{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,21]],"date-time":"2026-01-21T06:53:39Z","timestamp":1768978419165,"version":"3.49.0"},"reference-count":73,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100005891","name":"National Administration of Traditional Chinese Medicine","doi-asserted-by":"publisher","award":["GZY-KJS-SD-2023-061"],"award-info":[{"award-number":["GZY-KJS-SD-2023-061"]}],"id":[{"id":"10.13039\/501100005891","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100019446","name":"Medical and Health Science and Technology Development Project of Shandong Province","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100019446","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100020206","name":"Shandong Provincial Health Commission","doi-asserted-by":"publisher","award":["202302040300"],"award-info":[{"award-number":["202302040300"]}],"id":[{"id":"10.13039\/501100020206","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Bioorganic Chemistry"],"published-print":{"date-parts":[[2026,2]]},"DOI":"10.1016\/j.bioorg.2025.109394","type":"journal-article","created":{"date-parts":[[2025,12,15]],"date-time":"2025-12-15T17:00:02Z","timestamp":1765818002000},"page":"109394","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Protopine attenuates hepatic fibrosis via HDAC6-mediated NLRP3 inflammasome activation"],"prefix":"10.1016","volume":"169","author":[{"given":"Yamei","family":"Li","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Minyan","family":"Liang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xinjing","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qinghua","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jing","family":"Nie","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lei","family":"Sun","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"12","key":"10.1016\/j.bioorg.2025.109394_bb0005","article-title":"Diagnosis and treatment of liver disease: current trends and future directions","volume":"15","author":"Wazir","year":"2023","journal-title":"Cureus"},{"issue":"3","key":"10.1016\/j.bioorg.2025.109394_bb0010","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1038\/s41575-020-00372-7","article-title":"Molecular and cellular mechanisms of liver fibrosis and its regression","volume":"18","author":"Kisseleva","year":"2021","journal-title":"Nat. Rev. Gastroenterol. Hepatol."},{"issue":"2","key":"10.1016\/j.bioorg.2025.109394_bb0015","doi-asserted-by":"crossref","first-page":"516","DOI":"10.1016\/j.jhep.2023.03.017","article-title":"Global burden of liver disease: 2023 update","volume":"79","author":"Devarbhavi","year":"2023","journal-title":"J. Hepatol."},{"key":"10.1016\/j.bioorg.2025.109394_bb0020","series-title":"Pathogenesis and Reversal of Liver Fibrosis: Effects of Genes and Environment","author":"Sokolovic","year":"2013"},{"issue":"7","key":"10.1016\/j.bioorg.2025.109394_bb0025","doi-asserted-by":"crossref","first-page":"879","DOI":"10.1038\/s41401-018-0194-4","article-title":"Magnesium isoglycyrrhizinate ameliorates high fructose-induced liver fibrosis in rat by increasing miR-375-3p to suppress JAK2\/STAT3 pathway and TGF-\u03b21\/Smad signaling","volume":"40","author":"Yang","year":"2019","journal-title":"Acta Pharmacol. Sin."},{"issue":"8","key":"10.1016\/j.bioorg.2025.109394_bb0030","doi-asserted-by":"crossref","first-page":"789","DOI":"10.1089\/jmf.2015.0104","article-title":"Beneficial effects of silymarin after the discontinuation of CCl4-induced liver fibrosis","volume":"19","author":"Clichici","year":"2016","journal-title":"J. Med. Food"},{"key":"10.1016\/j.bioorg.2025.109394_bb0035","doi-asserted-by":"crossref","DOI":"10.3389\/fnut.2021.719197","article-title":"Clinical risk factors of Licorice-induced Pseudoaldosteronism based on glycyrrhizin-metabolite concentrations: a narrative review","volume":"8","author":"Yoshino","year":"2021","journal-title":"Front. Nutr."