{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T00:46:47Z","timestamp":1792025207604,"version":"4.4.0"},"reference-count":80,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100006769","name":"Russian Science Foundation","doi-asserted-by":"publisher","award":["24-74-00057"],"award-info":[{"award-number":["24-74-00057"]}],"id":[{"id":"10.13039\/501100006769","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012190","name":"Ministry of Science and Higher Education of the Russian Federation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100012190","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Bioorganic Chemistry"],"published-print":{"date-parts":[[2026,2]]},"DOI":"10.1016\/j.bioorg.2025.109396","type":"journal-article","created":{"date-parts":[[2025,12,18]],"date-time":"2025-12-18T00:20:10Z","timestamp":1766017210000},"page":"109396","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":2,"special_numbering":"C","title":["4\u2033-modified azithromycin derivatives bearing nitrogen-containing heterocycles with dual inhibitory activity"],"prefix":"10.1016","volume":"169","author":[{"given":"Maksim M.","family":"Martynov","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Inna A.","family":"Volynkina","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Natalia E.","family":"Grammatikova","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maksim A.","family":"Kryakvin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nikolai D.","family":"Dagaev","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anastasiia O.","family":"Karakchieva","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olga A.","family":"Dontsova","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"George V.","family":"Zatonsky","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexander S.","family":"Tikhomirov","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrey E.","family":"Shchekotikhin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"10325","key":"10.1016\/j.bioorg.2025.109396_bb0005","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1016\/S0140-6736(21)02724-0","article-title":"Global burden of bacterial antimicrobial resistance in 2019: a systematic analysis","volume":"399","author":"Antimicrobial Resistance","year":"2022","journal-title":"Lancet"},{"issue":"5","key":"10.1016\/j.bioorg.2025.109396_bb0010","doi-asserted-by":"crossref","first-page":"1535","DOI":"10.1007\/s11756-021-00697-x","article-title":"Antibiotic resistance crisis: challenges and imperatives","volume":"76","author":"Church","year":"2021","journal-title":"Biologia"},{"key":"10.1016\/j.bioorg.2025.109396_bb0015","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1016\/j.coph.2014.09.006","article-title":"Update on the antibiotic resistance crisis","volume":"18","author":"Rossolini","year":"2014","journal-title":"Curr. Opin. Pharmacol."},{"key":"10.1016\/j.bioorg.2025.109396_bb0020","doi-asserted-by":"crossref","DOI":"10.1016\/j.jhazmat.2025.140040","article-title":"Deciphering structuring mechanism and increased health risk of antibiotic resistome from a coastal river basin to the downstream estuary and bay under anthropogenic disturbances","volume":"499","author":"Huang","year":"2025","journal-title":"J. Hazard. Mater."},{"issue":"10","key":"10.1016\/j.bioorg.2025.109396_bb0025","article-title":"Genomic epidemiology and the evolution of erm(B)-mediated macrolide resistance in Campylobacter","volume":"11","author":"Gao","year":"2025","journal-title":"Microb Genom"},{"issue":"9","key":"10.1016\/j.bioorg.2025.109396_bb0030","doi-asserted-by":"crossref","first-page":"668","DOI":"10.1016\/j.tibs.2018.06.011","article-title":"How macrolide antibiotics work","volume":"43","author":"Vazquez-Laslop","year":"2018","journal-title":"Trends Biochem. Sci."