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.bioorg.2025.109171_bb0060","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2025.119935","article-title":"Mechanism of Rabdosia rubescens extract against gastric cancer microenvironment by SIRT1\/NF-\u03baB\/p53 pathway and promoting tumor-associated macrophage polarization","volume":"349","author":"Liu","year":"2025","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.bioorg.2025.109171_bb0065","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2025.118005","article-title":"Chemical constituents from the Korean endemic plant Pseudolysimachion pusanensis inhibit diffuse-type gastric cancer cells","volume":"186","author":"Cho","year":"2025","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.bioorg.2025.109171_bb0070","doi-asserted-by":"crossref","DOI":"10.1016\/j.taap.2024.117036","article-title":"Effects of catechin on the malignant biological behavior of gastric cancer cells through the PI3K\/Akt signaling pathway","volume":"490","author":"Ding","year":"2024","journal-title":"Toxicol. Appl. Pharmacol."},{"issue":"3","key":"10.1016\/j.bioorg.2025.109171_bb0075","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1080\/10286020.2024.2387756","article-title":"Kaempferol inhibited invasion and metastasis of gastric cancer cells by targeting AKT\/GSK3\u03b2 pathway based on network pharmacology and molecular docking","volume":"27","author":"Gao","year":"2025","journal-title":"J. Asian Nat. Prod. Res."},{"key":"10.1016\/j.bioorg.2025.109171_bb0080","doi-asserted-by":"crossref","DOI":"10.1016\/j.esmogo.2024.100073","article-title":"Real-world efficacy and toxicity data of paclitaxel and ramucirumab compared with other treatment regimens in patients with advanced gastric cancer","volume":"5","author":"Fountzilas","year":"2024","journal-title":"ESMO Gastrointestinal Oncology"},{"key":"10.1016\/j.bioorg.2025.109171_bb0085","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2025.119430","article-title":"Molecular mechanism of Gancao Xiexin decoction regulating EMT and suppressing hepatic metastasis of gastric cancer via the TGF-\u03b21\/SMAD pathway","volume":"342","author":"Liu","year":"2025","journal-title":"J. Ethnopharmacol."},{"issue":"11","key":"10.1016\/j.bioorg.2025.109171_bb0090","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1007\/s12032-024-02527-x","article-title":"Camptothecin and its derivatives: advancements, mechanisms and clinical potential in cancer therapy","volume":"41","author":"Kamle","year":"2024","journal-title":"Medical oncology (Northwood, London, England)"},{"key":"10.1016\/j.bioorg.2025.109171_bb0095","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejmech.2023.116049","article-title":"Camptothecin structure simplification elaborated new imidazo[2,1-b]quinazoline derivative as a human topoisomerase I inhibitor with efficacy against bone cancer cells and colon adenocarcinoma","volume":"265","author":"Khodair","year":"2024","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.bioorg.2025.109171_bb0100","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejmech.2024.116872","article-title":"Drug combinations of camptothecin derivatives promote the antitumor properties","volume":"279","author":"Liu","year":"2024","journal-title":"Eur. J. Med. Chem."},{"issue":"3","key":"10.1016\/j.bioorg.2025.109171_bb0105","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1016\/j.bbrc.2016.02.015","article-title":"Low toxic and high soluble camptothecin derivative 2\u201347 effectively induces apoptosis of tumor cells in vitro","volume":"472","author":"Zhou","year":"2016","journal-title":"Biochem. Biophys. Res. Commun."},{"issue":"5","key":"10.1016\/j.bioorg.2025.109171_bb0110","doi-asserted-by":"crossref","first-page":"3244","DOI":"10.1021\/acs.jmedchem.3c02115","article-title":"Unleashing the potential of Camptothecin: exploring innovative strategies for structural modification and therapeutic advancements","volume":"67","author":"Chen","year":"2024","journal-title":"J. Med. Chem."},{"issue":"2","key":"10.1016\/j.bioorg.2025.109171_bb0115","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1016\/S0039-6060(99)70159-5","article-title":"Inhibition of gastric cancer by camptothecin involves apoptosis and multiple cellular pathways","volume":"126","author":"Litvak","year":"1999","journal-title":"Surgery"},{"issue":"6","key":"10.1016\/j.bioorg.2025.109171_bb0120","doi-asserted-by":"crossref","first-page":"1000","DOI":"10.1002\/cmdc.202000753","article-title":"Synthesis and biological evaluation of 10-substituted Camptothecin derivatives with improved water solubility and activity","volume":"16","author":"Yang","year":"2021","journal-title":"ChemMedChem"},{"key":"10.1016\/j.bioorg.2025.109171_bb0125","doi-asserted-by":"crossref","DOI":"10.1016\/j.bioorg.2025.108610","article-title":"Antitumor activity of topoisomerase I targeted by camptothecin 7-propionyl derivatives against ampullary carcinoma","volume":"162","author":"Du","year":"2025","journal-title":"Bioorg. Chem."