},{"issue":"6","key":"10.1016\/j.bioorg.2025.109394_bb0040","doi-asserted-by":"crossref","first-page":"1627","DOI":"10.1002\/ptr.6361","article-title":"Safety and toxicity of silymarin, the major constituent of milk thistle extract: An updated review","volume":"33","author":"Soleimani","year":"2019","journal-title":"Phytotherapy Research : PTR"},{"key":"10.1016\/j.bioorg.2025.109394_bb0045","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2023.102691","article-title":"STING mediates hepatocyte pyroptosis in liver fibrosis by epigenetically activating the NLRP3 inflammasome","volume":"62","author":"Xiao","year":"2023","journal-title":"Redox Biol."},{"key":"10.1016\/j.bioorg.2025.109394_bb0050","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1146\/annurev-pathmechdis-032521-102529","article-title":"Role of the inflammasome in liver disease","volume":"17","author":"de Carvalho Ribeiro","year":"2022","journal-title":"Annu. Rev. Pathol."},{"issue":"3","key":"10.1016\/j.bioorg.2025.109394_bb0055","doi-asserted-by":"crossref","first-page":"727","DOI":"10.1002\/hep.32320","article-title":"NOD-like receptor protein 3 activation causes spontaneous inflammation and fibrosis that mimics human NASH","volume":"76","author":"Calcagno","year":"2022","journal-title":"Hepatology (Baltimore, Md.)"},{"issue":"8","key":"10.1016\/j.bioorg.2025.109394_bb0060","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1038\/s41577-019-0165-0","article-title":"The NLRP3 inflammasome: molecular activation and regulation to therapeutics","volume":"19","author":"Swanson","year":"2019","journal-title":"Nat. Rev. Immunol."},{"issue":"3","key":"10.1016\/j.bioorg.2025.109394_bb0065","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1016\/S1074-7613(04)00046-9","article-title":"NALP3 forms an IL-1beta-processing inflammasome with increased activity in muckle-Wells autoinflammatory disorder","volume":"20","author":"Agostini","year":"2004","journal-title":"Immunity"},{"issue":"12","key":"10.1016\/j.bioorg.2025.109394_bb0070","doi-asserted-by":"crossref","first-page":"1012","DOI":"10.1016\/j.tibs.2016.09.002","article-title":"Mechanism and regulation of NLRP3 inflammasome activation","volume":"41","author":"He","year":"2016","journal-title":"Trends Biochem. Sci."},{"issue":"6","key":"10.1016\/j.bioorg.2025.109394_bb0075","doi-asserted-by":"crossref","first-page":"1968","DOI":"10.1002\/hep.32776","article-title":"Interleukin-18 signaling promotes activation of hepatic stellate cells in mouse liver fibrosis","volume":"77","author":"Knorr","year":"2023","journal-title":"Hepatology (Baltimore, Md.)"},{"key":"10.1016\/j.bioorg.2025.109394_bb0080","doi-asserted-by":"crossref","DOI":"10.1016\/j.bcp.2023.115861","article-title":"NLRP3 inflammasome in hepatic diseases: a pharmacological target","volume":"217","author":"Ramos-Tovar","year":"2023","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.bioorg.2025.109394_bb0085","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2025.114678","article-title":"TJ0113 attenuates fibrosis in metabolic dysfunction-associated steatohepatitis by inducing mitophagy","volume":"156","author":"Huang","year":"2025","journal-title":"Int. Immunopharmacol."},{"key":"10.1016\/j.bioorg.2025.109394_bb0090","doi-asserted-by":"crossref","DOI":"10.1016\/j.scitotenv.2023.165500","article-title":"Dibutyl phthalate induces liver fibrosis via p38MAPK\/NF-\u03baB\/NLRP3-mediated pyroptosis","volume":"897","author":"Huo","year":"2023","journal-title":"Sci. Total Environ."