},{"issue":"40","key":"10.1016\/j.bioorg.2025.109396_bb0035","doi-asserted-by":"crossref","first-page":"17158","DOI":"10.1073\/pnas.1008685107","article-title":"Revisiting the structures of several antibiotics bound to the bacterial ribosome","volume":"107","author":"Bulkley","year":"2010","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"18","key":"10.1016\/j.bioorg.2025.109396_bb0040","doi-asserted-by":"crossref","first-page":"2967","DOI":"10.1111\/bph.13936","article-title":"The macrolide antibiotic renaissance","volume":"174","author":"Dinos","year":"2017","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.bioorg.2025.109396_bb0045","doi-asserted-by":"crossref","first-page":"368","DOI":"10.1016\/j.jgar.2024.07.016","article-title":"Understanding the evolution of macrolides resistance: a mini review","volume":"38","author":"Nor Amdan","year":"2024","journal-title":"J Glob Antimicrob Resist"},{"key":"10.1016\/j.bioorg.2025.109396_bb0050","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1146\/annurev-biochem-062917-011942","article-title":"Ribosome-targeting antibiotics: modes of action, mechanisms of Resistance, and implications for drug design","volume":"87","author":"Lin","year":"2018","journal-title":"Annu. Rev. Biochem."},{"issue":"12","key":"10.1016\/j.bioorg.2025.109396_bb0055","doi-asserted-by":"crossref","first-page":"3523","DOI":"10.1007\/s11172-024-4466-5","article-title":"Key areas of antibiotic research conducted at the Gause Institute of new Antibiotics","volume":"73","author":"Olsufyeva","year":"2024","journal-title":"Russ. Chem. Bull."},{"issue":"7","key":"10.1016\/j.bioorg.2025.109396_bb0060","doi-asserted-by":"crossref","DOI":"10.59761\/RCR5125","article-title":"The chemistry of heterocycles in the 21st century","volume":"93","author":"Charushin","year":"2024","journal-title":"Russ. Chem. Rev."},{"key":"10.1016\/j.bioorg.2025.109396_bb0065","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejmech.2020.112222","article-title":"Design, synthesis and structure-activity relationships of novel 15-membered macrolides: quinolone\/quinoline-containing sidechains tethered to the C-6 position of azithromycin acylides","volume":"193","author":"Fan","year":"2020","journal-title":"Eur. J. Med. Chem."},{"issue":"6","key":"10.1016\/j.bioorg.2025.109396_bb0070","doi-asserted-by":"crossref","first-page":"1045","DOI":"10.1021\/jm990618n","article-title":"Design, synthesis, and antimicrobial activity of 6-O-substituted ketolides active against resistant respiratory tract pathogens","volume":"43","author":"Or","year":"2000","journal-title":"J. Med. Chem."},{"issue":"8","key":"10.1016\/j.bioorg.2025.109396_bb0075","doi-asserted-by":"crossref","first-page":"2671","DOI":"10.1016\/j.bmcl.2010.01.153","article-title":"Synthesis and antibacterial activity of new 9-O-arylpropenyloxime ketolides","volume":"20","author":"Nam","year":"2010","journal-title":"Bioorg. Med. Chem. Lett."},{"issue":"15","key":"10.1016\/j.bioorg.2025.109396_bb0080","doi-asserted-by":"crossref","first-page":"5868","DOI":"10.1021\/jm100711p","article-title":"Synthesis and structure-activity relationships of novel 8a-aza-8a-homoerythromycin a ketolides","volume":"53","author":"Pavlovic","year":"2010","journal-title":"J. Med. Chem."},{"issue":"16","key":"10.1016\/j.bioorg.2025.109396_bb0085","doi-asserted-by":"crossref","first-page":"5198","DOI":"10.1016\/j.bmc.2015.04.078","article-title":"Exploiting translational stalling peptides in an effort to extend azithromycin interaction within the prokaryotic ribosome nascent peptide exit tunnel","volume":"23","author":"Washington","year":"2015","journal-title":"Bioorg. Med. Chem."