{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T19:16:52Z","timestamp":1790795812182,"version":"4.1.0"},"reference-count":25,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["22507091"],"award-info":[{"award-number":["22507091"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004731","name":"Zhejiang Province Natural Science Foundation","doi-asserted-by":"publisher","award":["TGD23C040012"],"award-info":[{"award-number":["TGD23C040012"]}],"id":[{"id":"10.13039\/501100004731","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Bioorganic Chemistry"],"published-print":{"date-parts":[[2026,1]]},"DOI":"10.1016\/j.bioorg.2025.109326","type":"journal-article","created":{"date-parts":[[2025,12,2]],"date-time":"2025-12-02T00:17:46Z","timestamp":1764634666000},"page":"109326","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"special_numbering":"C","title":["A FAP-\u03b1-activatable near-infrared theranostic probe for fluorescence imaging of pancreatic cancer and potent in vitro photodynamic activity"],"prefix":"10.1016","volume":"168","author":[{"given":"Zhipeng","family":"Li","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiao","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chan","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianliang","family":"Shen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bo","family":"Peng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bioorg.2025.109326_bb0005","doi-asserted-by":"crossref","first-page":"610","DOI":"10.1016\/j.molmed.2024.11.007","article-title":"Splicing dysregulation: hallmark and therapeutic opportunity in pancreatic cancer","volume":"31","author":"Naro","year":"2025","journal-title":"Trends Mol. Med."},{"key":"10.1016\/j.bioorg.2025.109326_bb0010","doi-asserted-by":"crossref","DOI":"10.1002\/mco2.216","article-title":"Targeted therapy for pancreatic ductal adenocarcinoma: mechanisms and clinical study","volume":"4","author":"Kung","year":"2023","journal-title":"Medcomm"},{"key":"10.1016\/j.bioorg.2025.109326_bb0015","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1016\/j.semcancer.2021.03.006","article-title":"Heterogeneity and plasticity of cancer-associated fibroblasts in the pancreatic tumor microenvironment","volume":"82","author":"Boyd","year":"2022","journal-title":"Semin. Cancer Biol."},{"key":"10.1016\/j.bioorg.2025.109326_bb0020","doi-asserted-by":"crossref","first-page":"6188","DOI":"10.3390\/cancers13246188","article-title":"Tumor microenvironment in pancreatic intraepithelial neoplasia","volume":"13","author":"Opitz","year":"2021","journal-title":"Cancers"},{"key":"10.1016\/j.bioorg.2025.109326_bb0025","doi-asserted-by":"crossref","first-page":"3621","DOI":"10.1021\/acs.molpharmaceut.5c00482","article-title":"Fibroblast activation protein as a molecular handle in cancer phototheranostics: recent advances","volume":"22","author":"Basak","year":"2025","journal-title":"Mol. Pharm."},{"key":"10.1016\/j.bioorg.2025.109326_bb0030","doi-asserted-by":"crossref","DOI":"10.3389\/or.2025.1617487","article-title":"Fibroblast activation protein and the tumour microenvironment: challenges and therapeutic opportunities","volume":"19","author":"Lee","year":"2025","journal-title":"Oncol. Rev."},{"key":"10.1016\/j.bioorg.2025.109326_bb0035","doi-asserted-by":"crossref","first-page":"840","DOI":"10.3748\/wjg.v18.i8.840","article-title":"Expression of fibroblast activation protein in human pancreatic adenocarcinoma and its clinicopathological significance","volume":"18","author":"Shi","year":"2012","journal-title":"World J. Gastroenterol."},{"key":"10.1016\/j.bioorg.2025.109326_bb0040","doi-asserted-by":"crossref","first-page":"5943","DOI":"10.1158\/1538-7445.AM2024-5943","article-title":"Development of a SMART theranostic agent for precision pancreatic cancer therapeutics","volume":"84","author":"Motea","year":"2024","journal-title":"Cancer Res."},{"key":"10.1016\/j.bioorg.2025.109326_bb0045","doi-asserted-by":"crossref","DOI":"10.1016\/j.ccr.2025.216897","article-title":"Serial stimuli-responsive theranostic nanomaterials for cancer therapy and imaging","volume":"542","author":"Sathuvan","year":"2025","journal-title":"Coord. Chem. Rev."},{"key":"10.1016\/j.bioorg.2025.109326_bb0050","doi-asserted-by":"crossref","first-page":"1883","DOI":"10.1039\/D2BM00067A","article-title":"Enzyme-responsive strategy as a prospective cue to construct intelligent biomaterials for disease diagnosis and therapy","volume":"10","author":"Wang","year":"2022","journal-title":"Biomater. Sci."},{"key":"10.1016\/j.bioorg.2025.109326_bb0055","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1002\/agt2.10","article-title":"Recent advances in stimuli-responsive theranostic systems with aggregation-induced emission characteristics","volume":"2","author":"Hu","year":"2021","journal-title":"Aggregate"},{"key":"10.1016\/j.bioorg.2025.109326_bb0060","doi-asserted-by":"crossref","DOI":"10.1002\/adfm.202422693","article-title":"Second near-infrared window fluorescence materials for in vivo dynamic multiplexed imaging","volume":"35","author":"Fan","year":"2025","journal-title":"Adv. Funct. Mater."