{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T14:24:11Z","timestamp":1788272651008,"version":"build-2803163510"},"reference-count":45,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Bioorganic Chemistry"],"published-print":{"date-parts":[[2025,12]]},"DOI":"10.1016\/j.bioorg.2025.109205","type":"journal-article","created":{"date-parts":[[2025,11,5]],"date-time":"2025-11-05T16:52:27Z","timestamp":1762361547000},"page":"109205","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":2,"special_numbering":"C","title":["Newly synthesized pyranopyrazole nicotinamides derivatives as potent anti-inflammatory agents: In-silico, in-vitro, and in-vivo studies"],"prefix":"10.1016","volume":"167","author":[{"given":"Hala F.","family":"Rizk","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Doha M.","family":"Beltagy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seham A.","family":"Ibrahim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hadeer M.","family":"El-Sayed","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amira K.","family":"Fares","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9108-6932","authenticated-orcid":false,"given":"Maha M.","family":"Salem","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bioorg.2025.109205_bb0005","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2021.114619","article-title":"Systemic and topical Ginkgo biloba leaf extract (Egb-761) ameliorated rat paw inflammation in comparison to dexamethasone","volume":"282","author":"Abdel-Emam","year":"2022","journal-title":"J. Ethnopharmacol."},{"issue":"1","key":"10.1016\/j.bioorg.2025.109205_bb0010","article-title":"Anti-inflammatory activity of Lactobacillus on carrageenan-induced paw Edema in male Wistar rats","volume":"2012","author":"Amdekar","year":"2012","journal-title":"Int. J. Inflamm."},{"issue":"1","key":"10.1016\/j.bioorg.2025.109205_bb0015","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1016\/S0022-3565(25)28209-X","article-title":"Biphasic development of carrageenin edema in rats","volume":"166","author":"Vinegar","year":"1969","journal-title":"J. Pharmacol. Exp. Ther."},{"issue":"1","key":"10.1016\/j.bioorg.2025.109205_bb0020","first-page":"1","article-title":"NF-\u03baB signaling in inflammation","volume":"2","author":"Liu","year":"2017","journal-title":"Signal Transduct. Target. Ther."},{"issue":"3","key":"10.1016\/j.bioorg.2025.109205_bb0025","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1111\/all.14032","article-title":"Progress in understanding hypersensitivity reactions to nonsteroidal anti-inflammatory drugs","volume":"75","author":"Do\u00f1a","year":"2020","journal-title":"Allergy"},{"key":"10.1016\/j.bioorg.2025.109205_bb0030","doi-asserted-by":"crossref","DOI":"10.1016\/j.bcp.2020.114147","article-title":"Non-steroidal anti-inflammatory drugs (NSAIDs) and organ damage: a current perspective","volume":"180","author":"Bindu","year":"2020","journal-title":"Biochem. Pharmacol."},{"issue":"9450","key":"10.1016\/j.bioorg.2025.109205_bb0035","doi-asserted-by":"crossref","first-page":"2021","DOI":"10.1016\/S0140-6736(04)17514-4","article-title":"Risk of cardiovascular events and rofecoxib: cumulative meta-analysis","volume":"364","author":"J\u00fcni","year":"2004","journal-title":"Lancet"},{"issue":"3","key":"10.1016\/j.bioorg.2025.109205_bb0040","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1080\/19490976.2016.1156827","article-title":"The microbiota-derived metabolite indole decreases mucosal inflammation and injury in a murine model of NSAID enteropathy","volume":"7","author":"Whitfield-Cargile","year":"2016","journal-title":"Gut Microbes"},{"issue":"2","key":"10.1016\/j.bioorg.2025.109205_bb0045","doi-asserted-by":"crossref","first-page":"5149","DOI":"10.4067\/S0717-97072021000205149","article-title":"Approaches for chemical synthesis and diverse pharmacological significance of pyrazolone derivatives: a review","volume":"66","author":"Asif","year":"2021","journal-title":"J. Chil. Chem. Soc."