},{"key":"10.1016\/j.bioorg.2025.109396_bb0090","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1016\/j.ejmech.2019.03.037","article-title":"Synthesis and structure-bactericidal activity relationships of non-ketolides: 9-oxime clarithromycin 11,12-cyclic carbonate featured with three-to eight-atom-length spacers at 3-OH","volume":"171","author":"Li","year":"2019","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.bioorg.2025.109396_bb0095","doi-asserted-by":"crossref","DOI":"10.1016\/j.bioorg.2022.106020","article-title":"Synthesis and biological evaluation of antibacterial activity of novel clarithromycin derivatives incorporating 1,2,3-triazole moieties at the 4\u2033- and 11-OH positions","volume":"127","author":"Qin","year":"2022","journal-title":"Bioorg. Chem."},{"issue":"21","key":"10.1016\/j.bioorg.2025.109396_bb0100","doi-asserted-by":"crossref","first-page":"3075","DOI":"10.1016\/S0960-894X(99)00534-X","article-title":"Synthesis and antibacterial activity of HMR 3647 a new ketolide highly potent against erythromycin-resistant and susceptible pathogens","volume":"9","author":"Denis","year":"1999","journal-title":"Bioorg. Med. Chem. Lett."},{"issue":"2","key":"10.1016\/j.bioorg.2025.109396_bb0105","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1517\/13543784.10.2.343","article-title":"ABT-773: a new ketolide antibiotic","volume":"10","author":"Dougherty","year":"2001","journal-title":"Expert Opin. Investig. Drugs"},{"issue":"4","key":"10.1016\/j.bioorg.2025.109396_bb0110","doi-asserted-by":"crossref","first-page":"1588","DOI":"10.1128\/AAC.01469-10","article-title":"In vitro antibacterial activity of modithromycin, a novel 6,11-bridged bicyclolide, against respiratory pathogens, including macrolide-resistant gram-positive cocci","volume":"55","author":"Sato","year":"2011","journal-title":"Antimicrob. Agents Chemother."},{"issue":"10","key":"10.1016\/j.bioorg.2025.109396_bb0115","doi-asserted-by":"crossref","first-page":"4010","DOI":"10.1016\/j.ejmech.2009.04.030","article-title":"Synthesis and antibacterial activity of novel 15-membered macrolide derivatives: 4\u2033-carbamate, 11,12-cyclic carbonate-4\u2033-carbamate and 11,4\u2033-di-O-arylcarbamoyl analogs of azithromycin","volume":"44","author":"Ma","year":"2009","journal-title":"Eur. J. Med. Chem."},{"issue":"10","key":"10.1016\/j.bioorg.2025.109396_bb0120","doi-asserted-by":"crossref","first-page":"5196","DOI":"10.1016\/j.ejmech.2011.08.001","article-title":"Novel C-4\u2033 modified azithromycin analogs with remarkably enhanced activity against erythromycin-resistant Streptococcus pneumoniae: the synthesis and antimicrobial evaluation","volume":"46","author":"Ma","year":"2011","journal-title":"Eur. J. Med. Chem."},{"issue":"3","key":"10.1016\/j.bioorg.2025.109396_bb0125","doi-asserted-by":"crossref","first-page":"915","DOI":"10.1016\/j.ejmech.2009.11.032","article-title":"Synthesis and antibacterial activity of novel 3-O-carbamoyl derivatives of clarithromycin and 11,12-cyclic carbonate azithromycin","volume":"45","author":"Zhang","year":"2010","journal-title":"Eur. J. Med. Chem."},{"issue":"2","key":"10.1016\/j.bioorg.2025.109396_bb0130","doi-asserted-by":"crossref","DOI":"10.3390\/ph17020187","article-title":"Hybrid molecules of azithromycin with chloramphenicol and metronidazole: synthesis and study of antibacterial properties","volume":"17","author":"Volynkina","year":"2024","journal-title":"Pharmaceuticals (Basel)"},{"issue":"7","key":"10.1016\/j.bioorg.2025.109396_bb0135","doi-asserted-by":"crossref","first-page":"3105","DOI":"10.1016\/j.ejmech.2011.04.004","article-title":"Synthesis and antibacterial activity of novel 4-O-benzimidazolyl clarithromycin derivatives","volume":"46","author":"Cong","year":"2011","journal-title":"Eur. J. Med. Chem."