{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T14:26:44Z","timestamp":1787754404802,"version":"build-2784847793"},"reference-count":101,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100023673","name":"Deanship of Scientific Research, Imam Mohammed Ibn Saud Islamic University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100023673","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002713","name":"Imam Mohammed Ibn Saud Islamic University","doi-asserted-by":"publisher","award":["IMSIU-DDRSP2601"],"award-info":[{"award-number":["IMSIU-DDRSP2601"]}],"id":[{"id":"10.13039\/501100002713","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Bioorganic Chemistry"],"published-print":{"date-parts":[[2026,3]]},"DOI":"10.1016\/j.bioorg.2025.109399","type":"journal-article","created":{"date-parts":[[2025,12,26]],"date-time":"2025-12-26T07:33:31Z","timestamp":1766734411000},"page":"109399","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":3,"special_numbering":"C","title":["Mucoadhesive lignin\u2013liposome nanocarriers of coptisine: A multifunctional strategy against antibiotic-resistant Helicobacter pylori biofilms"],"prefix":"10.1016","volume":"170","author":[{"given":"Mohamed","family":"Sharaf","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zainab Naser","family":"Al-Laith","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tehsin Ullah","family":"Khan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amr","family":"Elkelish","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohamed S.","family":"Abdel-Maksoud","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nadia G.","family":"Elrefaei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abdullah S.","family":"Alawam","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chen-Guang","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bioorg.2025.109399_bb0005","first-page":"19","volume":"9","author":"Malfertheiner","year":"2023","journal-title":"Helicobacter pylori infection."},{"key":"10.1016\/j.bioorg.2025.109399_bb0010","series-title":"Blaser MJJNcpO. Mechanisms of disease: inflammation and the origins of cancer","first-page":"90","volume":"2","author":"Moss","year":"2005"},{"key":"10.1016\/j.bioorg.2025.109399_bb0015","series-title":"Histopathological features of Helicobacter pylori infection in gastric mucosa","first-page":"6231","author":"Wang","year":"2022"},{"issue":"1113\u201324","key":"10.1016\/j.bioorg.2025.109399_bb0020","volume":"150","author":"Lee","year":"2016","journal-title":"Association between Helicobacter pylori eradication and gastric cancer incidence: a systematic review and meta-analysis."},{"key":"10.1016\/j.bioorg.2025.109399_bb0025","first-page":"26","article-title":"Alara ORJID-DT","volume":"24","author":"Alara","year":"2024","journal-title":"An overview of the global alarming increase of multiple drug resistant: a major challenge in clinical diagnosis."},{"key":"10.1016\/j.bioorg.2025.109399_bb0030","first-page":"21","volume":"11","author":"Shetty","year":"2019","journal-title":"High primary resistance to metronidazole and levofloxacin, and a moderate resistance to clarithromycin in Helicobacter pylori isolated from Karnataka patients."},{"key":"10.1016\/j.bioorg.2025.109399_bb0035","doi-asserted-by":"crossref","first-page":"646","DOI":"10.1136\/gutjnl-2012-302084","article-title":"Management of Helicobacter pylori infection\u2014the Maastricht IV\/Florence consensus report","volume":"61","author":"Malfertheiner","year":"2012","journal-title":"Gut"},{"key":"10.1016\/j.bioorg.2025.109399_bb0040","first-page":"212","volume":"112","author":"Chey","year":"2017","journal-title":"ACG clinical guideline: treatment of Helicobacter pylori infection."