},{"key":"10.1016\/j.bioorg.2025.109205_bb0050","doi-asserted-by":"crossref","DOI":"10.1016\/j.molstruc.2023.137354","article-title":"Pyrazolopyrimidine and 4\u02d7 pyrimidylpyrazolone analogues as promising novel sulfa drugs: design, synthesis, antibacterial, antibiofilm, antiquorum agents, computational details and molecular docking studies","volume":"1301","author":"Rizk","year":"2024","journal-title":"J. Mol. Struct."},{"key":"10.1016\/j.bioorg.2025.109205_bb0055","doi-asserted-by":"crossref","DOI":"10.1016\/j.molstruc.2021.130602","article-title":"Assessment of anti-hemolytic, cytotoxicity, antioxidant activities and molecular docking study based on thienopyrazole scaffold as pharmacophore","volume":"1240","author":"El-Borai","year":"2021","journal-title":"J. Mol. Struct."},{"issue":"3","key":"10.1016\/j.bioorg.2025.109205_bb0060","doi-asserted-by":"crossref","first-page":"373","DOI":"10.2174\/138527212799499921","article-title":"Chemistry of pyrazolinones and their applications","volume":"16","author":"Hamama","year":"2012","journal-title":"Curr. Org. Chem."},{"issue":"10","key":"10.1016\/j.bioorg.2025.109205_bb0065","doi-asserted-by":"crossref","first-page":"2787","DOI":"10.1002\/jhet.3658","article-title":"An eco-friendly synthesis and biological screening of fused heterocyclic compounds containing a thiophene moiety via gewald reaction","volume":"56","author":"El-Borai","year":"2019","journal-title":"J. Heterocyclic Chem."},{"issue":"4","key":"10.1016\/j.bioorg.2025.109205_bb0070","doi-asserted-by":"crossref","first-page":"882","DOI":"10.1067\/mai.2003.163","article-title":"IgE-mediated immediate-type hypersensitivity to the pyrazolone drug propyphenazone","volume":"111","author":"Himly","year":"2003","journal-title":"J. Allergy Clin. Immunol."},{"issue":"5397","key":"10.1016\/j.bioorg.2025.109205_bb0075","doi-asserted-by":"crossref","first-page":"1553","DOI":"10.1136\/bmj.1.5397.1553","article-title":"Trial of nifenazone (\u201cThylin\u201d)","volume":"1","author":"Hart","year":"1964","journal-title":"Br. Med. J."},{"issue":"1","key":"10.1016\/j.bioorg.2025.109205_bb0080","doi-asserted-by":"crossref","first-page":"15420","DOI":"10.1038\/s41598-023-42137-7","article-title":"Simple dihydropyridine-based colorimetric chemosensors for heavy metal ion detection, biological evaluation, molecular docking, and ADMET profiling","volume":"13","author":"Hamada","year":"2023","journal-title":"Sci. Rep."},{"issue":"3","key":"10.1016\/j.bioorg.2025.109205_bb0085","doi-asserted-by":"crossref","first-page":"699","DOI":"10.1007\/s13738-023-02952-1","article-title":"Functionalized gold nanorods turn-on chemosensor for selective detection of Cd2+ ions, bio-imaging, and antineoplastic evaluations","volume":"21","author":"El-Nahass","year":"2024","journal-title":"J. Iran. Chem. Soc."},{"key":"10.1016\/j.bioorg.2025.109205_bb0090","series-title":"Anti-inflammatory action of Lannea coromandelica by HRBC membrane stabilization","author":"Gandhidasan","year":"1991"},{"key":"10.1016\/j.bioorg.2025.109205_bb0095","first-page":"1072","article-title":"Evaluation of anti-inflammatory activity of methanol extract of Murraya Koenigi leaves by in vivo and in vitro methods","volume":"1","author":"Gambhire Manoj","year":"2009","journal-title":"Pharmacologyonline"},{"issue":"2","key":"10.1016\/j.bioorg.2025.109205_bb0100","doi-asserted-by":"crossref","first-page":"94","DOI":"10.4103\/0976-500X.72351","article-title":"Improving bioscience research reporting: the ARRIVE guidelines for reporting animal research","volume":"1","author":"Kilkenny","year":"2010","journal-title":"J. Pharmacol. Pharmacother."},{"issue":"3","key":"10.1016\/j.bioorg.2025.109205_bb0105","doi-asserted-by":"crossref","first-page":"292","DOI":"10.4103\/0253-7613.157127","article-title":"A study of the mechanisms underlying the anti-inflammatory effect of ellagic acid in carrageenan-induced paw edema in rats","volume":"47","author":"Mansouri","year":"2015","journal-title":"Indian journal of pharmacology"},{"issue":"19","key":"10.1016\/j.bioorg.2025.109205_bb0110","doi-asserted-by":"crossref","first-page":"2894","DOI":"10.3748\/wjg.v19.i19.2894","article-title":"Long-term aspirin pretreatment in the prevention of cerulein-induced acute pancreatitis in rats","volume":"19","author":"Akyazi","year":"2013","journal-title":"World J Gastroenterol: WJG"},{"key":"10.1016\/j.bioorg.2025.109205_bb0115","first-page":"882","article-title":"Improved method for the determination of blood glutathione","volume":"61","author":"Beutler","year":"1963","journal-title":"J. Lab. Clin. Med."