},{"issue":"11","key":"10.1016\/j.bioorg.2025.109396_bb0140","doi-asserted-by":"crossref","first-page":"3244","DOI":"10.1016\/j.bmcl.2010.04.062","article-title":"Novel 8a-aza-8a-homoerythromycin--4\u2033-(3-substituted-amino)propionates with broad spectrum antibacterial activity","volume":"20","author":"Hutinec","year":"2010","journal-title":"Bioorg. Med. Chem. Lett."},{"issue":"23","key":"10.1016\/j.bioorg.2025.109396_bb0145","doi-asserted-by":"crossref","first-page":"7270","DOI":"10.1016\/j.bmc.2011.07.011","article-title":"Synthesis and activity of new macrolones: conjugates between 6(7)-(2\u2032-aminoethyl)-amino-1-cyclopropyl-3-carboxylic acid (2\u2032-hydroxyethyl) amides and 4\u2033-propenoyl-azithromycin","volume":"19","author":"Kapic","year":"2011","journal-title":"Bioorg. Med. Chem."},{"issue":"8","key":"10.1016\/j.bioorg.2025.109396_bb0150","doi-asserted-by":"crossref","first-page":"3388","DOI":"10.1016\/j.ejmech.2011.05.002","article-title":"Synthesis, activity and pharmacokinetics of novel antibacterial 15-membered ring macrolones","volume":"46","author":"Fajdetic","year":"2011","journal-title":"Eur. J. Med. Chem."},{"issue":"17","key":"10.1016\/j.bioorg.2025.109396_bb0155","doi-asserted-by":"crossref","first-page":"6547","DOI":"10.1016\/j.bmc.2010.06.050","article-title":"Synthesis and biological activity of 4-O-acyl derivatives of 14- and 15-membered macrolides linked to omega-quinolone-carboxylic unit","volume":"18","author":"Skugor","year":"2010","journal-title":"Bioorg. Med. Chem."},{"issue":"17","key":"10.1016\/j.bioorg.2025.109396_bb0160","doi-asserted-by":"crossref","first-page":"6578","DOI":"10.1016\/j.bmc.2010.07.007","article-title":"Synthesis and properties of macrolones characterized by two ether bonds in the linker","volume":"18","author":"Jakopovic","year":"2010","journal-title":"Bioorg. Med. Chem."},{"issue":"6","key":"10.1016\/j.bioorg.2025.109396_bb0165","doi-asserted-by":"crossref","first-page":"1255","DOI":"10.1016\/j.bmc.2016.01.055","article-title":"Synthesis and antibacterial evaluation of novel 4\u2033-glycyl linked quinolyl-azithromycins with potent activity against macrolide-resistant pathogens","volume":"24","author":"Pavlovic","year":"2016","journal-title":"Bioorg. Med. Chem."},{"issue":"9","key":"10.1016\/j.bioorg.2025.109396_bb0170","doi-asserted-by":"crossref","first-page":"5337","DOI":"10.1128\/AAC.00524-16","article-title":"Macrolones are a novel class of macrolide antibiotics active against key resistant respiratory pathogens in vitro and in vivo","volume":"60","author":"Cipcic Paljetak","year":"2016","journal-title":"Antimicrob. Agents Chemother."},{"issue":"1","key":"10.1016\/j.bioorg.2025.109396_bb0175","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1038\/s41421-024-00702-y","article-title":"Synthetic macrolides overcoming MLS(B)K-resistant pathogens","volume":"10","author":"Ma","year":"2024","journal-title":"Cell Discov."},{"issue":"24","key":"10.1016\/j.bioorg.2025.109396_bb0180","doi-asserted-by":"crossref","first-page":"3131","DOI":"10.2174\/15680266113136660223","article-title":"Structure-activity relationships and mechanism of action of macrolides derived from erythromycin as antibacterial agents","volume":"13","author":"Liang","year":"2013","journal-title":"Curr. Top. Med. Chem."},{"issue":"5","key":"10.1016\/j.bioorg.2025.109396_bb0185","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1021\/ml100253p","article-title":"Discovery of 4\u2033-ether linked azithromycin-quinolone hybrid series: influence of the central linker on the antibacterial activity","volume":"2","author":"Pavlovic","year":"2011","journal-title":"ACS Med. Chem. Lett."