},{"key":"10.1016\/j.bioorg.2025.109399_bb0045","first-page":"2361","volume":"19","author":"Salehi","year":"2018","journal-title":"Phytochemicals in Helicobacter pylori infections: What are we doing now?"},{"key":"10.1016\/j.bioorg.2025.109399_bb0050","first-page":"407","volume":"15","author":"Yamaoka","year":"2018","journal-title":"How to eliminate gastric cancer-related death worldwide?"},{"key":"10.1016\/j.bioorg.2025.109399_bb0055","first-page":"1260","volume":"12","author":"Elshenawi","year":"2023","journal-title":"Biofilm of Helicobacter pylori: life cycle, features, and treatment options."},{"key":"10.1016\/j.bioorg.2025.109399_bb0060","first-page":"549","volume":"21","author":"Moghadam","year":"2021","journal-title":"Helicobacter pylori biofilm and new strategies to combat it."},{"key":"10.1016\/j.bioorg.2025.109399_bb0065","volume":"31","author":"Rocha","year":"2025","journal-title":"Overcoming antibiotic-resistant Helicobacter pylori infection: Current challenges and emerging approaches."},{"key":"10.1016\/j.bioorg.2025.109399_bb0070","first-page":"6064","article-title":"Hanafiah AJIJoMS","volume":"26","author":"Muttiah","year":"2025","journal-title":"Towards Effective Helicobacter pylori Eradication: Emerging Therapies in the Wake of Antibiotic Resistance."},{"key":"10.1016\/j.bioorg.2025.109399_bb0075","first-page":"2433","volume":"80","author":"Singh","year":"2025","journal-title":"Overcoming antimicrobial resistance in Helicobacter pylori: the roles of collateral sensitivity and biofilm dynamics."},{"key":"10.1016\/j.bioorg.2025.109399_bb0080","doi-asserted-by":"crossref","first-page":"20983","DOI":"10.3390\/ijms141020983","article-title":"Biofilm matrix and its regulation in Pseudomonas aeruginosa","volume":"14","author":"Wei","year":"2013","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.bioorg.2025.109399_bb0085","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s13756-019-0533-3","article-title":"Antibiotics versus biofilm: an emerging battleground in microbial communities","volume":"8","author":"Sharma","year":"2019","journal-title":"Antimicrob. Resist. Infect. Control"},{"key":"10.1016\/j.bioorg.2025.109399_bb0090","doi-asserted-by":"crossref","first-page":"425","DOI":"10.3390\/microorganisms8030425","article-title":"Quorum-sensing regulation of antimicrobial resistance in bacteria","volume":"8","author":"Zhao","year":"2020","journal-title":"Microorganisms"},{"key":"10.1016\/j.bioorg.2025.109399_bb0095","series-title":"Effect of Biofilm on Production of Poultry","author":"Mondal","year":"2022"},{"key":"10.1016\/j.bioorg.2025.109399_bb0100","doi-asserted-by":"crossref","first-page":"1171","DOI":"10.1038\/nature03912","article-title":"Aminoglycoside antibiotics induce bacterial biofilm formation","volume":"436","author":"Hoffman","year":"2005","journal-title":"Nature"},{"key":"10.1016\/j.bioorg.2025.109399_bb0105","doi-asserted-by":"crossref","first-page":"737","DOI":"10.5301\/ijao.5000027","article-title":"Antibiotic-induced biofilm formation","volume":"34","author":"Kaplan","year":"2011","journal-title":"Int. J. Artif. Organs"},{"key":"10.1016\/j.bioorg.2025.109399_bb0110","doi-asserted-by":"crossref","first-page":"890","DOI":"10.1089\/mdr.2018.0319","article-title":"Multidrug-resistant bacteria and alternative methods to control them: an overview","volume":"25","author":"Vivas","year":"2019","journal-title":"Microb. Drug Resist."},{"key":"10.1016\/j.bioorg.2025.109399_bb0115","doi-asserted-by":"crossref","DOI":"10.1177\/1756287219832174","article-title":"Appropriate use of antibiotics: an unmet need","volume":"11","author":"Lopez Romo","year":"2019","journal-title":"Ther. Adv. Urol."