},{"issue":"1","key":"10.1016\/j.bioorg.2025.109171_bb0130","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/j.bbcan.2012.09.002","article-title":"Topoisomerase degradation, DSB repair, p53 and IAPs in cancer cell resistance to camptothecin-like topoisomerase I inhibitors","volume":"1835","author":"Tomicic","year":"2013","journal-title":"Biochimica et Biophysica acta (BBA) - reviews on Cancer"},{"key":"10.1016\/j.bioorg.2025.109171_bb0135","doi-asserted-by":"crossref","first-page":"546","DOI":"10.1016\/j.ejps.2018.08.018","article-title":"Two novel camptothecin derivatives inhibit colorectal cancer proliferation via induction of cell cycle arrest and apoptosis in vitro and in vivo","volume":"123","author":"Du","year":"2018","journal-title":"Eur. J. Pharm. Sci."},{"key":"10.1016\/j.bioorg.2025.109171_bb0140","doi-asserted-by":"crossref","first-page":"1235","DOI":"10.1016\/j.ejmech.2016.11.013","article-title":"Synthesis and antitumor activity of novel substituted uracil-1\u2032(N)-acetic acid ester derivatives of 20(S)-camptothecins","volume":"125","author":"Li","year":"2017","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.bioorg.2025.109171_bb0145","doi-asserted-by":"crossref","DOI":"10.1016\/j.bioorg.2021.105065","article-title":"Design and synthesis of novel 20(S)-\u03b1-aminophosphonate derivatives of camptothecin as potent antitumor agents","volume":"114","author":"Chen","year":"2021","journal-title":"Bioorg. Chem."},{"key":"10.1016\/j.bioorg.2025.109171_bb0150","doi-asserted-by":"crossref","DOI":"10.1016\/j.bioorg.2024.107436","article-title":"Biological impact and therapeutic potential of a novel camptothecin derivative (FLQY2) in pancreatic cancer through inactivation of the PDK1\/AKT\/mTOR pathway","volume":"148","author":"Wang","year":"2024","journal-title":"Bioorg. Chem."},{"issue":"2","key":"10.1016\/j.bioorg.2025.109171_bb0155","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1080\/10286020.2023.2300374","article-title":"Facile synthesis and cytotoxicity of substituted uracil-1\u2019(N)-acetic acid and 4-pyridone-1\u2019(N)-acetic acid esters of 20(S)-camptothecins","volume":"26","author":"Li","year":"2024","journal-title":"J. Asian Nat. Prod. Res."},{"key":"10.1016\/j.bioorg.2025.109171_bb0160","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejphar.2022.174898","article-title":"9-Nitro-20(S)-carbonate-camptothecin (NCP4), a novel prodrug of 9-nitrocamptothecin (9-NC), exhibits potent chemotherapeutic efficacy and improved safety against hepatocarcinoma","volume":"923","author":"Zhou","year":"2022","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.bioorg.2025.109171_bb0165","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1016\/j.ejmech.2016.02.070","article-title":"Design, synthesis, cytotoxic activity and molecular docking studies of new 20(S)-sulfonylamidine camptothecin derivatives","volume":"115","author":"Song","year":"2016","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.bioorg.2025.109171_bb0170","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1016\/j.phytol.2021.08.014","article-title":"Camptothecin derivatives induce apoptosis and inhibit proliferation of prostate cancer PC-3M cells through downregulation of PI3K\/Akt signaling pathway","volume":"46","author":"Zhao","year":"2021","journal-title":"Phytochem. Lett."},{"key":"10.1016\/j.bioorg.2025.109171_bb0175","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejphar.2022.175408","article-title":"CFNC, a neocryptolepine derivative, inhibited the growth of gastric cancer AGS cells by inhibiting PI3K\/AKT signaling pathway","volume":"938","author":"Ma","year":"2023","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.bioorg.2025.109171_bb0180","doi-asserted-by":"crossref","DOI":"10.1016\/j.lfs.2022.121105","article-title":"Anti-tumor effects and mechanism of a novel camptothecin derivative YCJ100","volume":"311","author":"Zhang","year":"2022","journal-title":"Life Sci."