{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T21:56:40Z","timestamp":1792792600086,"version":"4.5.0"},"reference-count":53,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Bioorganic Chemistry"],"published-print":{"date-parts":[[2026,3]]},"DOI":"10.1016\/j.bioorg.2026.109533","type":"journal-article","created":{"date-parts":[[2026,1,21]],"date-time":"2026-01-21T15:55:04Z","timestamp":1769010904000},"page":"109533","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":4,"special_numbering":"C","title":["Dancing with KAT6A: Current advances and therapeutic potential in oncology of KAT6A inhibitors"],"prefix":"10.1016","volume":"170","author":[{"given":"Zhuo","family":"Xi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jin","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoxue","family":"Ge","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongyan","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yawen","family":"Ma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bioorg.2026.109533_bb0005","doi-asserted-by":"crossref","first-page":"646","DOI":"10.1016\/j.cell.2011.02.013","article-title":"Hallmarks of cancer: the next generation","volume":"144","author":"Hanahan","year":"2011","journal-title":"Cell"},{"key":"10.1016\/j.bioorg.2026.109533_bb0010","doi-asserted-by":"crossref","first-page":"723","DOI":"10.1016\/j.tcb.2018.04.006","article-title":"Two-step senescence-focused Cancer therapies","volume":"28","author":"Sieben","year":"2018","journal-title":"Trends Cell Biol."},{"key":"10.1016\/j.bioorg.2026.109533_bb0015","first-page":"426","article-title":"The chemistry of senescence, nature reviews","volume":"3","author":"Lozano-Torres","year":"2019","journal-title":"Chemistry"},{"key":"10.1016\/j.bioorg.2026.109533_bb0020","doi-asserted-by":"crossref","DOI":"10.3389\/fonc.2021.740002","article-title":"Palbociclib induces senescence in melanoma and breast Cancer cells and leads to additive growth arrest in combination with irradiation","volume":"11","author":"Jost","year":"2021","journal-title":"Front. Oncol."},{"key":"10.1016\/j.bioorg.2026.109533_bb0025","first-page":"1191","article-title":"Discovery of a highly potent, selective, orally bioavailable inhibitor of KAT6A\/B histone acetyltransferases with efficacy against KAT6A-high ER+ breast cancer, cell","volume":"30","author":"Sharma","year":"2023","journal-title":"Chem. Biol."},{"key":"10.1016\/j.bioorg.2026.109533_bb0030","doi-asserted-by":"crossref","first-page":"1175","DOI":"10.1101\/gad.1382606","article-title":"Monocytic leukemia zinc finger protein is essential for the development of long-term reconstituting hematopoietic stem cells","volume":"20","author":"Thomas","year":"2006","journal-title":"Genes Dev."},{"key":"10.1016\/j.bioorg.2026.109533_bb0035","doi-asserted-by":"crossref","first-page":"2307","DOI":"10.1182\/blood-2015-10-676072","article-title":"MOZ (KAT6A) is essential for the maintenance of classically defined adult hematopoietic stem cells","volume":"128","author":"Sheikh","year":"2016","journal-title":"Blood"},{"key":"10.1016\/j.bioorg.2026.109533_bb0040","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/j.exphem.2016.10.006","article-title":"MOZ and BMI1 act synergistically to maintain hematopoietic stem cells","volume":"47","author":"Sheikh","year":"2017","journal-title":"Exp. Hematol."