},{"key":"10.1016\/j.bioorg.2025.109399_bb0120","first-page":"2121","article-title":"Li CJTAJoCM","volume":"51","author":"Lu","year":"2023","journal-title":"Coptisine, the characteristic constituent from Coptis chinensis, exhibits significant therapeutic potential in treating cancers, metabolic and inflammatory diseases."},{"key":"10.1016\/j.bioorg.2025.109399_bb0125","doi-asserted-by":"crossref","first-page":"2121","DOI":"10.1142\/S0192415X2350091X","article-title":"Coptisine, the characteristic constituent from Coptis chinensis, exhibits significant therapeutic potential in treating cancers, metabolic and inflammatory diseases","volume":"51","author":"Lu","year":"2023","journal-title":"Am. J. Chin. Med."},{"key":"10.1016\/j.bioorg.2025.109399_bb0130","doi-asserted-by":"crossref","DOI":"10.1016\/j.prmcm.2024.100383","article-title":"Natural alkaloid coptisine, isolated from Coptis chinensis, inhibits fungal growth by disrupting membranes and triggering apoptosis","volume":"10","author":"Zhong","year":"2024","journal-title":"Pharmacological Research-Modern Chinese Medicine."},{"key":"10.1016\/j.bioorg.2025.109399_bb0135","doi-asserted-by":"crossref","first-page":"640","DOI":"10.1016\/j.ejmech.2019.01.007","article-title":"Composition design and medical application of liposomes","volume":"164","author":"Li","year":"2019","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.bioorg.2025.109399_bb0140","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1248\/bpb.b16-00624","article-title":"Liposomal delivery systems: design optimization and current applications","volume":"40","author":"Lila","year":"2017","journal-title":"Biol. Pharm. Bull."},{"key":"10.1016\/j.bioorg.2025.109399_bb0145","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1007\/s13346-020-00791-8","article-title":"Lipid-based nanosystems for targeting bone implant-associated infections: current approaches and future endeavors","volume":"11","author":"Ferreira","year":"2021","journal-title":"Drug Deliv. Transl. Res."},{"key":"10.1016\/j.bioorg.2025.109399_bb0150","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1016\/j.jconrel.2019.12.023","article-title":"The role of liposomes in clinical nanomedicine development. What now? Now what?","volume":"318","author":"Crommelin","year":"2020","journal-title":"J. Control. Release"},{"key":"10.1016\/j.bioorg.2025.109399_bb0155","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1016\/j.addr.2017.12.010","article-title":"Nanomaterials and molecular transporters to overcome the bacterial envelope barrier: towards advanced delivery of antibiotics","volume":"136","author":"Santos","year":"2018","journal-title":"Adv. Drug Deliv. Rev."},{"key":"10.1016\/j.bioorg.2025.109399_bb0160","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2024.155711","article-title":"Recent advance in preparation of lignin nanoparticles and their medical applications: a review","author":"Feng","year":"2024","journal-title":"Phytomedicine"},{"key":"10.1016\/j.bioorg.2025.109399_bb0165","doi-asserted-by":"crossref","first-page":"865","DOI":"10.3390\/antiox13070865","article-title":"Ocimum basilicum and Lagenaria siceraria loaded lignin nanoparticles as versatile antioxidant, immune modulatory, anti-efflux, and antimicrobial agents for combating multidrug-resistant Bacteria and Fungi","volume":"13","author":"El-Samahy","year":"2024","journal-title":"Antioxidants"},{"key":"10.1016\/j.bioorg.2025.109399_bb0170","doi-asserted-by":"crossref","first-page":"1610","DOI":"10.3390\/polym16111610","article-title":"Preparation and characterization of lignin nanoparticles from different plant sources","volume":"16","author":"Ortega-Sanhueza","year":"2024","journal-title":"Polymers"},{"key":"10.1016\/j.bioorg.2025.109399_bb0175","series-title":"Sipponen MHJB. Stabilized lignin nanoparticles for versatile hybrid and functional nanomaterials","first-page":"4597","volume":"23","author":"Morsali","year":"2022"},{"key":"10.1016\/j.bioorg.2025.109399_bb0180","first-page":"260","volume":"40","author":"Chen","year":"2014","journal-title":"Deformable liposomes by reverse-phase evaporation method for an enhanced skin delivery of (+)-catechin."