{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T21:04:22Z","timestamp":1790888662327,"version":"4.1.0"},"reference-count":38,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100012226","name":"Fundamental Research Funds for the Central Universities","doi-asserted-by":"publisher","award":["21624321"],"award-info":[{"award-number":["21624321"]}],"id":[{"id":"10.13039\/501100012226","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82270879"],"award-info":[{"award-number":["82270879"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82504844"],"award-info":[{"award-number":["82504844"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100013804","name":"Fundamental Research Funds for the Central Universities","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100013804","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100021171","name":"Basic and Applied Basic Research Foundation of Guangdong Province","doi-asserted-by":"publisher","award":["2023A1515110934"],"award-info":[{"award-number":["2023A1515110934"]}],"id":[{"id":"10.13039\/501100021171","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Bioorganic Chemistry"],"published-print":{"date-parts":[[2026,2]]},"DOI":"10.1016\/j.bioorg.2025.109357","type":"journal-article","created":{"date-parts":[[2025,12,12]],"date-time":"2025-12-12T07:52:31Z","timestamp":1765525951000},"page":"109357","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":3,"special_numbering":"C","title":["Melatonin impedes NCOA4\/ACSL4-dependent ferroptosis by targeting STING to ameliorate diabetic cognitive dysfunction"],"prefix":"10.1016","volume":"169","author":[{"given":"Tao","family":"Xu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhaoyu","family":"Xie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yongting","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhengrui","family":"Ren","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miaomiao","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhixu","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Han","family":"Meng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mengqi","family":"Wan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chao","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Han","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hui","family":"Che","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"1","key":"10.1016\/j.bioorg.2025.109357_bb0005","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1007\/s00125-019-04977-9","article-title":"Cognitive dysfunction in diabetes: how to implement emerging guidelines","volume":"63","author":"Biessels","year":"2020","journal-title":"Diabetologia"},{"issue":"3","key":"10.1016\/j.bioorg.2025.109357_bb0010","doi-asserted-by":"crossref","first-page":"840","DOI":"10.1111\/dom.15376","article-title":"Associations between complexity of glucose time series and cognitive function in adults with type 2 diabetes","volume":"26","author":"Yu","year":"2024","journal-title":"Diabetes Obes. Metab."},{"issue":"3","key":"10.1016\/j.bioorg.2025.109357_bb0015","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1016\/S2213-8587(20)30431-9","article-title":"Trends in predominant causes of death in individuals with and without diabetes in England from 2001 to 2018: an epidemiological analysis of linked primary care records","volume":"9","author":"Pearson-Stuttard","year":"2021","journal-title":"Lancet Diabetes Endocrinol."},{"issue":"4","key":"10.1016\/j.bioorg.2025.109357_bb0020","doi-asserted-by":"crossref","first-page":"5282","DOI":"10.1096\/fj.201902692R","article-title":"Melatonin alleviates cardiac fibrosis via inhibiting lncRNA MALAT1\/miR-141-mediated NLRP3 inflammasome and TGF-\u03b21\/Smads signaling in diabetic cardiomyopathy","volume":"34","author":"Che","year":"2020","journal-title":"FASEB J."