{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T21:44:31Z","timestamp":1773351871527,"version":"3.50.1"},"reference-count":32,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100017596","name":"Natural Science Basic Research Program of Shaanxi Province","doi-asserted-by":"publisher","award":["2024JC-YBMS-747"],"award-info":[{"award-number":["2024JC-YBMS-747"]}],"id":[{"id":"10.13039\/501100017596","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100015401","name":"Shaanxi Province Key Research and Development Projects","doi-asserted-by":"publisher","award":["2024CY-JJQ-40"],"award-info":[{"award-number":["2024CY-JJQ-40"]}],"id":[{"id":"10.13039\/501100015401","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100016067","name":"Shaanxi Administration of Traditional Chinese Medicine","doi-asserted-by":"publisher","award":["2025-CXTD-05"],"award-info":[{"award-number":["2025-CXTD-05"]}],"id":[{"id":"10.13039\/100016067","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012226","name":"Fundamental Research Funds for the Central Universities","doi-asserted-by":"publisher","award":["xtr062025005"],"award-info":[{"award-number":["xtr062025005"]}],"id":[{"id":"10.13039\/501100012226","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100013804","name":"Fundamental Research Funds for the Central Universities","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100013804","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82173742"],"award-info":[{"award-number":["82173742"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82373793"],"award-info":[{"award-number":["82373793"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["823B2096"],"award-info":[{"award-number":["823B2096"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Bioorganic Chemistry"],"published-print":{"date-parts":[[2025,11]]},"DOI":"10.1016\/j.bioorg.2025.109191","type":"journal-article","created":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T15:59:47Z","timestamp":1762012787000},"page":"109191","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Identification of RIPK1 as a novel target for angiogenesis regulation based on ABT-869 conjugated photoaffinity probes"],"prefix":"10.1016","volume":"166","author":[{"given":"Yanchen","family":"Li","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tingting","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Weihua","family":"Cheng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lifeng","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yangchao","family":"Wei","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jin","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Junyu","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jie","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"6801","key":"10.1016\/j.bioorg.2025.109191_bb0005","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1038\/35025220","article-title":"Angiogenesis in cancer and other diseases","volume":"407","author":"Carmeliet","year":"2000","journal-title":"Nature"},{"issue":"9","key":"10.1016\/j.bioorg.2025.109191_bb0010","doi-asserted-by":"crossref","first-page":"2084","DOI":"10.1007\/s12094-024-03432-5","article-title":"Advances in tumor vascular growth inhibition","volume":"26","author":"Zhang","year":"2024","journal-title":"Clin. Transl. Oncol."},{"issue":"8","key":"10.1016\/j.bioorg.2025.109191_bb0015","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1016\/j.tcm.2010.02.006","article-title":"Hypoxia-regulated angiogenic inhibitors","volume":"19","author":"Messmer-Blust","year":"2009","journal-title":"Trends Cardiovasc. Med."},{"issue":"1","key":"10.1016\/j.bioorg.2025.109191_bb0020","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1007\/s12079-017-0433-3","article-title":"Integration of pro- and anti-angiogenic signals by endothelial cells","volume":"12","author":"Kazerounian","year":"2018","journal-title":"J. Cell Commun Signal."},{"issue":"6","key":"10.1016\/j.bioorg.2025.109191_bb0025","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1038\/nrc1093","article-title":"Tumorigenesis and the angiogenic switch","volume":"3","author":"Bergers","year":"2003","journal-title":"Nat. Rev. Cancer"},{"issue":"1","key":"10.1016\/j.bioorg.2025.109191_bb0030","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1186\/s43556-022-00081-4","article-title":"The inhibition of protein translation promotes tumor angiogenic switch","volume":"3","author":"Luo","year":"2022","journal-title":"Mol. Biomed."