},{"key":"10.1016\/j.bioorg.2026.109533_bb0045","first-page":"1818","article-title":"MOZ and MORF acetyltransferases: molecular interaction, animal development and human disease","volume":"2015","author":"Yang","year":"1853","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.bioorg.2026.109533_bb0050","doi-asserted-by":"crossref","first-page":"1910","DOI":"10.1182\/blood-2014-08-594655","article-title":"MOZ regulates B-cell progenitors and, consequently, Moz haploinsufficiency dramatically retards MYC-induced lymphoma development","volume":"125","author":"Sheikh","year":"2015","journal-title":"Blood"},{"key":"10.1016\/j.bioorg.2026.109533_bb0055","doi-asserted-by":"crossref","first-page":"5807","DOI":"10.1038\/onc.2015.33","article-title":"MOZ (MYST3, KAT6A) inhibits senescence via the INK4A-ARF pathway","volume":"34","author":"Sheikh","year":"2015","journal-title":"Oncogene"},{"key":"10.1016\/j.bioorg.2026.109533_bb0060","doi-asserted-by":"crossref","first-page":"6278","DOI":"10.7150\/thno.57455","article-title":"KAT6A, a novel regulator of \u03b2-catenin, promotes tumorigenicity and chemoresistance in ovarian cancer by acetylating COP1","volume":"11","author":"Liu","year":"2021","journal-title":"Theranostics"},{"key":"10.1016\/j.bioorg.2026.109533_bb0065","doi-asserted-by":"crossref","first-page":"D506","DOI":"10.1093\/nar\/gky1049","volume":"47","year":"2019","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.bioorg.2026.109533_bb0070","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1002\/humu.22932","article-title":"Boerwinkle, dbNSFP v3.0: a one-stop database of functional predictions and annotations for human nonsynonymous and splice-site SNVs","volume":"37","author":"Liu","year":"2016","journal-title":"Hum. Mutat."},{"key":"10.1016\/j.bioorg.2026.109533_bb0075","doi-asserted-by":"crossref","first-page":"894","DOI":"10.1002\/humu.21517","article-title":"dbNSFP: a lightweight database of human nonsynonymous SNPs and their functional predictions","volume":"32","author":"Liu","year":"2011","journal-title":"Hum. Mutat."},{"key":"10.1016\/j.bioorg.2026.109533_bb0080","doi-asserted-by":"crossref","first-page":"2242","DOI":"10.1038\/s41591-024-03060-0","article-title":"Inhibition of lysine acetyltransferase KAT6 in ER(+)HER2(\u2212) metastatic breast cancer: a phase 1 trial","volume":"30","author":"Mukohara","year":"2024","journal-title":"Nat. Med."},{"key":"10.1016\/j.bioorg.2026.109533_bb0085","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1186\/s13045-024-01610-0","article-title":"The small inhibitor WM-1119 effectively targets KAT6A-rearranged AML, but not KMT2A-rearranged AML, despite shared KAT6 genetic dependency","volume":"17","author":"Sheridan","year":"2024","journal-title":"J. Hematol. Oncol."},{"key":"10.1016\/j.bioorg.2026.109533_bb0090","doi-asserted-by":"crossref","first-page":"1002","DOI":"10.1021\/acs.jmedchem.4c02613","article-title":"Targeting KAT6A\/B as a new therapeutic strategy for Cancer therapy","volume":"68","author":"Zheng","year":"2025","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.bioorg.2026.109533_bb0095","doi-asserted-by":"crossref","first-page":"574","DOI":"10.1093\/nar\/gkac1188","article-title":"The histone acetyltransferase KAT6A is recruited to unmethylated CpG islands via a DNA binding winged helix domain","volume":"51","author":"Weber","year":"2023","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.bioorg.2026.109533_bb0100","doi-asserted-by":"crossref","first-page":"1115903","DOI":"10.3389\/fcell.2022.1115903","article-title":"The MOZ-BRPF1 acetyltransferase complex in epigenetic crosstalk linked to gene regulation, development, and human diseases","volume":"10","author":"Viita","year":"2022","journal-title":"Front. Cell Dev. Biol."},{"key":"10.1016\/j.bioorg.2026.109533_bb0105","doi-asserted-by":"crossref","first-page":"472","DOI":"10.1093\/nar\/gkv1321","article-title":"Bivalent interaction of the PZP domain of BRPF1 with the nucleosome impacts chromatin dynamics and acetylation","volume":"44","author":"Klein","year":"2016","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.bioorg.2026.109533_bb0110","doi-asserted-by":"crossref","first-page":"4724","DOI":"10.1038\/s41467-019-12551-5","article-title":"Histone H3K23-specific acetylation by MORF is coupled to H3K14 acylation","volume":"10","author":"Klein","year":"2019","journal-title":"Nat. Commun."