},{"issue":"1","key":"10.1016\/j.bioorg.2025.109357_bb0025","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1038\/s41380-024-02691-6","article-title":"Melatonin: a potential nighttime guardian against Alzheimer\u2019s","volume":"30","author":"Zhang","year":"2025","journal-title":"Mol. Psychiatry"},{"issue":"2","key":"10.1016\/j.bioorg.2025.109357_bb0030","doi-asserted-by":"crossref","DOI":"10.1111\/jpi.12449","article-title":"Melatonin prevents endothelial cell pyroptosis via regulation of long noncoding RNA MEG3\/miR-223\/NLRP3 axis","volume":"64","author":"Zhang","year":"2018","journal-title":"J. Pineal Res."},{"key":"10.1016\/j.bioorg.2025.109357_bb0035","doi-asserted-by":"crossref","DOI":"10.1155\/2021\/5566019","article-title":"Association of serum melatonin level with mild cognitive impairment in type 2 diabetic patients: a cross-sectional study","volume":"2021","author":"Zhang","year":"2021","journal-title":"Int. J. Endocrinol."},{"key":"10.1016\/j.bioorg.2025.109357_bb0040","doi-asserted-by":"crossref","DOI":"10.1016\/j.lfs.2020.117427","article-title":"Exogenous melatonin restrains neuroinflammation in high fat diet induced diabetic rats through attenuating indoleamine 2,3-dioxygenase 1 expression","volume":"247","author":"Maher","year":"2020","journal-title":"Life Sci."},{"issue":"4","key":"10.1016\/j.bioorg.2025.109357_bb0045","doi-asserted-by":"crossref","DOI":"10.1016\/j.isci.2024.109511","article-title":"A mechanism linking ferroptosis and ferritinophagy in melatonin-related improvement of diabetic brain injury","volume":"27","author":"Yu","year":"2024","journal-title":"iScience"},{"key":"10.1016\/j.bioorg.2025.109357_bb0050","doi-asserted-by":"crossref","DOI":"10.1016\/j.bcp.2023.115846","article-title":"Melatonin protects HT-22 cells against palmitic acid-induced glucolipid metabolic dysfunction and cell injuries: involved in the regulation of synaptic plasticity and circadian rhythms","volume":"217","author":"Gao","year":"2023","journal-title":"Biochem. Pharmacol."},{"issue":"4","key":"10.1016\/j.bioorg.2025.109357_bb0055","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1038\/s41580-020-00324-8","article-title":"Ferroptosis: mechanisms, biology and role in disease","volume":"22","author":"Jiang","year":"2021","journal-title":"Nat. Rev. Mol. Cell Biol."},{"issue":"8","key":"10.1016\/j.bioorg.2025.109357_bb0060","doi-asserted-by":"crossref","first-page":"2105","DOI":"10.1007\/s11064-024-04185-x","article-title":"Electroacupuncture downregulating neuronal Ferroptosis in MCAO\/R rats by activating Nrf2\/SLC7A11\/GPX4 Axis","volume":"49","author":"Zhu","year":"2024","journal-title":"Neurochem. Res."},{"key":"10.1016\/j.bioorg.2025.109357_bb0065","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2023.154993","article-title":"Dendrobine rescues cognitive dysfunction in diabetic encephalopathy by inhibiting ferroptosis via activating Nrf2\/GPX4 axis","volume":"119","author":"Shi","year":"2023","journal-title":"Phytomedicine"},{"issue":"13","key":"10.1016\/j.bioorg.2025.109357_bb0070","doi-asserted-by":"crossref","first-page":"846","DOI":"10.1097\/WNR.0000000000002074","article-title":"Propofol ameliorates cognitive deficits following splenectomy in aged rats by inhibiting ferroptosis via the SIRT1\/Nrf2\/GPX4 pathway","volume":"35","author":"Wen","year":"2024","journal-title":"Neuroreport"},{"issue":"5","key":"10.1016\/j.bioorg.2025.109357_bb0075","doi-asserted-by":"crossref","first-page":"664","DOI":"10.1021\/acschemneuro.1c00819","article-title":"Ferristatin II, an Iron uptake inhibitor, exerts neuroprotection against traumatic brain injury via suppressing ferroptosis","volume":"13","author":"Cheng","year":"2022","journal-title":"ACS Chem. Neurosci."},{"issue":"2","key":"10.1016\/j.bioorg.2025.109357_bb0080","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1038\/s41422-020-00441-1","article-title":"Ferroptosis: molecular mechanisms and health implications","volume":"31","author":"Tang","year":"2021","journal-title":"Cell Res."},{"key":"10.1016\/j.bioorg.2025.109357_bb0085","doi-asserted-by":"crossref","DOI":"10.1016\/j.molmet.2022.101470","article-title":"Ferroptosis and ferritinophagy in diabetes complications","volume":"60","author":"He","year":"2022","journal-title":"Mol. Metab."