{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T22:21:11Z","timestamp":1788992471678,"version":"build-2803163510"},"reference-count":62,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/100010002","name":"Ministry of Education","doi-asserted-by":"publisher","award":["DP2-TMU-114-C-06"],"award-info":[{"award-number":["DP2-TMU-114-C-06"]}],"id":[{"id":"10.13039\/100010002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100020595","name":"National Science and Technology Council","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100020595","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004663","name":"Ministry of Science and Technology, Taiwan","doi-asserted-by":"publisher","award":["111-2320-B-038- 040-MY3"],"award-info":[{"award-number":["111-2320-B-038- 040-MY3"]}],"id":[{"id":"10.13039\/501100004663","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004663","name":"Ministry of Science and Technology, Taiwan","doi-asserted-by":"publisher","award":["114-2326 B-038-002-MY3"],"award-info":[{"award-number":["114-2326 B-038-002-MY3"]}],"id":[{"id":"10.13039\/501100004663","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004663","name":"Ministry of Science and Technology, Taiwan","doi-asserted-by":"publisher","award":["113-2321-B-255-001"],"award-info":[{"award-number":["113-2321-B-255-001"]}],"id":[{"id":"10.13039\/501100004663","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004663","name":"Ministry of Science and Technology, Taiwan","doi-asserted-by":"publisher","award":["113-2628-B-038-009-MY3"],"award-info":[{"award-number":["113-2628-B-038-009-MY3"]}],"id":[{"id":"10.13039\/501100004663","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Bioorganic Chemistry"],"published-print":{"date-parts":[[2025,12]]},"DOI":"10.1016\/j.bioorg.2025.109255","type":"journal-article","created":{"date-parts":[[2025,11,18]],"date-time":"2025-11-18T05:32:30Z","timestamp":1763443950000},"page":"109255","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":9,"special_numbering":"C","title":["Unusual diterpenoids featuring a 4\/9-fused ring system from Sclerophytum humesi trigger intrinsic apoptosis via caspase-dependent PARP cleavage in pancreatic cancer"],"prefix":"10.1016","volume":"167","author":[{"given":"Phuong Vu","family":"Luu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bo-Rong","family":"Peng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thuy-Tien Thi","family":"Phan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cuong-Quoc","family":"Nguyen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Quoc-Dung Tran","family":"Huynh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ngoc-Thac","family":"Pham","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huong-Giang","family":"Le","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lo-Yun","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yao-An","family":"Shen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu-Jui","family":"Fan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kuei-Hung","family":"Lai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bioorg.2025.109255_bb0005","doi-asserted-by":"crossref","first-page":"228","DOI":"10.3389\/fonc.2013.00228","article-title":"The elephant and the blind Men: making sense of PARP inhibitors in homologous recombination deficient tumor cells","volume":"3","author":"De Lorenzo","year":"2013","journal-title":"Front. Oncol."},{"issue":"18","key":"10.1016\/j.bioorg.2025.109255_bb0010","doi-asserted-by":"crossref","first-page":"1725","DOI":"10.1056\/NEJMra1407390","article-title":"Applying synthetic lethality for the selective targeting of cancer","volume":"371","author":"McLornan","year":"2014","journal-title":"N Engl J Med."},{"key":"10.1016\/j.bioorg.2025.109255_bb0015","doi-asserted-by":"crossref","DOI":"10.1016\/j.bioorg.2025.108188","article-title":"Role of PARP-1 structural and functional features in PARP-1 inhibitors development","author":"Merkuryev","year":"2025","journal-title":"Bioorg. Chem."