},{"key":"10.1016\/j.bioorg.2025.109399_bb0185","article-title":"Liu C-GJJoDDS, et al","volume":"107233","author":"Khan","year":"2025","journal-title":"Optimization and bactericidal inhibitory activities of Nanostructured Lipid Carrier-Mediated Co-delivery of Myricetin and Amoxicillin for eradication of Helicobacter pylori in vitro."},{"key":"10.1016\/j.bioorg.2025.109399_bb0190","article-title":"Liu C-GJJoDDS, et al","volume":"107545","author":"Sharaf","year":"2025","journal-title":"Ultrasonic Nanoengineering of Biocompatible Lignin-Ergothioneine Hybrids for Targeted Membrane Disruption and Sustained Oral Eradication of Helicobacter pylori."},{"key":"10.1016\/j.bioorg.2025.109399_bb0195","series-title":"Melittin alcalase-hydrolysate: a novel chemically characterized multifunctional bioagent; antibacterial, anti-biofilm and anticancer","first-page":"1419917","volume":"15","author":"El-Didamony","year":"2024"},{"key":"10.1016\/j.bioorg.2025.109399_bb0200","article-title":"Rhamnolipid-coated iron oxide nanoparticles as a novel multitarget candidate against major foodborne e. coli serotypes and methicillin-resistant s. aureus. Microbiology","volume":"10","author":"Sharaf","year":"2022","journal-title":"Spectrum"},{"key":"10.1016\/j.bioorg.2025.109399_bb0205","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1016\/j.jtcme.2017.05.008","article-title":"Attenuation of quorum-sensing-dependent virulence factors and biofilm formation by medicinal plants against antibiotic resistant Pseudomonas aeruginosa","volume":"8","author":"Ganesh","year":"2018","journal-title":"J. Tradit. Complement. Med."},{"key":"10.1016\/j.bioorg.2025.109399_bb0210","first-page":"2252","volume":"56","author":"Adachi","year":"2011","journal-title":"Intragastrically administered lysophosphatidic acids protect against gastric ulcer in rats under water-immersion restraint stress."},{"key":"10.1016\/j.bioorg.2025.109399_bb0215","first-page":"105","volume":"193","author":"Cheng","year":"2023","journal-title":"Berberine-loaded mannosylerythritol lipid-B nanomicelles as drug delivery carriers for the treatment of Helicobacter pylori biofilms in vivo."},{"key":"10.1016\/j.bioorg.2025.109399_bb0220","series-title":"Analysis of coptisine, berberine and palmatine in adulterated Chinese medicine by capillary electrophoresis\u2013electrospray ion trap mass spectrometry","first-page":"273","volume":"866","author":"Chen","year":"2000"},{"key":"10.1016\/j.bioorg.2025.109399_bb0225","first-page":"135","volume":"687","author":"Dost\u00e1l","year":"2004","journal-title":"Berberine and coptisine free bases."},{"key":"10.1016\/j.bioorg.2025.109399_bb0230","series-title":"Development and characterization of lignin microparticles for physical and antioxidant enhancement of biodegradable polymers","first-page":"1326","volume":"28","author":"Gomide","year":"2020"},{"key":"10.1016\/j.bioorg.2025.109399_bb0235","series-title":"Structural Studies of Lipid Based Nanosystems for Drug Delivery: X-Ray Diffraction (XRD) and Cryogenic Transmission Electron Microscopy (Cryo-TEM)","first-page":"861","author":"Esposito","year":"2015"},{"key":"10.1016\/j.bioorg.2025.109399_bb0240","first-page":"4281","article-title":"Clift MDJOl","volume":"20","author":"Mori-Quiroz","year":"2018","journal-title":"A unified strategy for the syntheses of the isoquinolinium alkaloids berberine, coptisine, and jatrorrhizine."