},{"issue":"7","key":"10.1016\/j.bioorg.2025.109357_bb0090","doi-asserted-by":"crossref","first-page":"444","DOI":"10.1016\/j.tem.2021.04.010","article-title":"Ferritinophagy and ferroptosis in the management of metabolic diseases","volume":"32","author":"Ajoolabady","year":"2021","journal-title":"Trends Endocrinol. Metab."},{"issue":"10","key":"10.1016\/j.bioorg.2025.109357_bb0095","doi-asserted-by":"crossref","first-page":"2639","DOI":"10.1080\/15548627.2023.2213984","article-title":"Impaired lipophagy induced-microglial lipid droplets accumulation contributes to the buildup of TREM1 in diabetes-associated cognitive impairment","volume":"19","author":"Li","year":"2023","journal-title":"Autophagy"},{"issue":"9","key":"10.1016\/j.bioorg.2025.109357_bb0100","doi-asserted-by":"crossref","DOI":"10.1111\/cns.70575","article-title":"ApoE4 upregulates GSK-3\u03b2 to aggravate Alzheimer-like pathologies and cognitive impairment in type 2 diabetic mice","volume":"31","author":"Wang","year":"2025","journal-title":"CNS Neurosci. Ther."},{"issue":"4","key":"10.1016\/j.bioorg.2025.109357_bb0105","doi-asserted-by":"crossref","DOI":"10.1096\/fj.202002247RR","article-title":"Melatonin prevents diabetes-associated cognitive dysfunction from microglia-mediated neuroinflammation by activating autophagy via TLR4\/Akt\/mTOR pathway","volume":"35","author":"Cui","year":"2021","journal-title":"FASEB J."},{"issue":"2","key":"10.1016\/j.bioorg.2025.109357_bb0110","doi-asserted-by":"crossref","DOI":"10.1016\/j.acthis.2020.151677","article-title":"Melatonin ameliorates diabetes-induced brain injury in rats","volume":"123","author":"Amer","year":"2021","journal-title":"Acta Histochem."},{"issue":"10","key":"10.1016\/j.bioorg.2025.109357_bb0115","doi-asserted-by":"crossref","first-page":"1287","DOI":"10.1038\/s42255-022-00643-4","article-title":"Microglial hexokinase 2 deficiency increases ATP generation through lipid metabolism leading to \u03b2-amyloid clearance","volume":"4","author":"Leng","year":"2022","journal-title":"Nat. Metab."},{"issue":"1","key":"10.1016\/j.bioorg.2025.109357_bb0120","doi-asserted-by":"crossref","DOI":"10.1111\/jpi.12578","article-title":"Pharmacological doses of melatonin impede cognitive decline in tau-related Alzheimer models, once tauopathy is initiated, by restoring the autophagic flux","volume":"67","author":"Luengo","year":"2019","journal-title":"J. Pineal Res."},{"issue":"7","key":"10.1016\/j.bioorg.2025.109357_bb0125","doi-asserted-by":"crossref","first-page":"653","DOI":"10.1038\/s41419-022-05115-x","article-title":"The interaction between STING and NCOA4 exacerbates lethal sepsis by orchestrating ferroptosis and inflammatory responses in macrophages","volume":"13","author":"Wu","year":"2022","journal-title":"Cell Death Dis."},{"issue":"8","key":"10.1016\/j.bioorg.2025.109357_bb0130","doi-asserted-by":"crossref","first-page":"3848","DOI":"10.1007\/s12035-021-02390-1","article-title":"The mTOR\/NF-\u03baB pathway mediates Neuroinflammation and synaptic plasticity in diabetic encephalopathy","volume":"58","author":"Xu","year":"2021","journal-title":"Mol. Neurobiol."},{"key":"10.1016\/j.bioorg.2025.109357_bb0135","doi-asserted-by":"crossref","DOI":"10.1016\/j.brainres.2025.149824","article-title":"P2X7R activation promotes ferroptosis in dopaminergic neurons via NF-\u03baB signaling pathway in vitro and in vivo models of MPP(+)\/MPTP-induced Parkinson\u2019s disease","volume":"1865","author":"Si","year":"2025","journal-title":"Brain Res."},{"key":"10.1016\/j.bioorg.2025.109357_bb0140","doi-asserted-by":"crossref","DOI":"10.1016\/j.expneurol.2023.114414","article-title":"Erythropoietin ameliorates cognitive dysfunction in mice with type 2 diabetes mellitus via inhibiting iron overload and ferroptosis","volume":"365","author":"Guo","year":"2023","journal-title":"Exp. Neurol."