},{"issue":"6330","key":"10.1016\/j.bioorg.2025.109255_bb0020","doi-asserted-by":"crossref","first-page":"1152","DOI":"10.1126\/science.aam7344","article-title":"PARP inhibitors: Synthetic lethality in the clinic","volume":"355","author":"Lord","year":"2017","journal-title":"Science"},{"issue":"5","key":"10.1016\/j.bioorg.2025.109255_bb0025","doi-asserted-by":"crossref","first-page":"755","DOI":"10.1016\/j.molcel.2015.10.013","article-title":"PARP-1 activation requires local unfolding of an autoinhibitory domain","volume":"60","author":"Dawicki-McKenna","year":"2015","journal-title":"Mol. Cell"},{"key":"10.1016\/j.bioorg.2025.109255_bb0030","doi-asserted-by":"crossref","DOI":"10.1016\/j.bmcl.2025.130313","article-title":"Design, synthesis, and biological evaluation of naphthoaurones against colon cancer cells","volume":"127","author":"Lee","year":"2025","journal-title":"Bioorg. Med. Chem. Lett."},{"issue":"3","key":"10.1016\/j.bioorg.2025.109255_bb0035","doi-asserted-by":"crossref","first-page":"273","DOI":"10.7150\/ijbs.14951","article-title":"The landscape of pancreatic cancer therapeutic resistance mechanisms","volume":"12","author":"Chand","year":"2016","journal-title":"Int. J. Biol. Sci."},{"issue":"3","key":"10.1016\/j.bioorg.2025.109255_bb0040","first-page":"608","article-title":"Mechanisms of resistance to PARP inhibitors - an evolving challenge in oncology","volume":"2","author":"Mweempwa","year":"2019","journal-title":"Cancer Drug Resist."},{"issue":"1\u20132","key":"10.1016\/j.bioorg.2025.109255_bb0045","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1053\/j.seminoncol.2023.08.001","article-title":"PARP1 roles in DNA repair and DNA replication: The basi(c)s of PARP inhibitor efficacy and resistance","volume":"51","author":"Kanev","year":"2024","journal-title":"Semin. Oncol."},{"issue":"1","key":"10.1016\/j.bioorg.2025.109255_bb0050","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1186\/s13073-018-0612-8","article-title":"Mechanisms of PARP inhibitor resistance in cancer and insights into the DNA damage response","volume":"10","author":"Francica","year":"2018","journal-title":"Genome Med."},{"issue":"1","key":"10.1016\/j.bioorg.2025.109255_bb0055","doi-asserted-by":"crossref","DOI":"10.1186\/s12943-025-02355-1","article-title":"Clinical approaches to overcome PARP inhibitor resistance","volume":"24","author":"Zou","year":"2025","journal-title":"Mol. Cancer"},{"key":"10.1016\/j.bioorg.2025.109255_bb0060","article-title":"Apoptosis triggering, an important way for natural products from herbal medicines to treat pancreatic cancers","volume":"12","author":"Li","year":"2021","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.bioorg.2025.109255_bb0065","doi-asserted-by":"crossref","DOI":"10.1016\/j.bioorg.2025.108931","article-title":"Structural hybridization of alepterolic acid with piperazine-benzamide motifs yields potent anticancer agents","volume":"165","author":"Wang","year":"2025","journal-title":"Bioorg. Chem."},{"issue":"9","key":"10.1016\/j.bioorg.2025.109255_bb0070","doi-asserted-by":"crossref","first-page":"647","DOI":"10.1038\/nrc883","article-title":"The Bcl2 family: regulators of the cellular life-or-death switch","volume":"2","author":"Cory","year":"2002","journal-title":"Nat. Rev. Cancer"},{"issue":"1","key":"10.1016\/j.bioorg.2025.109255_bb0075","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1038\/nrm2308","article-title":"The BCL-2 protein family: opposing activities that mediate cell death","volume":"9","author":"Youle","year":"2008","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.bioorg.2025.109255_bb0080","doi-asserted-by":"crossref","DOI":"10.1021\/acs.jnatprod.5c00457","article-title":"Zoanthamine-type alkaloids derived from cultured Zoanthus kuroshio with therapeutic potential against osteoporosis","author":"Pham","year":"2025","journal-title":"J. Nat. Prod."},{"issue":"19","key":"10.1016\/j.bioorg.2025.109255_bb0085","doi-asserted-by":"crossref","first-page":"11804","DOI":"10.1021\/acs.joc.8b01738","article-title":"Diaporindenes A\u2013D: Four unusual 2, 3-dihydro-1 H-indene analogues with anti-inflammatory activities from the mangrove endophytic fungus Diaporthe sp. SYSU-HQ3","volume":"83","author":"Cui","year":"2018","journal-title":"J. Org. Chem."