},{"key":"10.1016\/j.bioorg.2026.109533_bb0115","article-title":"Modulation of the substrate preference of a MYST acetyltransferase by a scaffold protein","volume":"301","author":"Sengupta","year":"2025","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bioorg.2026.109533_bb0120","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1038\/s41420-025-02730-3","article-title":"BRPF1 in cancer epigenetics: a key regulator of histone acetylation and a promising therapeutic target","volume":"11","author":"Alexandrova","year":"2025","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.bioorg.2026.109533_bb0125","doi-asserted-by":"crossref","first-page":"4068","DOI":"10.3390\/cancers14174068","article-title":"BRPF1-KAT6A\/KAT6B complex: molecular structure, biological function and human disease","volume":"14","author":"Zu","year":"2022","journal-title":"Cancers (Basel)"},{"key":"10.1016\/j.bioorg.2026.109533_bb0130","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1038\/ng0996-33","article-title":"The translocation t(8;16)(p11;p13) of acute myeloid leukaemia fuses a putative acetyltransferase to the CREB\u2013binding protein","volume":"14","author":"Borrow","year":"1996","journal-title":"Nat. Genet."},{"key":"10.1016\/j.bioorg.2026.109533_bb0135","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1002\/gcc.10137","article-title":"Genomic characterization of MOZ\/CBP and CBP\/MOZ chimeras in acute myeloid leukemia suggests the involvement of a damage-repair mechanism in the origin of the t(8;16)(p11;p13)","volume":"36","author":"Panagopoulos","year":"2003","journal-title":"Genes Chromosom. Cancer"},{"key":"10.1016\/j.bioorg.2026.109533_bb0140","doi-asserted-by":"crossref","first-page":"644","DOI":"10.1016\/j.neo.2014.07.007","article-title":"KAT6A, a chromatin modifier from the 8p11-p12 amplicon is a candidate oncogene in luminal breast cancer","volume":"16","author":"Turner-Ivey","year":"2014","journal-title":"Neoplasia"},{"key":"10.1016\/j.bioorg.2026.109533_bb0145","doi-asserted-by":"crossref","first-page":"6190","DOI":"10.1158\/0008-5472.CAN-17-1388","article-title":"Histone acetyltransferase KAT6A upregulates PI3K\/AKT signaling through TRIM24 binding","volume":"77","author":"Lv","year":"2017","journal-title":"Cancer Res."},{"key":"10.1016\/j.bioorg.2026.109533_bb0150","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1186\/s13287-021-02164-5","article-title":"KAT6A regulates stemness of aging bone marrow-derived mesenchymal stem cells through Nrf2\/ARE signaling pathway","volume":"12","author":"Fei","year":"2021","journal-title":"Stem Cell Res. Ther."},{"key":"10.1016\/j.bioorg.2026.109533_bb0155","article-title":"Combined inhibition of KAT6A\/B and Menin reverses estrogen receptor-driven gene expression programs in breast cancer","volume":"6","author":"Olsen","year":"2025","journal-title":"Cell Rep. Med."},{"key":"10.1016\/j.bioorg.2026.109533_bb0160","doi-asserted-by":"crossref","first-page":"26935","DOI":"10.1038\/s41598-024-78432-0","article-title":"ER\u03b1 status of invasive ductal breast carcinoma as a result of regulatory interactions between lysine deacetylases KAT6A and KAT6B","volume":"14","author":"Olbromski","year":"2024","journal-title":"Sci. Rep."},{"key":"10.1016\/j.bioorg.2026.109533_bb0165","doi-asserted-by":"crossref","first-page":"36603","DOI":"10.1074\/jbc.M705812200","article-title":"The human monocytic leukemia zinc finger histone acetyltransferase domain contains DNA-binding activity implicated in chromatin targeting","volume":"282","author":"Holbert","year":"2007","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bioorg.2026.109533_bb0170","doi-asserted-by":"crossref","first-page":"5731","DOI":"10.21873\/anticanres.16080","article-title":"The expression of histone acetyltransferase KAT6A in non-small cell lung Cancer","volume":"42","author":"Partynska","year":"2022","journal-title":"Anticancer Res."