{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T00:19:45Z","timestamp":1790727585015,"version":"4.1.0"},"reference-count":28,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,1,15]],"date-time":"2026-01-15T00:00:00Z","timestamp":1768435200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100007397","name":"Charles University","doi-asserted-by":"publisher","award":["SVV 260661"],"award-info":[{"award-number":["SVV 260661"]}],"id":[{"id":"10.13039\/100007397","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000780","name":"European Commission","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000780","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100008530","name":"European Regional Development Fund","doi-asserted-by":"publisher","award":["CZ.02.01.01\/00\/22_008\/0004607"],"award-info":[{"award-number":["CZ.02.01.01\/00\/22_008\/0004607"]}],"id":[{"id":"10.13039\/501100008530","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005357","name":"Slovak Research and Development Agency","doi-asserted-by":"publisher","award":["APVV-19-0189"],"award-info":[{"award-number":["APVV-19-0189"]}],"id":[{"id":"10.13039\/501100005357","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Bioorganic Chemistry"],"published-print":{"date-parts":[[2026,3]]},"DOI":"10.1016\/j.bioorg.2026.109510","type":"journal-article","created":{"date-parts":[[2026,1,17]],"date-time":"2026-01-17T15:44:59Z","timestamp":1768664699000},"page":"109510","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":2,"special_numbering":"C","title":["4-[(Aryloylhydrazineylidene)methyl]-N-phenylbenzamides as a new class of antimycobacterial agents: design, synthesis and biological evaluation"],"prefix":"10.1016","volume":"170","author":[{"given":"V\u00e1clav","family":"Pfl\u00e9gr","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Apolena","family":"Koklarov\u00e1","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ji\u0159ina","family":"Stola\u0159\u00edkov\u00e1","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabriela","family":"Svobodov\u00e1","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin","family":"Ambro\u017e","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Monika","family":"Z\u00e1horszk\u00e1","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jana","family":"Kordul\u00e1kov\u00e1","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin","family":"Kr\u00e1tk\u00fd","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bioorg.2026.109510_bb0005","unstructured":"WHO, Global tuberculosis report 2024. ISBN 978-92-4-010153-1."},{"key":"10.1016\/j.bioorg.2026.109510_bb0010","unstructured":"WHO, WHO consolidated guidelines on tuberculosis: module 4: treatment and care. ISBN 978-92-4-010724-3."},{"key":"10.1016\/j.bioorg.2026.109510_bb0015","unstructured":"WHO, Guidelines on the management of latent tuberculosis infection. ISBN 978-92\u20134-154890-8."},{"key":"10.1016\/j.bioorg.2026.109510_bb0020","doi-asserted-by":"crossref","first-page":"468","DOI":"10.1056\/NEJMoa2400327","article-title":"Oral regimens for rifampin-resistant, fluoroquinolone-susceptible tuberculosis","volume":"392","author":"Guglielmetti","year":"2025","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.bioorg.2026.109510_bb0025","doi-asserted-by":"crossref","DOI":"10.1183\/13993003.00066-2021","article-title":"The coming-of-age of bedaquiline: a tale with an open ending","volume":"57","author":"Guglielmetti","year":"2021","journal-title":"Eur. Respir. J."},{"key":"10.1016\/j.bioorg.2026.109510_bb0030","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1016\/j.tube.2018.04.008","article-title":"Delamanid: from discovery to its use for pulmonary multidrug-resistant tuberculosis (MDR-TB)","volume":"111","author":"Liu","year":"2018","journal-title":"Tuberculosis"},{"key":"10.1016\/j.bioorg.2026.109510_bb0035","doi-asserted-by":"crossref","first-page":"474","DOI":"10.1016\/j.meegid.2016.09.004","article-title":"Overview on mechanisms of isoniazid action and resistance in Mycobacterium tuberculosis","volume":"45","author":"Unissa","year":"2016","journal-title":"Infect. Genet. Evol."