},{"key":"10.1016\/j.bioorg.2025.109399_bb0245","first-page":"37070","volume":"7","author":"Piccinino","year":"2022","journal-title":"Lignin nanoparticles as sustainable photoprotective carriers for sunscreen filters."},{"key":"10.1016\/j.bioorg.2025.109399_bb0250","first-page":"1362","volume":"33","author":"Li","year":"2018","journal-title":"Coptisine-induced inhibition of Helicobacter pylori: elucidation of specific mechanisms by probing urease active site and its maturation process."},{"key":"10.1016\/j.bioorg.2025.109399_bb0255","first-page":"1","article-title":"Prabhu AJJoCS","author":"Rani","year":"2024","journal-title":"Carmustine-Loaded Liposomal Delivery Effectively Targets Malignant Glioma Cells and Seizes Endothelial Sprouting In vitro."},{"key":"10.1016\/j.bioorg.2025.109399_bb0260","first-page":"23","article-title":"Hoet PHJEsp, impacts","volume":"15","author":"Luyts","year":"2013","journal-title":"How physico-chemical characteristics of nanoparticles cause their toxicity: complex and unresolved interrelations."},{"key":"10.1016\/j.bioorg.2025.109399_bb0265","first-page":"1153","article-title":"Hsueh P-RJFip","volume":"10","author":"Lee","year":"2019","journal-title":"Nanoparticles in the treatment of infections caused by multidrug-resistant organisms."},{"key":"10.1016\/j.bioorg.2025.109399_bb0270","first-page":"8340","volume":"5","author":"Zhao","year":"2013","journal-title":"Multiple strategies to activate gold nanoparticles as antibiotics."},{"key":"10.1016\/j.bioorg.2025.109399_bb0275","series-title":"Sharma RJNBTAQSMMP. Dynamic light scattering (DLS) technique, principle, theoretical considerations and applications","first-page":"135","author":"Sandhu","year":"2018"},{"key":"10.1016\/j.bioorg.2025.109399_bb0280","series-title":"Marie RJNc. Size and surface charge characterization of nanoparticles with a salt gradient","first-page":"2337","volume":"11","author":"Rasmussen","year":"2020"},{"key":"10.1016\/j.bioorg.2025.109399_bb0285","series-title":"Chemistry b. Zeta potential: a case study of cationic, anionic, and neutral liposomes","first-page":"5779","volume":"409","author":"Smith","year":"2017"},{"key":"10.1016\/j.bioorg.2025.109399_bb0290","series-title":"Morphological behavior of liposomes and lipid nanoparticles","first-page":"3185","volume":"39","author":"Zhigaltsev","year":"2023"},{"key":"10.1016\/j.bioorg.2025.109399_bb0295","series-title":"Unlocking high-efficiency charge storage: Co-assembled nanoparticles of lignin and polyaniline molecules","first-page":"40","volume":"678","author":"Sun","year":"2025"},{"key":"10.1016\/j.bioorg.2025.109399_bb0300","series-title":"Improvement on stability, loading capacity and sustained release of rhamnolipids modified curcumin liposomes","volume":"183","author":"Cheng","year":"2019"},{"key":"10.1016\/j.bioorg.2025.109399_bb0305","first-page":"150","article-title":"Al-Jamal WTJIjop","volume":"514","author":"Pereira","year":"2016","journal-title":"Docetaxel-loaded liposomes: The effect of lipid composition and purification on drug encapsulation and in vitro toxicity."