},{"key":"10.1016\/j.bioorg.2026.109533_bb0175","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1002\/pbc.26450","article-title":"FISH identifies a KAT6A\/CREBBP fusion caused by a cryptic insertional t(8;16) in a case of spontaneously remitting congenital acute myeloid leukemia with a normal karyotype","volume":"64","author":"Barrett","year":"2017","journal-title":"Pediatr. Blood Cancer"},{"key":"10.1016\/j.bioorg.2026.109533_bb0180","doi-asserted-by":"crossref","first-page":"314","DOI":"10.1182\/blood-2016-04-712075","article-title":"Acute myeloid leukemia with erythrophagocytosis indicative of KAT6A rearrangement","volume":"128","author":"Montewis","year":"2016","journal-title":"Blood"},{"key":"10.1016\/j.bioorg.2026.109533_bb0185","doi-asserted-by":"crossref","DOI":"10.1097\/MD.0000000000034258","article-title":"KAT6A::EP300 fusion in congenital myeloid sarcoma: yet another novel molecular marker indicating spontaneous remission?: a case report","volume":"102","author":"Hosahalli Vasanna","year":"2023","journal-title":"Medicine (Baltimore)"},{"key":"10.1016\/j.bioorg.2026.109533_bb0190","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1021\/ci300461a","article-title":"Broad coverage of commercially available lead-like screening space with fewer than 350,000 compounds","volume":"53","author":"Baell","year":"2013","journal-title":"J. Chem. Inf. Model."},{"key":"10.1016\/j.bioorg.2026.109533_bb0195","doi-asserted-by":"crossref","first-page":"1196","DOI":"10.1177\/1087057111421631","article-title":"An efficient high-throughput screening method for MYST family acetyltransferases, a new class of epigenetic drug targets","volume":"16","author":"Falk","year":"2011","journal-title":"SLAS Discovery"},{"key":"10.1016\/j.bioorg.2026.109533_bb0200","doi-asserted-by":"crossref","first-page":"7146","DOI":"10.1021\/acs.jmedchem.9b00665","article-title":"Discovery of Benzoylsulfonohydrazides as potent inhibitors of the histone acetyltransferase KAT6A","volume":"62","author":"Leaver","year":"2019","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.bioorg.2026.109533_bb0205","doi-asserted-by":"crossref","first-page":"4655","DOI":"10.1021\/acs.jmedchem.9b02071","article-title":"Discovery of acylsulfonohydrazide-derived inhibitors of the lysine acetyltransferase, KAT6A, as potent senescence-inducing anti-cancer agents","volume":"vol. 63","author":"Priebbenow","year":"2020","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.bioorg.2026.109533_bb0210","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1038\/s41586-018-0387-5","article-title":"Inhibitors of histone acetyltransferases KAT6A\/B induce senescence and arrest tumour growth","volume":"560","author":"Baell","year":"2018","journal-title":"Nature"},{"key":"10.1016\/j.bioorg.2026.109533_bb0215","doi-asserted-by":"crossref","first-page":"929","DOI":"10.1038\/nrd3287","article-title":"The effect of plasma protein binding on in vivo efficacy: misconceptions in drug discovery","volume":"9","author":"Smith","year":"2010","journal-title":"Nat. Rev. Drug Discov."