},{"key":"10.1016\/j.bioorg.2026.109510_bb0040","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejmech.2021.113668","article-title":"Design and synthesis of 2-(2-isonicotinoylhydrazineylidene)propanamides as InhA inhibitors with high antitubercular activity","volume":"223","author":"Pfl\u00e9gr","year":"2021","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.bioorg.2026.109510_bb0045","doi-asserted-by":"crossref","first-page":"20903","DOI":"10.1021\/acs.jmedchem.5c01100","article-title":"Scaffold hopping in tuberculosis drug discovery: principles, applications, and case studies","volume":"68","author":"Kovar","year":"2025","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.bioorg.2026.109510_bb0050","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1016\/j.ejmech.2017.04.002","article-title":"Isoniazid derivatives and their anti-tubercular activity","volume":"133","author":"Hu","year":"2017","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.bioorg.2026.109510_bb0055","doi-asserted-by":"crossref","DOI":"10.1016\/j.bioorg.2020.104189","article-title":"Design, synthesis and biological evaluation of novel (E)-N-phenyl-4-(pyridine-acylhydrazone) benzamide derivatives as potential antitumor agents for the treatment of multiple myeloma (MM)","volume":"103","author":"Li","year":"2020","journal-title":"Bioorg. Chem."},{"key":"10.1016\/j.bioorg.2026.109510_bb0060","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1002\/cmdc.201900716","article-title":"Design, synthesis, and pharmacological evaluation of first-in-class multitarget N-acylhydrazone derivatives as selective HDAC6\/8 and PI3K\u03b1 inhibitors","volume":"15","author":"Rodrigues","year":"2020","journal-title":"ChemMedChem"},{"key":"10.1016\/j.bioorg.2026.109510_bb0065","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1016\/j.ejmech.2014.04.077","article-title":"Design, synthesis and biological evaluation of novel isoniazid derivatives with potent antitubercular activity","volume":"81","author":"Martins","year":"2014","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.bioorg.2026.109510_bb0070","doi-asserted-by":"crossref","first-page":"1002","DOI":"10.1021\/acsmedchemlett.8b00247","article-title":"Discovery of a biologically active bromodomain inhibitor by target-directed dynamic combinatorial chemistry","volume":"9","author":"Garc\u00eda","year":"2018","journal-title":"ACS Med. Chem. Lett."},{"key":"10.1016\/j.bioorg.2026.109510_bb0075","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0324608","article-title":"5-(3,5-dinitrophenyl)-1,3,4-oxadiazol-2-amine derivatives, their precursors, and analogues: synthesis and evaluation of novel highly potent antitubercular agent","volume":"20","author":"Pflegr","year":"2025","journal-title":"PLoS ONE"},{"key":"10.1016\/j.bioorg.2026.109510_bb0080","doi-asserted-by":"crossref","DOI":"10.1371\/journal.ppat.1000645","article-title":"High content screening identifies decaprenyl-phosphoribose 2\u2032 epimerase as a target for intracellular antimycobacterial inhibitors","volume":"5","author":"Christophe","year":"2009","journal-title":"PLoS Pathog."},{"key":"10.1016\/j.bioorg.2026.109510_bb0085","doi-asserted-by":"crossref","first-page":"2362","DOI":"10.1021\/acs.jmedchem.5b00608","article-title":"Development of 3,5-dinitrobenzylsulfanyl-1,3,4-oxadiazoles and thiadiazoles as selective antitubercular agents active against replicating and nonreplicating Mycobacterium tuberculosis","volume":"59","author":"Karabanovich","year":"2016","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.bioorg.2026.109510_bb0090","doi-asserted-by":"crossref","first-page":"324","DOI":"10.1016\/j.ejmech.2014.05.069","article-title":"1-substituted-5-[(3,5-dinitrobenzyl)sulfanyl]-1H-tetrazoles and their isosteric analogs: a new class of selective antitubercular agents active against drug-susceptible and multidrug-resistant mycobacteria","volume":"82","author":"Karabanovich","year":"2014","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.bioorg.2026.109510_bb0095","doi-asserted-by":"crossref","first-page":"267","DOI":"10.2217\/fmb-2021-0119","article-title":"3,5-dinitrobenzoylhydrazone derivatives as a scaffold for antituberculosis drug development","volume":"17","author":"Valverde","year":"2022","journal-title":"Future Microbiol."