},{"issue":"1","key":"10.1016\/j.bioorg.2025.109205_bb0120","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1186\/s10020-022-00432-5","article-title":"Quercetin mitigates rheumatoid arthritis by inhibiting adenosine deaminase in rats","volume":"28","author":"El-Said","year":"2022","journal-title":"Mol. Med."},{"issue":"2","key":"10.1016\/j.bioorg.2025.109205_bb0125","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1016\/0003-2697(79)90738-3","article-title":"Assay for lipid peroxides in animal tissues by thiobarbituric acid reaction","volume":"95","author":"Ohkawa","year":"1979","journal-title":"Anal. Biochem."},{"key":"10.1016\/j.bioorg.2025.109205_bb0130","first-page":"123","article-title":"The determination of nitrite in water","volume":"1","author":"Montgomery","year":"1971","journal-title":"Analyst"},{"key":"10.1016\/j.bioorg.2025.109205_bb0135","series-title":"[13] catalase in vitro, methods in enzymology, Elsevier","first-page":"121","author":"Aebi","year":"1984"},{"issue":"1","key":"10.1016\/j.bioorg.2025.109205_bb0140","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1093\/ajcp\/28.1.56","article-title":"A colorimetric method for the determination of serum glutamic oxalacetic and glutamic pyruvic transaminases","volume":"28","author":"Reitman","year":"1957","journal-title":"Am. J. Clin. Pathol."},{"issue":"1","key":"10.1016\/j.bioorg.2025.109205_bb0145","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1016\/0009-8981(71)90365-2","article-title":"Albumin standards and the measurement of serum albumin with bromcresol green","volume":"31","author":"Doumas","year":"1971","journal-title":"Clin. Chim. Acta"},{"key":"10.1016\/j.bioorg.2025.109205_bb0150","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1016\/j.jss.2018.10.004","article-title":"Hepatoprotective effect of echinochrome pigment in septic rats","volume":"234","author":"Mohamed","year":"2019","journal-title":"J. Surg. Res."},{"issue":"1964","key":"10.1016\/j.bioorg.2025.109205_bb0155","first-page":"1018","article-title":"Plasma creatinine as rough indicator of renal function","volume":"89","author":"Schirmeister","year":"1946","journal-title":"Dtsch. Med. Wochenschr."},{"issue":"1","key":"10.1016\/j.bioorg.2025.109205_bb0160","doi-asserted-by":"crossref","first-page":"7703","DOI":"10.1038\/s41598-023-34626-6","article-title":"Anticancer role of mango (Mangifera indica L.) peel and seed kernel extracts against 7, 12-dimethylbenz [a] anthracene-induced mammary carcinogenesis in female rats","volume":"13","author":"Shaban","year":"2023","journal-title":"Sci. Rep."},{"issue":"12","key":"10.1016\/j.bioorg.2025.109205_bb0165","doi-asserted-by":"crossref","first-page":"2190","DOI":"10.1002\/jhet.4551","article-title":"Ultrasonic-assisted condensation of aromatic and aliphatic aldehydes with 3-(thiophen-2-yl)-5-pyrazolone: synthesis, characterization and stereoselective application","volume":"59","author":"Rizk","year":"2022","journal-title":"J. Heterocyclic Chem."},{"key":"10.1016\/j.bioorg.2025.109205_bb0170","doi-asserted-by":"crossref","DOI":"10.1016\/j.bioorg.2024.107353","article-title":"Design, synthesis, docking, and antiviral evaluation of some novel pyrimidinone-based \u03b1-aminophosphonates as potent H1N1 and HCoV-229E inhibitors","volume":"147","author":"Hekal","year":"2024","journal-title":"Bioorg. Chem."