},{"issue":"12","key":"10.1016\/j.bioorg.2025.109255_bb0090","doi-asserted-by":"crossref","first-page":"3404","DOI":"10.1002\/cjoc.202100542","article-title":"Peniazaphilones A-I, Produced by Co-culturing of Mangrove Endophytic Fungi, Penicillium sclerotiorum THSH-4 and Penicillium sclerotiorum ZJHJJ-18","volume":"39","author":"Yang","year":"2021","journal-title":"Chin. J. Chem."},{"key":"10.1016\/j.bioorg.2025.109255_bb0095","doi-asserted-by":"crossref","DOI":"10.1016\/j.phytochem.2025.114611","article-title":"Anti-inflammatory cyclopropanes and benzofurans from mangrove endophytic fungus Schizophyllum sp. QYM-12","volume":"240","author":"Chen","year":"2025","journal-title":"Phytochemistry"},{"issue":"38","key":"10.1016\/j.bioorg.2025.109255_bb0100","doi-asserted-by":"crossref","first-page":"31965","DOI":"10.1039\/D5RA04971G","article-title":"Bioassay-guided isolation of terpenoids from the soft coral Sclerophytum humesi and assessment of their antidiabetic and cytotoxic activities","volume":"15","author":"Luu","year":"2025","journal-title":"RSC Adv."},{"key":"10.1016\/j.bioorg.2025.109255_bb0105","doi-asserted-by":"crossref","DOI":"10.1016\/j.bioorg.2025.108892","article-title":"Structurally diverse diterpenoids from cones of Taxodium ascendens inhibit colorectal cancer proliferation via regulating mitophagy","volume":"164","author":"Su","year":"2025","journal-title":"Bioorg. Chem."},{"issue":"1","key":"10.1016\/j.bioorg.2025.109255_bb0110","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/0022-1759(83)90303-4","article-title":"Rapid colorimetric assay for cellular growth and survival: Application to proliferation and cytotoxicity assays","volume":"65","author":"Mosmann","year":"1983","journal-title":"J. Immunol. Methods"},{"issue":"14","key":"10.1016\/j.bioorg.2025.109255_bb0115","doi-asserted-by":"crossref","first-page":"10639","DOI":"10.1039\/D4RA09007A","article-title":"Cytotoxicity-guided isolation of elatostemanosides I\u2013VI from Elatostema tenuicaudatum WT Wang and their cytotoxic activities","volume":"15","author":"Huynh","year":"2025","journal-title":"RSC Adv."},{"key":"10.1016\/j.bioorg.2025.109255_bb0120","doi-asserted-by":"crossref","DOI":"10.1016\/j.ecoenv.2020.110223","article-title":"Cytotoxicity and toxicoproteomic analyses of human lung epithelial cells exposed to extracts of atmospheric particulate matters on PTFE filters using acetone and water","volume":"191","author":"Tang","year":"2020","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"10.1016\/j.bioorg.2025.109255_bb0125","doi-asserted-by":"crossref","DOI":"10.1016\/j.bioorg.2025.108809","article-title":"Synthesis and biological evaluation of diosgenin derivatives as potential anti-breast cancer agents","author":"Huang","year":"2025","journal-title":"Bioorg. Chem."},{"key":"10.1016\/j.bioorg.2025.109255_bb0130","doi-asserted-by":"crossref","DOI":"10.1016\/j.bioorg.2025.108342","article-title":"Unusual chaetoglobosins and a new type of ferroptosis inducer from an endophytic fungus Chaetomium sp. UJN-EF006","volume":"158","author":"Wang","year":"2025","journal-title":"Bioorg. Chem."},{"key":"10.1016\/j.bioorg.2025.109255_bb0135","doi-asserted-by":"crossref","DOI":"10.1016\/j.molstruc.2025.143193","article-title":"Pharmacoinformatics model based on the Para-aminochalcone core to screening dual alpha-amylase\/alpha-glucosidase and \u03b2-TC-6 inhibitors: combining experimental and machine learning for diabetes drug discovery","author":"Nguyen","year":"2025","journal-title":"J. Mol. Struct."},{"issue":"30","key":"10.1016\/j.bioorg.2025.109255_bb0140","doi-asserted-by":"crossref","DOI":"10.1002\/slct.202401730","article-title":"Anti-phytopathogenic and phytotoxic effects of Annona glabra Lin. and Annona muricata Lin. seed extracts: in vitro and in vivo assessment, bioactive compound quantification, and mechanism involved","volume":"9","author":"Le Dang","year":"2024","journal-title":"ChemistrySelect"},{"key":"10.1016\/j.bioorg.2025.109255_bb0145","doi-asserted-by":"crossref","DOI":"10.1016\/j.pmpp.2023.102123","article-title":"Insight into the role of phytoalexin naringenin and phytohormone abscisic acid in defense against phytopathogens Phytophthora infestans and Magnaporthe oryzae: in vitro and in silico approaches","volume":"127","author":"Nguyen-Ngoc","year":"2023","journal-title":"Physiol. Mol. Plant Pathol."