},{"issue":"5","key":"10.1016\/j.bioorg.2025.109191_bb0035","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1016\/j.semcancer.2009.05.003","article-title":"The angiogenic switch in carcinogenesis","volume":"19","author":"Baeriswyl","year":"2009","journal-title":"Semin. Cancer Biol."},{"issue":"10","key":"10.1016\/j.bioorg.2025.109191_bb0040","doi-asserted-by":"crossref","first-page":"611","DOI":"10.1038\/nrm.2016.87","article-title":"Mechanisms and regulation of endothelial VEGF receptor signalling","volume":"17","author":"Simons","year":"2016","journal-title":"Nat. Rev. Mol. Cell Biol."},{"issue":"4","key":"10.1016\/j.bioorg.2025.109191_bb0045","doi-asserted-by":"crossref","DOI":"10.1016\/j.bbcan.2023.188927","article-title":"Epidermal growth factor receptor PROTACs as an effective strategy for cancer therapy: a review","volume":"1878","author":"Wang","year":"2023","journal-title":"Biochim. Biophys. Acta Rev. Cancer"},{"issue":"4","key":"10.1016\/j.bioorg.2025.109191_bb0050","doi-asserted-by":"crossref","DOI":"10.1111\/cpr.13009","article-title":"Inhibition of FGF-FGFR and VEGF-VEGFR signalling in cancer treatment","volume":"54","author":"Liu","year":"2021","journal-title":"Cell Prolif."},{"issue":"8","key":"10.1016\/j.bioorg.2025.109191_bb0055","doi-asserted-by":"crossref","DOI":"10.1002\/jcp.31291","article-title":"Targeting endothelial PDGFR-\u03b2 facilitates angiogenesis-associated bone formation through the PAK1\/NICD axis","volume":"239","author":"Lin","year":"2024","journal-title":"J Cell Physiol."},{"issue":"Suppl. 3","key":"10.1016\/j.bioorg.2025.109191_bb0060","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1159\/000088478","article-title":"VEGF as a key mediator of angiogenesis in cancer","volume":"69","author":"Carmeliet","year":"2005","journal-title":"Oncology"},{"key":"10.1016\/j.bioorg.2025.109191_bb0065","article-title":"Tetrandrine promotes angiogenesis via transcriptional regulation of VEGF-A","volume":"141","author":"Hong Wang","year":"2021","journal-title":"Vascul Pharmacol."},{"issue":"12","key":"10.1016\/j.bioorg.2025.109191_bb0070","doi-asserted-by":"crossref","first-page":"1999","DOI":"10.1016\/j.cmet.2022.10.012","article-title":"Cancer cells co-opt nociceptive nerves to thrive in nutrient-poor environments and upon nutrient-starvation therapies","volume":"34","author":"Zhang","year":"2022","journal-title":"Cell Metab."},{"issue":"5706","key":"10.1016\/j.bioorg.2025.109191_bb0075","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1126\/science.1104819","article-title":"Normalization of tumor vasculature: an emerging concept in antiangiogenic therapy","volume":"307","author":"Jain","year":"2005","journal-title":"Science"},{"issue":"9","key":"10.1016\/j.bioorg.2025.109191_bb0080","doi-asserted-by":"crossref","first-page":"2489","DOI":"10.1007\/s00432-021-03701-8","article-title":"Targeting tumor vascularization: promising strategies for vascular normalization","volume":"147","author":"Ruiqi","year":"2021","journal-title":"J. Cancer Res. Clin. Oncol."},{"key":"10.1016\/j.bioorg.2025.109191_bb0085","doi-asserted-by":"crossref","first-page":"29382","DOI":"10.1038\/srep29382","article-title":"Linifanib (ABT-869) potentiates the efficacy of chemotherapeutic agents through the suppression of receptor tyrosine kinase-mediated AKT\/mTOR signaling pathways in gastric Cancer","volume":"6","author":"Chen","year":"2016","journal-title":"Sci. Rep."},{"key":"10.1016\/j.bioorg.2025.109191_bb0090","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1186\/1756-8722-2-33","article-title":"ABT-869, a promising multi-targeted tyrosine kinase inhibitor: from bench to bedside","volume":"2","author":"Zhou","year":"2009","journal-title":"J. Hematol. Oncol."},{"issue":"9","key":"10.1016\/j.bioorg.2025.109191_bb0095","doi-asserted-by":"crossref","first-page":"665","DOI":"10.1042\/BCJ20230035","article-title":"The VEGFR\/PDGFR tyrosine kinase inhibitor, ABT-869, blocks necroptosis by targeting RIPK1 kinase","volume":"480","author":"Pierotti","year":"2023","journal-title":"Biochem. J."},{"issue":"1","key":"10.1016\/j.bioorg.2025.109191_bb0100","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1038\/s41420-023-01351-y","article-title":"Repositioning linifanib as a potent anti-necroptosis agent for sepsis","volume":"9","author":"Liang","year":"2023","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.bioorg.2025.109191_bb0105","doi-asserted-by":"crossref","DOI":"10.1016\/j.phrs.2023.106697","article-title":"Dimethyl fumarate inhibits necroptosis and alleviates systemic inflammatory response syndrome by blocking the RIPK1-RIPK3-MLKL axis","volume":"189","author":"Shi","year":"2023","journal-title":"Pharmacol. Res."