},{"issue":"5","key":"10.1016\/j.bioorg.2025.109394_bb0095","doi-asserted-by":"crossref","first-page":"1037","DOI":"10.1016\/j.jhep.2017.01.022","article-title":"NLRP3 inflammasome blockade reduces liver inflammation and fibrosis in experimental NASH in mice","volume":"66","author":"Mridha","year":"2017","journal-title":"J. Hepatol."},{"key":"10.1016\/j.bioorg.2025.109394_bb0100","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1016\/j.intimp.2019.02.016","article-title":"The selective NLRP3 inflammasome inhibitor MCC950 alleviates cholestatic liver injury and fibrosis in mice","volume":"70","author":"Qu","year":"2019","journal-title":"Int. Immunopharmacol."},{"issue":"11","key":"10.1016\/j.bioorg.2025.109394_bb0105","doi-asserted-by":"crossref","first-page":"1854","DOI":"10.1136\/gutjnl-2023-331447","article-title":"Neutrophil extracellular traps activate hepatic stellate cells and monocytes via NLRP3 sensing in alcohol-induced acceleration of MASH fibrosis","volume":"73","author":"Babuta","year":"2024","journal-title":"Gut"},{"issue":"5","key":"10.1016\/j.bioorg.2025.109394_bb0110","doi-asserted-by":"crossref","DOI":"10.3390\/biom12050634","article-title":"The mechanism and regulation of the NLRP3 inflammasome during fibrosis","volume":"12","author":"Artlett","year":"2022","journal-title":"Biomolecules"},{"issue":"2","key":"10.1016\/j.bioorg.2025.109394_bb0115","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1055\/s-0037-1601350","article-title":"Inflammasomes in liver fibrosis","volume":"37","author":"Alegre","year":"2017","journal-title":"Semin. Liver Dis."},{"issue":"2021","key":"10.1016\/j.bioorg.2025.109394_bb0120","volume":"12","author":"Zhang","year":"2021","journal-title":"Inflammasomes and Fibrosis"},{"issue":"4","key":"10.1016\/j.bioorg.2025.109394_bb0125","doi-asserted-by":"crossref","first-page":"1497","DOI":"10.1159\/000490866","article-title":"Effects of the TLR4\/Myd88\/NF-\u03baB Signaling pathway on NLRP3 inflammasome in coronary microembolization-induced myocardial injury","volume":"47","author":"Su","year":"2018","journal-title":"Cell. Physiol. Biochem."},{"issue":"9","key":"10.1016\/j.bioorg.2025.109394_bb0130","doi-asserted-by":"crossref","first-page":"1980","DOI":"10.1038\/s12276-024-01298-9","article-title":"STAT3 promotes NLRP3 inflammasome activation by mediating NLRP3 mitochondrial translocation","volume":"56","author":"Luo","year":"2024","journal-title":"Exp. Mol. Med."},{"key":"10.1016\/j.bioorg.2025.109394_bb0135","doi-asserted-by":"crossref","DOI":"10.3389\/fnagi.2022.879021","article-title":"The NLRP3 inflammasome pathway: a review of mechanisms and inhibitors for the treatment of inflammatory diseases","volume":"14","author":"Blevins","year":"2022","journal-title":"Front. Aging Neurosci."},{"issue":"12","key":"10.1016\/j.bioorg.2025.109394_bb0140","doi-asserted-by":"crossref","first-page":"2746","DOI":"10.1021\/acschembio.1c00681","article-title":"Attenuation of NLRP3 inflammasome activation by indirubin-derived PROTAC targeting HDAC6","volume":"16","author":"Cao","year":"2021","journal-title":"ACS Chem. Biol."},{"issue":"6510","key":"10.1016\/j.bioorg.2025.109394_bb0145","doi-asserted-by":"crossref","DOI":"10.1126\/science.aas8995","article-title":"HDAC6 mediates an aggresome-like mechanism for NLRP3 and pyrin inflammasome activation","volume":"369","author":"Magupalli","year":"2020","journal-title":"Science (New York, N.Y.)"},{"issue":"4","key":"10.1016\/j.bioorg.2025.109394_bb0150","doi-asserted-by":"crossref","first-page":"671","DOI":"10.1083\/jcb.201001039","article-title":"Disease-causing mutations in parkin impair mitochondrial ubiquitination, aggregation, and HDAC6-dependent mitophagy","volume":"189","author":"Lee","year":"2010","journal-title":"J. Cell Biol."