},{"key":"10.1016\/j.bioorg.2025.109171_bb0185","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejmech.2022.114610","article-title":"Design, synthesis, and biological evaluation of novel 7-substituted 10,11-methylenedioxy-camptothecin derivatives against drug-resistant small-cell lung cancer in vitro and in vivo","volume":"241","author":"Zhang","year":"2022","journal-title":"Eur. J. Med. Chem."},{"issue":"6","key":"10.1016\/j.bioorg.2025.109171_bb0190","doi-asserted-by":"crossref","first-page":"2223","DOI":"10.1016\/j.ejmech.2010.01.063","article-title":"Synthesis and evaluation of 9-benzylideneamino derivatives of homocamptothecin as potent inhibitors of DNA topoisomerase I","volume":"45","author":"Guo","year":"2010","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.bioorg.2025.109171_bb0195","doi-asserted-by":"crossref","DOI":"10.1016\/j.bioorg.2025.108780","article-title":"Antitumor activity of XSJ81, a 20-sulfonated camptothecin derivative, targeting topoisomerase I against ampullary carcinoma","volume":"163","author":"Du","year":"2025","journal-title":"Bioorg. Chem."},{"issue":"15","key":"10.1016\/j.bioorg.2025.109171_bb0200","doi-asserted-by":"crossref","first-page":"15563","DOI":"10.1021\/acs.jmedchem.5c00466","article-title":"A soluble Triantennary N-Acetylgalactosamine Camptothecin prodrug for hepatocellular carcinoma-targeted therapy","volume":"68","author":"Li","year":"2025","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.bioorg.2025.109171_bb0205","doi-asserted-by":"crossref","DOI":"10.1016\/j.bioorg.2024.107723","article-title":"Identification of 7-aminourea or 7-aminothiourea derivatives of camptothecin as selective topoisomerase I inhibitors with anti-colorectal cancer activities","volume":"152","author":"Tu","year":"2024","journal-title":"Bioorg. Chem."},{"key":"10.1016\/j.bioorg.2025.109171_bb0210","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1016\/j.ejmech.2016.06.054","article-title":"Synthesis and biological evaluation of 6-fluoro-3-phenyl-7-piperazinyl quinolone derivatives as potential topoisomerase I inhibitors","volume":"122","author":"Ge","year":"2016","journal-title":"Eur. J. Med. Chem."},{"issue":"1","key":"10.1016\/j.bioorg.2025.109171_bb0215","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/j.bbrc.2011.04.108","article-title":"Induction of apoptosis in colon cancer cells by a novel topoisomerase I inhibitor TopIn","volume":"409","author":"Bae","year":"2011","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.bioorg.2025.109171_bb0220","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejmech.2022.114560","article-title":"Discovery of dual inhibitors of topoisomerase I and Cyclooxygenase-2 for colon cancer therapy","volume":"240","author":"Hu","year":"2022","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.bioorg.2025.109171_bb0225","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/j.semcdb.2022.03.011","article-title":"Histone H2A variants: diversifying chromatin to ensure genome integrity","volume":"135","author":"Oberdoerffer","year":"2023","journal-title":"Semin. Cell Dev. Biol."},{"key":"10.1016\/j.bioorg.2025.109171_bb0230","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.mrrev.2015.07.001","article-title":"Persistent \u03b3H2AX: a promising molecular marker of DNA damage and aging","volume":"766","author":"Siddiqui","year":"2015","journal-title":"Mutat. Res. Rev. Mutat. Res."},{"key":"10.1016\/j.bioorg.2025.109171_bb0235","doi-asserted-by":"crossref","DOI":"10.1016\/j.dnarep.2021.103243","article-title":"Recent advances in \u03b3H2AX biomarker-based genotoxicity assays: a marker of DNA damage and repair","volume":"108","author":"Rahmanian","year":"2021","journal-title":"DNA Repair"},{"issue":"6","key":"10.1016\/j.bioorg.2025.109171_bb0240","doi-asserted-by":"crossref","DOI":"10.1016\/j.isci.2025.112565","article-title":"Dynamic properties of enhancer and promoter during DNA damage in hepatocellular carcinoma","volume":"28","author":"Zhang","year":"2025","journal-title":"iScience"},{"key":"10.1016\/j.bioorg.2025.109171_bb0245","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijbiomac.2025.147498","article-title":"Circ_IGF2BP1\/miR-885-3p\/TK1 axis regulates the malignant phenotype and chemotherapeutic resistance of lung adenocarcinoma cells via DNA damage and apoptosis","volume":"327","author":"Wang","year":"2025","journal-title":"Int. J. Biol. Macromol."