},{"key":"10.1016\/j.bioorg.2025.109326_bb0065","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1038\/s44222-022-00002-8","article-title":"Near-infrared luminescence high-contrast in vivo biomedical imaging","volume":"1","author":"Chen","year":"2023","journal-title":"Nat. Rev. Bioeng."},{"key":"10.1016\/j.bioorg.2025.109326_bb0070","doi-asserted-by":"crossref","first-page":"1332","DOI":"10.3390\/pharmaceutics13091332","article-title":"Photodynamic therapy review: principles, photosensitizers, applications, and future directions","volume":"13","author":"Correia","year":"2021","journal-title":"Pharmaceutics"},{"key":"10.1016\/j.bioorg.2025.109326_bb0075","doi-asserted-by":"crossref","DOI":"10.1002\/mco2.603","article-title":"Photodynamic therapy for cancer: mechanisms, photosensitizers, nanocarriers, and clinical studies","volume":"5","author":"Zhao","year":"2024","journal-title":"Medcomm"},{"key":"10.1016\/j.bioorg.2025.109326_bb0080","doi-asserted-by":"crossref","DOI":"10.1002\/anie.202202966","article-title":"A dual-locked activatable phototheranostic probe for biomarker-regulated photodynamic and photothermal cancer therapy","volume":"61","author":"Wei","year":"2022","journal-title":"Angew. Chem. Int. Ed."},{"key":"10.1016\/j.bioorg.2025.109326_bb0085","doi-asserted-by":"crossref","first-page":"3610","DOI":"10.7150\/thno.70308","article-title":"Fibroblast activation protein \u03b1 activatable theranostic pro-photosensitizer for accurate tumor imaging and highly-specific photodynamic therapy","volume":"12","author":"Luo","year":"2022","journal-title":"Theranostics"},{"key":"10.1016\/j.bioorg.2025.109326_bb0090","doi-asserted-by":"crossref","first-page":"6501","DOI":"10.1021\/acs.analchem.1c00413","article-title":"A novel chemiluminescence probe for sensitive detection of fibroblast activation protein-alpha in vitro and in living systems","volume":"93","author":"Fu","year":"2021","journal-title":"Anal. Chem."},{"key":"10.1016\/j.bioorg.2025.109326_bb0095","doi-asserted-by":"crossref","first-page":"14873","DOI":"10.1021\/acs.analchem.9b02117","article-title":"Bioluminescent probe for monitoring endogenous fibroblast activation protein-alpha","volume":"91","author":"Lin","year":"2019","journal-title":"Anal. Chem."},{"key":"10.1016\/j.bioorg.2025.109326_bb0100","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejmech.2024.116787","article-title":"Development of fibroblast activation protein-\u03b1 radiopharmaceuticals: recent advances and perspectives","volume":"277","author":"Yu","year":"2024","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.bioorg.2025.109326_bb0105","doi-asserted-by":"crossref","first-page":"1837","DOI":"10.1021\/acssensors.2c00126","article-title":"Ultrasensitive fibroblast activation protein-\u03b1-activated fluorogenic probe enables selective imaging and killing of melanoma in vivo","volume":"7","author":"Liu","year":"2022","journal-title":"ACS Sens."},{"key":"10.1016\/j.bioorg.2025.109326_bb0110","article-title":"A tumor-microenvironment-activatable molecular pro-theranostic agent for photodynamic and immunotherapy of cancer","volume":"35","author":"Zhou","year":"2023","journal-title":"Adv. Mater."},{"key":"10.1016\/j.bioorg.2025.109326_bb0115","doi-asserted-by":"crossref","first-page":"11159","DOI":"10.1021\/acs.analchem.2c01189","article-title":"NQO-1 enzyme-activated NIR theranostic agent for pancreatic cancer","volume":"94","author":"Peng","year":"2022","journal-title":"Anal. Chem."},{"key":"10.1016\/j.bioorg.2025.109326_bb0120","doi-asserted-by":"crossref","DOI":"10.1016\/j.impact.2024.100521","article-title":"Improving the dichloro-dihydro-fluorescein (DCFH) assay for the assessment of intracellular reactive oxygen species formation by nanomaterials","volume":"35","author":"Ruijter","year":"2024","journal-title":"Nanoimpact"},{"key":"10.1016\/j.bioorg.2025.109326_bb0125","doi-asserted-by":"crossref","first-page":"3053","DOI":"10.1021\/jm500031w","article-title":"Extended structure\u2013activity relationship and pharmacokinetic investigation of (4-quinolinoyl)glycyl-2-cyanopyrrolidine inhibitors of fibroblast activation protein (FAP)","volume":"57","author":"Jansen","year":"2014","journal-title":"J. Med. Chem."}],"container-title":["Bioorganic Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0045206825012064?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0045206825012064?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,1,6]],"date-time":"2026-01-06T09:46:43Z","timestamp":1767692803000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0045206825012064"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1]]},"references-count":25,"alternative-id":["S0045206825012064"],"URL":"https:\/\/doi.org\/10.1016\/j.bioorg.2025.109326","relation":{},"ISSN":["0045-2068"],"issn-type":[{"value":"0045-2068","type":"print"}],"subject":[],"published":{"date-parts":[[2026,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"A FAP-\u03b1-activatable near-infrared theranostic probe for fluorescence imaging of pancreatic cancer and potent in vitro photodynamic activity","name":"articletitle","label":"Article Title"},{"value":"Bioorganic Chemistry","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bioorg.2025.109326","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"109326"}}