},{"issue":"1","key":"10.1016\/j.bioorg.2025.109394_bb0155","doi-asserted-by":"crossref","first-page":"3923","DOI":"10.1038\/s41598-017-04142-5","article-title":"Mito-xenophagic killing of bacteria is coordinated by a metabolic switch in dendritic cells","volume":"7","author":"Radomski","year":"2017","journal-title":"Sci. Rep."},{"issue":"12","key":"10.1016\/j.bioorg.2025.109394_bb0160","doi-asserted-by":"crossref","DOI":"10.1371\/journal.ppat.1006799","article-title":"HDAC6 controls innate immune and autophagy responses to TLR-mediated signalling by the intracellular bacteria listeria monocytogenes","volume":"13","author":"Moreno-Gonzalo","year":"2017","journal-title":"PLoS Pathog."},{"key":"10.1016\/j.bioorg.2025.109394_bb0165","doi-asserted-by":"crossref","first-page":"818","DOI":"10.1016\/j.biopha.2017.10.103","article-title":"Histone deacetylase 6 inhibitor ACY-1215 protects against experimental acute liver failure by regulating the TLR4-MAPK\/NF-\u03baB pathway","volume":"97","author":"Zhang","year":"2018","journal-title":"Biomed. Pharmacother."},{"issue":"2","key":"10.1016\/j.bioorg.2025.109394_bb0170","doi-asserted-by":"crossref","first-page":"644","DOI":"10.1002\/hep.25699","article-title":"Histone deacetylase 6 functions as a tumor suppressor by activating c-Jun NH2-terminal kinase-mediated beclin 1-dependent autophagic cell death in liver cancer","volume":"56","author":"Jung","year":"2012","journal-title":"Hepatology (Baltimore, Md.)"},{"issue":"10","key":"10.1016\/j.bioorg.2025.109394_bb0175","doi-asserted-by":"crossref","DOI":"10.3390\/ijms25105398","article-title":"Protopine and Allocryptopine interactions with plasma proteins","volume":"25","author":"Marciniak","year":"2024","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.bioorg.2025.109394_bb0180","series-title":"An isoquinoline alkaloid, Protopine from Corydalis govaniana growing in Himalayan region of Nepal","first-page":"106","volume":"28","author":"Shrestha","year":"2013"},{"issue":"1","key":"10.1016\/j.bioorg.2025.109394_bb0185","doi-asserted-by":"crossref","DOI":"10.3390\/molecules27010215","article-title":"Identification and quantification, metabolism and pharmacokinetics, pharmacological activities, and botanical preparations of protopine: a review","volume":"27","author":"Huang","year":"2021","journal-title":"Molecules (Basel, Switzerland)"},{"issue":"6","key":"10.1016\/j.bioorg.2025.109394_bb0190","doi-asserted-by":"crossref","first-page":"84","DOI":"10.15586\/aei.v50i6.669","article-title":"Protopine alleviates lipopolysaccharide-triggered intestinal epithelial cell injury through retarding the NLRP3 and NF-\u03baB signaling pathways to reduce inflammation and oxidative stress","volume":"50","author":"Li","year":"2022","journal-title":"Allergol. Immunopathol."},{"key":"10.1016\/j.bioorg.2025.109394_bb0195","article-title":"Protopine promotes the proteasomal degradation of pathological tau in Alzheimer's disease models via HDAC6 inhibition","volume":"96","author":"Sreenivasmurthy","year":"2022","journal-title":"Phytomed. Int. J. Phytother. Phytopharm."},{"issue":"1","key":"10.1016\/j.bioorg.2025.109394_bb0200","doi-asserted-by":"crossref","first-page":"396","DOI":"10.1186\/s12935-021-02105-5","article-title":"Protopine triggers apoptosis via the intrinsic pathway and regulation of ROS\/PI3K\/Akt signalling pathway in liver carcinoma","volume":"21","author":"Nie","year":"2021","journal-title":"Cancer Cell Int."},{"issue":"2","key":"10.1016\/j.bioorg.2025.109394_bb0205","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1016\/j.toxlet.2011.03.015","article-title":"Protopine and allocryptopine increase mRNA levels of cytochromes P450 1A in human hepatocytes and HepG2 cells independently of AhR","volume":"203","author":"Vrba","year":"2011","journal-title":"Toxicol. Lett."