},{"issue":"12","key":"10.1016\/j.bioorg.2025.109396_bb0190","doi-asserted-by":"crossref","first-page":"1680","DOI":"10.1038\/s41589-024-01685-3","article-title":"Macrolones target bacterial ribosomes and DNA gyrase and can evade resistance mechanisms","volume":"20","author":"Aleksandrova","year":"2024","journal-title":"Nat. Chem. Biol."},{"issue":"1","key":"10.1016\/j.bioorg.2025.109396_bb0195","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1038\/s41429-018-0107-2","article-title":"Synthesis and evaluation of biological activity of benzoxaborole derivatives of azithromycin","volume":"72","author":"Tevyashova","year":"2019","journal-title":"J. Antibiot. (Tokyo)"},{"key":"10.1016\/j.bioorg.2025.109396_bb0200","doi-asserted-by":"crossref","first-page":"1","DOI":"10.2174\/0113852728404096250908065829","article-title":"Synthesis and estimation of the antibacterial potency of a series of azithromycin- Siderophore conjugates","volume":"30","author":"Martynov","year":"2026","journal-title":"Curr. Org. Chem."},{"issue":"16","key":"10.1016\/j.bioorg.2025.109396_bb0205","doi-asserted-by":"crossref","first-page":"3872","DOI":"10.1016\/j.bmcl.2017.06.044","article-title":"Synthesis and antibacterial activity of novel 4-O-(1-aralkyl-1,2,3-triazol-4-methyl-carbamoyl) azithromycin analogs","volume":"27","author":"Wang","year":"2017","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"10.1016\/j.bioorg.2025.109396_bb0210","doi-asserted-by":"crossref","DOI":"10.1016\/j.bioorg.2019.103475","article-title":"Synthesis and antibacterial activity of 11,12-cyclic carbonate 4-O-aralkylacetylhydrazineacyl azithromycin derivatives","volume":"94","author":"Yan","year":"2020","journal-title":"Bioorg. Chem."},{"key":"10.1016\/j.bioorg.2025.109396_bb0215","doi-asserted-by":"crossref","first-page":"3422","DOI":"10.25083\/rbl\/27.2\/3422.3428","article-title":"Antitumor antibiotics: representatives, mechanisms of action and side effects","volume":"27","author":"Mihaescu","year":"2022","journal-title":"Rom. Biotechnol. Lett."},{"issue":"3","key":"10.1016\/j.bioorg.2025.109396_bb0220","doi-asserted-by":"crossref","first-page":"193","DOI":"10.2174\/1568005043340777","article-title":"Macrolide resistance based on the Erm-mediated rRNA methylation","volume":"4","author":"Maravic","year":"2004","journal-title":"Curr. Drug Targets Infect. Disord."},{"issue":"4","key":"10.1016\/j.bioorg.2025.109396_bb0225","doi-asserted-by":"crossref","first-page":"797","DOI":"10.1128\/AAC.39.4.797","article-title":"Insights into erythromycin action from studies of its activity as inducer of resistance","volume":"39","author":"Weisblum","year":"1995","journal-title":"Antimicrob. Agents Chemother."},{"issue":"3","key":"10.1016\/j.bioorg.2025.109396_bb0230","doi-asserted-by":"crossref","first-page":"866","DOI":"10.1128\/AAC.01266-07","article-title":"Induction of erm(C) expression by noninducing antibiotics","volume":"52","author":"Bailey","year":"2008","journal-title":"Antimicrob. Agents Chemother."},{"issue":"9","key":"10.1016\/j.bioorg.2025.109396_bb0235","doi-asserted-by":"crossref","first-page":"1429","DOI":"10.1016\/j.str.2024.06.013","article-title":"Berberine analog of chloramphenicol exhibits a distinct mode of action and unveils ribosome plasticity","volume":"32","author":"Batool","year":"2024","journal-title":"Structure"},{"issue":"6","key":"10.1016\/j.bioorg.2025.109396_bb0240","doi-asserted-by":"crossref","first-page":"715","DOI":"10.1261\/rna.073817.119","article-title":"Insights into the improved macrolide inhibitory activity from the high-resolution cryo-EM structure of dirithromycin bound to the E. Coli 70S ribosome","volume":"26","author":"Pichkur","year":"2020","journal-title":"RNA"},{"issue":"5","key":"10.1016\/j.bioorg.2025.109396_bb0245","doi-asserted-by":"crossref","first-page":"2559","DOI":"10.1128\/AAC.06187-11","article-title":"Target- and resistance-based mechanistic studies with TP-434, a novel fluorocycline antibiotic","volume":"56","author":"Grossman","year":"2012","journal-title":"Antimicrob. Agents Chemother."