},{"key":"10.1016\/j.bioorg.2026.109533_bb0220","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejmech.2023.115770","article-title":"Discovery of N-(2-oxoethyl) sulfanilamide-derived inhibitors of KAT6A (MOZ) against leukemia by an isostere strategy","volume":"260","author":"Duan","year":"2023","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.bioorg.2026.109533_bb0225","doi-asserted-by":"crossref","DOI":"10.1016\/j.bmcl.2024.129948","article-title":"Identification of triazolyl KAT6 inhibitors via a templated fragment approach","volume":"113","author":"Chen","year":"2024","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"10.1016\/j.bioorg.2026.109533_bb0230","first-page":"1","article-title":"Introduction to fragment-based drug discovery","volume":"317","author":"Erlanson","year":"2012","journal-title":"Top. Curr. Chem."},{"key":"10.1016\/j.bioorg.2026.109533_bb0235","doi-asserted-by":"crossref","first-page":"4309","DOI":"10.3390\/molecules24234309","article-title":"Concepts and Core principles of fragment-based drug design","volume":"24","author":"Kirsch","year":"2019","journal-title":"Molecules"},{"key":"10.1016\/j.bioorg.2026.109533_bb0240","doi-asserted-by":"crossref","first-page":"3761","DOI":"10.1002\/1878-0261.13277","article-title":"Fragment-based drug discovery-the importance of high-quality molecule libraries","volume":"16","author":"Bon","year":"2022","journal-title":"Mol. Oncol."},{"key":"10.1016\/j.bioorg.2026.109533_bb0245","doi-asserted-by":"crossref","first-page":"19282","DOI":"10.1021\/acs.jmedchem.4c01709","article-title":"Discovery and characterization of BAY-184: a new potent and selective Acylsulfonamide-Benzofuran in vivo-active KAT6AB inhibitor","volume":"67","author":"Ter Laak","year":"2024","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.bioorg.2026.109533_bb0250","doi-asserted-by":"crossref","first-page":"2091","DOI":"10.1021\/jm5019093","article-title":"PAINS in the assay: chemical mechanisms of assay interference and promiscuous enzymatic inhibition observed during a sulfhydryl-scavenging HTS","volume":"58","author":"Dahlin","year":"2015","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.bioorg.2026.109533_bb0255","series-title":"Methods in Enzymology","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1016\/bs.mie.2016.01.016","article-title":"Chapter six - in vitro activity assays for MYST histone acetyltransferases and adaptation for high-throughput inhibitor screening","author":"McCullough","year":"2016"},{"key":"10.1016\/j.bioorg.2026.109533_bb0260","doi-asserted-by":"crossref","first-page":"1739","DOI":"10.1021\/jm0306430","article-title":"Glide: a new approach for rapid, accurate docking and scoring. 1. Method and assessment of docking accuracy","volume":"47","author":"Friesner","year":"2004","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.bioorg.2026.109533_bb0265","doi-asserted-by":"crossref","first-page":"1750","DOI":"10.1021\/jm030644s","article-title":"Glide: a new approach for rapid, accurate docking and scoring. 2. Enrichment factors in database screening","volume":"47","author":"Halgren","year":"2004","journal-title":"J. Med. Chem."}],"container-title":["Bioorganic Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0045206826000696?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0045206826000696?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,2,2]],"date-time":"2026-02-02T21:14:32Z","timestamp":1770066872000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0045206826000696"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,3]]},"references-count":53,"alternative-id":["S0045206826000696"],"URL":"https:\/\/doi.org\/10.1016\/j.bioorg.2026.109533","relation":{},"ISSN":["0045-2068"],"issn-type":[{"value":"0045-2068","type":"print"}],"subject":[],"published":{"date-parts":[[2026,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Dancing with KAT6A: Current advances and therapeutic potential in oncology of KAT6A inhibitors","name":"articletitle","label":"Article Title"},{"value":"Bioorganic Chemistry","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bioorg.2026.109533","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"109533"}}