},{"issue":"10","key":"10.1016\/j.bioorg.2025.109394_bb0210","first-page":"1795","article-title":"Study on alkaloids of Corydalis ochotensis and their antitumor bioactivity","volume":"37","author":"Yu","year":"2014","journal-title":"Zhong yao cai = Zhongyaocai = J. Chinese Med. Mater."},{"issue":"1","key":"10.1016\/j.bioorg.2025.109394_bb0215","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1006\/phrs.1997.0195","article-title":"Anti-thrombotic and anti-inflammatory activities of protopine","volume":"36","author":"Saeed","year":"1997","journal-title":"Pharmacol. Res."},{"issue":"2","key":"10.1016\/j.bioorg.2025.109394_bb0220","doi-asserted-by":"crossref","first-page":"415","DOI":"10.4314\/ajtcam.v11i2.28","article-title":"Protopine inhibits heterotypic cell adhesion in MDA-MB-231 cells through down-regulation of multi-adhesive factors","volume":"11","author":"He","year":"2014","journal-title":"African Journal of Traditional, Complementary, and Alternative Medicines\u202f: AJTCAM"},{"key":"10.1016\/j.bioorg.2025.109394_bb0225","doi-asserted-by":"crossref","first-page":"709","DOI":"10.3389\/fcell.2020.00709","article-title":"Hepatic stellate cells and hepatocarcinogenesis","volume":"8","author":"Barry","year":"2020","journal-title":"Front. Cell Develop. Biol."},{"issue":"4","key":"10.1016\/j.bioorg.2025.109394_bb0230","doi-asserted-by":"crossref","DOI":"10.3390\/cells9040875","article-title":"Liver fibrosis: mechanistic concepts and therapeutic perspectives","volume":"9","author":"Roehlen","year":"2020","journal-title":"Cells"},{"issue":"23","key":"10.1016\/j.bioorg.2025.109394_bb0235","doi-asserted-by":"crossref","DOI":"10.3390\/ijms222312782","article-title":"Proteomic changes of activated hepatic stellate cells","volume":"22","author":"Schinagl","year":"2021","journal-title":"Int. J. Mol. Sci."},{"issue":"1","key":"10.1016\/j.bioorg.2025.109394_bb0240","doi-asserted-by":"crossref","first-page":"17403","DOI":"10.1038\/s41598-025-02613-8","article-title":"Adherence to plant based diets reduce the risk of hepatic fibrosis in nonalcoholic fatty liver disease","volume":"15","author":"Miryan","year":"2025","journal-title":"Sci. Rep."},{"issue":"1","key":"10.1016\/j.bioorg.2025.109394_bb0245","doi-asserted-by":"crossref","first-page":"18","DOI":"10.4062\/biomolther.2024.188","article-title":"New insights into AMPK, as a potential therapeutic target in metabolic dysfunction-associated Steatotic liver disease and hepatic fibrosis","volume":"33","author":"An","year":"2025","journal-title":"Biomol. Ther."},{"key":"10.1016\/j.bioorg.2025.109394_bb0250","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2021.108051","article-title":"Crosstalk between hepatic stellate cells and surrounding cells in hepatic fibrosis","volume":"99","author":"Yang","year":"2021","journal-title":"Int. Immunopharmacol."},{"key":"10.1016\/j.bioorg.2025.109394_bb0255","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2023.1284742","article-title":"The regulatory role and mechanism of exosomes in hepatic fibrosis","volume":"14","author":"Yao","year":"2023","journal-title":"Front. Pharmacol."},{"issue":"5","key":"10.1016\/j.bioorg.2025.109394_bb0260","doi-asserted-by":"crossref","first-page":"168","DOI":"10.21037\/atm.2020.02.21","article-title":"Palmitic acid stimulates NLRP3 inflammasome activation through TLR4-NF-\u03baB signal pathway in hepatic stellate cells","volume":"8","author":"Dong","year":"2020","journal-title":"Ann. Transl. Med."},{"issue":"1","key":"10.1016\/j.bioorg.2025.109394_bb0265","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1097\/HEP.0000000000001133","article-title":"The desulfinylation enzyme sulfiredoxin-1 attenuates HSC activation and liver fibrosis by modulating the PTPN12-NLRP3 axis","volume":"82","author":"Kim","year":"2025","journal-title":"Hepatology (Baltimore, Md.)"