},{"issue":"3","key":"10.1016\/j.bioorg.2025.109205_bb0175","first-page":"189","article-title":"Invitro anti-inflammatory activity of methanol extract of Enicostemma axillare","volume":"3","author":"Leelaprakash","year":"2011","journal-title":"International Journal of Drug Development and Research"},{"issue":"1","key":"10.1016\/j.bioorg.2025.109205_bb0180","first-page":"96","article-title":"Antioxidant and anti-inflammatory activities of proteins isolated from eight Curcuma species","volume":"4","author":"Angel","year":"2013","journal-title":"Phytopharmacology"},{"key":"10.1016\/j.bioorg.2025.109205_bb0185","series-title":"Anti-Nociceptive and Anti-Inflammatory Activities of Asparacosin a Involve Selective Cyclooxygenase 2 and Inflammatory Cytokines Inhibition: An In-Vitro, In-Vivo, and in-Silico Approach","author":"Al-Harrasi","year":"2020"},{"issue":"1","key":"10.1016\/j.bioorg.2025.109205_bb0190","doi-asserted-by":"crossref","first-page":"621","DOI":"10.1146\/annurev.immunol.18.1.621","article-title":"Phosphorylation meets ubiquitination: the control of NF-\u03baB activity","volume":"18","author":"Karin","year":"2000","journal-title":"Annu. Rev. Immunol."},{"key":"10.1016\/j.bioorg.2025.109205_bb0195","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1007\/BF01967625","article-title":"Carrageenan: a review of its effects on the immune system","volume":"11","author":"Thomson","year":"1981","journal-title":"Agents Actions"},{"issue":"6","key":"10.1016\/j.bioorg.2025.109205_bb0200","first-page":"e316","article-title":"Causes and outcomes of markedly elevated C-reactive protein levels","volume":"63","author":"Landry","year":"2017","journal-title":"Can. Fam. Physician"},{"issue":"4","key":"10.1016\/j.bioorg.2025.109205_bb0205","first-page":"409","article-title":"The effect of reactive oxygen species on the synthesis of prostanoids from arachidonic acid","volume":"64","author":"Korbecki","year":"2013","journal-title":"J. Physiol. Pharmacol."},{"issue":"5","key":"10.1016\/j.bioorg.2025.109205_bb0210","doi-asserted-by":"crossref","first-page":"614","DOI":"10.1016\/S0168-8278(02)00022-3","article-title":"Liver injury due to sequential activation of natural killer cells and natural killer T cells by carrageenan","volume":"36","author":"Abe","year":"2002","journal-title":"J. Hepatol."},{"issue":"9","key":"10.1016\/j.bioorg.2025.109205_bb0215","doi-asserted-by":"crossref","first-page":"2758","DOI":"10.1007\/s11172-024-4389-1","article-title":"Synthesis and anti-inflammatory activity of N-substituted 4-aryl-2-[(3-cyano-4, 5, 6, 7-tetrahydrobenzo [b] thiophen-2-yl) amino]-4-oxobut-2-enamides","volume":"73","author":"Gorbunova","year":"2024","journal-title":"Russ. Chem. Bull."},{"issue":"8","key":"10.1016\/j.bioorg.2025.109205_bb0220","doi-asserted-by":"crossref","first-page":"1049","DOI":"10.1016\/j.ejmech.2007.01.007","article-title":"Syntheses of new tetrasubstituted thiophenes as novel anti-inflammatory agents","volume":"42","author":"Molvi","year":"2007","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.bioorg.2025.109205_bb0225","doi-asserted-by":"crossref","first-page":"451","DOI":"10.2147\/JIR.S262132","article-title":"Recent updates on anti-inflammatory and antimicrobial effects of furan natural derivatives","author":"Alizadeh","year":"2020","journal-title":"J. Inflamm. Res."}],"container-title":["Bioorganic Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0045206825010855?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0045206825010855?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,12,16]],"date-time":"2025-12-16T05:34:32Z","timestamp":1765863272000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0045206825010855"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,12]]},"references-count":45,"alternative-id":["S0045206825010855"],"URL":"https:\/\/doi.org\/10.1016\/j.bioorg.2025.109205","relation":{},"ISSN":["0045-2068"],"issn-type":[{"value":"0045-2068","type":"print"}],"subject":[],"published":{"date-parts":[[2025,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Newly synthesized pyranopyrazole nicotinamides derivatives as potent anti-inflammatory agents: In-silico, in-vitro, and in-vivo studies","name":"articletitle","label":"Article Title"},{"value":"Bioorganic Chemistry","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bioorg.2025.109205","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"109205"}}