},{"issue":"8","key":"10.1016\/j.bioorg.2025.109396_bb0250","doi-asserted-by":"crossref","first-page":"3367","DOI":"10.1128\/AAC.49.8.3367-3372.2005","article-title":"Fluorescence polarization method to characterize macrolide-ribosome interactions","volume":"49","author":"Yan","year":"2005","journal-title":"Antimicrob. Agents Chemother."},{"issue":"6","key":"10.1016\/j.bioorg.2025.109396_bb0255","doi-asserted-by":"crossref","first-page":"842","DOI":"10.1016\/j.jmb.2018.01.016","article-title":"Binding and action of amino acid analogs of chloramphenicol upon the bacterial ribosome","volume":"430","author":"Tereshchenkov","year":"2018","journal-title":"J. Mol. Biol."},{"issue":"4","key":"10.1016\/j.bioorg.2025.109396_bb0260","doi-asserted-by":"crossref","first-page":"459","DOI":"10.4155\/fmc.14.157","article-title":"Targeting bacterial topoisomerase I to meet the challenge of finding new antibiotics","volume":"7","author":"Tse-Dinh","year":"2015","journal-title":"Future Med. Chem."},{"issue":"1","key":"10.1016\/j.bioorg.2025.109396_bb0265","doi-asserted-by":"crossref","first-page":"59","DOI":"10.32607\/actanaturae.11058","article-title":"Diversity and functions of type II topoisomerases","volume":"13","author":"Sutormin","year":"2021","journal-title":"Acta Nat."},{"key":"10.1016\/j.bioorg.2025.109396_bb0270","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1146\/annurev.biochem.70.1.369","article-title":"DNA topoisomerases: structure, function, and mechanism","volume":"70","author":"Champoux","year":"2001","journal-title":"Annu. Rev. Biochem."},{"issue":"1","key":"10.1016\/j.bioorg.2025.109396_bb0275","doi-asserted-by":"crossref","first-page":"4524","DOI":"10.1038\/s41467-022-32106-5","article-title":"Interaction between transcribing RNA polymerase and topoisomerase I prevents R-loop formation in E. Coli","volume":"13","author":"Sutormin","year":"2022","journal-title":"Nat. Commun."},{"issue":"23","key":"10.1016\/j.bioorg.2025.109396_bb0280","doi-asserted-by":"crossref","first-page":"16659","DOI":"10.1074\/jbc.274.23.16659","article-title":"Escherichia coli DNA topoisomerase I inhibits R-loop formation by relaxing transcription-induced negative supercoiling","volume":"274","author":"Masse","year":"1999","journal-title":"J. Biol. Chem."},{"issue":"4","key":"10.1016\/j.bioorg.2025.109396_bb0285","doi-asserted-by":"crossref","first-page":"888","DOI":"10.1046\/j.1365-2958.2000.01763.x","article-title":"Identification of a unique domain essential for Escherichia coli DNA topoisomerase III-catalysed decatenation of replication intermediates","volume":"35","author":"Li","year":"2000","journal-title":"Mol. Microbiol."},{"issue":"20","key":"10.1016\/j.bioorg.2025.109396_bb0290","doi-asserted-by":"crossref","first-page":"10432","DOI":"10.1093\/nar\/gks780","article-title":"Bacterial topoisomerase I and topoisomerase III relax supercoiled DNA via distinct pathways","volume":"40","author":"Terekhova","year":"2012","journal-title":"Nucleic Acids Res."},{"issue":"1","key":"10.1016\/j.bioorg.2025.109396_bb0295","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1016\/0092-8674(80)90252-4","article-title":"Formation and resolution of DNA catenanes by DNA gyrase","volume":"20","author":"Kreuzer","year":"1980","journal-title":"Cell"},{"issue":"6","key":"10.1016\/j.bioorg.2025.109396_bb0300","doi-asserted-by":"crossref","first-page":"748","DOI":"10.1101\/gad.872301","article-title":"Topoisomerase IV, alone, unknots DNA in E. coli","volume":"15","author":"Deibler","year":"2001","journal-title":"Genes Dev."