},{"key":"10.1016\/j.bioorg.2025.109399_bb0310","series-title":"Design and Development of Dual Drug-Loaded Liposomes Encapsulating Gentamicin and Curcumin via Microfluidic Synthesis: A Box-Behnken Experimental Approach","volume":"107750","author":"Yugatama","year":"2025"},{"key":"10.1016\/j.bioorg.2025.109399_bb0315","series-title":"Analysing \u03c0-\u03c0 Stacking Interactions in Lignin Nanoparticles from Molecular Simulations\u2013Insights and Lessons Learned","author":"Hackenstrass","year":"2025"},{"key":"10.1016\/j.bioorg.2025.109399_bb0320","series-title":"A pH-Sensitive Lignin-Based Material for Sustained Release of 8-Hydroxyquinoline","first-page":"1867","volume":"15","author":"Zheng","year":"2023"},{"key":"10.1016\/j.bioorg.2025.109399_bb0325","first-page":"856","volume":"50","author":"Sarma","year":"2024","journal-title":"pH sensitive lipid polymeric hybrid nanoparticle (LPHNP) of paclitaxel and curcumin for targeted delivery in breast cancer."},{"key":"10.1016\/j.bioorg.2025.109399_bb0330","first-page":"908","volume":"12","author":"Ibrahim Khan","year":"2017","journal-title":"Nanoparticles: Properties, applications and toxicities."},{"key":"10.1016\/j.bioorg.2025.109399_bb0335","series-title":"Kumar SSDJAic, science i. Multifunctional lipid-based nanoparticles for wound healing and antibacterial applications: A review.","volume":"321","author":"Motsoene","year":"2023"},{"key":"10.1016\/j.bioorg.2025.109399_bb0340","doi-asserted-by":"crossref","first-page":"2549","DOI":"10.1016\/S0045-6535(98)00462-7","article-title":"Growth of 1044 strains and species of fungi on 7 phenolic lignin model compounds","volume":"38","author":"Rahouti","year":"1999","journal-title":"Chemosphere"},{"key":"10.1016\/j.bioorg.2025.109399_bb0345","first-page":"4461","article-title":"Syed RJJoMCB","volume":"7","author":"Alqahtani","year":"2019","journal-title":"Novel lignin nanoparticles for oral drug delivery."},{"key":"10.1016\/j.bioorg.2025.109399_bb0350","first-page":"23","article-title":"Lignocellulosic biomass as source for lignin-based environmentally benign antioxidants","author":"Alzagameem","year":"2018","journal-title":"Molecules (Basel, Switzerland)"},{"key":"10.1016\/j.bioorg.2025.109399_bb0355","doi-asserted-by":"crossref","first-page":"763","DOI":"10.1016\/j.ijbiomac.2018.08.109","article-title":"Synthesis and characterization of silver nanoparticles loaded poly(vinyl alcohol)-lignin electrospun nanofibers and their antimicrobial activity","volume":"120","author":"Aadil","year":"2018","journal-title":"Int. J. Biol. Macromol."},{"key":"10.1016\/j.bioorg.2025.109399_bb0360","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2021.114578","article-title":"In-vitro anti-Helicobacter pylori activity and preliminary mechanism of action of Canarium album Raeusch. Fruit extracts","volume":"283","author":"Yan","year":"2022","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.bioorg.2025.109399_bb0365","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1016\/j.ijpharm.2017.01.014","article-title":"Docosahexaenoic acid loaded lipid nanoparticles with bactericidal activity against Helicobacter pylori","volume":"519","author":"Seabra","year":"2017","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.bioorg.2025.109399_bb0370","doi-asserted-by":"crossref","first-page":"2677","DOI":"10.1021\/mp300243w","article-title":"Antibacterial activities of liposomal linolenic acids against antibiotic-resistant Helicobacter pylori","volume":"9","author":"Obonyo","year":"2012","journal-title":"Mol. Pharm."},{"key":"10.1016\/j.bioorg.2025.109399_bb0375","first-page":"7","article-title":"Morphological and bactericidal effects of different antibiotics on Helicobacter pylori","author":"Faghri","year":"2014","journal-title":"Jundishapur J. Microbiol."