},{"issue":"6","key":"10.1016\/j.bioorg.2025.109255_bb0150","doi-asserted-by":"crossref","first-page":"390","DOI":"10.1038\/nchembio.1246","article-title":"Structure-guided design of a selective BCL-XL inhibitor","volume":"9","author":"Lessene","year":"2013","journal-title":"Nat. Chem. Biol."},{"issue":"1","key":"10.1016\/j.bioorg.2025.109255_bb0155","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1016\/j.bmcl.2008.10.113","article-title":"Tetrahydroisoquinoline amide substituted phenyl pyrazoles as selective Bcl-2 inhibitors","volume":"19","author":"Porter","year":"2009","journal-title":"Bioorg. Med. Chem. Lett."},{"issue":"10","key":"10.1016\/j.bioorg.2025.109255_bb0160","doi-asserted-by":"crossref","first-page":"1547","DOI":"10.1246\/bcsj.79.1547","article-title":"New \u03b2-Caryophyllene-Derived Terpenoids from the Formosan Soft Coral Sinularia gibberosa","volume":"79","author":"Chen","year":"2006","journal-title":"Bull. Chem. Soc."},{"issue":"29","key":"10.1016\/j.bioorg.2025.109255_bb0165","doi-asserted-by":"crossref","first-page":"6802","DOI":"10.1016\/j.tet.2006.04.088","article-title":"Sinugibberosides A\u2013E, new terpenoids with cyclic peroxyhemiketal from the soft coral Sinularia gibberosa","volume":"62","author":"Chen","year":"2006","journal-title":"Tetrahedron"},{"issue":"5","key":"10.1016\/j.bioorg.2025.109255_bb0170","doi-asserted-by":"crossref","first-page":"1790","DOI":"10.1021\/ja00031a038","article-title":"Total synthesis of (\u00b1)-chondrillin, (\u00b1)-plakorin, and related peroxy ketals. Development of a general route to 3,6-dihydro-1,2-dioxin-3-ols","volume":"114","author":"Snider","year":"1992","journal-title":"J. Am. Chem. Soc."},{"issue":"11","key":"10.1016\/j.bioorg.2025.109255_bb0175","doi-asserted-by":"crossref","first-page":"2545","DOI":"10.1016\/S0031-9422(00)84096-0","article-title":"Tetrahydrofuran-type terpenoids from Tanacetum vulgare","volume":"23","author":"Appendino","year":"1984","journal-title":"Phytochemistry"},{"issue":"2","key":"10.1016\/j.bioorg.2025.109255_bb0180","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1248\/cpb.57.162","article-title":"Novel norhumulene and xeniaphyllane-derived terpenoids from a formosan soft coral Sinularia gibberosa","volume":"57","author":"Chen","year":"2009","journal-title":"Chem. Pharm. Bull."},{"issue":"8","key":"10.1016\/j.bioorg.2025.109255_bb0185","doi-asserted-by":"crossref","first-page":"276","DOI":"10.3390\/md16080276","article-title":"New cembranoids and a biscembranoid peroxide from the soft coral Sarcophyton cherbonnieri","volume":"16","author":"Peng","year":"2018","journal-title":"Mar. Drugs"},{"issue":"1","key":"10.1016\/j.bioorg.2025.109255_bb0190","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1248\/cpb.42.138","article-title":"Constituents of Sindora sumatrana MIQ.I. isolation and NMR spectral analysis of sesquiterpenes from the dried pods","volume":"42","author":"Heymann","year":"1994","journal-title":"Chem. Pharm. Bull."},{"issue":"12","key":"10.1016\/j.bioorg.2025.109255_bb0195","doi-asserted-by":"crossref","first-page":"2893","DOI":"10.1016\/0031-9422(85)80022-4","article-title":"Foliage sesquiterpenes of Dacrydium cupressinum: identification, variation and biosynthesis","volume":"24","author":"Berry","year":"1985","journal-title":"Phytochemistry"},{"issue":"7","key":"10.1016\/j.bioorg.2025.109255_bb0200","doi-asserted-by":"crossref","first-page":"1135","DOI":"10.1016\/S0031-9422(00)94305-X","article-title":"Neue furanoeremophilane und andere sesquiterpene aus vertretern der gattung Euryops","volume":"17","author":"Bohlmann","year":"1978","journal-title":"Phytochemistry"},{"issue":"3","key":"10.1016\/j.bioorg.2025.109255_bb0205","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1016\/S0031-9422(00)84168-0","article-title":"Sesquiterpenes from three Senecio species","volume":"20","author":"Bohlmann","year":"1981","journal-title":"Phytochemistry"},{"issue":"15","key":"10.1016\/j.bioorg.2025.109255_bb0210","doi-asserted-by":"crossref","first-page":"1359","DOI":"10.1080\/14786410701773295","article-title":"A new norsesquiterpene from Hainan soft coral Sinularia sp","volume":"22","author":"Li","year":"2008","journal-title":"Nat. Prod. Res."