},{"key":"10.1016\/j.bioorg.2026.109510_bb0100","doi-asserted-by":"crossref","DOI":"10.1002\/slct.202501301","article-title":"Exploration of pyridine-4-hydrazide derivatives as promising antitubercular agents: synthesis, biological evaluation, and in silico studies","volume":"10","author":"Kumar","year":"2025","journal-title":"ChemistrySelect"},{"key":"10.1016\/j.bioorg.2026.109510_bb0105","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1016\/S0021-9258(18)64849-5","article-title":"A simple method for the isolation and purification of total lipides from animal tissues","volume":"226","author":"Folch","year":"1957","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bioorg.2026.109510_bb0110","doi-asserted-by":"crossref","first-page":"1042","DOI":"10.1128\/AAC.43.5.1042","article-title":"Antimycobacterial activities of isoxyl and new derivatives through the inhibition of mycolic acid synthesis","volume":"43","author":"Phetsuksiri","year":"1999","journal-title":"Antimicrob. Agents Chemother."},{"key":"10.1016\/j.bioorg.2026.109510_bb0115","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1046\/j.1365-2958.2002.03162.x","article-title":"Overexpression of inhA, but not kasA, confers resistance to isoniazid and ethionamide in Mycobacterium smegmatis, M. bovis BCG and M. tuberculosis","volume":"46","author":"Larsen","year":"2002","journal-title":"Mol. Microbiol."},{"key":"10.1016\/j.bioorg.2026.109510_bb0120","doi-asserted-by":"crossref","first-page":"1805","DOI":"10.3390\/ijms19061805","article-title":"Inter-individual variability in acute toxicity of R-pulegone and R-menthofuran in human liver slices and their influence on miRNA expression changes in comparison to acetaminophen","volume":"19","author":"Zarybnicky","year":"2018","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.bioorg.2026.109510_bb0125","doi-asserted-by":"crossref","first-page":"1223","DOI":"10.1046\/j.1365-2958.1998.00774.x","article-title":"Mechanisms involved in the intrinsic isoniazid resistance of Mycobacterium avium","volume":"27","author":"Mdluli","year":"1998","journal-title":"Mol. Microbiol."},{"key":"10.1016\/j.bioorg.2026.109510_bb0130","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1124\/pharmrev.123.000863","article-title":"Halogenated antimicrobial agents to combat drug-resistant pathogens","volume":"76","author":"Faleye","year":"2023","journal-title":"Pharmacol. Rev."},{"key":"10.1016\/j.bioorg.2026.109510_bb0135","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/S0169-409X(00)00129-0","article-title":"Experimental and computational approaches to estimate solubility and permeability in drug discovery and development settings","volume":"46","author":"Lipinski","year":"2001","journal-title":"Adv. Drug Deliv. Rev."},{"key":"10.1016\/j.bioorg.2026.109510_bb0140","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1038\/358591a0","article-title":"The catalase-peroxidase gene and isoniazid resistance of mycobacterium tuberculosis","volume":"358","author":"Zhang","year":"1992","journal-title":"Nature"}],"container-title":["Bioorganic Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0045206826000465?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0045206826000465?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,2,2]],"date-time":"2026-02-02T21:16:36Z","timestamp":1770066996000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0045206826000465"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,3]]},"references-count":28,"alternative-id":["S0045206826000465"],"URL":"https:\/\/doi.org\/10.1016\/j.bioorg.2026.109510","relation":{},"ISSN":["0045-2068"],"issn-type":[{"value":"0045-2068","type":"print"}],"subject":[],"published":{"date-parts":[[2026,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"4-[(Aryloylhydrazineylidene)methyl]-N-phenylbenzamides as a new class of antimycobacterial agents: design, synthesis and biological evaluation","name":"articletitle","label":"Article Title"},{"value":"Bioorganic Chemistry","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bioorg.2026.109510","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Author(s). Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"109510"}}