},{"key":"10.1016\/j.bioorg.2025.109171_bb0250","first-page":"1520","article-title":"Isoquinolinone\u2013Naphthoquinone Hybrids as Potent PARP-1 Inhibitors Induce Apoptosis in Glioma via DNA Damage and ROS Generation","author":"Pathi","year":"2025","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.bioorg.2025.109171_bb0255","doi-asserted-by":"crossref","DOI":"10.1016\/j.bbrc.2025.151847","article-title":"p14ARF interacts with \u03b3-H2AX and is involved in the DNA damage response","volume":"765","author":"Huang","year":"2025","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.bioorg.2025.109171_bb0260","doi-asserted-by":"crossref","DOI":"10.1016\/j.tice.2025.102811","article-title":"NEK kinases in cell cycle regulation, DNA damage response, and cancer progression","volume":"94","author":"Folahan","year":"2025","journal-title":"Tissue Cell"},{"issue":"7","key":"10.1016\/j.bioorg.2025.109171_bb0265","doi-asserted-by":"crossref","DOI":"10.1016\/j.jbc.2025.110328","article-title":"Live-cell imaging of DNA damage and cell cycle progression uncovers distinct responses during neural differentiation of hiPSCs","volume":"301","author":"Shimada","year":"2025","journal-title":"J. Biol. Chem."},{"issue":"12","key":"10.1016\/j.bioorg.2025.109171_bb0270","doi-asserted-by":"crossref","DOI":"10.1016\/j.isci.2024.111513","article-title":"Zinc finger protein 593 promotes breast cancer development by ensuring DNA damage repair and cell-cycle progression","volume":"27","author":"Zhang","year":"2024","journal-title":"iScience"},{"key":"10.1016\/j.bioorg.2025.109171_bb0275","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejca.2024.114794","article-title":"279 (PB267): combination of genomics-based targeted therapy and standard chemotherapy in xenografts derived from patients with non-small cell lung cancer","volume":"211","author":"Decaudin","year":"2024","journal-title":"Eur. J. Cancer"},{"key":"10.1016\/j.bioorg.2025.109171_bb0280","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/j.lungcan.2021.11.020","article-title":"Brain penetration and efficacy of tepotinib in orthotopic patient-derived xenograft models of MET-driven non-small cell lung cancer brain metastases","volume":"163","author":"Friese-Hamim","year":"2022","journal-title":"Lung Cancer"},{"key":"10.1016\/j.bioorg.2025.109171_bb0285","doi-asserted-by":"crossref","DOI":"10.1016\/j.neo.2024.101039","article-title":"The antitumor activity of osimertinib plus palbociclib in non-small cell lung cancer patient-derived xenograft (PDX)\/2D\/3D culture models harboring EGFR amplification and CDKN2A\/2B homozygous deletions","volume":"57","author":"Fu","year":"2024","journal-title":"Neoplasia"},{"key":"10.1016\/j.bioorg.2025.109171_bb0290","doi-asserted-by":"crossref","first-page":"S455","DOI":"10.1016\/j.jtho.2024.09.832","article-title":"EP.03F.03 orally bioavailable cyclin a\/B Rxl macrocycle has antitumor effect in SCLC & NSCLC cell line derived (CDX) & patient derived xenograft (PDX) models","volume":"19","author":"Levin","year":"2024","journal-title":"J. Thorac. Oncol."},{"key":"10.1016\/j.bioorg.2025.109171_bb0295","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2021.153909","article-title":"Quercetin- and rutin-based nano-formulations for cancer treatment: a systematic review of improved efficacy and molecular mechanisms","volume":"97","author":"Ghanbari-Movahed","year":"2022","journal-title":"Phytomedicine"},{"key":"10.1016\/j.bioorg.2025.109171_bb0300","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijbiomac.2024.130856","article-title":"Hyaluronan-based nano-formulation with mesoporous silica enhances the anticancer efficacy of phloroglucinol against gastrointestinal cancers","volume":"265","author":"Shanmugam","year":"2024","journal-title":"Int. J. Biol. Macromol."}],"container-title":["Bioorganic Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S004520682501051X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S004520682501051X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T11:59:35Z","timestamp":1777463975000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S004520682501051X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,11]]},"references-count":60,"alternative-id":["S004520682501051X"],"URL":"https:\/\/doi.org\/10.1016\/j.bioorg.2025.109171","relation":{},"ISSN":["0045-2068"],"issn-type":[{"value":"0045-2068","type":"print"}],"subject":[],"published":{"date-parts":[[2025,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Camptothecin 20(S)-sulfonyl amidine derivative inhibits gastric cancer cell proliferation by targeting topoisomerase I to trigger the DNA damage-apoptosis cascade","name":"articletitle","label":"Article Title"},{"value":"Bioorganic Chemistry","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bioorg.2025.109171","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"109171"}}