},{"key":"10.1016\/j.bioorg.2025.109394_bb0270","doi-asserted-by":"crossref","DOI":"10.1155\/2020\/7269150","article-title":"The role of autophagy and NLRP3 inflammasome in liver fibrosis","volume":"2020","author":"Tao","year":"2020","journal-title":"Biomed. Res. Int."},{"issue":"12","key":"10.1016\/j.bioorg.2025.109394_bb0275","doi-asserted-by":"crossref","first-page":"1787","DOI":"10.1007\/s00109-022-02270-8","article-title":"Hepatic HRC induces hepatocyte pyroptosis and HSCs activation via NLRP3\/caspase-1 pathway","volume":"100","author":"Wu","year":"2022","journal-title":"J. Mol. Med. (Berl)"},{"key":"10.1016\/j.bioorg.2025.109394_bb0280","doi-asserted-by":"crossref","DOI":"10.1016\/j.bioorg.2022.105971","article-title":"Dehydromevalonolactone ameliorates liver fibrosis and inflammation by repressing activation of NLRP3 inflammasome","volume":"127","author":"Niu","year":"2022","journal-title":"Bioorg. Chem."},{"issue":"13","key":"10.1016\/j.bioorg.2025.109394_bb0285","doi-asserted-by":"crossref","DOI":"10.3390\/ijms23136996","article-title":"Fibrogenic pathways in metabolic dysfunction associated fatty liver disease (MAFLD)","volume":"23","author":"Subramanian","year":"2022","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.bioorg.2025.109394_bb0290","doi-asserted-by":"crossref","DOI":"10.3389\/fbioe.2023.1223737","article-title":"Characterization of human stem cell-derived hepatic stellate cells and liver sinusoidal endothelial cells during extended in vitro culture","volume":"11","author":"Wilhelmsen","year":"2023","journal-title":"Front. Bioeng. Biotechnol."},{"issue":"3","key":"10.1016\/j.bioorg.2025.109394_bb0295","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1111\/1759-7714.12974","article-title":"Targeted inhibition of histone deacetylase 6 in inflammatory diseases","volume":"10","author":"Ran","year":"2019","journal-title":"Thoracic Cancer"},{"issue":"6","key":"10.1016\/j.bioorg.2025.109394_bb0300","doi-asserted-by":"crossref","first-page":"569","DOI":"10.1165\/rcmb.2021-0269ED","article-title":"HDAC6: a neglected player in chronic obstructive pulmonary disease?","volume":"65","author":"Ito","year":"2021","journal-title":"Am. J. Respir. Cell Mol. Biol."},{"key":"10.1016\/j.bioorg.2025.109394_bb0305","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2021.763831","article-title":"The role of HDAC6 in autophagy and NLRP3 inflammasome","volume":"12","author":"Chang","year":"2021","journal-title":"Front. Immunol."},{"issue":"4","key":"10.1016\/j.bioorg.2025.109394_bb0310","doi-asserted-by":"crossref","first-page":"3080","DOI":"10.1021\/acs.jmedchem.1c02067","article-title":"Chasing a breath of fresh air in cystic fibrosis (CF): therapeutic potential of selective HDAC6 inhibitors to tackle multiple pathways in CF pathophysiology","volume":"65","author":"Barone","year":"2022","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.bioorg.2025.109394_bb0315","doi-asserted-by":"crossref","DOI":"10.1016\/j.metabol.2024.156108","article-title":"HDAC6 mediates NLRP3 inflammasome activation in the pathogenesis of diabetic retinopathy","volume":"164","author":"Kim","year":"2025","journal-title":"Metab. Clin. Exp."},{"key":"10.1016\/j.bioorg.2025.109394_bb0320","series-title":"HDAC6 and CXCL13 Mediate Atopic Dermatitis by Regulating Cellular Interactions and Expression Levels of miR-9 and SIRT1","first-page":"2021","volume":"12","author":"Kwon","year":"2021"},{"key":"10.1016\/j.bioorg.2025.109394_bb0325","doi-asserted-by":"crossref","DOI":"10.1016\/j.fct.2019.110583","article-title":"Protopine attenuates inflammation stimulated by carrageenan and LPS via the MAPK\/NF-\u03baB pathway","volume":"131","author":"Alam","year":"2019","journal-title":"Food Chem. Toxicol."