},{"key":"10.1016\/j.bioorg.2025.109399_bb0380","doi-asserted-by":"crossref","first-page":"184","DOI":"10.3390\/pathogens9030184","article-title":"Transformation of Helicobacter pylori into coccoid forms as a challenge for research determining activity of antimicrobial substances","volume":"9","author":"Krzy\u017cek","year":"2020","journal-title":"Pathogens"},{"key":"10.1016\/j.bioorg.2025.109399_bb0385","series-title":"Transcriptome analysis of the response of mature Helicobacter pylori biofilm to different doses of Lactobacillus salivarius LN12 with amoxicillin and clarithromycin","first-page":"262","volume":"11","author":"Jin","year":"2022"},{"key":"10.1016\/j.bioorg.2025.109399_bb0390","series-title":"Biofilm formation as a complex result of virulence and adaptive responses of Helicobacter pylori","first-page":"1062","volume":"9","author":"Krzy\u017cek","year":"2020"},{"key":"10.1016\/j.bioorg.2025.109399_bb0395","series-title":"Combined bactericidal process of lignin and silver in a hybrid nanoparticle on E. Coli","first-page":"1841","volume":"5","author":"Ran","year":"2022"},{"key":"10.1016\/j.bioorg.2025.109399_bb0400","first-page":"2418407","volume":"15","author":"Xiao","year":"2024","journal-title":"Study of the relationships among known virulence genes, coccoid transformation and cytotoxicity of Helicobacter pylori in different clinical diseases."},{"key":"10.1016\/j.bioorg.2025.109399_bb0405","first-page":"5397","article-title":"Rothen-Rutishauser BJCsr","volume":"50","author":"de Almeida","year":"2021","journal-title":"Understanding nanoparticle endocytosis to improve targeting strategies in nanomedicine."},{"key":"10.1016\/j.bioorg.2025.109399_bb0410","first-page":"149","article-title":"Czyzowska AJCrifs, nutrition","volume":"61","author":"Efenberger-Szmechtyk","year":"2021","journal-title":"Plant extracts rich in polyphenols: Antibacterial agents and natural preservatives for meat and meat products."},{"key":"10.1016\/j.bioorg.2025.109399_bb0415","article-title":"Qiu XJIJoBM","volume":"277","author":"Li","year":"2024","journal-title":"Rapid synthesis of ferulic acid-derived lignin coated silver nanoparticles with low cytotoxicity and high antibacterial activity."},{"key":"10.1016\/j.bioorg.2025.109399_bb0420","first-page":"14885","volume":"13","author":"Morena","year":"2021","journal-title":"Hybrid tellurium\u2013lignin nanoparticles with enhanced antibacterial properties."},{"key":"10.1016\/j.bioorg.2025.109399_bb0425","volume":"92","author":"Maruthapandi","year":"2023","journal-title":"Ultrasonic-assisted synthesis of lignin-capped Cu2O nanocomposite with antibiofilm properties."},{"key":"10.1016\/j.bioorg.2025.109399_bb0430","first-page":"3124","article-title":"Guiney DGJJob","volume":"186","author":"Cole","year":"2004","journal-title":"Characterization of monospecies biofilm formation by Helicobacter pylori."},{"key":"10.1016\/j.bioorg.2025.109399_bb0435","series-title":"Reviews MB. Helicobacter pylori biofilm formation and its potential role in pathogenesis","first-page":"82","author":"Hathroubi","year":"2018"},{"key":"10.1016\/j.bioorg.2025.109399_bb0440","series-title":"Helicobacter pylori biofilm-related drug resistance and new developments in its anti-biofilm agents","first-page":"1561","author":"Hou","year":"2022"},{"key":"10.1016\/j.bioorg.2025.109399_bb0445","first-page":"80","article-title":"Recio MCJJoe","volume":"100","author":"Rios","year":"2005","journal-title":"Medicinal plants and antimicrobial activity."},{"key":"10.1016\/j.bioorg.2025.109399_bb0450","first-page":"132","article-title":"Shimamura TJBeBA-B","volume":"1147","author":"Ikigai","year":"1993","journal-title":"Bactericidal catechins damage the lipid bilayer."},{"key":"10.1016\/j.bioorg.2025.109399_bb0455","first-page":"18","volume":"8","author":"Rukavina","year":"2016","journal-title":"Current trends in development of liposomes for targeting bacterial biofilms."