},{"issue":"1","key":"10.1016\/j.bioorg.2025.109357_bb0145","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1186\/s12964-023-01328-5","article-title":"Neuron-targeted overexpression of caveolin-1 alleviates diabetes-associated cognitive dysfunction via regulating mitochondrial fission-mitophagy axis","volume":"21","author":"Tang","year":"2023","journal-title":"Cell Commun. Signal"},{"issue":"Pt B","key":"10.1016\/j.bioorg.2025.109357_bb0150","article-title":"Targeting ferroptosis in the neurovascular unit: a promising approach for treating diabetic cognitive impairment","volume":"142","author":"Zhang","year":"2024","journal-title":"Int. Immunopharmacol."},{"key":"10.1016\/j.bioorg.2025.109357_bb0155","doi-asserted-by":"crossref","DOI":"10.1155\/2024\/5661751","article-title":"Insufficient plasma melatonin and its association with neuropsychiatric impairments in patients with T2DM","volume":"2024","author":"He","year":"2024","journal-title":"J. Diabetes Res."},{"issue":"7","key":"10.1016\/j.bioorg.2025.109357_bb0160","doi-asserted-by":"crossref","first-page":"1415","DOI":"10.1007\/s11010-022-04596-w","article-title":"The protective effects of melatonin in high glucose environment by alleviating autophagy and apoptosis on primary cortical neurons","volume":"478","author":"Xiong","year":"2023","journal-title":"Mol. Cell. Biochem."},{"issue":"9","key":"10.1016\/j.bioorg.2025.109357_bb0165","doi-asserted-by":"crossref","first-page":"548","DOI":"10.1038\/s41577-021-00524-z","article-title":"The cGAS-STING pathway as a therapeutic target in inflammatory diseases","volume":"21","author":"Decout","year":"2021","journal-title":"Nat. Rev. Immunol."},{"issue":"3","key":"10.1016\/j.bioorg.2025.109357_bb0170","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2023.112185","article-title":"NF-\u03baB activation enhances STING signaling by altering microtubule-mediated STING trafficking","volume":"42","author":"Zhang","year":"2023","journal-title":"Cell Rep."},{"issue":"1","key":"10.1016\/j.bioorg.2025.109357_bb0175","doi-asserted-by":"crossref","first-page":"6770","DOI":"10.1038\/s41467-023-42150-4","article-title":"ARF1 prevents aberrant type I interferon induction by regulating STING activation and recycling","volume":"14","author":"Hirschenberger","year":"2023","journal-title":"Nat. Commun."},{"key":"10.1016\/j.bioorg.2025.109357_bb0180","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2019.101215","article-title":"STING-IRF3 contributes to lipopolysaccharide-induced cardiac dysfunction, inflammation, apoptosis and pyroptosis by activating NLRP3","volume":"24","author":"Li","year":"2019","journal-title":"Redox Biol."},{"issue":"1","key":"10.1016\/j.bioorg.2025.109357_bb0185","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1038\/s41392-022-01304-4","article-title":"Intratumoral microbiota: roles in cancer initiation, development and therapeutic efficacy","volume":"8","author":"Yang","year":"2023","journal-title":"Signal Transduct. Target. Ther."},{"key":"10.1016\/j.bioorg.2025.109357_bb0190","doi-asserted-by":"crossref","first-page":"348","DOI":"10.1016\/j.freeradbiomed.2023.08.025","article-title":"STING promotes ferroptosis through NCOA4-dependent ferritinophagy in acute kidney injury","volume":"208","author":"Jin","year":"2023","journal-title":"Free Radic. Biol. Med."}],"container-title":["Bioorganic Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0045206825012374?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0045206825012374?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,1,17]],"date-time":"2026-01-17T13:48:36Z","timestamp":1768657716000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0045206825012374"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,2]]},"references-count":38,"alternative-id":["S0045206825012374"],"URL":"https:\/\/doi.org\/10.1016\/j.bioorg.2025.109357","relation":{},"ISSN":["0045-2068"],"issn-type":[{"value":"0045-2068","type":"print"}],"subject":[],"published":{"date-parts":[[2026,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Melatonin impedes NCOA4\/ACSL4-dependent ferroptosis by targeting STING to ameliorate diabetic cognitive dysfunction","name":"articletitle","label":"Article Title"},{"value":"Bioorganic Chemistry","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bioorg.2025.109357","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"109357"}}