},{"issue":"4","key":"10.1016\/j.bioorg.2025.109396_bb0305","doi-asserted-by":"crossref","first-page":"1097","DOI":"10.1021\/acsinfecdis.4c00128","article-title":"Gyrase and topoisomerase IV: recycling old targets for new Antibacterials to combat fluoroquinolone Resistance","volume":"10","author":"Collins","year":"2024","journal-title":"ACS Infect Dis"},{"issue":"1","key":"10.1016\/j.bioorg.2025.109396_bb0310","doi-asserted-by":"crossref","first-page":"1437","DOI":"10.1038\/s41598-018-19944-4","article-title":"Discovery of novel bacterial topoisomerase I inhibitors by use of in silico docking and in vitro assays","volume":"8","author":"Sandhaus","year":"2018","journal-title":"Sci. Rep."},{"issue":"4","key":"10.1016\/j.bioorg.2025.109396_bb0315","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1038\/s41429-022-00503-z","article-title":"Chrysomycin a inhibits the topoisomerase I of mycobacterium tuberculosis","volume":"75","author":"Muralikrishnan","year":"2022","journal-title":"J. Antibiot. (Tokyo)"},{"issue":"12","key":"10.1016\/j.bioorg.2025.109396_bb0320","doi-asserted-by":"crossref","first-page":"6640","DOI":"10.1073\/pnas.120163297","article-title":"One-step inactivation of chromosomal genes in Escherichia coli K-12 using PCR products","volume":"97","author":"Datsenko","year":"2000","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"12","key":"10.1016\/j.bioorg.2025.109396_bb0325","doi-asserted-by":"crossref","first-page":"7481","DOI":"10.1128\/AAC.02117-16","article-title":"Sorting out antibiotics\u2019 mechanisms of action: a double fluorescent protein reporter for high-throughput screening of ribosome and DNA biosynthesis inhibitors","volume":"60","author":"Osterman","year":"2016","journal-title":"Antimicrob. Agents Chemother."},{"issue":"18","key":"10.1016\/j.bioorg.2025.109396_bb0330","doi-asserted-by":"crossref","first-page":"3108","DOI":"10.1038\/emboj.2010.180","article-title":"The key function of a conserved and modified rRNA residue in the ribosomal response to the nascent peptide","volume":"29","author":"Vazquez-Laslop","year":"2010","journal-title":"EMBO J."},{"issue":"12","key":"10.1016\/j.bioorg.2025.109396_bb0335","doi-asserted-by":"crossref","first-page":"5994","DOI":"10.1128\/AAC.01673-13","article-title":"Tools for characterizing bacterial protein synthesis inhibitors","volume":"57","author":"Orelle","year":"2013","journal-title":"Antimicrob. Agents Chemother."},{"key":"10.1016\/j.bioorg.2025.109396_bb0340","doi-asserted-by":"crossref","unstructured":"A.P. Chernyshova, V.I. Marina, A.G. Tereshchenkov, V.E. Sagitova, M.A. Kryakvin, N.D. Dagaev, E.G. Yurchenko, K.A. Arzamazova, E.B. Guglya, O.A. Belozerova, S.I. Kovalchuk, M.N. Baranova, A.M. Kudzhaev, A.E. Shikov, M.N. Romanenko, A.Y. Rudenko, V.K. Chebotar, M.S. Gancheva, M.E. Baganova, M.V. Biryukov, T.V. Panova, M.G. Khrenova, V.N. Tashlitsky, N.V. Sumbatyan, Y.V. Zakalyukina, K.S. Antonets, A.A. Nizhnikov, V.I. Polshakov, S.S. Terekhov, M.I. Zvereva, O.A. Dontsova, P.V. Sergiev, V.A. Alferova, D.A. Lukianov, Characterization of Bacillus velezensis EV17 and K-3618 and Their Polyketide Antibiotic Oxydifficidin, an Inhibitor of Prokaryotic Translation with Low Cytotoxicity, Int. J. Mol. Sci. 26 (24) (2025) 11777, doi:10.3390\/ijms262411777.","DOI":"10.3390\/ijms262411777"},{"key":"10.1016\/j.bioorg.2025.109396_bb0345","year":"2022"},{"key":"10.1016\/j.bioorg.2025.109396_bb0350","series-title":"EUCAST. EUCAST QC Tables, v. 14.0, 2024. https:\/\/www.eucast.org\/fileadmin\/src\/media\/PDFs\/EUCAST_files\/QC\/v_14.0_EUCAST_QC_tables_routine_and_extended_QC.pdf (accessed 1 July 2025)","year":"2024"},{"issue":"1\u20132","key":"10.1016\/j.bioorg.2025.109396_bb0355","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/0022-1759(83)90303-4","article-title":"Rapid colorimetric assay for cellular growth