},{"key":"10.1016\/j.bioorg.2025.109399_bb0460","first-page":"211","article-title":"Doroszkiewicz WJIjop","volume":"367","author":"Drulis-Kawa","year":"2009","journal-title":"The interaction between Pseudomonas aeruginosa cells and cationic PC: Chol: DOTAP liposomal vesicles versus outer-membrane structure and envelope properties of bacterial cell."},{"key":"10.1016\/j.bioorg.2025.109399_bb0465","first-page":"43","volume":"21","author":"Martin","year":"2015","journal-title":"Strategies for antimicrobial drug delivery to biofilm."},{"key":"10.1016\/j.bioorg.2025.109399_bb0470","first-page":"16982","volume":"15","author":"Tenchov","year":"2021","journal-title":"Lipid nanoparticles from liposomes to mRNA vaccine delivery, a landscape of research diversity and advancement."},{"key":"10.1016\/j.bioorg.2025.109399_bb0475","doi-asserted-by":"crossref","first-page":"3469525","DOI":"10.1155\/2019\/3469525","article-title":"Cytotoxicity evaluation of endodontic pins on L929 cell line","volume":"2019","author":"Cannella","year":"2019","journal-title":"Biomed. Res. Int."},{"key":"10.1016\/j.bioorg.2025.109399_bb0480","doi-asserted-by":"crossref","DOI":"10.1016\/j.inoche.2024.112991","article-title":"Green synthesis of almond peel-mediated lignin nanoparticles as a potential photocatalytic agent with cytotoxicity response","volume":"168","author":"Shafiee","year":"2024","journal-title":"Inorg. Chem. Commun."},{"key":"10.1016\/j.bioorg.2025.109399_bb0485","first-page":"850","article-title":"Coenye TJTim","volume":"27","author":"Crabb\u00e9","year":"2019","journal-title":"Antimicrobial tolerance and metabolic adaptations in microbial biofilms."},{"key":"10.1016\/j.bioorg.2025.109399_bb0490","first-page":"4","volume":"11","author":"Park","year":"2020","journal-title":"Synergistic effect of Rubus crataegifolius and Ulmus macrocarpa against Helicobacter pylori clinical isolates and gastritis."},{"key":"10.1016\/j.bioorg.2025.109399_bb0495","first-page":"2105738","volume":"34","author":"Zhang","year":"2022","journal-title":"Metal\u2013organic-framework-based hydrogen-release platform for multieffective Helicobacter pylori targeting therapy and intestinal flora protective capabilities."},{"key":"10.1016\/j.bioorg.2025.109399_bb0500","first-page":"17600","article-title":"Zhang LJPotNAoS","volume":"111","author":"Thamphiwatana","year":"2014","journal-title":"In vivo treatment of Helicobacter pylori infection with liposomal linolenic acid reduces colonization and ameliorates inflammation."},{"key":"10.1016\/j.bioorg.2025.109399_bb0505","volume":"29","author":"Bendary","year":"2024","journal-title":"Boosting the anti-Helicobacter efficacy of Azithromycin through natural compounds: Insights from in vitro, in vivo, histopathological, and molecular docking investigations."}],"container-title":["Bioorganic Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0045206825012799?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0045206825012799?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,3,20]],"date-time":"2026-03-20T03:47:10Z","timestamp":1773978430000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0045206825012799"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,3]]},"references-count":101,"alternative-id":["S0045206825012799"],"URL":"https:\/\/doi.org\/10.1016\/j.bioorg.2025.109399","relation":{},"ISSN":["0045-2068"],"issn-type":[{"value":"0045-2068","type":"print"}],"subject":[],"published":{"date-parts":[[2026,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Mucoadhesive lignin\u2013liposome nanocarriers of coptisine: A multifunctional strategy against antibiotic-resistant Helicobacter pylori biofilms","name":"articletitle","label":"Article Title"},{"value":"Bioorganic Chemistry","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bioorg.2025.109399","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"109399"}}