},{"issue":"1","key":"10.1016\/j.bioorg.2025.109394_bb0330","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.canlet.2011.09.042","article-title":"Protopine, a novel microtubule-stabilizing agent, causes mitotic arrest and apoptotic cell death in human hormone-refractory prostate cancer cell lines","volume":"315","author":"Chen","year":"2012","journal-title":"Cancer Lett."},{"key":"10.1016\/j.bioorg.2025.109394_bb0335","doi-asserted-by":"crossref","DOI":"10.1016\/j.phrs.2022.106126","article-title":"Natural isoquinoline alkaloids: pharmacological features and multi-target potential for complex diseases","volume":"177","author":"Plazas","year":"2022","journal-title":"Pharmacol. Res."},{"key":"10.1016\/j.bioorg.2025.109394_bb0340","article-title":"4-OI attenuates carbon tetrachloride-induced hepatic injury via regulating oxidative stress and the inflammatory response","volume":"12","author":"Li","year":"2021","journal-title":"Front. Pharmacol."},{"issue":"2","key":"10.1016\/j.bioorg.2025.109394_bb0345","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1080\/713611034","article-title":"Hepatotoxicity and mechanism of action of haloalkanes: carbon tetrachloride as a toxicological model","volume":"33","author":"Weber","year":"2003","journal-title":"Crit. Rev. Toxicol."},{"key":"10.1016\/j.bioorg.2025.109394_bb0350","doi-asserted-by":"crossref","DOI":"10.1016\/j.bcp.2023.115693","article-title":"Pharmacological inhibition of HDAC6 suppresses NLRP3 inflammasome-mediated IL-1\u03b2 release","volume":"215","author":"Bockstiegel","year":"2023","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.bioorg.2025.109394_bb0355","article-title":"Berberine ameliorate inflammation and apoptosis via modulating PI3K\/AKT\/NF\u03baB and MAPK pathway on dry eye","volume":"121","author":"Han","year":"2023","journal-title":"Phytomed. Int. J. Phytother. Phytopharm."},{"issue":"12","key":"10.1016\/j.bioorg.2025.109394_bb0360","doi-asserted-by":"crossref","first-page":"3282","DOI":"10.1080\/07391102.2018.1509731","article-title":"Interaction and photo-induced cleavage studies of meropenem drug with human serum albumin using spectroscopic and molecular docking investigations","volume":"37","author":"Abdo Esmail","year":"2019","journal-title":"J. Biomol. Struct. Dyn."},{"issue":"24","key":"10.1016\/j.bioorg.2025.109394_bb0365","doi-asserted-by":"crossref","first-page":"21841","DOI":"10.1021\/acs.jmedchem.4c01306","article-title":"Probing the biomolecular interactions of DNA\/HSA with the new Sn(IV) complex and computational perspectives: design, synthesis, characterization, anticancer activity, and molecular modeling approach","volume":"67","author":"Shamsi","year":"2024","journal-title":"J. Med. Chem."}],"container-title":["Bioorganic Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S004520682501274X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S004520682501274X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,1,20]],"date-time":"2026-01-20T18:12:22Z","timestamp":1768932742000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S004520682501274X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,2]]},"references-count":73,"alternative-id":["S004520682501274X"],"URL":"https:\/\/doi.org\/10.1016\/j.bioorg.2025.109394","relation":{},"ISSN":["0045-2068"],"issn-type":[{"value":"0045-2068","type":"print"}],"subject":[],"published":{"date-parts":[[2026,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Protopine attenuates hepatic fibrosis via HDAC6-mediated NLRP3 inflammasome activation","name":"articletitle","label":"Article Title"},{"value":"Bioorganic Chemistry","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bioorg.2025.109394","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"109394"}}