and survival: application to proliferation and cytotoxicity assays","volume":"65","author":"Mosmann","year":"1983","journal-title":"J. Immunol. Methods"},{"issue":"5","key":"10.1016\/j.bioorg.2025.109396_bb0360","article-title":"Triphenilphosphonium analogs of chloramphenicol as dual-acting Antimicrobial and Antiproliferating agents","volume":"10","author":"Pavlova","year":"2021","journal-title":"Antibiotics (Basel)"},{"issue":"3","key":"10.1016\/j.bioorg.2025.109396_bb0365","doi-asserted-by":"crossref","first-page":"1807","DOI":"10.1093\/nar\/gks1282","article-title":"A novel mechanism of eukaryotic translation initiation that is neither m7G-cap-, nor IRES-dependent","volume":"41","author":"Terenin","year":"2013","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.bioorg.2025.109396_bb0370","doi-asserted-by":"crossref","DOI":"10.1038\/srep37905","article-title":"Four translation initiation pathways employed by the leaderless mRNA in eukaryotes","volume":"6","author":"Akulich","year":"2016","journal-title":"Sci. Rep."},{"key":"10.1016\/j.bioorg.2025.109396_bb0375","doi-asserted-by":"crossref","DOI":"10.1038\/srep27720","article-title":"Amicoumacin a induces cancer cell death by targeting the eukaryotic ribosome","volume":"6","author":"Prokhorova","year":"2016","journal-title":"Sci. Rep."},{"key":"10.1016\/j.bioorg.2025.109396_bb0380","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0076-6879(07)30001-3","article-title":"Transient kinetics, fluorescence, and FRET in studies of initiation of translation in bacteria","volume":"430","author":"Milon","year":"2007","journal-title":"Methods Enzymol."},{"issue":"14","key":"10.1016\/j.bioorg.2025.109396_bb0385","doi-asserted-by":"crossref","DOI":"10.1093\/nar\/gkt526","article-title":"Identifying the targets of aminoacyl-tRNA synthetase inhibitors by primer extension inhibition","volume":"41","author":"Orelle","year":"2013","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.bioorg.2025.109396_bb0390","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1007\/978-1-59745-246-5_2","article-title":"Methods to assay inhibitors of DNA gyrase and topoisomerase IV activities","volume":"142","author":"Fisher","year":"2008","journal-title":"Methods Mol. Med."},{"key":"10.1016\/j.bioorg.2025.109396_bb0395","first-page":"95 (5)","article-title":"Nybomycin inhibits both types of E. Coli DNA gyrase - fluoroquinolone-sensitive and fluoroquinolone-resistant","author":"Shiriaev","year":"2023","journal-title":"Antimicrob. Agents Chemother."},{"key":"10.1016\/j.bioorg.2025.109396_bb0400","first-page":"163","article-title":"Overexpression and purification of bacterial topoisomerase IV","volume":"94","author":"Peng","year":"1999","journal-title":"Methods Mol. Biol."}],"container-title":["Bioorganic Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0045206825012763?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0045206825012763?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T11:59:01Z","timestamp":1777463941000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0045206825012763"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,2]]},"references-count":80,"alternative-id":["S0045206825012763"],"URL":"https:\/\/doi.org\/10.1016\/j.bioorg.2025.109396","relation":{},"ISSN":["0045-2068"],"issn-type":[{"value":"0045-2068","type":"print"}],"subject":[],"published":{"date-parts":[[2026,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"4\u2033-modified azithromycin derivatives bearing nitrogen-containing heterocycles with dual inhibitory activity","name":"articletitle","label":"Article Title"},{"value":"Bioorganic Chemistry","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bioorg.2025.109396","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"109396"}}