},{"issue":"10","key":"10.1016\/j.bioorg.2025.109255_bb0215","doi-asserted-by":"crossref","first-page":"1471","DOI":"10.1248\/cpb.55.1471","article-title":"Xeniaphyllane-derived terpenoids from the Formosan soft coral Sinularia gibberosa","volume":"55","author":"Chen","year":"2007","journal-title":"Chem. Pharm. Bull."},{"key":"10.1016\/j.bioorg.2025.109255_bb0220","doi-asserted-by":"crossref","first-page":"4","DOI":"10.3390\/md20040272","article-title":"An uncommon 17,19-Dinorxeniaphyllanoid, and nine related new Terpenoids from the Hainan soft coral Sinularia hirta","volume":"20","author":"Chen","year":"2022","journal-title":"Mar. Drugs"},{"issue":"4","key":"10.1016\/j.bioorg.2025.109255_bb0225","doi-asserted-by":"crossref","first-page":"592","DOI":"10.1021\/np030286w","article-title":"New \u03b2-Caryophyllene-Derived Terpenoids from the Soft Coral Sinularia nanolobata","volume":"67","author":"Ahmed","year":"2004","journal-title":"J. Nat. Prod."},{"issue":"5","key":"10.1016\/j.bioorg.2025.109255_bb0230","doi-asserted-by":"crossref","first-page":"683","DOI":"10.3390\/antiox10050683","article-title":"Exploring mycosporine-like amino acids (MAAs) as safe and natural protective agents against UV-induced skin damage","volume":"10","author":"Singh","year":"2021","journal-title":"Antioxidants"},{"issue":"4","key":"10.1016\/j.bioorg.2025.109255_bb0235","doi-asserted-by":"crossref","first-page":"765","DOI":"10.1093\/icb\/icz014","article-title":"Chemical ecology of marine sponges: new opportunities through \u201c-omics\u201d","volume":"59","author":"Paul","year":"2019","journal-title":"Integr. Comp. Biol."},{"issue":"1","key":"10.1016\/j.bioorg.2025.109255_bb0240","doi-asserted-by":"crossref","first-page":"63","DOI":"10.3390\/ph14010063","article-title":"Mycosporine-Like Amino Acids (MAAs): Biology, Chemistry and Identification Features","volume":"14","author":"Geraldes","year":"2021","journal-title":"Pharmaceuticals"},{"key":"10.1016\/j.bioorg.2025.109255_bb0245","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1016\/j.ejmech.2017.11.031","article-title":"Synthesis and biological evaluation of sulfur-containing shikonin oxime derivatives as potential antineoplastic agents","volume":"143","author":"Huang","year":"2018","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.bioorg.2025.109255_bb0250","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1016\/j.ejmech.2019.01.005","article-title":"Discovery and synthesis of sulfur-containing 6-substituted 5, 8-dimethoxy-1, 4-naphthoquinone oxime derivatives as new and potential anti-MDR cancer agents","volume":"165","author":"Huang","year":"2019","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.bioorg.2025.109255_bb0255","doi-asserted-by":"crossref","DOI":"10.1016\/j.bioorg.2025.108310","article-title":"Structurally diverse tetrahydroxanthone analogues from Paraconiothyrium sp. AC31 with pyroptosis induction through targeted inhibition of PARP1 in hepatocellular carcinoma cells","volume":"157","author":"Zhang","year":"2025","journal-title":"Bioorg. Chem."},{"key":"10.1016\/j.bioorg.2025.109255_bb0260","doi-asserted-by":"crossref","DOI":"10.1016\/j.bioorg.2025.108513","article-title":"Discovery of polycyclic polyprenylated acylphloroglucinols with antitumor activities from Garcinia pedunculata Roxb. Fruits based on molecular networking","volume":"161","author":"Zou","year":"2025","journal-title":"Bioorg. Chem."},{"key":"10.1016\/j.bioorg.2025.109255_bb0265","doi-asserted-by":"crossref","DOI":"10.1016\/j.bioorg.2025.108262","article-title":"7S,15R-stereoisomer of phenylethylamino derivative of colchicine exhibits potent in-vitro and in-vivo anti-cancer activity against prostate Cancer: assessing the impact of stereochemistry on biological activity","volume":"157","author":"Reddy","year":"2025","journal-title":"Bioorg. Chem."