},{"issue":"7631","key":"10.1016\/j.bioorg.2025.109191_bb0110","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1038\/nature20558","article-title":"RIPK1 counteracts ZBP1-mediated necroptosis to inhibit inflammation","volume":"540","author":"Lin","year":"2016","journal-title":"Nature"},{"issue":"5","key":"10.1016\/j.bioorg.2025.109191_bb0115","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1038\/s41580-023-00689-6","article-title":"A guide to cell death pathways","volume":"25","author":"Yuan","year":"2024","journal-title":"Nat. Rev. Mol. Cell Biol."},{"issue":"2","key":"10.1016\/j.bioorg.2025.109191_bb0120","doi-asserted-by":"crossref","DOI":"10.1038\/cddis.2017.20","article-title":"RIPK1\/RIPK3 promotes vascular permeability to allow tumor cell extravasation independent of its necroptotic function","volume":"8","author":"H\u00e4nggi","year":"2017","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.bioorg.2025.109191_bb0125","article-title":"Photoaffinity labeling approaches to elucidate lipid-protein interactions","volume":"69","author":"Weizhi","year":"2022","journal-title":"Curr. Opin. Chem. Biol."},{"issue":"1","key":"10.1016\/j.bioorg.2025.109191_bb0130","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1021\/acs.accounts.2c00505","article-title":"Multifunctional photo-cross-linking probes: from target protein searching to imaging applications","volume":"56","author":"Kozoriz","year":"2023","journal-title":"Acc. Chem. Res."},{"issue":"46","key":"10.1016\/j.bioorg.2025.109191_bb0135","doi-asserted-by":"crossref","first-page":"21174","DOI":"10.1021\/jacs.2c08257","article-title":"Design and evaluation of a Cyclobutane Diazirine alkyne tag for Photoaffinity labeling in cells","volume":"144","author":"West","year":"2022","journal-title":"J. Am. Chem. Soc."},{"issue":"1","key":"10.1016\/j.bioorg.2025.109191_bb0140","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1124\/jpet.110.178061","article-title":"ABT-869, a multitargeted receptor tyrosine kinase inhibitor, reduces tumor microvascularity and improves vascular wall integrity in preclinical tumor models","volume":"338","author":"Jiang","year":"2011","journal-title":"J. Pharmacol. Exp. Ther."},{"issue":"45","key":"10.1016\/j.bioorg.2025.109191_bb0145","doi-asserted-by":"crossref","first-page":"18281","DOI":"10.1073\/pnas.1207759109","article-title":"Molecular conformations, interactions, and properties associated with drug efficiency and clinical performance among VEGFR TK inhibitors","volume":"109","author":"McTigue","year":"2012","journal-title":"Proc. Natl. Acad. Sci. USA"},{"issue":"15","key":"10.1016\/j.bioorg.2025.109191_bb0150","doi-asserted-by":"crossref","first-page":"7447","DOI":"10.1080\/07391102.2022.2122568","article-title":"Anti-angiogenic potential of bioactive phytochemicals from Helicteres isora targeting VEGFR-2 to fight cancer through molecular docking and molecular dynamics simulation","volume":"41","author":"Oliur Rahman","year":"2023","journal-title":"J. Biomol. Struct. Dyn."},{"key":"10.1016\/j.bioorg.2025.109191_bb0155","doi-asserted-by":"crossref","DOI":"10.1016\/j.bioorg.2023.107062","article-title":"Iodoquinazoline-derived VEGFR-2 and EGFRT790M dual inhibitors: design, synthesis, molecular docking and anticancer evaluations","volume":"143","author":"Mohamed","year":"2024","journal-title":"Bioorg. Chem."},{"issue":"1","key":"10.1016\/j.bioorg.2025.109191_bb0160","doi-asserted-by":"crossref","first-page":"1173","DOI":"10.1186\/s12885-023-11625-4","article-title":"In vivo antiangiogenic effect of nimbolide, trans-chalcone and piperine for use against glioblastoma","volume":"23","author":"Senrung","year":"2023","journal-title":"BMC Cancer"}],"container-title":["Bioorganic Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0045206825010715?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0045206825010715?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T11:04:26Z","timestamp":1773313466000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0045206825010715"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,11]]},"references-count":32,"alternative-id":["S0045206825010715"],"URL":"https:\/\/doi.org\/10.1016\/j.bioorg.2025.109191","relation":{},"ISSN":["0045-2068"],"issn-type":[{"value":"0045-2068","type":"print"}],"subject":[],"published":{"date-parts":[[2025,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Identification of RIPK1 as a novel target for angiogenesis regulation based on ABT-869 conjugated photoaffinity probes","name":"articletitle","label":"Article Title"},{"value":"Bioorganic Chemistry","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bioorg.2025.109191","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"109191"}}