},{"issue":"12","key":"10.1016\/j.bioorg.2025.109255_bb0270","doi-asserted-by":"crossref","first-page":"526","DOI":"10.1016\/S0962-8924(01)02173-0","article-title":"Programmed cell death: alive and well in the new millennium","volume":"11","author":"Kaufmann","year":"2001","journal-title":"Trends Cell Biol."},{"issue":"13","key":"10.1016\/j.bioorg.2025.109255_bb0275","doi-asserted-by":"crossref","first-page":"7124","DOI":"10.1073\/pnas.97.13.7124","article-title":"Structure-based discovery of an organic compound that binds Bcl-2 protein and induces apoptosis of tumor cells","volume":"97","author":"Wang","year":"2000","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.bioorg.2025.109255_bb0280","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1016\/j.celrep.2022.111826","article-title":"BCL-xL inhibition potentiates cancer therapies by redirecting the outcome of p53 activation from senescence to apoptosis","volume":"41","author":"Bharti","year":"2022","journal-title":"Cell Rep."},{"issue":"11","key":"10.1016\/j.bioorg.2025.109255_bb0285","doi-asserted-by":"crossref","first-page":"1264","DOI":"10.1016\/j.dnarep.2009.07.010","article-title":"PARP inhibition during alkylation-induced genotoxic stress signals a cell cycle checkpoint response mediated by ATM","volume":"8","author":"Carrozza","year":"2009","journal-title":"DNA Repair"},{"issue":"6811","key":"10.1016\/j.bioorg.2025.109255_bb0290","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1038\/35044005","article-title":"The DNA damage response: putting checkpoints in perspective","volume":"408","author":"Zhou","year":"2000","journal-title":"Nature"},{"issue":"4","key":"10.1016\/j.bioorg.2025.109255_bb0295","doi-asserted-by":"crossref","first-page":"239","DOI":"10.18632\/oncotarget.134","article-title":"The anti-apoptotic members of the Bcl-2 family are attractive tumor-associated antigens","volume":"1","author":"Thor Straten","year":"2010","journal-title":"Oncotarget"},{"issue":"3","key":"10.1016\/j.bioorg.2025.109255_bb0300","first-page":"461","article-title":"Reinstating apoptosis using putative Bcl-xL natural product inhibitors: Molecular docking and ADMETox profiling investigations","volume":"18","author":"Boyenle","year":"2023","journal-title":"J. Taibah Univ. Med. Sci."},{"issue":"6","key":"10.1016\/j.bioorg.2025.109255_bb0305","doi-asserted-by":"crossref","first-page":"468","DOI":"10.6026\/97320630016468","article-title":"Molecular docking analysis of Bcl-2 with phyto-compounds","volume":"16","author":"Kirubhanand","year":"2020","journal-title":"Bioinformation"},{"issue":"5","key":"10.1016\/j.bioorg.2025.109255_bb0310","doi-asserted-by":"crossref","first-page":"544","DOI":"10.3390\/biom14050544","article-title":"Virtual screening of small molecules targeting BCL2 with machine learning, molecular docking, and MD simulation","volume":"14","author":"Tondar","year":"2024","journal-title":"Biomolecules"}],"container-title":["Bioorganic Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0045206825011356?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0045206825011356?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,12,19]],"date-time":"2025-12-19T03:43:48Z","timestamp":1766115828000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0045206825011356"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,12]]},"references-count":62,"alternative-id":["S0045206825011356"],"URL":"https:\/\/doi.org\/10.1016\/j.bioorg.2025.109255","relation":{},"ISSN":["0045-2068"],"issn-type":[{"value":"0045-2068","type":"print"}],"subject":[],"published":{"date-parts":[[2025,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Unusual diterpenoids featuring a 4\/9-fused ring system from Sclerophytum humesi trigger intrinsic apoptosis via caspase-dependent PARP cleavage in pancreatic cancer","name":"articletitle","label":"Article Title"},{"value":"Bioorganic Chemistry","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bioorg.2025.109255","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"109255"}}